Wada, Jun - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

A Multicenter, Prospective, Observational, and Single-Arm Interventional Study of Mirogabalin in Diabetic Peripheral Neuropathic Pain: Rationale and Design of Dia-NeP

FullText URL	fulltext.pdf
Author	Kamiya, Hideki\| Suzuki, Ryo\| Wada, Jun\| Deguchi, Takahisa\| Himeno, Tatsuhito\| Yamamoto, Shuhei\| Toyama, Taiki\| Nakamura, Jiro\|
Keywords	Diabetic peripheral neuropathic pain Diabetic polyneuropathy Epidemiological survey Exploratory study Mirogabalin Quality of life
Published Date	2025-10-24
Publication Title	Diabetes Therapy
Volume	volume16
Issue	issue12
Publisher	Springer Science and Business Media LLC
Start Page	2351
End Page	2363
ISSN	1869-6953
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	41134469
DOI	10.1007/s13300-025-01809-5
Web of Science KeyUT	001599497600001
Related Url	isVersionOf https://doi.org/10.1007/s13300-025-01809-5

Elucidation of puberulic acid–induced nephrotoxicity using stem cell-based kidney organoids

FullText URL	fulltext.pdf
Author	Nakanoh, Hiroyuki\| Tsuji, Kenji\| Uchida, Naruhiko\| Fukushima, Kazuhiko\| Haraguchi, Soichiro\| Kitamura, Shinji\| Wada, Jun\|
Keywords	Kidney organoid Kidney stem cell Puberulic acid Nephrotoxicity Mitochondrial dysfunction
Published Date	2025-11-26
Publication Title	Scientific Reports
Volume	volume15
Issue	issue1
Publisher	Springer Science and Business Media LLC
Start Page	42195
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	41298719
DOI	10.1038/s41598-025-26155-1
Related Url	isVersionOf https://doi.org/10.1038/s41598-025-26155-1

Missing the Target: A Scoping Review of the Use of Percent Weight Loss for Obesity Management

FullText URL	fulltext.pdf
Author	Sherifali, Diana\| Racey, Megan\| Fitzpatrick‐Lewis, Donna\| Greenway, Michelle\| Sockalingam, Sanjeev\| Wada, Jun\| Teoh, Soo Huat\| Patton, Ian\| Macklin, David\| van Rossum, Elizabeth F. C.\| Busetto, Luca\| Horn, Deborah Bade\| Patricia Nece, J. D.\| Leguede, Morgan Emile Gabriel Salmon\| Pearce, Nicole\| Le Roux, Carel\| Ard, Jamy\| Alberga, Angela S.\| Kaplan, Lee\| Sharma, Arya M.\| Wharton, Sean\|
Keywords	obesity management percent body weight scoping review target weight loss
Published Date	2025-06-03
Publication Title	Obesity Reviews
Volume	volume26
Issue	issue11
Publisher	Wiley
Start Page	e13960
ISSN	1467-7881
NCID	AA11706334
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Author(s).
File Version	publisher
PubMed ID	40461407
DOI	10.1111/obr.13960
Web of Science KeyUT	001500867400001
Related Url	isVersionOf https://doi.org/10.1111/obr.13960

First-time diagnosis and referral practices for individuals with CKD by primary care physicians: a study of electronic medical records across multiple clinics in Japan

FullText URL	fulltext.pdf
Author	Uchida, Haruhito A.\| Wada, Jun\| Nagao, Yuji\| Ihara, Katsuhito\|
Keywords	Chronic kidney disease Electronic medical records Japan Primary care physician Disease code
Published Date	2025-05-16
Publication Title	Clinical and Experimental Nephrology
Volume	volume29
Issue	issue10
Publisher	Springer Science and Business Media LLC
Start Page	1342
End Page	1353
ISSN	1342-1751
NCID	AA11126935
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	40377839
DOI	10.1007/s10157-025-02695-8
Web of Science KeyUT	001489300000001
Related Url	isVersionOf https://doi.org/10.1007/s10157-025-02695-8

