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Author Matsuoka, Atsushi| Shien, Kazuhiko| Tomida, Shuta| Ohki, Masayoshi| Hisamatsu, Kazuya| Fujiwara, Ryota| Ishimura, Kosei| Fujii, Ryunosuke| Higashihara, Tomoaki| Hayashi, Naohiro| Okada, Kazuhiro| Yoshichika, Ryo| Mukohara, Fumiaki| Yoshikawa, Mao| Fukumoto, Yuma| Suzawa, Ken| Tomioka, Yasuaki| Tanaka, Shin| Miyoshi, Kentaroh| Okazaki, Mikio| Sugimoto, Seiichiro| Otani, Yusuke| Tanaka, Atsushi| Inoue, Hirofumi| Togashi, Yosuke| Yamamoto, Hidetaka| Ennishi, Daisuke| Toyooka, Shinichi|
Published Date 2025-12-16
Publication Title Communications Biology
Volume volume8
Issue issue1
Publisher Springer Science and Business Media LLC
Start Page 1773
ISSN 2399-3642
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 41402584
DOI 10.1038/s42003-025-09162-w
Related Url isVersionOf https://doi.org/10.1038/s42003-025-09162-w
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Author Baba, Takahiro| Inoue, Hirofumi| Matsuoka, Hiromi| Kyakuno, Mio| Yoshinaga, Yusuke| Takeguchi, Tetsuya| Fujiwara, Miho| Yamada, Kotaro| Nakamura, Eri| Morita, Ayako| Hara, Naofumi| Ninomiya, Kiichiro| Higo, Hisao| Fujii, Masanori| Ichihara, Eiki| Rai, Kammei| Ohashi, Kadoaki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Togashi, Yosuke| Makimoto, Go|
Keywords lung adenocarcinoma EML4-ALK AmoyDxⓇ Pan Lung Cancer PCR Panel alectinib
Published Date 2025-12-01
Publication Title Internal Medicine
Volume volume64
Issue issue23
Publisher Japanese Society of Internal Medicine
Start Page 3413
End Page 3418
ISSN 0918-2918
NCID AA10827774
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 by The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 40399085
DOI 10.2169/internalmedicine.5397-25
Web of Science KeyUT 001494126400001
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.5397-25
Author Nakao, Shin| Kojima, Keiichi| Sato, Keita| Kemmotsu, Naoya| Ohuchi, Hideyo| Togashi, Yosuke| Sudo, Yuki|
Note This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemical Society, copyright © 2025 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/jacs.5c13053.| This fulltext file will be available in Nov. 2026.|
Published Date 2025-11-04
Publication Title Journal of the American Chemical Society
Publisher American Chemical Society (ACS)
ISSN 0002-7863
NCID AA00692602
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 American Chemical Society
File Version author
PubMed ID 41186408
DOI 10.1021/jacs.5c13053
Web of Science KeyUT 001607655700001
Related Url isVersionOf https://doi.org/10.1021/jacs.5c13053
FullText URL fulltext.pdf 41586_2024_8439_MOESM1_ESM.pdf Supplementary Tables-legends.docx 2022-12-20357D-Supplementary Table 1.xlsx 2022-12-20357D-Supplementary Table 2.xlsx 2022-12-20357D-Supplementary Table 3.pdf 2022-12-20357D-Supplementary Table 4.xlsx 2022-12-20357D-Supplementary Table 5.pdf 2022-12-20357D-Supplementary Table 6.pdf
Author Ikeda, Hideki| Kawase, Katsushige| Nishi, Tatsuya| Watanabe, Tomofumi| Takenaga, Keizo| Inozume, Takashi| Ishino, Takamasa| Aki, Sho| Lin, Jason| Kawashima, Shusuke| Nagasaki, Joji| Ueda, Youki| Suzuki, Shinichiro| Makinoshima, Hideki| Itami, Makiko| Nakamura, Yuki| Tatsumi, Yasutoshi| Suenaga, Yusuke| Morinaga, Takao| Honobe-Tabuchi, Akiko| Ohnuma, Takehiro| Kawamura, Tatsuyoshi| Umeda, Yoshiyasu| Nakamura, Yasuhiro| Kiniwa, Yukiko| Ichihara, Eiki| Hayashi, Hidetoshi| Ikeda, Jun-ichiro| Hanazawa, Toyoyuki| Toyooka, Shinichi| Mano, Hiroyuki| Suzuki, Takuji| Osawa, Tsuyoshi| Kawazu, Masahito| Togashi, Yosuke|
