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ID 54815
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Author
Kanazawa, Yui Department of aPediatrics, Okayama University Hospital
Yamashita, Yuka Clinical Research Center, Nagoya Medical Center
Fujiwara, Mitsuhiro Department of Pediatrics, Kurashiki Central Hospital
Muraoka, Michiko Department of aPediatrics, Okayama University Hospital
Washio, Kana Department of aPediatrics, Okayama University Hospital
Kanamitsu, Kiichiro Department of aPediatrics, Okayama University Hospital
Ishida, Hisashi Department of aPediatrics, Okayama University Hospital
Nakano, Takae Department of aPediatrics, Okayama University Hospital
Yamada, Miho Clinical Research Center, Nagoya Medical Center
Horibe, Keizo Clinical Research Center, Nagoya Medical Center
Tanaka, Takehiro Department of Pathology, Okayama University Hospital Kakenhi
Yoshino, Tadashi Department of Pathology, Okayama University Hospital Kakenhi
Shimada, Akira Department of aPediatrics, Okayama University Hospital
Abstract
Childhood anaplastic large cell lymphoma (ALCL) accounts for approx. 10–30 of cases of non-Hodgkin lymphoma, and the ALCL99 study reported 60–75 disease-free survival; however, a relatively high relapse rate was observed (25–30 ). We report 2 patients with Stage III ALCL who relapsed 6–18 months after the end of ALCL99 chemotherapy. A retrospective molecular analysis identified the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) fusion gene in the first diagnostic bone marrow samples taken from both patients. However, antibodies against the ALK protein appeared to be relatively low in the serum of both patients (×100 and ×750). An increase in chemotherapy intensity may be beneficial if Stage III ALCL patients are shown to be NPM-ALK chimera-positive in the first diagnostic bone marrow sample.
Keywords
ALCL
NPM-ALK fusion
lymphoma
Amo Type
Case Report
Published Date
2016-12
Publication Title
Acta Medica Okayama
Volume
volume70
Issue
issue6
Publisher
Okayama University Medical School
Start Page
503
End Page
506
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2016 by Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID