FullText URL | fulltext.pdf |
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Author | Hara, Naofumi| Ichihara, Eiki| Kano, Hirohisa| Ando, Chihiro| Morita, Ayako| Nishi, Tatsuya| Okawa, Sachi| Nakasuka, Takamasa| Hirabae, Atsuko| Abe, Masaya| Asada, Noboru| Ninomiya, Kiichiro| Makimoto, Go| Fujii, Masanori| Kubo, Toshio| Ohashi, Kadoaki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | Epidermal growth factor receptor (EGFR) non-small cell lung cancer (NSCLC) cell cycle CDK4/6 inhibitor |
Published Date | 2023-10-31 |
Publication Title | Translational Lung Cancer Research |
Volume | volume12 |
Issue | issue10 |
Publisher | AME Publishing Company |
ISSN | 2218-6751 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © Translational Lung Cancer Research. |
File Version | publisher |
PubMed ID | 38025818 |
DOI | 10.21037/tlcr-23-99 |
Web of Science KeyUT | 001091030600001 |
Related Url | isVersionOf https://doi.org/10.21037/tlcr-23-99 |
FullText URL | fulltext20240226-04.pdf |
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Author | Kuribayashi, Tadahiro| Ohashi, Kadoaki| Nishii, Kazuya| Ninomiya, Kiichiro| Tsubata, Yukari| Ishikawa, Nobuhisa| Kodani, Masahiro| Kanaji, Nobuhiro| Yamasaki, Masahiro| Fujitaka, Kazunori| Kuyama, Shoichi| Takigawa, Nagio| Fujimoto, Nobukazu| Kubota, Tetsuya| Inoue, Masaaki| Fujiwara, Keiichi| Harita, Shingo| Takata, Ichiro| Takada, Kenji| Okawa, Sachi| Kiura, Katsuyuki| Hotta, Katsuyuki| |
Keywords | EGFR EGFR-TKI Lung cancer Immune checkpoint inhibitors Performance status |
Note | The version of record of this article, first published in Journal of Cancer Research and Clinical Oncology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00432-024-05618-4| |
Published Date | 2024-02-12 |
Publication Title | Journal of Cancer Research and Clinical Oncology |
Volume | volume150 |
Issue | issue2 |
Publisher | Springer Science and Business Media LLC |
Start Page | 89 |
ISSN | 1432-1335 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2024 |
File Version | publisher |
PubMed ID | 38347279 |
DOI | 10.1007/s00432-024-05618-4 |
Web of Science KeyUT | 001160773600002 |
Related Url | isVersionOf https://doi.org/10.1007/s00432-024-05618-4 |
FullText URL | fulltext.pdf |
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Author | Taoka, Masataka| Makimoto, Go| Umakoshi, Noriyuki| Ninomiya, Kiichiro| Higo, Hisao| Kato, Yuka| Fujii, Masanori| Kubo, Toshio| Ichihara, Eiki| Ohashi, Kadoaki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | Hemoptysis Bronchial artery embolization Endoscopic bronchial occlusion Endobronchial Watanabe Spigot |
Published Date | 2022 |
Publication Title | Respiratory Medicine Case Reports |
Volume | volume38 |
Publisher | Elsevier |
Start Page | 101669 |
ISSN | 2213-0071 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 The Authors. |
File Version | publisher |
PubMed ID | 35646587 |
DOI | 10.1016/j.rmcr.2022.101669 |
Web of Science KeyUT | 001089212200003 |
Related Url | isVersionOf https://doi.org/10.1016/j.rmcr.2022.101669 |
Author | Kemmotsu, Naoya| Ninomiya, Kiichiro| Kunimasa, Kei| Ishino, Takamasa| Nagasaki, Joji| Otani, Yoshihiro| Michiue, Hiroyuki| Ichihara, Eiki| Ohashi, Kadoaki| Inoue, Takako| Tamiya, Motohiro| Sakai, Kazuko| Ueda, Youki| Dansako, Hiromichi| Nishio, Kazuto| Kiura, Katsuyuki| Date, Isao| Togashi, Yosuke| |
---|---|
Keywords | cancer immunotherapy intracranial metastasis intracranial progression memory precursor effector T cell nonsmall-cell lung cancer |
