FullText URL Epilepsia_49_3_521.pdf
Author Ohmori, Iori| Ouchida, Mamoru| Kobayashi, Katsuhiro| Jitsumori, Yoshimi| Inoue, Takushi| Shimizu, Kenji| Matsui, Hideki| Ohtsuka, Yoko| Maegaki, Yoshihiro|
Keywords Rasmussen encephalitis SCN1A genetic-environmental interaction
Published Date 2007-11-21
Publication Title Epilepsia
Volume volume49
Issue issue3
Publisher Blackwell
Start Page 521
End Page 526
ISSN 0013-9580
NCID AA00180597
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 18031552
DOI 10.1111/j.1528-1167.2007.01411.x
Web of Sience KeyUT 000253477800020
Related Url isVersionOf https://doi.org/10.1111/j.1528-1167.2007.01411.x
Author Yasuda, Yukiko| Sakai, Akiko| Ito, Sachio| Sasai, Kaori| Yamamoto, Hiromasa| Matsubara, Nagahide| Ouchida, Mamoru| Katayama, Hiroshi| Shimizu, Kenji|
Published Date 2017-02
Publication Title Acta Medica Okayama
Volume volume71
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/54826
JaLCDOI 10.18926/AMO/47013
FullText URL 65_5_315.pdf
Author Wang, Lei| Kaku, Haruki| Huang, Peng| Xu, Kexin| Yang, Kai| Zhang, Jiheng| Li, Ming| Xie, Liping| Wang, Xiaofeng| Sakai, Akiko| Watanabe, Masami| Nasu, Yasutomo| Shimizu, Kenji| Kumon, Hiromi| Na, Yanqun|
Abstract Deficiencies in the human DNA repair gene WRN are the cause of Werner syndrome, a rare autosomal recessive disorder characterized by premature aging and a predisposition to cancer. This study evaluated the association of WRN Leu1074Phe (rs1801195), a common missense single nucleotide polymorphism in WRN, with prostate cancer susceptibility in Chinese subjects. One hundred and forty-seven prostate cancer patients and 111 male cancer-free control subjects from 3 university hospitals in China were included. Blood samples were obtained from each subject, and the single nucleotide polymorphism WRN Leu1074Phe was genotyped by using a Snapshot assay. The results showed that WRN Leu1074Phe was associated with the risk of prostate cancer in Chinese men and that the TG/GG genotype displayed a decreased prevalence of prostate cancer compared with the TT genotype (OR=0.58, 95%CI:0.35-0.97, p=0.039). Through stratified analysis, more significant associations were revealed for the TG/GG genotype in the subgroup with diagnosis age <_ 72 yr (OR=0.27, 95%CI:0.12-0.61, p=0.002) and in patients with localized diseases (OR=0.36, 95%CI:0.19-0.70, p=0.003). However, no statistically significant difference was found in the subgroup with age >72 yr or in patients with advanced diseases. We concluded that the genetic variant Leu1074Phe in the DNA repair gene WRN might play a role in the risk of prostate cancer in Chinese subjects.
Keywords polymorphism prostatic neoplasms single nucleotide susceptibility WRN
Amo Type Original Article
Published Date 2011-10
Publication Title Acta Medica Okayama
Volume volume65
Issue issue5
Publisher Okayama University Medical School
Start Page 315
End Page 323
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2011 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 22037267
Web of Sience KeyUT 000296116400005
FullText URL fulltext.pdf
Author Yano, Masaaki| Ouchida, Mamoru| Shigematsu, Hisayuki| Tanaka, Noriyoshi| Ichimura, Koichi| Kobayashi, Kazuyasu| Inaki, Yasuhiko| Toyooka, Shinichi| Tsukuda, Kazunori| Shimizu, Nobuyoshi| Shimizu, Kenji|
Keywords alternative splicing HELLS loss of heterozygosity lung cancer SMARCA6
Note Digital Object Identifer:10.1002/ijc.20407<br> Published with permission from the copyright holder. This is the author's copy, as published in the Journal of International Journal of Cancer, October 2004, Volume 112, Issue 1, Pages 8-13.<br> Publisher URL:<a href="http://dx.doi.org/10.1002/ijc.20407" >http://dx.doi.org/10.1002/ijc.20407</a><br> <a href="http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=Okayamauniv&SrcApp =Okayamauniv&DestLinkType=FullRecord&KeyUT=000223939100002&DestApp=WOS" >Direct access to Thomson Web of Science record</a><br> Copyright © 2004 Wiley-Liss, Inc. All rights reserved.;
Published Date 2004-10-20
Publication Title International Journal of Cancer
Volume volume112
Issue issue1
Publisher Wiley-Liss, Inc.
Start Page 8
End Page 13
ISSN 0020-7136
NCID AA00680002
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders Wiley-Liss, Inc.
File Version author
PubMed ID 15305370
DOI 10.1002/ijc.20407
Web of Sience KeyUT 000223939100002
Author Ito, Tatsuo| Ouchida, Mamoru| Morimoto, Yuki| Yoshida, Aki| Jitsumori, Yoshimi| Ozaki, Toshifumi| Sonobe, Hiroshi| Inoue, Hajime| Shimizu, Kenji|
Published Date 2005-06-28
Publication Title Cancer Letters
Volume volume224
Issue issue2
Content Type Journal Article
Author Shimizu, Kenji|
Published Date 1996-09
Publication Title 岡山実験動物研究会報
Volume volume13
Content Type Others
Author 清水 憲二|
Published Date 2003-01-31
Publication Title 岡山医学会雑誌
Volume volume114
Issue issue3
Content Type Journal Article
Author Ishii, Tatsuhiro| Murakami, Jun| Notohara, Kenji| Sasamoto, Hiromi| Kambara, Takeshi| Shirakawa, Yasuhiro| Naomoto, Yoshio| Ouchida, Mamoru| Shimizu, Kenji| Jeremy, R. Jass| Matsubara, Nagahide| Tanaka, Noriaki|
Published Date 2007-09-03
Publication Title 岡山医学会雑誌
Volume volume119
Issue issue2
Content Type Journal Article