FullText URL fulltext.pdf
Author Obata, Kyoichi| Okui, Tatsuo| Kishimoto, Koji| Ibaragi, Soichiro| Sasaki, Akira|
Published Date 2020-04-28
Publication Title Case Reports in Medicine
Volume volume2020
Publisher Hindawi
Start Page 4814519
ISSN 1687-9627
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Kyoichi Obata et al.
File Version publisher
PubMed ID 32411253
DOI 10.1155/2020/4814519
Web of Science KeyUT 000534278000001
Related Url isVersionOf https://doi.org/10.1155/2020/4814519
FullText URL fulltext.pdf
Author Murase, Yurika| Kishimoto, Koji| Yoshida, Shoko| Kunisada, Yuki| Kadoya, Koichi| Ibaragi, Soichiro| Sasaki, Akira|
Published Date 2020-03-28
Publication Title Journal of Surgical Case Reports
Issue issue3
Publisher Oxford University Press
Start Page rjaa061
ISSN 2042-8812
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020.
File Version publisher
PubMed ID 32257103
DOI 10.1093/jscr/rjaa061
Web of Science KeyUT 000535663800034
Related Url isVersionOf https://doi.org/10.1093/jscr/rjaa061
FullText URL IJO54_1_283.pdf
Author Shimizu, Rieko| Ibaragi, Soichiro| Eguchi, Takanori| Kuwajima, Daisuke| Kodama, Shinichi| Nishioka, Takashi| Okui, Tatsuo| Obata, Kyoichi| Takabatake, Kiyofumi| Kawai, Hotaka| Ono, Kisho| Okamoto, Kuniaki| Nagatsuka, Hitoshi| Sasaki, Akira|
Keywords nicotine head and neck squamous cell carcinoma lymph node metastasis cetuximab
Published Date 2018-11-12
Publication Title International Journal of Oncology
Volume volume54
Issue issue1
Publisher Spandidos Publications
Start Page 283
End Page 294
ISSN 1019-6439
NCID AA10992511
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 30431077
DOI 10.3892/ijo.2018.4631
Web of Science KeyUT 000451845400025
Related Url isVersionOf https://doi.org/10.3892/ijo.2018.4631
JaLCDOI 10.18926/AMO/55204
FullText URL 71_3_219.pdf
Author Takakura, Hiroaki| Domae, Shohei| Ono, Toshiro| Sasaki, Akira|
Abstract  Anticancer drugs induce cell-cycle arrest and apoptosis not only in tumor cells, but also in immune cells. However, many preclinical and clinical findings show that some chemotherapeutic agents can improve the antitumor efficacy of immunotherapy. We immunohistochemically analyzed the degree of immune cell infiltration and the relevance of programmed cell death 1 ligand-1 (PD-L1) expression in surgically resected oral squamous cell carcinoma (OSCC) specimens from patients who had undergone pretreatment with certain chemotherapies and other patients without pretreatment. We divided the patients into the group of neoadjuvant chemotherapy (NAC) patients (n=8) and the nNAC (without NAC) patient group (n=10). We observed that NAC induced infiltrations of CD4, CD8 T cells and CD56 NK cells into the tumor microenvironment. Decreased numbers of Tregs and PD-1-positive cells were observed in the NAC group. No significant difference was observed in the degree of immune-cell infiltration between the patient groups except for CD56 NK cells in the stroma and PD-1 cells in cancer nests. Eighty percent of the nNAC specimens showed intermediate-to-strong PD-L1 protein expression, whereas 75% of the NAC specimens showed down-regulation of the PD-L1 protein, indicating the effectiveness of the chemotherapeutic treatment before surgery.
Keywords oral squamous cell carcinoma programmed cell death 1 ligand-1 tumor microenvironment neoadjuvant chemotherapy immunohistochemistry
Amo Type Original Article
Published Date 2017-06
Publication Title Acta Medica Okayama
Volume volume71
Issue issue3
Publisher Okayama University Medical School
Start Page 219
End Page 226
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28655941
JaLCDOI 10.18926/AMO/54506
FullText URL 70_4_291.pdf
Author Yoshioka, Norie| Shimo, Tsuyoshi| Ibaragi, Soichiro| Sasaki, Akira|
Abstract Temporomandibular joint (TMJ) dislocation can occur during daily activities and negatively affect a patientʼs quality of life. Although both nonsurgical and surgical techniques have been used to treat recurrent TMJ dislocation, the former is not always successful and the latter, although having a high success rate, is invasive and requires hospitalization. Recently, autologous blood injection has been used to treat recurrent TMJ dislocation. However, this technique is not yet widely used in clinical practice. We designed this study to obtain further information as to efficacy, safety and stability of autologous blood injection for recurrent TMJ dislocation.