Efficacy and safety of esaxerenone in hypertensive patients with chronic kidney disease, with or without type 2 diabetes mellitus: a pooled analysis of five clinical studies

FullText URL	fulltext.pdf
Author	Uchida, Haruhito A.\| Wada, Jun\| Motoki, Hirohiko\| Kuwahara, Koichiro\| Kario, Kazuomi\| Katsuya, Tomohiro\| Shimosawa, Tatsuo\| Tsujita, Kenichi\| Suzuki, Shoko\| Suedomi, Tomohiro\| Taguchi, Takashi\|
Keywords	albuminuria chronic kidney disease esaxerenone morning hypertension type 2 diabetes mellitus
Published Date	2025-06-30
Publication Title	Hypertension Research
Volume	volume48
Issue	issue9
Publisher	Springer Science and Business Media LLC
Start Page	2413
End Page	2426
ISSN	0916-9636
NCID	AA10847079
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025.
File Version	publisher
PubMed ID	40588503
DOI	10.1038/s41440-025-02259-z
Web of Science KeyUT	001520103300001
Related Url	isVersionOf https://doi.org/10.1038/s41440-025-02259-z

A Case of IgA Nephropathy With Membranoproliferative Glomerulonephritis-Like Features Miyu Kanazawa,

Author	Kanazawa, Miyu\| Tsuji, Kenji\| Aoki, Ryoya\| Sue, Mihiro\| Miyake, Hiromasa\| Uchida, Naruhiko\| Nakanoh, Hiroyuki\| Fukushima, Kazuhiko\| Uchida, Haruhito A.\| Wada, Jun\|
Keywords	Gd-IgA1 IgA nephropathy membranoproliferative glomerulonephritis nephrotic syndrome rheumatoid arthritis
Note	This is the peer reviewed version of the following article: Kanazawa, M., Tsuji, K., Aoki, R., Sue, M., Miyake, H., Uchida, N., Nakanoh, H., Fukushima, K., Uchida, H.A. and Wada, J. (2025), A Case of IgA Nephropathy With Membranoproliferative Glomerulonephritis-Like Features. Nephrology, 30: e70057. https://doi.org/10.1111/nep.70057, which has been published in final form at https://doi.org/10.1111/nep.70057. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.\| This fulltext file will be available in May 2026.\|
Published Date	2025-05
Publication Title	Nephrology
Volume	volume30
Issue	issue5
Publisher	Wiley
Start Page	e70057
ISSN	1320-5358
NCID	AA11055666
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 Asian Pacific Society of Nephrology.
File Version	author
PubMed ID	40369892
DOI	10.1111/nep.70057
Web of Science KeyUT	001496130600010
Related Url	isVersionOf https://doi.org/10.1111/nep.70057

Relation between obesity and health disorders as revealed by the J-ORBIT clinical information collection system directly linked to electronic medical records (J-ORBIT 1)

FullText URL	fulltext.pdf
Author	Nishikage, Seiji\| Hirota, Yushi\| Nakagawa, Yasushi\| Ishii, Masamichi\| Ohsugi, Mitsuru\| Maeda, Eiichi\| Yoshimura, Kai\| Yamamoto, Akane\| Takayoshi, Tomofumi\| Kato, Takehiro\| Yabe, Daisuke\| Matsuhisa, Munehide\| Eguchi, Jun\| Wada, Jun\| Fujita, Yukihiro\| Kume, Shinji\| Maegawa, Hiroshi\| Miyake, Kana\| Shojima, Nobuhiro\| Yamauchi, Toshimasa\| Yokote, Koutaro\| Ueki, Kohjiro\| Miyo, Kengo\| Ogawa, Wataru\|
Keywords	Body mass index Electronic medical records Obesity
Published Date	2025-03-27
Publication Title	Journal of Diabetes Investigation
Volume	volume16
Issue	issue6
Publisher	Wiley
Start Page	1100
End Page	1111
ISSN	2040-1116
NCID	AA12488319
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Author(s).
File Version	publisher
PubMed ID	40143709
DOI	10.1111/jdi.70021
Web of Science KeyUT	001501619800012
Related Url	isVersionOf https://doi.org/10.1111/jdi.70021