Note | This is the peer reviewed version of the following article: [Kemmotsu, N, Ninomiya, K, Kunimasa, K, et al. Low frequency of intracranial progression in advanced NSCLC patients treated with cancer immunotherapies. Int J Cancer. 2023; 1-11. doi:10.1002/ijc.34700], which has been published in final form at [https://doi.org/10.1002/ijc.34700]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in Aug. 2024.| |
Published Date | 2023-08-23 |
Publication Title | International Journal of Cancer |
Publisher | Wiley |
ISSN | 0020-7136 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 UICC. |
File Version | author |
PubMed ID | 37611176 |
DOI | 10.1002/ijc.34700 |
Web of Science KeyUT | 001069876600001 |
Related Url | isVersionOf https://doi.org/10.1002/ijc.34700 |
FullText URL | fulltext.pdf |
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Author | Ando, Chihiro| Ichihara, Eiki| Nishi, Tatsuya| Morita, Ayako| Hara, Naofumi| Takada, Kenji| Nakasuka, Takamasa| Watanabe, Hiromi| Kano, Hirohisa| Nishii, Kazuya| Makimoto, Go| Kondo, Takumi| Ninomiya, Kiichiro| Fujii, Masanori| Kubo, Toshio| Ohashi, Kadoaki| Matsuoka, Ken-Ichi| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | alectinib ALK gilteritinib non-small cell lung cancer TKI |
Published Date | 2023-09-15 |
Publication Title | Cancer Science |
Volume | volume114 |
Issue | issue11 |
Publisher | Wiley |
Start Page | 4343 |
End Page | 4354 |
ISSN | 1347-9032 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 The Authors. |
File Version | publisher |
PubMed ID | 37715310 |
DOI | 10.1111/cas.15958 |
Web of Science KeyUT | 001067479000001 |
Related Url | isVersionOf https://doi.org/10.1111/cas.15958 |
Author | Nakasuka, Takamasa| Ohashi, Kadoaki| Nishii, Kazuya| Hirabae, Atsuko| Okawa, Sachi| Tomonobu, Nahoko| Takada, Kenji| Ando, Chihiro| Watanabe, Hiromi| Makimoto, Go| Ninomiya, Kiichiro| Fujii, Masanori| Kubo, Toshio| Ichihara, Eiki| Hotta, Katsuyuki| Tabata, Masahiro| Kumon, Hiromi| Maeda, Yoshinobu| Kiura, Katsuyuki| |
---|---|
Keywords | EGFR mutation Non-small cell lung cancer Antitumor immunity Non-inflamed tumor Ad-SGE-REIC Gene therapy PD-1 |
Note | ©2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.lungcan.2023.01.018.| This fulltext file will be available in Apr. 2024.| |
Published Date | 2023-04 |
Publication Title | Lung Cancer |
Volume | volume178 |
Publisher | Elsevier BV |
Start Page | 1 |
End Page | 10 |
ISSN | 0169-5002 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 Elsevier B.V. |
File Version | author |
PubMed ID | 36753780 |
DOI | 10.1016/j.lungcan.2023.01.018 |
Web of Science KeyUT | 000931976300001 |
Related Url | isVersionOf https://doi.org/10.1016/j.lungcan.2023.01.018 |
FullText URL | fulltext.pdf |
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Author | Makimoto, Go| Shimonishi, Atsushi| Ohashi, Kadoaki| Ninomiya, Kiichiro| Higo, Hisao| Kato, Yuka| Fujii, Masanori| Kubo, Toshio| Ichihara, Eiki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | MET Tepotinib Non-small-cell lung cancer |
Published Date | 2022 |
Publication Title | Case Reports In Oncology |
Volume | volume15 |
Issue | issue2 |
Publisher | Karger |
Start Page | 494 |
End Page | 498 |
ISSN | 1662-6575 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 The Author(s). |
File Version | publisher |
PubMed ID | 35702678 |
DOI | 10.1159/000524326 |
Web of Science KeyUT | 000864085100005 |