Published Date 2025-01-22
Publication Title Nature
Volume volume638
Issue issue8049
Publisher Springer Science and Business Media LLC
Start Page 225
End Page 236
ISSN 0028-0836
NCID AA00752384
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025, corrected publication 2025
File Version publisher
PubMed ID 39843734
DOI 10.1038/s41586-024-08439-0
Web of Science KeyUT 001401954800001
Related Url isVersionOf https://doi.org/10.1038/s41586-024-08439-0
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Author Matsuura, Hiroaki| Ishino, Takamasa| Ninomiya, Toshifumi| Ninomiya, Kiichiro| Tachibana, Kota| Honobe-Tabuchi, Akiko| Muto, Yoshinori| Inozume, Takashi| Ueda, Youki| Ohashi, Kadoaki| Maeda, Yoshinobu| Nagasaki, Joji| Togashi, Yosuke|
Keywords antigenicity cancer immunotherapy CTLA-4 PD-1 regulatory T cell
Published Date 2025-02-27
Publication Title Cancer Science
Volume volume116
Issue issue5
Publisher Wiley
Start Page 1214
End Page 1226
ISSN 1347-9032
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Author(s).
File Version publisher
PubMed ID 40017103
DOI 10.1111/cas.70029
Web of Science KeyUT 001479679200005
Related Url isVersionOf https://doi.org/10.1111/cas.70029
FullText URL fulltext20250213-02.pdf suppl20250213-02.pdf
Author Mukohara, Fumiaki| Iwata, Kazuma| Ishino, Takamasa| Inozume, Takashi| Nagasaki, Joji| Ueda, Youki| Suzawa, Ken| Ueno, Toshihide| Ikeda, Hideki| Kawase, Katsushige| Saeki, Yuka| Kawashima, Shusuke| Yamashita, Kazuo| Kawahara, Yu| Nakamura, Yasuhiro| Honobe-Tabuchi, Akiko| Watanabe, Hiroko| Dansako, Hiromichi| Kawamura, Tatsuyoshi| Suzuki, Yutaka| Honda, Hiroaki| Mano, Hiroyuki| Toyooka, Shinichi| Kawazu, Masahito| Togashi, Yosuke|
Keywords cancer immunology somatic mutation T cell tumor-infiltrating lymphocytes
Note This is an Accepted Manuscript of an article published by Proceedings of the National Academy of Sciences.| This fulltext file will be available in Feb. 2025.|
Published Date 2024-08-21
Publication Title Proceedings of the National Academy of Sciences
Volume volume121
Issue issue35
Publisher Proceedings of the National Academy of Sciences
Start Page e2320189121
ISSN 0027-8424
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 the Author(s).
File Version author
PubMed ID 39167601
DOI 10.1073/pnas.2320189121
Web of Science KeyUT 001408603100001
Related Url isVersionOf https://doi.org/10.1073/pnas.2320189121
FullText URL fulltext.pdf
Author Fujimoto, Takuya| Yamasaki, Osamu| Kanehira, Noriyuki| Matsushita, Hirokazu| Sakurai, Yoshinori| Kenmotsu, Naoya| Mizuta, Ryo| Kondo, Natsuko| Takata, Takushi| Kitamatsu, Mizuki| Igawa, Kazuyo| Fujimura, Atsushi| Otani, Yoshihiro| Shirakawa, Makoto| Shigeyasu, Kunitoshi| Teraishi, Fuminori| Togashi, Yosuke| Suzuki, Minoru| Fujiwara, Toshiyoshi| Michiue, Hiroyuki|
Keywords abscopal effect advanced melanoma boron neutron capture therapy boron-neutron immunotherapy immune combination therapy
Published Date 2024-08-09
Publication Title Cancer Science
Volume volume115
Issue issue10
Publisher Wiley
Start Page 3231
End Page 3247
ISSN 1347-9032
NCID AA11808050
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 The Author(s).
