Author Inada, Ryo| Nagasaka, Takeshi| Mori, Yoshiko| Umeda, Yuzo| Kubota, Nobuhito| Morikawa, Tatsuya| Kondo, Yoshitaka| Uno, Futoshi| Sadamori, Yu| Yagi, Takahito| Fujiwara, Toshiyoshi|
Published Date 2013-04-01
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/49671
FullText URL 67_2_117.pdf
Author Sadamori, Hiroshi| Yagi, Takahito| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Sato, Daisuke| Nobuoka, Daisuke| Utsumi, Masashi| Fujiwara, Toshiyoshi|
Abstract We present a case of living donor liver transplantation to a 3-year disease-free survivor of liver resection for hepatocellular carcinoma (HCC) with major portal vein invasion. A 48-year-old man had HCC in the right lobe with a portal venous tumor thrombus extending into the left portal vein. An extended right lobectomy with thrombectomy was performed to remove the thrombus. Three years after liver resection, the patient experienced liver failure, with massive ascites and jaundice due to the formation of a thrombus in the main and left portal veins. During the 3 years after liver resection, no metastasis or recurrence of HCC had been detected, and tumor markers had been within normal ranges. The portal venous thrombus did not show any arterial enhancement under contrast-enhanced computed tomography, suggesting that the co-existence of any HCC component in the portal venous thrombus may have been negative. Based on these findings, living donor liver transplantation was performed using a right lobe graft from the patientʼs son. The patient is alive at 87 months after the transplantation, with no evidence of HCC recurrence.
Keywords living donor liver transplantation hepatocellular carcinoma portal vein invasion liver resection
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2013-04
Volume volume67
Issue issue2
Publisher Okayama University Medical School
Start Page 117
End Page 121
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23603929
Web of Science KeyUT 000317801700007
Author Tanaka, Shigetomi| Shiraha, Hidenori| Nakanishi, Yutaka| Nishina, Shin-Ichi| Matsubara, Minoru| Horiguchi, Shigeru| Takaoka, Nobuyuki| Iwamuro, Masaya| Kataoka, Junro| Kuwaki, Kenji| Hagihara, Hiroaki| Toshimori, Junichi| Ohnishi, Hideki| Takaki, Akinobu| Nakamura, Shinichiro| Nouso, Kazuhiro| Yagi, Takahito| Yamamoto, Kazuhide|
Published Date 2012-12-01
Publication Title International Journal of Cancer
Volume volume131
Issue issue11
Content Type Journal Article
Author Nobuoka, Daisuke| Yoshikawa, Toshiaki| Takahashi, Mari| Iwama, Tatsuaki| Horie, Kazutaka| Shimomura, Manami| Suzuki, Shiro| Sakemura, Noriko| Nakatsugawa, Munehide| Sadamori, Hiroshi| Yagi, Takahito| Fujiwara, Toshiyoshi| Nakatsura, Tetsuya|
Published Date 2013-04
Publication Title Cancer Immunology, Immunotherapy
Volume volume62
Issue issue4
Content Type Journal Article
FullText URL WorldJHepatology_5_4_189-195.pdf
Author Satoh, Daisuke| Yagi, Takahito| Nagasaka, Takeshi| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Utsumi, Masashi| Tanaka, Takehiro| Sadamori, Hiroshi| Fujiwara, Toshiyoshi|
Keywords Non-alcoholic fatty liver disease Pancreatoduodenectomy CD14 Endotoxin Kupffer cells
Published Date 2013-04-27
Publication Title World Journal of Hepatology
Volume volume5
Issue issue4
Start Page 189
End Page 195
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders ©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
File Version publisher
DOI 10.4254/wjh.v5.i4.189
Official Url http://www.wjgnet.com/1948-5182/full/v5/i4/189.htm|
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/51448
JaLCDOI 10.18926/AMO/52898
FullText URL 68_5_291.pdf
Author Tsuzaki, Ryuichiro| Takaki, Akinobu| Yagi, Takahito| Ikeda, Fusao| Koike, Kazuko| Iwasaki, Yoshiaki| Shiraha, Hidenori| Miyake, Yasuhiro| Sadamori, Hiroshi| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Nobuoka, Daisuke| Utsumi, Masashi| Nakayama, Eiichi| Fujiwara, Toshiyoshi| Yamamoto, Kazuhide|