Related Url | isVersionOf https://doi.org/10.1159/000524326 |
FullText URL | fulltext.pdf |
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Author | Ando, Eri| Nakasuka, Takamasa| Kubo, Toshio| Taniguchi, Akihiko| Ninomiya, Kiichiro| Kato, Yuka| Ichihara, Eiki| Ohashi, Kadoaki| Rai, Kammei| Hotta, Katsuyuki| Yamane, Masaomi| Miyahara, Nobuaki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | pulmonary aspergilloma allergic bronchopulmonary aspergillosis disaster |
Published Date | 2022-02-01 |
Publication Title | Internal Medicine |
Volume | volume61 |
Issue | issue3 |
Publisher | JAPAN SOC INTERNAL MEDICINE |
Start Page | 379 |
End Page | 383 |
ISSN | 0918-2918 |
NCID | AA10827774 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 The Japanese Society of Internal Medicine |
File Version | publisher |
PubMed ID | 34373373 |
DOI | 10.2169/internalmedicine.7124-21 |
Web of Science KeyUT | 000752787300015 |
Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.7124-21 |
FullText URL | fulltext.pdf |
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Author | Higo, Hisao| Ohashi, Kadoaki| Tomida, Shuta| Okawa, Sachi| Yamamoto, Hiromasa| Sugimoto, Seiichiro| Senoo, Satoru| Makimoto, Go| Ninomiya, Kiichiro| Nakasuka, Takamasa| Nishii, Kazuya| Taniguchi, Akihiko| Kubo, Toshio| Ichihara, Eiki| Hotta, Katsuyuki| Miyahara, Nobuaki| Maeda, Yoshinobu| Toyooka, Shinichi| Kiura, Katsuyuki| |
Keywords | Idiopathic pulmonary fibrosis RNA sequencing Molecular therapeutic target Personalized therapy |
Published Date | 2022-02-07 |
Publication Title | Respiratory Research |
Volume | volume23 |
Issue | issue1 |
Publisher | BMC |
Start Page | 20 |
ISSN | 1465-993X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2022. |
File Version | publisher |
PubMed ID | 35130915 |
DOI | 10.1186/s12931-022-01940-y |
Web of Science KeyUT | 000752386100002 |
Related Url | isVersionOf https://doi.org/10.1186/s12931-022-01940-y |
FullText URL | fulltext.pdf |
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Author | Okawa, Sachi| Rai, Kammei| Fujii, Nobuharu| Gion, Yuka| Ninomiya, Kiichiro| Kato, Yuka| Taniguchi, Akihiko| Kubo, Toshio| Ichihara, Eiki| Ohashi, Kadoaki| Miyahara, Nobuaki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | EGFR IgG4-related disease marginal zone lymphoma osimertinib |
Published Date | 2021-09-01 |
Publication Title | Internal Medicine |
Volume | volume60 |
Issue | issue17 |
Publisher | The Japanese Society of Internal Medicine |
Start Page | 2831 |
End Page | 2837 |
ISSN | 0918-2918 |
NCID | AA10827774 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 The Japanese Society of Internal Medicine |
File Version | publisher |
PubMed ID | 33775999 |
DOI | 10.2169/internalmedicine.6470-20 |
Web of Science KeyUT | 000695856000020 |
Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.6470-20 |
FullText URL | fulltext20210810-3.pdf |
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Author | Nishii, Kazuya| Ohashi, Kadoaki| Watanabe, Hiromi| Makimoto, Go| Nakasuka, Takamasa| Higo, Hisao| Ninomiya, Kiichiro| Kato, Yuka| Kubo, Toshio| Rai, Kammei| Ichihara, Eiki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | epidermal growth factor receptor osimertinib bevacizumab cetuximab hypoxia‑inducible factor‑1α transforming growth factor‑α |
Published Date | 2021-7-7 |
Publication Title | Oncology Letters |
Volume | volume22 |
Issue | issue3 |
Publisher | Spandidos Publications |
Start Page | 639 |