File Version publisher
PubMed ID 39119813
DOI 10.1111/cas.16298
Web of Science KeyUT 001287521700001
Related Url isVersionOf https://doi.org/10.1111/cas.16298
FullText URL fulltext20240226-03.pdf
Author Zhou, Wenhao| Kawashima, Shusuke| Ishino, Takamasa| Kawase, Katsushige| Ueda, Youki| Yamashita, Kazuo| Watanabe, Tomofumi| Kawazu, Masahito| Dansako, Hiromichi| Suzuki, Yutaka| Nishikawa, Hiroyoshi| Inozume, Takashi| Nagasaki, Joji| Togashi, Yosuke|
Keywords cancer immunology follicular helper T cell cytotoxic CD4+ T cell CXCL13 T cell exhaustion stem-like progenitor exhaustion terminally differentiated exhaustion PD-1 LAG-3 TCF1
Note Immune checkpoint inhibitors exert clinical efficacy against various types of cancer through reinvigoration of exhausted CD8+ T cells that attack cancer cells directly in the tumor microenvironment (TME). Using single-cell sequencing and mouse models, we show that CXCL13, highly expressed in tumor-infiltrating exhausted CD8+ T cells, induces CD4+ follicular helper T (TFH) cell infiltration, contributing to anti-tumor immunity. Furthermore, a part of the TFH cells in the TME exhibits cytotoxicity and directly attacks major histocompatibility complex-II-expressing tumors. TFH-like cytotoxic CD4+ T cells have high LAG-3/BLIMP1 and low TCF1 expression without self-renewal ability, whereas non-cytotoxic TFH cells express low LAG-3/BLIMP1 and high TCF1 with self-renewal ability, closely resembling the relationship between terminally differentiated and stem-like progenitor exhaustion in CD8+ T cells, respectively. Our findings provide deep insights into TFH-like CD4+ T cell exhaustion with helper progenitor and cytotoxic differentiated functions, mediating anti-tumor immunity orchestrally with CD8+ T cells.|
Published Date 2024-02-27
Publication Title Cell Reports
Volume volume43
Issue issue2
Publisher Elsevier BV
Start Page 113797
ISSN 2211-1247
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 The Author(s).
File Version publisher
PubMed ID 38363680
DOI 10.1016/j.celrep.2024.113797
Web of Science KeyUT 001185865700001
Related Url isVersionOf https://doi.org/10.1016/j.celrep.2024.113797
FullText URL fulltext20240226-02.pdf
Author Ikeda, Hideki| Nagasaki, Joji| Shimizu, Daiki| Katsuya, Yuki| Horinouchi, Hidehito| Hosomi, Yukio| Tanji, Etsuko| Iwata, Takekazu| Itami, Makiko| Kawazu, Masahito| Ohe, Yuichiro| Suzuki, Takuji| Togashi, Yosuke|
Keywords Thymic epithelial tumor Cancer immunotherapy CD80/CD86 MHC Memory precursor effector T cell
Published Date 2023-10
Publication Title JTO Clinical and Research Reports
Volume volume4
Issue issue10
Publisher Elsevier
Start Page 100573
ISSN 2666-3643
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 The Authors.