Hypoglycemia and hyperinsulinemia induced by phenolic uremic toxins in CKD and DKD patients

FullText URL	fulltext.pdf
Author	Tongu, Yoshiyasu\| Kasahara, Tomoko\| Akiyama, Yasutoshi\| Suzuki, Takehiro\| Ho, Hsin-Jung\| Matsumoto, Yotaro\| Kujirai, Ryota\| Kikuchi, Koichi\| Nata, Koji\| Kanzaki, Makoto\| Suzuki, Kenshin\| Watanabe, Shun\| Kawabe, Chiharu\| Miyata, Yui\| Itai, Shun\| Toyohara, Takafumi\| Suzuki, Chitose\| Tanaka, Tetsuhiro\| Wada, Jun\| Tomioka, Yoshihisa\| Abe, Takaaki\|
Keywords	CKD, DKD, Phenyl sulfate, Uremic toxin, Insulin secretion, Insulin resistance, Gut microbiota
Published Date	2025-02-17
Publication Title	Scientific Reports
Volume	volume15
Issue	issue1
Publisher	Springer Science and Business Media LLC
Start Page	5762
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	39962199
DOI	10.1038/s41598-025-87501-x
Web of Science KeyUT	001424375700011
Related Url	isVersionOf https://doi.org/10.1038/s41598-025-87501-x

A pilot transcriptomic study of a novel multitargeted BRT regimen for anti–MDA5 antibody-positive dermatomyositis: improving survival over conventional therapy

FullText URL	fulltext.pdf
Author	Tokunaga, Moe\| Nakai, Yu\| Sato, Yoshiharu\| Hiratsuka, Mitori\| Matsumoto, Yoshinori\| Nakatsue, Takeshi\| Saeki, Takako\| Umayahara, Takatsune\| Wada, Jun\| Koyama, Yoshinobu\|
Keywords	anti-MDA5 antibody-positive dermatomyositis (MDA5-DM) JAK inhibitor baricitinib rituximab multitargeted treatment IFN signature transcriptome analysis
Published Date	2025-08-07
Publication Title	Frontiers in Immunology
Volume	volume16
Publisher	Frontiers Media SA
Start Page	1568338
ISSN	1664-3224
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 Tokunaga, Nakai, Sato, Hiratsuka, Matsumoto, Nakatsue, Saeki, Umayahara, Wada and Koyama.
File Version	publisher
PubMed ID	40852724
DOI	10.3389/fimmu.2025.1568338
Web of Science KeyUT	001554021400001
Related Url	isVersionOf https://doi.org/10.3389/fimmu.2025.1568338

Association between proteinuria and mineral metabolism disorders in chronic kidney disease: the Japan chronic kidney disease database extension (J-CKD-DB-Ex)

FullText URL	fulltext.pdf
Author	Shimamoto, Sho\| Nakahara, Takako\| Yamada, Shunsuke\| Nagasu, Hajime\| Kishi, Seiji\| Nakashima, Naoki\| Tsuruya, Kazuhiko\| Okada, Hirokazu\| Tamura, Kouichi\| Narita, Ichiei\| Maruyama, Shoichi\| Yano, Yuichiro\| Yokoo, Takashi\| Wada, Takashi\| Wada, Jun\| Kanda, Eiichiro\| Kataoka, Hiromi\| Nangaku, Masaomi\| Kashihara, Naoki\| Nakano, Toshiaki\|
Keywords	CKD-MBD Proteinuria Hyperphosphatemia Hypocalcemia Hypomagnesemia J-CKD-DB-Ex
Published Date	2024-11-11
Publication Title	Scientific Reports
Volume	volume14
Issue	issue1
Publisher	Springer Science and Business Media LLC
Start Page	27481
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2024
File Version	publisher
PubMed ID	39523380
DOI	10.1038/s41598-024-79291-5
Web of Science KeyUT	001352833400004
Related Url	isVersionOf https://doi.org/10.1038/s41598-024-79291-5

