フルテキストURL ijo_51_2_625.pdf
著者 Takada, Hiroyuki| Ibaragi, Soichiro| Eguchi, Takanori| Okui, Tatsuo| Obata, Kyoichi| Masui, Masanori| Morisawa, Ayaka| Takabatake, Kiyofumi| Kawai, Hotaka| Yoshioka, Norie| Nur Mohammad Monsur Hassan| Shimo, Tsuyoshi| Hu, Guo-Fu| Nagatsuka, Hitoshi| Sasaki, Akira|
抄録 Head and neck squamous cell carcinomas (HNSCCs) frequently invade the bones of the facial skeleton. Semaphorin 4D (Sema4D) is an axon guidance molecule produced by oligodendrocytes. Sema4D was also identified in the bone microenvironment and many cancer tissues including HNSCC. To date, however, the role of Sema4D in cancer-associated bone disease is still unknown. This is the first study to demonstrate the role of Sema4D in bone invasion of cancer. In the clinical tissue samples of bone lesion of HNSCC, Sema4D was detected at high levels, and its expression was correlated with insulin-like growth factor-I (IGF-I) expression. In vitro experiments showed that IGF-I regulates Sema4D expression and Sema4D increased proliferation, migration and invasion in HNSCC cells. Sema4D also regulated the expression of receptor activator of nuclear factor κβ ligand (RANKL) in osteoblasts, and this stimulated osteoclastgenesis. Furthermore, knockdown of Sema4D in HNSCC cells inhibited tumor growth and decreased the number of osteoclasts in a mouse xenograft model. Taken together, IGF-I-driven production of Sema4D in HNSCCs promotes osteoclastogenesis and bone invasion.
備考 This is an article published by Spandidos Publications
発行日 2017-06-21
出版物タイトル International Journal of Oncology
51巻
2号
出版者 Spandidos Publications
開始ページ 625
終了ページ 632
ISSN 1019-6439
NCID AA10992511
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン publisher
PubMed ID 28656278
DOI 10.3892/ijo.2017.4050
Web of Sience KeyUT 000405642300025
関連URL isVersionOf https://doi.org/10.3892/ijo.2017.4050