FullText URL | fulltext.pdf |
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Author | Matsuo, Toshihiko| Tanaka, Takehiro| |
Keywords | conjunctival lymphoma extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) follicular lymphoma diffuse large B-cell lymphoma fluorodeoxyglucose positron emission tomography (FDG-PET) |
Published Date | 2024 |
Publication Title | Journal of Clinical and Experimental Hematopathology |
Volume | volume64 |
Issue | issue2 |
Publisher | Japanese Society for Lymphoreticular Tissue Research |
Start Page | 86 |
End Page | 96 |
ISSN | 1346-4280 |
NCID | AA11556796 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2024 The Japanese Society for Lymphoreticular Tissue Research |
File Version | publisher |
PubMed ID | 38684405 |
DOI | 10.3960/jslrt.24002 |
Web of Science KeyUT | 001218537700001 |
Related Url | isVersionOf https://doi.org/10.3960/jslrt.24002 |
FullText URL | fulltext20240513-03.pdf |
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Author | Matsuo, Toshihiko| Tanaka, Takehiro| Kimata, Yoshihiro| |
Keywords | hemangioma lymphangioma lymphatic malformation pathology trabeculectomy vascular malformation |
Published Date | 2024-05 |
Publication Title | Clinical Case Reports |
Volume | volume12 |
Issue | issue5 |
Publisher | Wiley |
Start Page | e8933 |
ISSN | 2050-0904 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2024 The Authors. |
File Version | publisher |
PubMed ID | 38741673 |
DOI | 10.1002/ccr3.8933 |
Web of Science KeyUT | 001218609400001 |
Related Url | isVersionOf https://doi.org/10.1002/ccr3.8933 |
FullText URL | fulltext.pdf |
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Author | Iwamuro, Masaya| Ennishi, Daisuke| Fujii, Nobuharu| Matsuoka, Ken-Ichi| Tanaka, Takehiro| Inokuchi, Toshihiro| Hiraoka, Sakiko| Otsuka, Motoyuki| |
Keywords | Colonoscopy Esophagogastroduodenoscopy Graft-versus-host disease Hematopoietic stem cell transplantation Intestinal transplant-associated microangiopathy iTAM |
Note | The version of record of this article, first published in BMC Gastroenterology, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12876-024-03221-y| |
Published Date | 2024-04-22 |
Publication Title | BMC Gastroenterology |
Volume | volume24 |
Issue | issue1 |
Publisher | BMC |
Start Page | 140 |
ISSN | 1471-230X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2024. |
File Version | publisher |
PubMed ID | 38649868 |
DOI | 10.1186/s12876-024-03221-y |
Web of Science KeyUT | 001206319800003 |
Related Url | isVersionOf https://doi.org/10.1186/s12876-024-03221-y |
JaLCDOI | 10.18926/AMO/66915 |
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FullText URL | 78_2_123.pdf |
Author | Saeki, Kyosuke| Fujiwara, Hideaki| Seike, Keisuke| Kuroi, Taiga| Nishimori, Hisakazu| Tanaka, Takehiro| Matsuoka, Ken-ichi| Fujii, Nobuharu| Maeda, Yoshinobu| |
Abstract | Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HCT), but its pathogenesis remains unclear. Recently, haplo-identical HCT with post-transplant cyclophosphamide (Haplo-HCT with PTCY) was found to achieve a low incidence rate of acute GVHD and chronic GVHD. However, while the pathogenesis of acute GVHD following Haplo-HCT with PTCY has been well investigated, that of chronic GVHD remains to be elucidated, especially in HLA-matched HCT with PTCY. Based on its safety profile, PTCY is currently applied for the human leucocyte antigen (HLA)-matched HCT setting. Here, we investigated the mechanisms of chronic GVHD following HLA-matched HCT with PTCY using a well-defined mouse chronic GVHD model. PTCY attenuated clinical and pathological chronic GVHD by suppressing effector T-cells and preserving regulatory T-cells compared with a control group. Additionally, we demonstrated that cyclosporine A (CsA) did not show any additional positive effects on attenuation of GVHD in PTCY-treated recipients. These results suggest that monotherapy with PTCY without CsA could be a promising strategy for the prevention of chronic GVHD following HLA-matched HCT. |
Keywords | GVHD posttransplant cyclophosphamide hematopoietic cell transplantation HLA-identical |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2024-04 |
Volume | volume78 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 123 |
End Page | 134 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 38688830 |
Web of Science KeyUT | 001229151800004 |
FullText URL | fulltext.pdf |
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Author | Iwamuro, Masaya| Takenaka, Ryuta| Miyahara, Koji| Okanoue, Shotaro| Yoshioka, Masao| Sakaguchi, Chihiro| Yamamoto, Kumiko| Kawai, Yoshinari| Toyokawa, Tatsuya| Tanaka, Takehiro| Otsuka, Motoyuki| |
Keywords | Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue Gastric neoplasms Esophagogastroduodenoscopy t(11;18) translocation, Trisomy 18 |
Note | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-55663-9| |
Published Date | 2024-02-29 |
Publication Title | Scientific Reports |
Volume | volume14 |
Issue | issue1 |
Publisher | Nature Portfolio |
Start Page | 4953 |
ISSN | 2045-2322 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2024 |
File Version | publisher |
PubMed ID | 38418651 |
DOI | 10.1038/s41598-024-55663-9 |
Web of Science KeyUT | 001178149200009 |
Related Url | isVersionOf https://doi.org/10.1038/s41598-024-55663-9 |
JaLCDOI | 10.18926/AMO/66668 |
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FullText URL | 78_1_029.pdf |
Author | Kitayama, Takahiro| Tanaka, Takashi| Kanie, Yuichiro| Marukawa, Yohei| Kojima, Katsuhide| Tanaka, Takehiro| Takao, Soshi| Hiraki, Takao| |
Abstract | This retrospective study investigated whether necrotic lesions detected on a computed tomography (CT) scan are more regressive than non-necrotic lesions after methotrexate withdrawal in patients pathologically diagnosed with methotrexate-associated lymphoproliferative disorders (MTX-LPD). In total, 89 lesions extracted from 24 patients on CT scans were included in the analysis. All patients had been evaluated for the presence of necrosis within lesions via CT scan upon first suspicion of MTX-LPD (baseline CT scan). The percentage lesion size reduction between the baseline and initial follow-up CT scan was calculated. The association between necrosis within lesions and size changes was estimated via linear regression analyses using both crude and adjusted models. Necrosis was significantly more common in extranodal lesions (27 out of 30 lesions, 90%) than in nodal lesions (9 out of 59 lesions, 15%, p<0.001). In the crude model, the regression of necrotic lesions was 58.5% greater than that of non-necrotic lesions; the difference was statistically significant (p<0.001). Additionally, the longest diameter of necrotic lesions at the baseline CT scan was significantly greater than that of non-necrotic lesions (p<0.001). Based on the adjusted model, necrotic lesions showed 49.3% greater regression than non-necrotic lesions (p=0.017). Necrosis detected on a CT scan was found to be an independent predictor of regression after MTX withdrawal in patients with MTX-LPD. |
Keywords | methotrexate lymphoproliferative disorder computed tomography necrosis |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2024-02 |
Volume | volume78 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 29 |
End Page | 36 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 38419312 |
Web of Science KeyUT | 001203658200001 |
FullText URL | fulltext20231223-01.pdf |
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Author | Matsuo, Toshihiko| Tanaka, Takehiro| Yamada, Kiyoshi| Nose, Motoko| Tanimoto, Yasushi| |
Keywords | debridement eyelid lacrimal sac Mycobacterium abscessus nontuberculous mycobacteria |
Published Date | 2023-12-21 |
Publication Title | Clinical Case Reports |
Volume | volume11 |
Issue | issue12 |
Publisher | Wiley |
Start Page | e8364 |
ISSN | 2050-0904 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 The Authors. |
File Version | publisher |
PubMed ID | 38130855 |
DOI | 10.1002/ccr3.8364 |
Web of Science KeyUT | 001128230600001 |
Related Url | isVersionOf https://doi.org/10.1002/ccr3.8364 |