Maternal circulating GPIHBP1 levels and neonatal outcomes in patients with gestational diabetes mellitus: a pilot study

FullText URL	fulltext.pdf
Author	Watanabe, Mayu\| Eguchi, Jun\| Kurooka, Naoko\| Eto, Eriko\| Masuyama, Hisashi\| Wada, Jun\|
Keywords	glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) gestational diabetes mellitus (GDM) perinatal outcomes placenta triglyceride (TG)
Published Date	2025-10-10
Publication Title	Frontiers in Clinical Diabetes and Healthcare
Volume	volume6
Publisher	Frontiers Media SA
Start Page	1682012
ISSN	2673-6616
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 Watanabe, Eguchi, Kurooka, Eto, Masuyama and Wada.
File Version	publisher
PubMed ID	41142641
DOI	10.3389/fcdhc.2025.1682012
Web of Science KeyUT	001599396300001
Related Url	isVersionOf https://doi.org/10.3389/fcdhc.2025.1682012

Kidney Organoids: Current Advances and Applications

FullText URL	fulltext.pdf
Author	Nakanoh, Hiroyuki\| Tsuji, Kenji\| Fukushima, Kazuhiko\| Uchida, Naruhiko\| Haraguchi, Soichiro\| Kitamura, Shinji\| Wada, Jun\|
Keywords	kidney organoid stem cell disease modeling drug toxicity drug screening regenerative medicine
Published Date	2025-10-29
Publication Title	Life
Volume	volume15
Issue	issue11
Publisher	MDPI AG
Start Page	1680
ISSN	2075-1729
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by the authors.
File Version	publisher
DOI	10.3390/life15111680
Related Url	isVersionOf https://doi.org/10.3390/life15111680

Continuous glucose monitoring reveals periodontitis-induced glucose variability, insulin resistance, and gut microbiota dysbiosis in mice

FullText URL	fulltext.pdf suppl1.tiff suppl2.tiff suppl3.tiff
Author	Kubota-Takamori, Moyuka\| Omori, Kazuhiro\| Kamei-Nagata, Chiaki\| Kiyama, Fumiko\| Ishii, Takayuki\| Nakayama, Masaaki\| Gotoh, Kazuyoshi\| Hirai, Kimito\| Shinoda-Ito, Yuki\| Okubo, Keisuke\| Nakamura, Shin\| Ikeda, Atsushi\| Saito, Tsugumichi\| Wada, Jun\| Takashiba, Shogo\|
Keywords	Continuous glucose monitoring Periodontal disease Insulin resistance Chronic inflammation Gut flora
Published Date	2025-10-06
Publication Title	Scientific Reports
Volume	volume15
Issue	issue1
Publisher	Springer Science and Business Media LLC
Start Page	34768
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	41053144
DOI	10.1038/s41598-025-18594-7
Related Url	isVersionOf https://doi.org/10.1038/s41598-025-18594-7

Successful Treatment for Life Threatening Recurrent Non-traumatic Rectus Sheath Hematoma in a Case with Microscopic Polyangiitis with Rapidly Progressive Glomerulonephritis

