FullText URL ijo_51_2_625.pdf
Author Takada, Hiroyuki| Ibaragi, Soichiro| Eguchi, Takanori| Okui, Tatsuo| Obata, Kyoichi| Masui, Masanori| Morisawa, Ayaka| Takabatake, Kiyofumi| Kawai, Hotaka| Yoshioka, Norie| Nur Mohammad Monsur Hassan| Shimo, Tsuyoshi| Hu, Guo-Fu| Nagatsuka, Hitoshi| Sasaki, Akira|
Abstract Head and neck squamous cell carcinomas (HNSCCs) frequently invade the bones of the facial skeleton. Semaphorin 4D (Sema4D) is an axon guidance molecule produced by oligodendrocytes. Sema4D was also identified in the bone microenvironment and many cancer tissues including HNSCC. To date, however, the role of Sema4D in cancer-associated bone disease is still unknown. This is the first study to demonstrate the role of Sema4D in bone invasion of cancer. In the clinical tissue samples of bone lesion of HNSCC, Sema4D was detected at high levels, and its expression was correlated with insulin-like growth factor-I (IGF-I) expression. In vitro experiments showed that IGF-I regulates Sema4D expression and Sema4D increased proliferation, migration and invasion in HNSCC cells. Sema4D also regulated the expression of receptor activator of nuclear factor κβ ligand (RANKL) in osteoblasts, and this stimulated osteoclastgenesis. Furthermore, knockdown of Sema4D in HNSCC cells inhibited tumor growth and decreased the number of osteoclasts in a mouse xenograft model. Taken together, IGF-I-driven production of Sema4D in HNSCCs promotes osteoclastogenesis and bone invasion.
Note This is an article published by Spandidos Publications
Published Date 2017-06-21
Publication Title International Journal of Oncology
Volume volume51
Issue issue2
Publisher Spandidos Publications
Start Page 625
End Page 632
ISSN 1019-6439
NCID AA10992511
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version publisher
PubMed ID 28656278
DOI 10.3892/ijo.2017.4050
Web of Sience KeyUT 000405642300025
Related Url isVersionOf https://doi.org/10.3892/ijo.2017.4050