ID | 61490 |
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Author |
Yoshino, Tadashi
Department of Pathology, Okayama University Graduate School
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Sato, Yasuharu
Department of Pathology, Okayama University Graduate School
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Abstract | Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) accounts for approximately 1% of all lymphomas in our department. In this article, we describe the differential diagnosis of CLL/SLL from other indolent lymphomas, with special reference to follicular lymphoma, marginal zone B-cell lymphoma, lymphoplasmacytic lymphoma, and mantle cell lymphoma, although the latter is considered to be aggressive. CLL/SLL often exhibits proliferation centers, similar to follicular lymphoma. Immunohistological examination can easily distinguish these two lymphomas. The most important characteristic of CLL/SLL is CD5 and CD23 positivity. Mantle cell lymphoma is also CD5-positive and there are some CD23-positive cases. Such cases should be carefully distinguished from CLL/SLL. Some marginal zone lymphomas are also positive for CD5 and such cases are often disseminated. Lymphoplasmacytic lymphoma should also be a differential diagnosis for CLL/SLL. It frequently demonstrates MYD88 L265P, which is a key differential finding. By immunohistological examination, the expression of lymphoid enhancer-binding factor 1 is specific for CLL/SLL and can be a good marker in the differential diagnosis.
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Keywords | chronic lymphocytic leukemia/small lymphocytic lymphoma
differential diagnosis
indolent lymphoma
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Published Date | 2020
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Publication Title |
Journal of Clinical and Experimental Hematopathology
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Volume | volume60
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Issue | issue4
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Publisher | Japanese Society for Lymphoreticular Tissue Research
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Start Page | 124
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End Page | 129
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ISSN | 1346-4280
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NCID | AA11556796
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © 2020 by The Japanese Society for Lymphoreticular Tissue Research
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File Version | publisher
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Related Url | isVersionOf https://doi.org/10.3960/jslrt.19041
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License | https://creativecommons.org/licenses/by-nc-sa/4.0/
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