FullText URL | fulltext.pdf |
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Author | Toyosawa, Junki| Yamasaki, Yasushi| Fujimoto, Tsuyoshi| Tanaka, Shouichi| Tanaka, Takehiro| Mitsuhashi, Toshiharu| Okada, Hiroyuki| |
Published Date | 2022-05-13 |
Publication Title | Endoscopy International Open |
Volume | volume10 |
Issue | issue05 |
Publisher | Georg Thieme Verlag KG |
Start Page | E602 |
End Page | E608 |
ISSN | 2364-3722 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022. The Author(s). |
File Version | publisher |
PubMed ID | 35571476 |
DOI | 10.1055/a-1785-8616 |
Web of Science KeyUT | 000794976400009 |
Related Url | isVersionOf https://doi.org/10.1055/a-1785-8616 |
FullText URL | fulltext.pdf |
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Author | Otani, Yusuke| Yoshikawa, Soichiro| Nagao, Kei| Tanaka, Takehiro| Toyooka, Shinichi| Fujimura, Atsushi| |
Keywords | Mast cells Connective tissue mast cells Noradrenaline Immunoelectron microscopy SLC22A3 |
Note | The version of record of this article, first published in The Journal of Physiological Sciences, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12576-023-00883-3| |
Published Date | 2023-10-12 |
Publication Title | The Journal of Physiological Sciences |
Volume | volume73 |
Issue | issue1 |
Publisher | BMC |
Start Page | 24 |
ISSN | 1880-6546 |
NCID | AA12129145 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2023. |
File Version | publisher |
PubMed ID | 37828465 |
DOI | 10.1186/s12576-023-00883-3 |
Web of Science KeyUT | 001089236900002 |
Related Url | isVersionOf https://doi.org/10.1186/s12576-023-00883-3 |
JaLCDOI | 10.18926/AMO/65978 |
---|---|
FullText URL | 77_5_545.pdf |
Author | Iwamuro, Masaya| Tanaka, Shouichi| Toyokawa, Tatsuya| Nishimura, Mamoru| Tsuzuki, Takao| Miyahara, Koji| Negishi, Shin| Ohya, Shogen| Tanaka, Takehiro| Otsuka, Motoyuki| |
Abstract | To determine the endoscopic and clinical features of localized gastric amyloid light-chain (AL) amyloidosis, we retrospectively examined the characteristics of nine patients (eight men and one woman) encountered by the hospitals in our network. Lesions were predominantly flat and depressed with surface vascular dilatation (n=5); others were characterized by subepithelial lesions (n=2), mucosal color change (n=1), and a mass-like morphology with swollen mucosal folds (n=1). Colonoscopy (n=7), video capsule enteroscopy (n=2), serum (n=5) and urine immunoelectrophoresis (n=4), and bone marrow examination (n=3) were performed to exclude involvement of organs other than the stomach. As treatment for gastric lesions of AL amyloidosis, one patient each underwent endoscopic submucosal dissection (n=1) and argon plasma coagulation (n=1), while the remaining seven patients underwent no specific treatment. During a mean follow-up of 4.2 years, one patient died 3.2 years after diagnosis, but the cause of death, which occurred in another hospital, was unknown. The remaining eight patients were alive at the last visit. In conclusion, although localized gastric AL amyloidosis can show various macroscopic features on esophagogastroduodenoscopy, flat, depressed lesions with vascular dilatation on the surface are predominant. |
Keywords | esophagogastroduodenoscopy gastric lesion amyloidosis light chain |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2023-10 |
Volume | volume77 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 545 |
End Page | 552 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 37899266 |
Web of Science KeyUT | 001094245100001 |
FullText URL | fulltext20230923-01.pdf |
---|---|
Author | Matsuo, Toshihiko| Tanaka, Takehiro| |
Keywords | myxoma orbital CD34 ethmoid sinus literature review |
Published Date | 2023-09-22 |
Publication Title | Journal of Investigative Medicine High Impact Case Reports |
Volume | volume11 |
Publisher | SAGE Publications |
Start Page | 1 |
End Page | 6 |
ISSN | 2324-7096 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 American Federation for Medical Research |
File Version | publisher |
PubMed ID | 37737575 |
DOI | 10.1177/23247096231201013 |
Web of Science KeyUT | 001070220300001 |
Related Url | isVersionOf https://doi.org/10.1177/23247096231201013 |
FullText URL | fulltext.pdf |
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Author | Yamamoto, Shumpei| Kinugasa, Hideaki| Yamasaki, Yasushi| Hirai, Mami| Ako, Soichiro| Takei, Kensuke| Igawa, Shoko| Yasutomi, Eriko| Oka, Shohei| Ohmori, Masayasu| Inokuchi, Toshihiro| Harada, Keita| Hiraoka, Sakiko| Nouso, Kazuhiro| Tanaka, Takehiro| Okada, Hiroyuki| |
Keywords | colorectal ESD PECS electrocoagulation syndrome immunosuppressants and steroids post-ESD fever |
Published Date | 2021-12-09 |
Publication Title | DEN Open |
Volume | volume2 |
Issue | issue1 |
Publisher | Wiley |
Start Page | e83 |
ISSN | 2692-4609 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 The Authors. |
File Version | publisher |
PubMed ID | 35310725 |
DOI | 10.1002/deo2.83 |
Web of Science KeyUT | 001047024900091 |
Related Url | isVersionOf https://doi.org/10.1002/deo2.83 |
FullText URL | fulltext.pdf |
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Author | Kanzaki, Hiromitsu| Horii, Joichiro| Takenaka, Ryuta| Nakagawa, Hiroyuki| Matsueda, Kazuhiro| Tsuzuki, Takao| Kita, Masahide| Yamasaki, Yasushi| Tanaka, Takehiro| Iwamuro, Masaya| Kawano, Seiji| Kawahara, Yoshiro| Tomoda, Jun| Okada, Hiroyuki| |
Published Date | 2022-06-10 |
Publication Title | Endoscopy International Open |
Volume | volume10 |
Issue | issue06 |
Publisher | Georg Thieme Verlag KG |
Start Page | E712 |
End Page | E718 |
ISSN | 2364-3722 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022. The Author(s). |
File Version | publisher |
PubMed ID | 35859656 |
DOI | 10.1055/a-1793-9439 |
Web of Science KeyUT | 000826506700001 |
Related Url | isVersionOf https://doi.org/10.1055/a-1793-9439 |
FullText URL | fulltext.pdf |
---|---|
Author | Chen, Mengxi| Tanaka, Takehiro| Igawa, Takuro| Han, Yanyan| Peng, Fangli| Jin, Zaishun| Yoshino, Tadashi| |
Keywords | PDX1 PTF1A SALL4 Ectopic pancreas Gastro-duodenum Jejunum |
Published Date | 2023-07 |
Publication Title | Heliyon |
Volume | volume9 |
Issue | issue7 |
Publisher | Cell Press |
Start Page | e18241 |
ISSN | 2405-8440 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 The Authors. |
File Version | publisher |
PubMed ID | 37519669 |
DOI | 10.1016/j.heliyon.2023.e18241 |
Web of Science KeyUT | 001043928200001 |
Related Url | isVersionOf https://doi.org/10.1016/j.heliyon.2023.e18241 |
JaLCDOI | 10.18926/AMO/65740 |
---|---|
FullText URL | 77_4_347.pdf |
Author | Iwamuro, Masaya| Kondo, Takumi| Ennishi, Daisuke| Fujii, Nobuharu| Matsuoka, Ken-ichi| Takahashi, Takahide| Hirabata, Araki| Tanaka, Takehiro| Otsuka, Fumio| Maeda, Yoshinobu| Okada, Hiroyuki| |
Abstract | The feasibility of lymphocyte isolation and flow cytometry using a single endoscopic biopsy specimen from the gastrointestinal tract of patients who have undergone hematopoietic stem cell transplantation has not been investigated. We acquired 51 endoscopic biopsy specimens from the gastrointestinal tract of 35 patients. We divided the flow cytometry samples into two groups: group A, successful lymphocyte isolation (n=24), and group B, incomplete isolation (n=27). We compared the backgrounds of the samples between the groups to reveal crucial elements in the successful isolation of lymphocytes residing in the gastrointestinal tract. Comparison between the groups revealed lymphocyte isolation success rates differed between biopsy sites. Isolation was most successful in samples from the duodenum (8/9, 88.9%), followed by the ileum (4/8, 50.0%), large intestine (4/11, 36.4%), and stomach (8/23, 34.8%). Tacrolimus was used more frequently in group B (92.6%) than in group A (62.5%) (p=0.015). Logistic regression analysis revealed that isolation from the duodenum or ileum was a significant factor for successful isolation, while tacrolimus use was not statistically significant. In conclusion, the duodenum and ileum are more suitable sites than the stomach and colorectum for acquiring samples for flow cytometry. |
