| ID | 58558 |
| FullText URL |
Table1.xlsx
14.4 KB
Table 2.xlsx
10.7 KB
|
| Author |
Miyake, Tomoko
Department of Dermatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
ORCID
Kaken ID
Iwatsuki, Keiji
Department of Dermatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Hirai, Yoji
Department of Dermatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Yamamoto, Takenobu
Department of Dermatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Hamada, Toshihisa
Department of Dermatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Fujii, Kazuyasu
Department of Dermatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
mamura, Hideaki
Department of Pediatrics, Faculty of Medicine, University of Miyazaki
Morizane, Shin
Department of Dermatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
ORCID
Kaken ID
publons
researchmap
|
| Abstract | Epstein‐Barr virus (EBV) DNA load in the blood increases in posttransplant lymphoproliferative disorders and chronic active EBV infection. In this report, we analyzed the EBV DNA load in the peripheral blood mononuclear cells (PBMCs) and plasma of patients with hydroa vacciniforme (HV) and/or hypersensitivity to mosquito bites (HMB) to understand the clinical significance of EBV DNA load. All 30 patients showed high DNA loads in the PBMCs over the cut‐off level. Of 16 plasma samples, extremely high in two samples obtained from patients with hemophagocytic lymphohistiocytosis (HLH). The amount of cell‐free DNA in plasma was correlated to the serum levels of lactate dehydrogenase and inversely correlated to platelet counts. These results indicate that the EBV DNA load in PBMCs can provide one of the diagnostic indicators for HV and HMB and marked elevation of cell‐free EBV DNA in plasma might be related to cytolysis such as that observed in HLH.
|
| Keywords | Epstein-Barr Virus DNA load
hydroa vaccniforme
hypersensitivity to mosquito bite
hemophagocytic lymphohistiocytosis
|
| Note | This fulltext is available in Apr. 2021.
|
| Published Date | 2020-04-07
|
| Publication Title |
Journal of Medical Virology
|
| Volume | volume92
|
| Issue | issue12
|
| Publisher | Wiley
|
| Start Page | 3689
|
| End Page | 3696
|
| ISSN | 01466615
|
| NCID | AA00702400
|
| Content Type |
Journal Article
|
| language |
English
|
| OAI-PMH Set |
岡山大学
|
| File Version | author
|
| PubMed ID | |
| DOI | |
| Web of Science KeyUT | |
| Related Url | isVersionOf https://doi.org/10.1002/jmv.25811
|
| Funder Name |
Ministry of Education, Culture, Sports, Science and Technology
Japan Agency for Medical Research and Development
|
| 助成番号 | 15k09744
17K16431
18K16063
17ek0109098
17ek0109124
|
