ID | 63935 |
FullText URL | |
Author |
Uchida, Haruhito A.
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
Nakajima, Hirofumi
Department of Internal Medicine, Nakashima Hospital
Hashimoto, Masami
Hashimoto Kidney Clinic
Nakamura, Akihiko
Osafune Clinic
Nunoue, Tomokazu
Nunoue Clinic
Murakami, Kazuharu
Murakami Clinic
Hosoya, Takeshi
Hosoya Clinic
Komoto, Kiichi
Innoshima General Hospital
Taguchi, Takashi
Primary Medical Science Department, Daiichi Sankyo Co., Ltd.
Akasaka, Takaaki
Primary Medical Science Department, Daiichi Sankyo Co., Ltd.
Shiosakai, Kazuhito
Data Intelligence Department, Daiichi Sankyo Co., Ltd.
Sugimoto, Kotaro
Primary Medical Science Department, Daiichi Sankyo Co., Ltd.
Wada, Jun
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
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Abstract | Introduction
Clinical data of esaxerenone in hypertensive patients with diabetic kidney disease (DKD) are lacking. We evaluated the efficacy and safety of esaxerenone in patients with DKD and an inadequate response to blood pressure (BP)-lowering treatment. Methods In this multicenter, open-label, prospective study, patients were divided into urinary albumin-to-creatinine ratio subcohorts (UACR < 30, 30 to < 300, and 300 to < 1000 mg/gCr). Esaxerenone was initiated at 1.25 mg/day and followed by incremental dose escalation based on BP and serum potassium level monitoring. The treatment period was 12 weeks. The primary endpoint was change in morning home systolic BP/diastolic BP (SBP/DBP) from baseline to end of treatment (EOT). Secondary endpoints included achievement rate of target BP, change in UACR from baseline, and safety. Results In total, 113 patients were enrolled. Morning home SBP/DBP significantly decreased from baseline to EOT in the total population (− 11.6/− 5.2 mmHg, both p < 0.001) and in all UACR subcohorts (all p < 0.001). The target BP achievement rate was 38.5%. Significant reductions in bedtime home and office BPs were also shown in the total population and all UACR subcohorts. UACR significantly improved from baseline to EOT in the total (− 50.9%, p < 0.001) and all UACR subcohorts (all p < 0.001). Incidence of serum potassium elevation as drug-related treatment emergent adverse events was 2.7%. The change from baseline in estimated glomerular filtration rate (eGFR) was − 4.8 mL/min/1.73 m2. Conclusion Esaxerenone demonstrated a BP-lowering effect and improved albuminuria. The effects were consistent regardless of the severity of albuminuria without clinically relevant serum potassium elevation and eGFR reduction. |
Published Date | 2022-9-7
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Publication Title |
Advances in Therapy
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Publisher | Springer Science and Business Media LLC
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ISSN | 0741-238X
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NCID | AA10703556
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © The Author(s) 2022
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File Version | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
License | https://creativecommons.org/licenses/by-nc/4.0
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Funder Name |
Daiichi Sankyo Company Limited
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