Keywords autologous blood injection recurrent temporomandibular joint dislocation
Amo Type Clinical Study Protocols
Published Date 2016-08
Publication Title Acta Medica Okayama
Volume volume70
Issue issue4
Publisher Okayama University Medical School
Start Page 291
End Page 294
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27549675
Web of Science KeyUT 000384748600010
Author Yamanaka, Reiko| Soga, Yoshihiko| Nawachi, Kumiko| Yanagi, Yoshinobu| Kodama, Naoki| Nakata, Takashi| Miura, Rumi| Hagawa, Misao| Takeuchi, Tetsuo| Yamane, Mieko| Morita, Manabu| Takashiba, Shogo| Asami, Jun-ichi| Minagi, Shogo| Yoshiyama, Masahiro| Shimono, Tsutomu| Kuboki, Takuo| Sasaki, Akira| Morita, Kiyoshi|
Published Date 2009-06
Publication Title 岡山歯学会雑誌
Volume volume28
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/49257
FullText URL 67_1_55.pdf
Author Shimo, Tsuyoshi| Nishiyama, Akiyoshi| Jinno, Tokiari| Sasaki, Akira|
Abstract In this article, we report the successful surgical treatment of a patient, 34 years of age, who had a severe gummy smile and a class II malocclusion. The patient had an 11-mm gingival exposure during full smile and a convex profile. A LeFort I osteotomy combined with a horseshoe osteotomy was used for the superior repositioning of the maxilla;then, an intraoral vertical ramus osteotomy (IVRO) and genioplasty were performed for mandibular advancement. The maxilla was acceptably impacted 8mm at the first incisor and 5mm at the first molar. Both the occlusion and facial appearance were significantly improved by this surgical-orthodontic treatment. Our results suggest that the combination of a horseshoe osteotomy with a LeFort I osteotomy is a useful technique for reliable superior repositioning of the maxilla.
Keywords LeFort I osteotomy horseshoe osteotomy gummy smile
Amo Type Case Report
Published Date 2013-02
Publication Title Acta Medica Okayama
Volume volume67
Issue issue1
Publisher Okayama University Medical School
Start Page 55
End Page 60
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23439509
Web of Science KeyUT 000316829900007
Author Fujioka, Shinsuke| Nishimura, Hiroaki| Nishihara, Katsunobu| Sasaki, Akira| Sunahara, Atsushi| Okuno, Tomoharu| Ueda, Nobuyoshi| Ando, Tsuyoshi| Tao, Yezheng| Shimada, Yoshinori| Hashimoto, Kazuhisa| Yamaura, Michiteru| Shigemori, Keisuke| Nakai, Mitsuo| Nagai, Keiji| Norimatsu, Takayoshi| Nishikawa, Takeshi| Miyanaga, Noriaki| Izawa, Yasukazu| Mima, Kunioki|
Published Date 2005-11
Publication Title Physical Review Letters
Volume volume95
Issue issue23
Content Type Journal Article
JaLCDOI 10.18926/21194
Title Alternative Stable isotope study of the hotsprings and volcanoes of Hokkaido, Japan
FullText URL pitsr_047_055_067.pdf
Author Matsubaya, Osamu| Sakai, Hitoshi| Ueda, Akira| Tsutsumi, Makoto| Kusakabe, Minoru| Sasaki, Akira|
Abstract Stable isotope ratios of hydrogen, oxygen, carbon and sulfur of precipitation, thermal and mineral waters, and volcanic gases were measured. The isotopic data combined with chemical and geological information were discussed in terms of origin and evolution of the hotsprings and volcanic gases. The hotsprings along the Uchiura Bay, Oshima Peninsula are mostly near-neutral NaCl-type thermal water and may be divided into three groups : (1) thermal waters isotopically similar to the precipitation of this area, (2) those similar in D/H to the local meteoric waters but enriched by 2 to 3‰ in (18)O compared to the latter, and (3) those enriched significantly in both D and (18)O relative to the local meteoric waters. The first and second types of thermal water probably form from local meteoric water which percolates through "Green Tuff" formations and acquires dissolved chemicals from them. However, high salt concentration and the oxygen isotope shift (thesecond type) may imply that the NaCl-type water of volcanic origin might be involved. On the other hand, the waters of the third group can be explained by mixing of modern sea water into the second type thermal water (in case of Yachigashira) or by incorporation of fossil sea water of Tertiary origin into modern meteoric water (Nigorigawa). Except for Esan, Noboribetsu and Atosanupuri volcanic systems, waters from all the hotsprings and volcanic fumaroles associated with Quaternary volcanic rocks are meteoric in origin. Thermal waters at Esan, Noboribetsu and Atosanupuri have δD = -30~-50 and δ(18)O = -1~+ 3‰ and are enriched in D and (18)O relative to local meteoric water of the respective area. The origin of these waters and the mechanism (s) controlling the isotope ratios could not be made clear by the present study. Interesting is the finding that at Esan, Noboribetsu and Atosanupuri, thermal waters are enriched in D and (18)O relative to near-by fumarolic gases. The enrichment factor is 18 to 26‰ for hydrogen and 4 to 6‰ for oxygen, implying that more than one stages of liquidvapor separation are taking place in underground hydrothermal systems.
Publication Title 岡山大学温泉研究所報告
Published Date 1978-03-25
Volume volume47
Start Page 55
End Page 67
ISSN 0369-7142
language 日本語
File Version publisher
NAID 40000321119
JaLCDOI 10.18926/21159
Title Alternative An isotope study of hot springs in Nagano Prefecture
FullText URL pitsr_050_017_024.pdf
Author Matsubaya, Osamu| Sakai, Hitoshi| Kusakabe, Minoru| Sasaki, Akira|
Abstract Water samples from 28 hotsprings and mineral springs in Nagano Prefecture, central Japan, were examined for their stable isotope ratios of hydrogen, oxygen, carbon, and sulfur. Spring waters of Kashio are highly saline and enriched in heavy isotopes of oxygen and hydrogen (δ(18)O=-2.5~-4.6‰, δD=-54~-57‰). Linear relationships among δD, δ(18)O, and Cl(-) suggest that spring waters are the mixtures of a deep brine and local surface water. Extrapolation of the linear relationships indicates that the deep brine is both isotopically and chemically very similar to the deep brine previously suggested for the springs of Arima, Takarazuka, and Ishibotoke of which δD, δ(18)O, and Cl(-) are estimated as -33‰, +8.0‰, and 44g/l, respectively. A common origin may be warranted among these postulated brines, while their provenance is yet to be worked out. The hot springs in Matsushiro are a Na-Ca-Cl type of high carbonate content. Their hydrogen and oxygen isotope ratios (δD=-71~-46‰, δ(18)O=-9.1~-2.0‰) are higher than the local surface water. On the basis of the relationships among δD, δ(18)O, and Cl(-), they are considered to be the mixtures of fossil sea water and certain water of meteoric origin of which Cl(-) is about 4g/l and δ(18)O is higher by about 3‰ than the local surface water. The latter may be meteoric water circulating in the marine sedimentary formations (Green Tuff formations) with soluble sea salts. Isotopic exchange with carbonate minerals in the formations explains its (18)O enrichment. Spring waters from Yashio and Isobe (Gunma Pref.) as well as Yunosawa and Yatate (Akita Pref.) were previously interpreted to be mixtures of fossil sea water and local surface water of low Cl(-) content. Re-examination of their data revealed that the meteoric waters responsible for these springs contain about 3g/l Cl(-), similar to the value obtained for Matsushiro. However, unlike Matsushiro, the meteoric waters in these areas are found to be isotopically similar to the local surface waters. Waters from other hot springs studied here are of simply meteoric origin, thus belonging to the GreenTuff type water previously defined.
Publication Title 岡山大学温泉研究所報告
Published Date 1980-03-25
Volume volume50
Start Page 17
End Page 24
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002310953
Author 佐々木 朗|
Published Date 1990-10-31
Publication Title
Content Type Thesis or Dissertation