FullText URL	fulltext.pdf
Author	Nakanoh, Hiroyuki\| Takeuchi, Hidemi\| Morimoto, Shiho\| Terajima, Yuya\| Okamoto, Shugo\| Onishi, Yasuhiro\| Tanaka, Keiko\| Katsuyama, Takayuki\| Tsuji, Kenji\| Matsumoto, Yoshinori\| Tanabe, Katsuyuki\| Morinaga, Hiroshi\| Uka, Mayu\| Tomita, Koji\| Uchida, Haruhito A.\| Hiraki, Takao\| Wada, Jun\|
Keywords	rectus sheath hematoma microscopic polyangiitis hemodialysis
Published Date	2024-12-01
Publication Title	Internal Medicine
Volume	volume63
Issue	issue23
Publisher	Japanese Society of Internal Medicine
Start Page	3243
End Page	3248
ISSN	0918-2918
NCID	AA10827774
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 by The Japanese Society of Internal Medicine
File Version	publisher
PubMed ID	38658341
DOI	10.2169/internalmedicine.3239-23
Web of Science KeyUT	001389172700020
Related Url	isVersionOf https://doi.org/10.2169/internalmedicine.3239-23

The association of fasting triglyceride variability with renal dysfunction and proteinuria in medical checkup participants

FullText URL	fulltext.pdf suppl.docx
Author	Matsuoka-Uchiyama, Natsumi\| Uchida, Haruhito A.\| Asakawa, Tomohiko\| Sakurabu, Yoshimasa\| Katayama, Katsuyoshi\| Okamoto, Shugo\| Onishi, Yasuhiro\| Tanaka, Keiko\| Takeuchi, Hidemi\| Takemoto, Rika\| Umebayashi, Ryoko\| Wada, Jun\|
Keywords	eGFR decline Proteinuria Renal dysfunction Triglyceride variability Fasting triglyceride
Note	The version of record of this article, first published in Clinical and Experimental Nephrology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10157-025-02640-9\|
Published Date	2025-02-28
Publication Title	Clinical and Experimental Nephrology
Volume	volume29
Issue	issue7
Publisher	Springer Science and Business Media LLC
Start Page	920
End Page	927
ISSN	1342-1751
NCID	AA11126935
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	40019721
DOI	10.1007/s10157-025-02640-9
Web of Science KeyUT	001469479600001
Related Url	isVersionOf https://doi.org/10.1007/s10157-025-02640-9

Dotinurad Treatment for Patients With Hyperuricemia Complicating CKD

FullText URL	fulltext.pdf suppl.pdf
Author	Tanabe, Katsuyuki\| Nunoue, Tomokazu\| Itabashi, Naoki\| Katayama, Akihiro\| Nakamura, Akihiko\| Ohbayashi, Hiroyuki\| Onishi, Yasuhiro\| Watanabe, Kyoko\| Maruyama, Keisuke\| Hosoya, Takeshi\| Okada, Shinichi\| Wada, Jun\|
Keywords	chronic kidney disease dotinurad efficacy hyperuricemia safety serum uric acid
Published Date	2025-06
Publication Title	Kidney International Reports
Volume	volume10
Issue	issue6
Publisher	Elsevier BV
Start Page	1711
End Page	1720
ISSN	2468-0249
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 International Society of Nephrology.
File Version	publisher
PubMed ID	40630278
DOI	10.1016/j.ekir.2025.03.047
Web of Science KeyUT	001517012500001
Related Url	isVersionOf https://doi.org/10.1016/j.ekir.2025.03.047

Inhibitory Effects of Vandetanib on Catecholamine Synthesis in Rat Pheochromocytoma PC12 Cells

FullText URL	fulltext.pdf
Author	Itoh, Yoshihiko\| Inagaki, Kenichi\| Terasaka, Tomohiro\| Morimoto, Eisaku\| Ishii, Takahiro\| Yamaoka, Kimitomo\| Fujisawa, Satoshi\| Wada, Jun\|
Keywords	tyrosine kinase inhibitor multiple endocrine neoplasia type 2 paraganglioma RET ERK AKT
Published Date	2025-07-18
Publication Title	International Journal of Molecular Sciences
Volume	volume26
Issue	issue14
Publisher	MDPI
Start Page	6927
ISSN	1422-0067
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by the authors.
File Version	publisher
DOI	10.3390/ijms26146927
Related Url	isVersionOf https://doi.org/10.3390/ijms26146927