Abstract It is not known how the immune system targets hepatitis C virus (HCV)-infected HLA-mismatched hepatocytes under immune-suppressed conditions after orthotopic liver transplantation (OLT). In addition, the relationship between the HCV-specific immune response and IL28B variants as predictors of HCV clearance has not been well-characterized. We determined the IL28B polymorphisms for 57 post-OLT HCV carriers, and we assessed the HCV-specific immune responses by measuring the peripheral blood mononuclear cell-derived HCV-specific interferon-gamma (IFN-γ) response using an enzyme-linked immunospot assay. At 1-3 years after OLT, patients with no active hepatitis showed higher total spots on the immunospot assay. At>3 years after OLT, patients with resolved HCV showed higher levels of core, NS3, NS5A, and total spots compared to the chronic hepatitis patients. The IL28B major genotype in the donors correlated with higher spot counts for NS5A and NS5B proteins at 1-3 years after OLT. In the post-OLT setting, the HCV-specific immune response could be strongly induced in patients with no active hepatitis with an IL28B major donor or sustained virological response. Strong immune responses in the patients with no active hepatitis could only be maintained for 3 years and diminished later. It may be beneficial to administer IFN treatment starting 3 years after OLT, to induce the maximum immunological effect.
Keywords interferon gamma ELISPOT assay single nucleotide polymorphisms dendritic cell CD4 T cell
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2014-10
Volume volume68
Issue issue5
Publisher Okayama University Medical School
Start Page 291
End Page 302
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25338486
Web of Science KeyUT 000343269300006
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/53129
Author Uchida, Daisuke| Shiraha, Hidenori| Kato, Hironari| Nagahara, Teruya| Iwamuro, Masaya| Kataoka, Junro| Horiguchi, Shigeru| Watanabe, Masami| Takaki, Akinobu| Nouso, Kazuhiro| Nasu, Yasutomo| Yagi, Takahito| Kumon, Hiromi| Yamamoto, Kazuhide|
Published Date 2014-05
Publication Title Journal of Gastroenterology and Hepatology
Volume volume29
Issue issue5
Content Type Journal Article
JaLCDOI 10.18926/AMO/54419
FullText URL 70_3_197.pdf
Author Takagi, Kosei| Yagi, Takahito| Yoshida, Ryuichi| Shinoura, Susumu| Umeda, Yuzo| Nobuoka, Daisuke| Kuise, Takashi| Watanabe, Nobuyuki| Sui, Kenta| Fuji, Tomokazu| Fujiwara, Toshiyoshi|
Abstract The operative mortality and morbidity of pancreaticoduodenectomy (PD) remain high. We analyzed PD patientsʼ clinical characteristics and surgical outcomes and discuss how PD clinical outcomes could be improved. We retrospectively reviewed the cases of 400 patients who underwent a PD between January 1998 and April 2014 at Okayama University Hospital, a very-high-volume center. We identified and compared the clinical outcomes between two time periods (period 1: 1998-2006 vs. period 2: 2007-2014). The total postoperative mortality and major complication rates were 0.75 and 15.8 , respectively, and the median postoperative length of stay (LOS) was 32 days. Subsequently, patients who underwent a PD during period 2 had a significantly shorter LOS than those who underwent a PD during period 1 (29 days vs. 38.5 days, p<0.001). The incidence of mortality and major complications did not differ between the two periods. In our multivariate analysis, period 1 was an independent factor associated with a long LOS (p<0.001). The improvement of the surgical procedure and perioperative care might be related to the shorter LOS in period 2 and ot the consistently maintained low mortality rate after PD. The development of multimodal strategies to accelerate postoperative recovery may further improve PDʼs clinical outcomes.