Keywords | flow cytometry stem cell transplantation transplantation-associated microangiopathy |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2023-08 |
Volume | volume77 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 347 |
End Page | 357 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 37635134 |
Web of Science KeyUT | 001163659800002 |
FullText URL | fulltext.pdf |
---|---|
Author | Iwamuro, Masaya| Tanaka, Takehiro| Otsuka, Motoyuki| |
Keywords | autoimmune gastritis esophagogastroduodenoscopy genetic predisposition lymphocyte oxidative stress |
Published Date | 2023-06-21 |
Publication Title | Current Issues in Molecular Biology |
Volume | volume45 |
Issue | issue7 |
Publisher | MDPI |
Start Page | 5263 |
End Page | 5275 |
ISSN | 1467-3037 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 by the authors. |
File Version | publisher |
PubMed ID | 37504250 |
DOI | 10.3390/cimb45070334 |
Web of Science KeyUT | 001035130200001 |
Related Url | isVersionOf https://doi.org/10.3390/cimb45070334 |
FullText URL | fulltext.pdf |
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Author | Iwamuro, Masaya| Tanaka, Takehiro| Kagawa, Shunsuke| Inoo, Shoko| Otsuka, Motoyuki| |
Keywords | immune checkpoint inhibitor chemotherapy-induced diarrhea immune-related adverse event colitis colonoscopy collagenous colitis |
Published Date | 2023-05-25 |
Publication Title | Cureus |
Volume | volume15 |
Issue | issue5 |
Publisher | Springer |
Start Page | e39466 |
ISSN | 2168-8184 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 Iwamuro et al. |
File Version | publisher |
PubMed ID | 37378156 |
DOI | 10.7759/cureus.39466 |
Web of Science KeyUT | 001023091300016 |
Related Url | isVersionOf https://doi.org/10.7759/cureus.39466 |
FullText URL | fulltext20230708-01.pdf |
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Author | Matsuo, Toshihiko| Tanaka, Takehiro| Okada, Kazuya| Notohara, Kenji| Fujii, Keiko| Fujii, Nobuharu| |
Keywords | mantle cell lymphoma lacrimal gland autologous peripheral blood stem cell transplantation breast cancer tracheal and bronchial infiltration |
Published Date | 2023-07-05 |
Publication Title | Journal of Investigative Medicine High Impact Case Reports |
Volume | volume11 |
Publisher | SAGE Publications |
ISSN | 2324-7096 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 American Federation for Medical Research |
File Version | publisher |
PubMed ID | 37403948 |
DOI | 10.1177/23247096231185483 |
Related Url | isVersionOf https://doi.org/10.1177/23247096231185483 |
FullText URL | fulltext.pdf |
---|---|
Author | Iwamuro, Masaya| Tanaka, Takehiro| Okada, Hiroyuki| |
Keywords | Diagnosis Diffuse large B-cell lymphoma Duodenal neoplasms Esoph-agogastroduodenoscopy Follicular lymphoma Gastrointestinal lymphoma |
Published Date | 2023-03-28 |
Publication Title | World Journal of Gastroenterology |
Volume | volume29 |
Issue | issue12 |
Publisher | Baishideng Publishing Group |
Start Page | 1852 |
End Page | 1862 |
ISSN | 1007-9327 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2023. |
File Version | publisher |
PubMed ID | 37032723 |
DOI | 10.3748/wjg.v29.i12.1852 |
Web of Science KeyUT | 000982154800007 |
Related Url | isVersionOf https://doi.org/10.3748/wjg.v29.i12.1852 |
FullText URL | fulltext.pdf |
---|---|
Author | Iwamuro, Masaya| Urata, Haruo| Iwasa, Satoshi| Tanaka, Takehiro| Kawahara, Yoshiro| Okada, Horoyuki| |
Keywords | fluorescence microscopy esophagogastroduodenoscopy scanning electron microscopy analysis lanthanum carbonate hyperphosphatemia |
Published Date | 2022-10-26 |
Publication Title | Cureus |
Volume | volume14 |
Issue | issue10 |
Publisher | Springer |
Start Page | e30729 |
ISSN | 2168-8184 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 Iwamuro et al. |
File Version | publisher |
PubMed ID | 36447703 |
DOI | 10.7759/cureus.30729 |
Web of Science KeyUT | 000978541800040 |
Related Url | isVersionOf https://doi.org/10.7759/cureus.30729 |