File Version publisher
PubMed ID 37799325
DOI 10.1016/j.jtocrr.2023.100573
Web of Science KeyUT 001161095400001
Related Url isVersionOf https://doi.org/10.1016/j.jtocrr.2023.100573
FullText URL fulltext20231110-01.pdf
Author Dansako, Hiromichi| Ikeda, Masanori| Ariumi, Yasuo| Togashi, Yosuke| Kato, Nobuyuki|
Keywords double-stranded RNA hepatitis C virus innate immunity RIG-I-like receptor RNA virus
Note This is the accepted version of the following article: Dansako, H., Ikeda, M., Ariumi, Y., Togashi, Y. and Kato, N. (2024), Hepatitis C virus NS5B triggers an MDA5-mediated innate immune response by producing dsRNA without the replication of viral genomes. FEBS J, 291: 1119-1130. https://doi.org/10.1111/febs.16980, which has been published in final form at https://doi.org/10.1111/febs.16980| This fulltext file will be available in Oct. 2024.|
Published Date 2023-10-20
Publication Title The FEBS Journal
Volume volume291
Issue issue6
Publisher Wiley
Start Page 1119
End Page 1130
ISSN 1742-464X
NCID AA11998513
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Federation of European Biochemical Societies.
File Version author
PubMed ID 37863517
DOI 10.1111/febs.16980
Web of Science KeyUT 001091349500001
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FullText URL fulltext20231004-03.pdf fig1_20231004-03.pdf fig2_20231004-03.pdf fig3_20231004-03.pdf fig4_20231004-03.pdf fig5_20231004-03.pdf Suppl20231004-03.pdf
Author Kemmotsu, Naoya| Ninomiya, Kiichiro| Kunimasa, Kei| Ishino, Takamasa| Nagasaki, Joji| Otani, Yoshihiro| Michiue, Hiroyuki| Ichihara, Eiki| Ohashi, Kadoaki| Inoue, Takako| Tamiya, Motohiro| Sakai, Kazuko| Ueda, Youki| Dansako, Hiromichi| Nishio, Kazuto| Kiura, Katsuyuki| Date, Isao| Togashi, Yosuke|
Keywords cancer immunotherapy intracranial metastasis intracranial progression memory precursor effector T cell nonsmall-cell lung cancer
Note This is the peer reviewed version of the following article: [Kemmotsu N, Ninomiya K, Kunimasa K, et al. Low frequency of intracranial progression in advanced NSCLC patients treated with cancer immunotherapies. Int J Cancer. 2024; 154(1): 169-179. doi:10.1002/ijc.34700], which has been published in final form at [https://doi.org/10.1002/ijc.34700]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in Aug. 2024.|
Published Date 2023-08-23
Publication Title International Journal of Cancer
Volume volume154
Issue issue1
Publisher Wiley
Start Page 169
End Page 179
ISSN 0020-7136
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 UICC.
File Version author
PubMed ID 37611176
DOI 10.1002/ijc.34700
Web of Science KeyUT 001069876600001
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Author Morinaga, Takao| Inozume, Takashi| Kawazu, Masahito| Ueda, Youki| Sax, Nicolas| Yamashita, Kazuo| Kawashima, Shusuke| Nagasaki, Joji| Ueno, Toshihide| Lin, Jason| Ohara, Yuuki| Kuwata, Takeshi| Yukami, Hiroki| Kawazoe, Akihito| Shitara, Kohei| Honobe-Tabuchi, Akiko| Ohnuma, Takehiro| Kawamura, Tatsuyoshi| Umeda, Yoshiyasu| Kawahara, Yu| Nakamura, Yasuhiro| Kiniwa, Yukiko| Morita, Ayako| Ichihara, Eiki| Kiura, Katsuyuki| Enokida, Tomohiro| Tahara, Makoto| Hasegawa, Yoshinori| Mano, Hiroyuki| Suzuki, Yutaka| Nishikawa, Hiroyoshi| Togashi, Yosuke|
Published Date 2022-07-28
Publication Title Cancer Research Communications
Volume volume2
Issue issue7
Publisher American Association for Cancer Research
Start Page 739
End Page 753
ISSN 2767-9764
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Authors