Keywords pancreaticoduodenectomy surgical outcome mortality major complication length of stay
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2016-06
Volume volume70
Issue issue3
Publisher Okayama University Medical School
Start Page 197
End Page 203
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27339209
Web of Science KeyUT 000379406100007
JaLCDOI 10.18926/AMO/54594
FullText URL 70_5_363.pdf
Author Takagi, Kosei| Yagi, Takahito| Yoshida, Ryuichi| Shinoura, Susumu| Umeda, Yuzo| Nobuoka, Daisuke| Kuise, Takashi| Watanabe, Nobuyuki| Fujiwara, Toshiyoshi|
Abstract Sarcopenia following liver surgery has been reported as a predictor of poor prognosis. Here we investigated predictors of outcomes in patients with hepatocellular carcinoma (HCC) and attempted to establish a new comprehensive preoperative assessment protocol. We retrospectively analyzed the cases of 254 patients who underwent curative hepatectomy for HCC with Child-Pugh classification A at our hospital between January 2007 and December 2013. Sarcopenia was evaluated by computed tomography measurement. The influence of sarcopenia on outcomes was evaluated. We used multivariate analyses to assess the impact of prognostic factors associated with outcomes, including sarcopenia. Of the 254 patients, 118 (46.5%) met the criteria for sarcopenia, and 32 had an American Society of Anesthesiologists (ASA) physical status ≥3. The sarcopenic group had a significantly lower 5-year overall survival rate than the non-sarcopenic group (58.2% vs. 82.4% , p=0.0002). In multivariate analyses of prognostic factors, sarcopenia was an independent predictor of poor survival (hazard ratio [HR]=2.28, p=0.002) and poor ASA status (HR=3.17, p=0.001). Sarcopenia and poor ASA status are independent preoperative predictors for poor outcomes after hepatectomy. The preoperative identification of sarcopenia and ASA status might enable the development of comprehensive approaches to assess surgical eligibility.
Keywords sarcopenia American Society of Anesthesiologists physical status hepatectomy hepatocellular carcinoma prognostic factor
Amo Type Original Articles
Publication Title Acta Medica Okayama
Published Date 2016-10
Volume volume70
Issue issue5
Publisher Okayama University Medical School
Start Page 363
End Page 370
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27777428
Web of Science KeyUT 000388098700005
Author Takagi, Kosei| Yagi, Takahito| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Nobuoka, Daisuke| Watanabe, Nobuyuki| Kuise, Takashi| Fuji, Tomokazu| Araki, Hiroyuki| Fujiwara, Toshiyoshi|
Published Date 2017-02
Publication Title Acta Medica Okayama
Volume volume71
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/54830
FullText URL JGastroenterol_54_11_1019.pdf Table.pdf Figure 1.jpg Figure 2.jpg Figure 3A.tif Figure 3B.tif supplemental figure 1.jpg
Author Matsumoto, Kazuyuki| Ohara, Toshiaki| Fujisawa, Masayoshi| Takaki, Akinobu| Takahara, Masahiro| Tanaka, Noriyuki| Kato, Hironari| Horiguchi, Shigeru| Yoshida, Ryuichi| Umeda, Yuzo| Fushimi, Soichiro| Yagi, Takahito| Matsukawa, Akihiro| Okada, Hiroyuki|
Keywords Immunohistochemistry PD-L1 Pancreatic cancer
Note This fulltext will be available in Apr 2020|
Published Date 2019-04-29
Publication Title Journal of Gastroenterology
Volume volume54
Issue issue11
Start Page 1019
End Page 1028
ISSN 09441174
NCID AA10988015
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31032528
DOI 10.1007/s00535-019-01586-6
Web of Science KeyUT 000492169400008
Related Url isVersionOf https://doi.org/10.1007/s00535-019-01586-6
FullText URL fulltext.pdf
Author Hiroi, Kazumasa| Matsusaki, Takashi| Kaku, Ryuji| Umeda, Yuzo| Yagi, Takahito| Morimatsu, Hiroshi|
Published Date 2019-10-31
Publication Title Transplantation Proceedings
Volume volume51
Issue issue8
Publisher Elsevier
Start Page 2750
End Page 2754
ISSN 00411345
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Authors. Published by Elsevier Inc.
File Version publisher
PubMed ID 31563245
DOI 10.1016/j.transproceed.2019.01.199
Web of Science KeyUT 000490063000048
Related Url isVersionOf https://doi.org/10.1016/j.transproceed.2019.01.199
FullText URL BJC97_6_934.pdf Fig.pdf Table.pdf
Author Yumoto, Yasuhiro| Yagi, Takahito| Sato, Shuhei| Nouso, Kazuhiro| Kobayashi, Yoshiyuki| Ohmoto, Masaki| Yumoto, Eiichiro| Nagaya, Isao| Nakatsukasa, Harushige|
Keywords hepatocellular carcinoma hepatic resection remnant hepatic function fusion image of SPECT and X-ray CT
Note "This is the peer reviewed version of the following article: Preoperative estimation of remnant hepatic function using fusion images obtained by Tc-99m-labelled galactosyl-human serum albumin liver scintigraphy and computed tomography, which has been published in final form at https://doi.org/10.1002/bjs.7025. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."|
Published Date 2010-04-22
Publication Title British Journal of Surgery
Volume volume97
Issue issue6
Publisher Wiley
Start Page 934
End Page 944
ISSN 0007-1323
NCID AA00575132
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 20474004
DOI 10.1002/bjs.7025
Web of Science KeyUT 000278244100022
Related Url isVersionOf https://doi.org/10.1002/bjs.7025
FullText URL fulltext.pdf
Author Ejiri Kentaro| Akagi, Satoshi| Nakamura, Kazufumi| Amioka, Naofumi| Ichikawa, Keishi| Yagi, Takahito| Ito, Hiroshi|
Keywords Rendu-Osler-Weber syndrome arteriovenous malformation pulmonary haemorrhage
Published Date 2019-12-18
Publication Title Pulmonary Circulation
Volume volume9
Issue issue4
Publisher SAGE Publications Inc
ISSN 2045-8932
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2019.
File Version publisher
PubMed ID 31903186
DOI 10.1177/2045894019896677
Web of Science KeyUT 000503484500001
Related Url isVersionOf https://doi.org/10.1177/2045894019896677
FullText URL fulltext.pdf
Author Matsumoto, Naohisa| Matsusaki, Takashi| Hiroi, Kazumasa| Kaku, Ryuji| Yoshida, Ryuichi| Umeda, Yuzo| Yagi, Takahito| Morimatsu, Hiroshi|
Note 11th Congress of the Andalusian-Society-of-Organ-and-Tissue-Transplantation (SATOT)|
Published Date 2020-03-31
Publication Title Transplantation Proceedings
Volume volume52
Issue issue2
Publisher Elsevier
Start Page 630
End Page 633
ISSN 00411345
NCID AA00868957
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors. Published by Elsevier Inc.
