Author Yokohari, Hideko| Okazaki, Masatoshi| Sendo, Toshiaki|
Published Date 2008-08-01
Publication Title 岡山医学会雑誌
Volume volume120
Issue issue2
Content Type Journal Article
Title Alternative Drug interaction (30. combination with therapeutic drugs for chronic pain)
FullText URL 126_159.pdf
Author Ogawa, Atsushi| Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title 岡山医学会雑誌
Published Date 2014-08-01
Volume volume126
Issue issue2
Start Page 159
End Page 163
ISSN 0030-1558
language Japanese
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
DOI 10.4044/joma.126.159
NAID 130004685269
Author Yamaji, Kazuhiko| Kawasaki, Yoichi| Yoshitome, Kei| Matsunaga, Hisashi| Sendo, Toshiaki|
Published Date 2012-10
Publication Title Biological & Pharmaceutical Bulletin
Volume volume35
Issue issue10
Content Type Journal Article
Author Hayashi, Keiichiro| Ueshima, Satoshi| Ouchida, Mamoru| Mashimo, Tomoji| Nishiki, Teiichi| Sendo, Toshiaki| Serikawa, Tadao| Matsui, Hideki| Ohmori, Iori|
Published Date 2011-05
Publication Title Epilepsia
Volume volume52
Issue issue5
Content Type Journal Article
Title Alternative Drug interaction (31. drug interaction in hormonal breast cancer therapy)
FullText URL 126_245.pdf
Author Masaoka, Yasuyuki| Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title 岡山医学会雑誌
Published Date 2014-12-01
Volume volume126
Issue issue3
Start Page 245
End Page 248
ISSN 0030-1558
language Japanese
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
DOI 10.4044/joma.126.245
NAID 130004903247
Author Katsube, Risa| Sendo, Toshiaki|
Published Date 2008-12-01
Publication Title 岡山医学会雑誌
Volume volume120
Issue issue3
Content Type Journal Article
Title Alternative Drug interaction (32. Drug interaction in novel oral anticoagulants)
FullText URL 127_59.pdf
Author Ida, Hiromi| Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title 岡山医学会雑誌
Published Date 2015-04-01
Volume volume127
Issue issue1
Start Page 59
End Page 61
ISSN 0030-1558
Related Url http://www.okayama-u.ac.jp/user/oma/
language Japanese
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.59
NAID 130005068338
Author Zamami, Yoshito| Koyama, Toshihiro| Aiba, Tetsuya| Amano, Manabu| Ando, Tetsuaki| Kurata, Naomi| Nawa, Hideki| Nakura, Hironori| Kitamura, Yoshihisa| Sendo, Toshiaki|
Published Date 2014
Publication Title 静脈経腸栄養
Volume volume29
Issue issue4
Content Type Journal Article
Title Alternative Drug interaction (33. Combination with antimicrobial agents)
FullText URL 127_151.pdf
Author Tasaka, Ken| Shiraishi, Naoko| Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title 岡山医学会雑誌
Published Date 2015-08-03
Volume volume127
Issue issue2
Start Page 151
End Page 154
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.127.151
language Japanese
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.151
NAID 130005096260
Title Alternative Drug interaction (34. Drug interactions of food and medicine)
FullText URL 127_245.pdf
Author Hino, Hayato| Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title 岡山医学会雑誌
Published Date 2015-12-01
Volume volume127
Issue issue3
Start Page 245
End Page 249
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.127.245
language Japanese
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.245
NAID 130005116813
Title Alternative Drug interaction (35. Opioid-analgesic drug interactions)
FullText URL 128_53.pdf
Author Sada, Hikaru| Kajizono, Makoto| Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title 岡山医学会雑誌
Published Date 2016-04-01
Volume volume128
Issue issue1
Start Page 53
End Page 59
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.128.53
language Japanese
Copyright Holders Copyright (c) 2016 岡山医学会
File Version publisher
DOI 10.4044/joma.128.53
NAID 130005149610
Title Alternative Drug interaction (48. Interaction of drug with extracorporeal membrane oxygenation (ECMO))
FullText URL 132_102.pdf
Author Okawa, Yasumasa| Esumi, Satoru| Sendo, Toshiaki|
Publication Title Journal of Okayama Medical Association
Published Date 2020-08-03
Volume volume132
Issue issue2
Start Page 102
End Page 107
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.132.102
language Japanese
Copyright Holders Copyright (c) 2020 岡山医学会
File Version publisher
DOI 10.4044/joma.132.102
NAID 130007895002
Author Nawa, Hideki| Sendo, Toshiaki|
Published Date 2009-04-01
Publication Title 岡山医学会雑誌
Volume volume121
Issue issue1
Content Type Journal Article
Author Sendo, Toshiaki|
Published Date 2009-08-03
Publication Title 岡山医学会雑誌
Volume volume121
Issue issue2
Content Type Journal Article
Title Alternative Drug interaction (36. Combination with oral molecular target drugs in lung cancer)
FullText URL 128_141.pdf
Author Higashionna, Tsukasa| Esumi, Satoru| Kitamura, Yoshihisa| Sendo, Toshiaki|
Publication Title Journal of Okayama Medical Association
Published Date 2016-08-01
Volume volume128
Issue issue2
Start Page 141
End Page 146
