Udono, Heiichiro - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Study about the Efficacy of Metformin to Immune Function in Cancer Patients

JaLCDOI	10.18926/AMO/54514
FullText URL	70_4_327.pdf
Author	Watanabe, Mototsugu\| Yamamoto, Hiromasa\| Eikawa, Shingo\| Shien, Kazuhiko\| Shien, Tadahiko\| Soh, Junichi\| Hotta, Katsuyuki\| Wada, Jun\| Hinotsu, Shiro\| Fujiwara, Toshiyoshi\| Kiura, Katsuyuki\| Doihara, Hiroyoshi\| Miyoshi, Shinichiro\| Udono, Heiichiro\| Toyooka, Shinichi\|
Abstract	A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8＋ T cells, which produce multiple cytokines.
Keywords	metformin CD8＋ T cells cancer immunology
Amo Type	Clinical Study Protocols
Publication Title	Acta Medica Okayama
Published Date	2016-08
Volume	volume70
Issue	issue4
Publisher	Okayama University Medical School
Start Page	327
End Page	330
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2016 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	27549683
Web of Science KeyUT	000384748600018

免疫チェックポイント制御とがん免疫治療

Author	Udono, Heiichiro\|
Published Date	2013-04-01
Publication Title	岡山医学会雑誌
Volume	volume125
Issue	issue1
Content Type	Journal Article

Attenuation of CD4+ CD25+ Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug

FullText URL	EBioMedicine_2017_154.pdf
Author	Kunisada, Yuki\| Eikawa, Shingo\| Tomonobu, Nahoko\| Domae, Shohei\| Uehara, Takenori\| Hori, Shohei\| Furusawa, Yukihiro\| Hase, Koji\| Sasaki, Akira\| Udono, Heiichiro\|
Keywords	Glycolysis Regulatory T cell (Treg) Tumor immunity Tumor microenvironment mTOR
Published Date	2017-10-16
Publication Title	EBioMedicine
Volume	volume25
Publisher	Elsevier Science
Start Page	154
End Page	164
ISSN	23523964
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2017 The Authors.
File Version	publisher
PubMed ID	29066174
DOI	10.1016/j.ebiom.2017.10.009
Web of Science KeyUT	000417440500026
Related Url	isVersionOf https://doi.org/10.1016/j.ebiom.2017.10.009

Nutrient Condition in the Microenvironment Determines Essential Metabolisms of CD8(+) T Cells for Enhanced IFN gamma Production by Metformin

FullText URL	fulltext.pdf
Author	Chao, Ruoyu\| Nishida, Mikako\| Yamashita, Nahoko\| Tokumasu, Miho\| Zhao, Weiyang\| Kudo, Ikuru\| Udono, Heiichiro\|
Keywords	CD8+T lymphocytes glycolysis FAO glutaminolysis IFNg autophagy plus T metformin
Published Date	2022-06-29
Publication Title	Frontiers In Immunology
Volume	volume13
Publisher	Frontiers Media SA
Start Page	864225
ISSN	1664-3224
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 Chao, Nishida, Yamashita, Tokumasu, Zhao, Kudo and Udono.
File Version	publisher
PubMed ID	35844589
DOI	10.3389/fimmu.2022.864225
Web of Science KeyUT	000826727800001
Related Url	isVersionOf https://doi.org/10.3389/fimmu.2022.864225

Blocking EP4 downregulates tumor metabolism and synergizes with anti-PD-1 therapy to activate natural killer cells in a lung adenocarcinoma model

FullText URL	fulltext20220301-1.pdf
Author	Tokumasu, Miho\| Nishida, Mikako\| Kawaguchi, Takamasa\| Kudo, Ikuru\| Kotani, Tohru\| Takeda, Kazuhiko\| Yoshida, Takao\| Udono, Heiichiro\|
Note	This is a pre-copyedited, author-produced version of an article accepted for publication in International Immunology following peer review. The version of record [Miho Tokumasu, Mikako Nishida, Takamasa Kawaguchi, Ikuru Kudo, Tohru Kotani, Kazuhiko Takeda, Takao Yoshida, Heiichiro Udono, Blocking EP4 downregulates tumor metabolism and synergizes with anti-PD-1 therapy to activate natural killer cells in a lung adenocarcinoma model, International Immunology, 2022;, dxac004, https://doi.org/10.1093/intimm/dxac004] is available online at: https://doi.org/10.1093/intimm/dxac004\|
Published Date	2022-2-8
Publication Title	International Immunology
Volume	volume34
Issue	issue6
Publisher	Oxford University Press (OUP)
Start Page	293
End Page	302
ISSN	1460-2377
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022. Published by Oxford University Press on behalf of The Japanese Society for Immunology.
File Version	author
DOI	10.1093/intimm/dxac004
Web of Science KeyUT	000784781800001
Related Url	isVersionOf https://doi.org/10.1093/intimm/dxac004

Dysfunction of CD8+PD-1+T cells in type 2 diabetes caused by the impairment of metabolism-immune axis

FullText URL	fulltext.pdf
Author	Nojima, Ichiro\| Eikawa, Shingo\| Tomonobu, Nahoko\| Hada, Yoshiko\| Kajitani, Nobuo\| Teshigawara, Sanae\| Miyamoto, Satoshi\| Tone, Atsuhito\| Uchida, Haruhito A.\| Nakatsuka, Atsuko\| Eguchi, Jun\| Shikata, Kenichi\| Udono, Heiichiro\| Wada, Jun\|
Keywords	Cytokines Diabetes Endocrine system and metabolic diseases Immunology Tumour immunology
Published Date	2020-09-10
Publication Title	Scientific Reports
Volume	volume10
Issue	issue1
Publisher	Nature Research
Start Page	14928
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2020
File Version	publisher
PubMed ID	32913271
DOI	10.1038/s41598-020-71946-3
Web of Science KeyUT	000571915100049
Related Url	isVersionOf https://doi.org/10.1038/s41598-020-71946-3

