ID | 31574 |
JaLCDOI | |
FullText URL | |
Author |
Imajo, Kenji
Tada, Shinya
Tsubota, Teruhiko
Kimura, Ikuro
|
Abstract | The activity of pulmonary lymphocytes was evaluated by the detection of interleukin-2 (IL-2) receptor alpha mRNA expression in lung cancer patients associated with diffuse interstitial shadow on roentgenograms of their lungs. Reverse transcription coupled with the polymerase chain reaction was used to detect mRNA expression. In 5 of 6 patients, IL-2R alpha mRNA expression was increased in pulmonary lymphocytes compared with 4 normal controls. The expression in this mRNA in peripheral blood lymphocytes was almost undetectable in either normal controls or these patients. These results suggest that pulmonary lymphocytes in patients with lung cancer associated with diffuse interstitial shadows are activated and may promote the inflammatory process generating pulmonary fibrosis.
|
Keywords | pulmonary fibrosis
lung cancer
pulmonary lymphocytes
IL-2R α mRNA
RT-PCR
|
Amo Type | Article
|
Publication Title |
Acta Medica Okayama
|
Published Date | 1993-04
|
Volume | volume47
|
Issue | issue2
|
Publisher | Okayama University Medical School
|
Start Page | 73
|
End Page | 78
|
ISSN | 0386-300X
|
NCID | AA00508441
|
Content Type |
Journal Article
|
language |
English
|
Copyright Holders | Copyright© 1999 Okayama University Medical School
|
File Version | publisher
|
Refereed |
True
|
PubMed ID | |
Web of Science KeyUT | |
Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/5957
|