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.128.141
language Japanese
Copyright Holders Copyright (c) 2016 岡山医学会
File Version publisher
DOI 10.4044/joma.128.141
NAID 130005262644
Author Taira, Kentaro| Matsunaga, Hisashi| Sendo, Toshiaki|
Published Date 2011-04-01
Publication Title 岡山医学会雑誌
Volume volume123
Issue issue1
Content Type Journal Article
Author Kuroda, Satoshi| Isozaki, Hideko| Matsunaga, Hisashi| Sendo, Toshiaki|
Published Date 2009-12-01
Publication Title 岡山医学会雑誌
Volume volume121
Issue issue3
Content Type Journal Article
JaLCDOI 10.18926/AMO/30940
FullText URL fulltext.pdf
Author Sagara, Hidenori| Kitamura, Yoshihisa| Esumi, Satoru| Sendo, Toshiaki| Araki, Hiroaki| Gomita, Yutaka|
Abstract

It is well known that priming stimulation promotes the motivational effects of intracranial self-stimulation(ICSS) behavior. An experimental methodology using the runway method could separately study the reward and motivational effects of ICSS behavior. In the present study, we examined the motivational effect of nicotine as measured by the runway method using priming stimulation of ICSS behavior. Electrodes were implanted chronically into the medial forebrain bundle (MFB) in rats. A lever for stimulation of the MFB was set on the opposite side of the start box in the apparatus, and rats were trained to get a reward stimulation (50-200 microA, 0.2 ms, 60 Hz) of MFB when the goal lever was pressed. After the rats were trained to press the lever, a priming stimulation of the MFB was performed. After receiving the priming stimulation, rats were placed at the start box of the runway apparatus, and the running time duration until the goal lever was pressed was measured. Subcutaneous injection of nicotine at a dose of 0.2mg/kg produced an increase in running speed to obtain the reward stimulation, and priming stimulation facilitated the motivational effect to obtain the electrical brain stimulation reward in the rats. These results suggest that nicotine significantly enhanced the motivational effect on ICSS behavior as determined using the runway method. The runway method using priming stimulation of ICSS behavior may become the new experimental methodology with which to measure the motivational effect of some drugs.

Keywords intracranial self-stimulation runway nicotine priming stimulation motivational effect
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2008-08
Volume volume62
Issue issue4
Publisher Okayama University Medical School
Start Page 227
End Page 233
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
File Version publisher
Refereed True
PubMed ID 18766205
Web of Science KeyUT 000258680900002
JaLCDOI 10.18926/AMO/40129
FullText URL 64_4_219.pdf
Author Doi, Maho| Miyazaki, Ikuko| Nagamachi, Tomoko| Shinomiya, Kazuaki| Matsunaga, Hisashi| Sendo, Toshiaki| Kawasaki, Hiromu| Asanuma, Masato| Gomita, Yutaka| Kitamura, Yoshihisa|
Abstract We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH.
Keywords ACTH imipramine lithium proliferation Ki-67
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2010-08
Volume volume64
Issue issue4
Publisher Okayama University Medical School
Start Page 219
End Page 223
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 20802538
Web of Science KeyUT 000281384400002
JaLCDOI 10.18926/AMO/40501
FullText URL 64_5_267.pdf
Author Sagara, Hidenori| Sendo, Toshiaki| Gomita, Yutaka|
Abstract In the runway model of intracranial self-stimulation (ICSS) experimentation, the experimental animal is timed in running a fixed distance to depress a lever that releases electrical stimulation to an electrode implanted along its medial forebrain bundle. This ICSS has both a reward and a motivational component. Using the runway method and priming stimulation, we designed an experimental method for directly measuring motivation. An assessment of pharmacological agents that are known to influence motivational states was also undertaken. Using the experimental methods that we created, we observed prominent changes in running speed when animals were exposed to methamphetamine and nicotine. According to these data, the runway method employing intracranial self-stimulation behavior may be useful for the evaluation of substances that act on motivation. We review the underlying neuropharmacological and anatomical functions associated with our experimental methods. We hope that this technique will be used to scientifically evaluate the impact of drugs and/or therapeutic interventions on human motivation.
Keywords intracranial self-stimulation behavior motivational effect methamphetamine nicotine
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2010-10
Volume volume64
Issue issue5
Publisher Okayama University Medical School
Start Page 267
End Page 275
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2010 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 20975759
Web of Science KeyUT 000283563300001