ISSN | 1792-1074 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © Nishii et al. This is an open access article distributed under the terms of Creative Commons Attribution License. |
File Version | publisher |
DOI | 10.3892/ol.2021.12900 |
Web of Science KeyUT | 000678494600001 |
Related Url | isVersionOf https://doi.org/10.3892/ol.2021.12900 |
FullText URL | fulltext.pdf |
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Author | Watanabe, Hiromi| Ichihara, Eiki| Kayatani, Hiroe| Makimoto, Go| Ninomiya, Kiichiro| Nishii, Kazuya| Higo, Hisao| Ando, Chihiro| Okawa, Sachi| Nakasuka, Takamasa| Kano, Hirohisa| Hara, Naofumi| Hirabae, Atsuko| Kato, Yuka| Ninomiya, Takashi| Kubo, Toshio| Rai, Kammei| Ohashi, Kadoaki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Published Date | 2021-01-07 |
Publication Title | Cancer science |
Publisher | Wiley |
ISSN | 1347-9032 |
NCID | AA11808050 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 The Authors. |
File Version | publisher |
PubMed ID | 33410241 |
NAID | 120007008532 |
DOI | 10.1111/cas.14801 |
Web of Science KeyUT | 000630136900001 |
Related Url | isVersionOf https://doi.org/10.1111/cas.14801 |
FullText URL | fulltext.pdf |
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Author | Nishii, Kazuya| Ohashi, Kadoaki| Tamura, Tomoki| Ninomiya, Kiichiro| Matsubara, Takehiro| Senoo, Satoru| Kano, Hirohisa| Watanabe, Hiromi| Oda, Naohiro| Makimoto, Go| Higo, Hisao| Kato, Yuka| Ninomiya, Takashi| Kubo, Toshio| Yamamoto, Hiromasa | Tomida, Shuta| Hotta, Katsuyuki| Tabata, Masahiro| Toyooka, Shinichi| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | non-small cell lung cancer epidermal growth factor receptor mutations droplet digital PCR exhaled breath condensate EGFR-TKIs |
Published Date | 2020-12 |
Publication Title | Oncology Letters |
Volume | volume20 |
Issue | issue6 |
Publisher | Spandidos Publications |
Start Page | 393 |
ISSN | 1792-1074 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | publisher |
PubMed ID | 33193853 |
DOI | 10.3892/ol.2020.12256 |
Web of Science KeyUT | 000595649300005 |
Related Url | isVersionOf https://doi.org/10.3892/ol.2020.12256 |
JaLCDOI | 10.18926/AMO/60796 |
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FullText URL | 74_5_371.pdf |
Author | Makimoto, Go| Ohashi, Kadoaki| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Abstract | The prognosis of advanced non-small cell lung cancer (NSCLC) patients has improved in recent decades, especially for patients with an oncogenic driver mutation. Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) are effective for patients with the echinoderm microtubule-associated protein-like 4-ALK fusion gene. Several ALK-TKIs have been established: the first-generation ALK-TKI, crizotinib; second-generation ALK-TKIs, alectinib and ceritinib; and third-generation ALK-TKI, lorlatinib. Some ALK-TKIs are effective for tumors that are resistant to other ALK-TKIs; however, as is known in epidermal growth factor receptormutant lung cancer, tumor resistance is inevitable. ALK-positive NSCLCs acquire resistance via various mechanisms, making it a heterogeneous disease. Therefore, it is necessary to develop next-generation treatment strategies, such as the use of next-generation ALK-TKIs for secondary mutations, or combination therapies with ALK-TKIs and other TKIs. In this review, we summarize the development and use of ALK-TKIs, prior pivotal clinical trials, and resistance mechanisms. |
