ID | 64373 |
FullText URL | |
Author |
Iwamuro, Masaya
Department of Gastroenterology and Hepatology, Okayama University Hospital
ORCID
Kaken ID
publons
researchmap
Takahashi, Takahide
Division of Medical Support, Okayama University Hospital
Hirabata, Araki
Division of Medical Support, Okayama University Hospital
Otsuka, Fumio
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
ORCID
Kaken ID
publons
researchmap
Okada, Horoyuki
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
|
Abstract | The composition of lymphocytes in the gastric mucosa following the eradication of Helicobacter pylori (H. pylori) in patients with and without gastric cancer has not been compared. This study performed a single spot analysis of gastric mucosal lymphocytes after H. pylori eradication in patients with (n = 13) and without (n = 20) gastric cancer. Our comprehensive analysis of lymphocyte composition in the gastric mucosa revealed that: i) the proportion of CD8+/CD3+ cells was relatively higher in the peri-tumor mucosa than in the background mucosa; ii) the proportion of CCR4+/CD3+ cells was higher, and the ratio of CD62L+/CD3+CD4+ cells was relatively lower in the gastric mucosa of cancer patients than in non-cancer patients; and iii) the proportion of CD45RA-CD62L+/CD3+CD4+ cells, namely, the central memory CD4+ T -cell fraction, was lower in the gastric mucosa of cancer patients than in non-cancer patients. Although the exact mechanism of the altered proportions of CCR4+/CD3+ and central memory CD4+ cells in the gastric mucosa of patients with cancer is unknown, focusing on lymphocytes in the gastric mucosa might help improve our understanding of gastric cancer development after H. pylori eradication.
|
Keywords | carcinogenesis
lymphocytes
helicobacter pylori
gastric adenocarcinoma
flow cytometry
|
Published Date | 2022-11-20
|
Publication Title |
Cureus Journal Of Medical Science
|
Volume | volume14
|
Issue | issue11
|
Publisher | Cureus Inc.
|
Start Page | e31713
|
ISSN | 2168-8184
|
Content Type |
Journal Article
|
language |
English
|
OAI-PMH Set |
岡山大学
|
Copyright Holders | © 2022 Iwamuro et al.
|
File Version | publisher
|
PubMed ID | |
DOI | |
Web of Science KeyUT | |
Related Url | isVersionOf https://doi.org/10.7759/cureus.31713
|
License | https://creativecommons.org/licenses/by/4.0/
|