Nephronophthisis and Retinitis Pigmentosa (Senior-Loken Syndrome) After Living-Donor Kidney Transplantation: Twelve-Year Follow-Up in a Young Woman

FullText URL	fulltext20250602-01.pdf
Author	Matsuo, Toshihiko\| Onishi, Yasuhiro\| Morinaga, Hiroshi\| Wada, Jun\| Tanaka, Takehiro\| Araki, Motoo\|
Keywords	Retinitis pigmentosa Nephronophthisis Senior-Loken syndrome Kidney transplantation Living donor Kidney biopsy Pathology Computed tomography scan Ciliopathy Optical coherence tomography
Published Date	2025-05
Publication Title	Journal of Medical Cases
Volume	volume16
Issue	issue5
Publisher	Elmer Press, Inc.
Start Page	164
End Page	173
ISSN	1923-4155
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The authors
File Version	publisher
PubMed ID	40503542
DOI	10.14740/jmc4356
Web of Science KeyUT	001506125600002
Related Url	isVersionOf https://doi.org/10.14740/jmc4356

Role of galectin-9 in the development of gestational diabetes mellitus

FullText URL	fulltext.pdf
Author	Albuayjan, Haya Hamed Hassan\| Watanabe, Mayu\| Sugawara, Ryosuke\| Katsuyama, Eri\| Mise, Koki\| Oi, Yukiko\| Kanno, Ayaka\| Yang, BoXuan\| Tahara, Toshihisa\| Nojima, Ichiro\| Nakatsuka, Atsuko\| Eguchi, Jun\| Maki, Jota\| Eto, Eriko\| Hayata, Kei\| Masuyama, Hisashi\| Wada, Jun\|
Published Date	2025-05-30
Publication Title	Scientific Reports
Volume	volume15
Issue	issue1
Publisher	Springer Science and Business Media LLC
Start Page	18981
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	40447728
DOI	10.1038/s41598-025-03879-8
Web of Science KeyUT	001499629300002
Related Url	isVersionOf https://doi.org/10.1038/s41598-025-03879-8

Immunometabolic Regulation of Innate Immunity in Systemic Lupus Erythematosus

JaLCDOI	10.18926/AMO/68722
FullText URL	79_3_147.pdf
Author	Watanabe, Haruki\| Matsumoto, Yoshinori\| Wada, Jun\|
Abstract	Pathogens or their components can induce long-lasting changes in the behavior of innate immune cells, a process analogous to “training” for future threats or environmental adaptation. However, such training can sometimes have unintended consequences, such as the development of autoimmunity. Systemic lupus erythematosus (SLE) is a chronic and heterogeneous autoimmune disease characterized by the production of autoantibodies and progressive organ damage. Innate immunity plays a central role in its pathogenesis, contributing through impaired clearance of apoptotic cells, excessive type I interferon production, and dysregulated formation of neutrophil extracellular traps. Recent studies have revealed that metabolites and nucleic acids derived from mitochondria, a crucial energy production site, directly regulate type I interferon and anti-inflammatory cytokine production. These insights have fueled interest in targeting metabolic pathways as a novel therapeutic approach for SLE, offering promise for improving long-term patient outcomes.
Keywords	systemic lupus erythematosus interferon tricarboxylic acid cycle innate immune memory trained immunity
Amo Type	Review
Publication Title	Acta Medica Okayama
Published Date	2025-06
Volume	volume79
Issue	issue3
Publisher	Okayama University Medical School
Start Page	147
End Page	155
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2025 by Okayama University Medical School
File Version	publisher
Refereed	True