HSP90α plays an important role in piRNA biogenesis and retrotransposon repression in mouse

Author	Ichiyanagi, Tomoko\| Ichiyanagi, Kenji\| Ogawa, Ayako\| Kuramochi-Miyagawa, Satomi\| Nakano, Toru\| Chuma, Shinichiro\| Sasaki, Hiroyuki\| Udono, Heiichiro\|
Published Date	2014-09-27
Publication Title	Nucleic Acids Research
Volume	volume42
Issue	issue19
Content Type	Journal Article

第９回臨床ストレス応答学会大会開催報告

Title Alternative	The 9th Annual Meeting of the Biomedical Society for Stress Response
FullText URL	127_73.pdf
Author	Udono, Heiichiro\|
Publication Title	岡山医学会雑誌
Published Date	2015-04-01
Volume	volume127
Issue	issue1
Start Page	73
End Page	74
ISSN	0030-1558
Related Url	http://www.okayama-u.ac.jp/user/oma/
language	Japanese
Copyright Holders	Copyright (c) 2015 岡山医学会
File Version	publisher
DOI	10.4044/joma.127.73
NAID	130005068339

Diabetes drug helps towards immunity against cancer

Author	Udono, Heiichiro\|
Published Date	2015-03
Publication Title	Okayama University Medical Research Updates
Volume	volume9
Content Type	Others

Evidence for Hypoxia-Induced Shift in ATP Production from Glycolysis to Mitochondrial Respiration in Pulmonary Artery Smooth Muscle Cells in Pulmonary Arterial Hypertension

FullText URL	fulltext.pdf
Author	Akagi, Satoshi\| Nakamura, Kazufumi\| Kondo, Megumi\| Hirohata, Satoshi\| Udono, Heiichiro\| Nishida, Mikako\| Saito, Yukihiro\| Yoshida, Masashi\| Miyoshi, Toru\| Ito, Hiroshi\|
Keywords	glycolysis mitochondrial respiration pulmonary arterial hypertension pulmonary artery smooth muscle cells Seahorse technology hypoxia ATP production
Published Date	2023-07-31
Publication Title	Journal of Clinical Medicine
Volume	volume12
Issue	issue15
Publisher	MDPI
Start Page	5028
ISSN	2077-0383
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 by the authors.
File Version	publisher
PubMed ID	37568430
DOI	10.3390/jcm12155028
Web of Science KeyUT	001045690800001
Related Url	isVersionOf https://doi.org/10.3390/jcm12155028

Metformin-ROS-Nrf2 connection in the host defense mechanism against oxidative stress, apoptosis, cancers, and ageing

FullText URL	fulltext20220630-1.pdf
Author	Udono, Heiichiro\| Nishida, Mikako\|
Keywords	Mitochondrial ROS Oxidative stress Apoptosis Ageing Nrf2
Note	© 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.bbagen.2022.130171] . This fulltext is available in Aug. 2023.\|
Published Date	2022-08
Publication Title	Biochimica et Biophysica Acta (BBA) - General Subjects
Volume	volume1866
Issue	issue8
Publisher	Elsevier BV
Start Page	130171
ISSN	0304-4165
NCID	AA00564679
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 Elsevier B.V.
File Version	author
PubMed ID	35588955
DOI	10.1016/j.bbagen.2022.130171
Web of Science KeyUT	000806942900004
Related Url	isVersionOf https://doi.org/10.1016/j.bbagen.2022.130171

Berberine improved experimental chronic colitis by regulating interferon-gamma- and IL-17A-producing lamina propria CD4(+) T cells through AMPK activation

FullText URL	SR9_1_11934.pdf
Author	Takahara, Masahiro\| Takaki, Akinobu\| Hiraoka, Sakiko\| Adach, Takuya\| Shimomura, Yasuyuki\| Matsushita, Hiroshi\| Nguyen Tien Thi Thuy\| Koike, Kazuko\| Ikeda, Airi\| Takashima, Shiho\| Yamasaki, Yasushi\| Inokuchi, Toshihiro\| Kinugasa, Hideaki\| Sugihara, Yusaku\| Harada, Keita\| Eikawa, Shingo\| Morita, Hidetoshi\| Udono, Heiichiro\| Okada, Hiroyuki\|
Published Date	2019-8-15
Publication Title	Scientific Reports
Volume	volume9
Publisher	Nature Publishing Group
Start Page	11934
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2019
File Version	publisher
PubMed ID	31417110
DOI	10.1038/s41598-019-48331-w
Web of Science KeyUT	000480680800048
Related Url	isVersionOf https://doi.org/10.1038/s41598-019-48331-w

メトホルミンによるミトコンドリア活性酸素誘導と生体防御機構

Title Alternative	Metformin-induced mitochondrial reactive oxygen species and host defense mechanisms
Author	Udono, Heiichiro\|
Keywords	CD8T 細胞活性酸素 Nrf2 解糖系ミトコンドリア
Publication Title	Journal of Okayama Medical Association
Published Date	2024-08-01
Volume	volume136
Issue	issue2
Start Page	63
End Page	68
ISSN	0030-1558
Related Url	isVersionOf https://doi.org/10.4044/joma.136.63
language	Japanese
Copyright Holders	Copyright (c) 2024 岡山医学会
File Version	publisher
DOI	10.4044/joma.136.63