File Version publisher
PubMed ID 32029317
DOI 10.1016/j.transproceed.2019.11.032
Web of Science KeyUT 000518473000059
Related Url isVersionOf https://doi.org/10.1016/j.transproceed.2019.11.032
FullText URL fulltext.pdf
Author Takagi, Kosei| Kuise, Takashi| Umeda, Yuzo| Yoshida, Ryuichi| Teraishi, Fuminori| Yagi, Takahito| Fujiwara, Toshiyoshi|
Keywords Laparoscopic Liver Segment seven
Published Date 2020
Publication Title International Journal of Surgery Case Reports
Volume volume73
Publisher Elsevier
Start Page 168
End Page 171
ISSN 2210-2612
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 32688239
DOI 10.1016/j.ijscr.2020.06.107
Web of Science KeyUT 000558775100010
Related Url isVersionOf https://doi.org/10.1016/j.ijscr.2020.06.107
FullText URL fulltext.pdf
Author Kojima, Toru| Umeda, Yuzo| Fuji, Tomokazu| Niguma, Takefumi| Satoh, Daisuke| Endo, Yoshikatsu| Sui, Kenta| Inagaki, Masaru| Oishi, Masahiro| Ota, Tetsuya| Hioki, Katsuyoshi| Matsuda, Tadakazu| Aoki, Hideki| Hirai, Ryuji| Kimura, Masashi| Yagi, Takahito| Fujiwara, Toshiyoshi|
Published Date 2020-09-03
Publication Title PLOS ONE
Volume volume15
Issue issue9
Publisher PUBLIC LIBRARY SCIENCE
Start Page e0238392
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Kojima et al.
File Version publisher
PubMed ID 32881910
DOI 10.1371/journal.pone.0238392
Web of Science KeyUT 000571063300054
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0238392
FullText URL fulltext.pdf
Author Miyamoto, Kazuya| Matsumoto, Kazuyuki| Kato, Hironari| Yoshida, Ryuichi| Umeda, Yuzo| Inoue, Hirohumi| Tanaka, Takehiro| Matsumi, Akihiro| Saragai, Yosuke| Fujii, Yuki| Yamazaki, Tatsuhiro| Uchida, Daisuke| Tomoda, Takeshi| Horiguchi, Shigeru| Yagi, Takahito| Okada, Hiroyuki|
Keywords IPMN PJC LBC BD SurePath
Published Date 2020-09-29
Publication Title BMC Gastroenterology
Volume volume20
Issue issue1
Publisher BMC
Start Page 319
ISSN 1471-230X
NCID AA12034934
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 32993498
DOI 10.1186/s12876-020-01465-y
Web of Science KeyUT 000576989100004
Related Url isVersionOf https://doi.org/10.1186/s12876-020-01465-y
FullText URL fulltext.pdf
Author Takagi, Kosei| Umeda, Yuzo| Kuise, Takashi| Yoshida, Ryuichi| Yoshida, Kazuhiro| Yasui, Kazuya| Tani, Yuma| Yagi, Takahito| Fujiwara, Toshiyoshi|
Keywords Hanging maneuver Laparoscopic Liver resection
Published Date 2020-10-08
Publication Title International Journal of Surgery Case Reports
Volume volume76
Publisher Elsevier
Start Page 251
End Page 253
ISSN 2210-2612
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 33053483
DOI 10.1016/j.ijscr.2020.10.002
Related Url isVersionOf https://doi.org/10.1016/j.ijscr.2020.10.002
FullText URL fulltext.pdf
Author Yoshida, Kazuhiro| Umeda, Yuzo| Iwamuro, Masaya| Matsumoto, Kazuyuki| Kato, Hironari| Uka, Mayu| Matsui, Yusuke| Yoshida, Ryuichi| Kuise, Takashi| Yasui, Kazuya| Takagi, Kosei| Araki, Hiroyuki| Yagi, Takahito| Fujiwara, Toshiyoshi|
Keywords Hemobilia Bile duct resection Hepatectomy Endoscopic balloon tamponade Case report
Published Date 2020-12-01
Publication Title BMC Surgery
Volume volume20
Issue issue1
Publisher BMC
Start Page 307
ISSN 1471-2482
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020.
File Version publisher
PubMed ID 33261613
DOI 10.1186/s12893-020-00981-8
Web of Science KeyUT 000595042700001
Related Url isVersionOf https://doi.org/10.1186/s12893-020-00981-8