File Version publisher
PubMed ID 36923281
DOI 10.1158/2767-9764.CRC-22-0050
Web of Science KeyUT 001048412300001
Related Url isVersionOf https://doi.org/10.1158/2767-9764.CRC-22-0050
FullText URL fulltext20230817-01.pdf fig20230817-01.pdf suppl_fig20230817-01.pdf suppl_table20230817-01.pdf
Author Kawase, Katsushige| Kawashima, Shusuke| Nagasaki, Joji| Inozume, Takashi| Tanji, Etsuko| Kawazu, Masahito| Hanazawa, Toyoyuki| Togashi, Yosuke|
Note This is an Accepted Manuscript of an article published by American Association for Cancer Research.| This fulltext file will be available in Jul. 2024.|
Published Date 2023-07-05
Publication Title Cancer Immunology Research
Volume volume11
Issue issue7
Publisher American Association for Cancer Research (AACR)
Start Page 895
End Page 908
ISSN 2326-6066
NCID AA12626809
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 American Association for Cancer Research
File Version author
PubMed ID 37062030
DOI 10.1158/2326-6066.cir-22-0815
Web of Science KeyUT 001038030200001
Related Url isVersionOf https://doi.org/10.1158/2326-6066.CIR-22-0815
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Author Kemmotsu, Naoya| Zhu, Li| Nagasaki, Joji| Otani, Yoshihiro| Ueda, Youki| Dansako, Hiromichi| Fang, Yue| Date, Isao| Togashi, Yosuke|
Keywords abscopal effect dendritic cell hydrogen peroxide radiosensitizer radiotherapy tumor-draining lymph node
Published Date 2023-07-23
Publication Title Cancer Science
Volume volume114
Issue issue10
Publisher Wiley
Start Page 3848
End Page 3856
ISSN 1347-9032
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 The Authors.
File Version publisher
PubMed ID 37485636
DOI 10.1111/cas.15911
Web of Science KeyUT 001034657700001
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Author Watanabe, Tomofumi| Ishino, Takamasa| Ueda, Youki| Nagasaki, Joji| Sadahira, Takuya| Dansako, Hiromichi| Araki, Motoo| Togashi, Yosuke|
Keywords antibody-dependent cell cytotoxicity cytotoxic T-lymphocyte-associated antigen 4 immune checkpoint inhibitors regulatory T cell renal cell carcinoma
Published Date 2023-02-10
Publication Title Cancer Science
Publisher Wiley
ISSN 1347-9032
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 The Authors.
File Version publisher
PubMed ID 36762794
DOI 10.1111/cas.15756
Web of Science KeyUT 000940385500001
Related Url isVersionOf https://doi.org/10.1111/cas.15756
FullText URL fulltext20230228-1.pdf
Author Ishino, Takamasa| Kawashima, Shusuke| Tanji, Etsuko| Ueno, Toshihide| Ueda, Youki| Ogasawara, Sadahisa| Sato, Kazuhito| Mano, Hiroyuki| Ishihara, Soichiro| Kato, Naoya| Kawazu, Masahito| Togashi, Yosuke|
Published Date 2023-02-02
Publication Title British Journal of Cancer
Publisher Springer Science and Business Media LLC
ISSN 0007-0920
NCID AA00574355
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023
File Version publisher
PubMed ID 36732592
DOI 10.1038/s41416-023-02165-6
Web of Science KeyUT 000925746000001
Title Alternative Cancer-immunotherapy biomarkers in the tumor microenvironment
FullText URL 133_151.pdf
Author Togashi, Yosuke|
Keywords tumor microenvironment cancer immunology tumor-infiltrating T cell PD-1/PD-L1
Publication Title Journal of Okayama Medical Association
Published Date 2021-12-01
Volume volume133
Issue issue3
Start Page 151
End Page 157
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.133.151
language Japanese
Copyright Holders Copyright (c) 2021 岡山医学会
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DOI 10.4044/joma.133.151