Keywords | lung cancer anaplastic lymphoma kinase tyrosine kinase inhibitors resistance mechanism |
Amo Type | Review |
Publication Title | Acta Medica Okayama |
Published Date | 2020-10 |
Volume | volume74 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 371 |
End Page | 379 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33106692 |
Web of Science KeyUT | 000581970100001 |
NAID | 120006892922 |
FullText URL | fulltext.pdf figs.pdf tables.pdf |
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Author | Itano, Junko| Higo, Hisao| Ohashi, Kadoaki| Makimoto, Go| Nishii, Kazuya| Hotta, Katsuyuki| Miyahara, Nobuaki| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | osimertinib drug-induced ILD reversed halo sign organizing pneumonia pattern re-administration |
Published Date | 2020-03-15 |
Publication Title | Internal Medicine |
Volume | volume59 |
Issue | issue6 |
Publisher | The Japanese Society of Internal Medicine |
Start Page | 823 |
End Page | 828 |
ISSN | 0918-2918 |
NCID | AA10827774 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by The Japanese Society of Internal Medicine |
File Version | author |
PubMed ID | 31787696 |
DOI | 10.2169/internalmedicine.3689-19 |
Web of Science KeyUT | 000521137500011 |
Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.3689-19 |
FullText URL | fulltext.pdf |
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Author | Makimoto, Go| Ohashi, Kadoaki| Taniguchi, Kohei| Soh, Junichi| Taniguchi, Akihiko| Miyahara, Nobuaki| Toyooka, Shinichi| Yoshino, Tadashi| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | IgG4-related disease Pleural effusion Adenosine deaminase Pleural biopsy Spontaneous remission |
Published Date | 2019 |
Publication Title | Respiratory Medicine Case Reports |
Volume | volume28 |
Publisher | Elsevier |
Start Page | 100938 |
ISSN | 2213-0071 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2019 The Authors. |
File Version | publisher |
PubMed ID | 31667074 |
DOI | 10.1016/j.rmcr.2019.100938 |
Web of Science KeyUT | 000511444900052 |
Related Url | isVersionOf https://doi.org/10.1016/j.rmcr.2019.100938 |
FullText URL | fulltext.pdf |
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Author | Itano, Junko| Ohashi, Kadoaki| Senoo, Satoru| Oda, Naohiro| Nishii, Kazuya| Taniguchi, Akihiko| Miyahara, Nobuaki| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | Axillary lymphadenitis Mycobacterium avium complex infection Mycobacterium intracellulare |
Published Date | 2019 |
Publication Title | Respiratory Medicine Case Reports |
Volume | volume28 |
Publisher | Elsevier |
Start Page | 100947 |
ISSN | 2213-0071 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2019 The Authors. |
File Version | publisher |
PubMed ID | 31681532 |
DOI | 10.1016/j.rmcr.2019.100947 |
Web of Science KeyUT | 000511444900001 |
Related Url | isVersionOf https://doi.org/10.1016/j.rmcr.2019.100947 |
FullText URL | J_Thorac_Oncol_201907017.pdf |
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Author | Makimoto, Go| Ohashi, Kadoaki| Tomida, Shuta| Nishii, Kazuya| Matsubara, Takehiro| Kayatani, Hiroe| Higo, Hisao| Ninomiya, Kiichiro| Sato, Akiko| Watanabe, Hiromi| Kano, Hirohisa| Ninomiya, Takashi| Kubo, Toshio| Rai, Kammei| Ichihara, Eiki| Hotta, Katsuyuki| Tabata, Masahiro| Toyooka, Shinichi| Takata, Minoru| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | ALK G1202R Alectinib Amphiregulin MET NSCLC |
Published Date | 2019-07-30 |
