The aim of the measurement of Epstein‐Barr virus DNA in hydroa vacciniforme and hypersensitivity to mosquito bites

Miyake, Tomoko; Iwatsuki, Keiji; Hirai, Yoji; Yamamoto, Takenobu; Hamada, Toshihisa; Fujii,  Kazuyasu; mamura, Hideaki; Morizane, Shin

doi:10.1002/jmv.25811

Permalink : https://ousar.lib.okayama-u.ac.jp/58558

ID	58558
フルテキストURL	fulltext.pdf 379 KB ( 限定公開 ) Table1.xlsx 14.4 KB Table 2.xlsx 10.7 KB Fig1.tif 2.64 MB Fig2.tif 2.64 MB Fig3.tif 2.64 MB
著者	Miyake, Tomoko Department of Dermatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University ORCID Kaken ID Iwatsuki, Keiji Department of Dermatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Hirai, Yoji Department of Dermatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Yamamoto, Takenobu Department of Dermatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Hamada, Toshihisa Department of Dermatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Fujii, Kazuyasu Department of Dermatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University mamura, Hideaki Department of Pediatrics, Faculty of Medicine, University of Miyazaki Morizane, Shin Department of Dermatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University ORCID Kaken ID publons researchmap
抄録	Epstein‐Barr virus (EBV) DNA load in the blood increases in posttransplant lymphoproliferative disorders and chronic active EBV infection. In this report, we analyzed the EBV DNA load in the peripheral blood mononuclear cells (PBMCs) and plasma of patients with hydroa vacciniforme (HV) and/or hypersensitivity to mosquito bites (HMB) to understand the clinical significance of EBV DNA load. All 30 patients showed high DNA loads in the PBMCs over the cut‐off level. Of 16 plasma samples, extremely high in two samples obtained from patients with hemophagocytic lymphohistiocytosis (HLH). The amount of cell‐free DNA in plasma was correlated to the serum levels of lactate dehydrogenase and inversely correlated to platelet counts. These results indicate that the EBV DNA load in PBMCs can provide one of the diagnostic indicators for HV and HMB and marked elevation of cell‐free EBV DNA in plasma might be related to cytolysis such as that observed in HLH.
キーワード	Epstein-Barr Virus DNA load hydroa vaccniforme hypersensitivity to mosquito bite hemophagocytic lymphohistiocytosis
備考	This fulltext is available in Apr. 2021.
発行日	2020-04-07
出版物タイトル	Journal of Medical Virology
巻	92巻
号	12号
出版者	Wiley
開始ページ	3689
終了ページ	3696
ISSN	01466615
NCID	AA00702400
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	32255500
DOI	10.1002/jmv.25811
Web of Science KeyUT	000528227700001
関連URL	isVersionOf https://doi.org/10.1002/jmv.25811
助成機関名	文部科学省 Japan Agency for Medical Research and Development
助成番号	15k09744 17K16431 18K16063 17ek0109098 17ek0109124