Publication Title | Journal of Thoracic Oncology |
Volume | volume14 |
Issue | issue11 |
Publisher | Elsevier |
Start Page | 2009 |
End Page | 2018 |
ISSN | 15560864 |
NCID | AA12058455 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2019 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved. |
File Version | author |
PubMed ID | 31374369 |
DOI | 10.1016/j.jtho.2019.07.017 |
Web of Science KeyUT | 000492678300025 |
Related Url | isVersionOf https://doi.org/10.1016/j.jtho.2019.07.017 |
JaLCDOI | 10.18926/AMO/54499 |
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FullText URL | 70_4_243.pdf |
Author | Osawa, Masahiro| Ohashi, Kadoaki| Kubo, Toshio| Ichihara, Eiki| Takata, Saburo| Takigawa, Nagio| Takata , Minoru| Tanimoto, Mitsune| Kiura, Katsuyuki| |
Abstract | Vandetanib (ZactimaTM) is a novel, orally available inhibitor of both vascular endothelial growth factor receptor-2 (VEGFR-2) and epidermal growth factor receptor (EGFR) tyrosine kinase. In the present study, a line of transgenic mice with a mouse Egfr gene mutation (delE748-A752) corresponding to a human EGFR mutation (delE746-A750) was established. The transgenic mice developed atypical adenomatous hyperplasia to adenocarcinoma of the lung at around 5 weeks of age and died of lung tumors at approximately 17 weeks of age. In the mice treated with vandetanib (6mg/kg/day), these lung tumors disappeared and the phosphorylations of EGFR and VEGFR-2 were reduced in lung tissues to levels comparable to those of non-transgenic control mice. The median overall survival time of the transgenic mice was 28 weeks in the vandetanib-treated group and 17 weeks in the vehicle-treated group. Vandetanib significantly prolonged the survival of the transgenic mice (log-rank test, p<0.01); resistance to vandetanib occurred at 20 weeks of age and the animals died from their lung tumors at about 28 weeks of age. These data suggest that vandetanib could suppress the progression of tumors harboring an activating EGFR mutation. |
Keywords | vandetanib VEGFR EGFR nonsmall cell lung cancer transgenic mouse |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2016-08 |
Volume | volume70 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 243 |
End Page | 253 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 27549668 |
Web of Science KeyUT | 000384748600003 |
Title Alternative | A prospective cohort study to define the clinical and pathological features of lung cancers harboring HER2 gene aberrations (the HER2-CS Study) and a phase II study of trastuzumab emtansine (recombinant) in patients with HER2-positive non-small cell lung cancer who recurred, progressed after standard chemotherapy, or were primarily refractory to standard chemotherapy |
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FullText URL | 127_127.pdf |
Author | Kiura, Katsuyuki| Hotta, Katsuyuki| Sato, Akiko| Ohashi, Kadoaki| Ninomiya, Takashi| Minnami, Daisuke| Tabata, Masahiro| Kubo, Toshio| Kato, Yuka| Hirata, Taizo| |
Keywords | 臨床研究中核病院 国立研究開発法人日本医療研究開発機構 文部科学省橋渡し研究加速ネットワークプログラム HER2-CS study trastuzumab emtansine |
Publication Title | 岡山医学会雑誌 |
Published Date | 2015-08-03 |
Volume | volume127 |
Issue | issue2 |
Start Page | 127 |
End Page | 132 |
ISSN | 0030-1558 |
Related Url | isVersionOf https://doi.org/10.4044/joma.127.127 |
language | Japanese |
Copyright Holders | Copyright (c) 2015 岡山医学会 |
File Version | publisher |
DOI | 10.4044/joma.127.127 |
NAID | 130005096256 |