| FullText URL | fulltext.pdf figs.pdf tables.pdf |
|---|---|
| Author | Itano, Junko| Higo, Hisao| Ohashi, Kadoaki| Makimoto, Go| Nishii, Kazuya| Hotta, Katsuyuki| Miyahara, Nobuaki| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| Keywords | osimertinib drug-induced ILD reversed halo sign organizing pneumonia pattern re-administration |
| Published Date | 2020-03-15 |
| Publication Title | Internal Medicine |
| Volume | volume59 |
| Issue | issue6 |
| Publisher | The Japanese Society of Internal Medicine |
| Start Page | 823 |
| End Page | 828 |
| ISSN | 0918-2918 |
| NCID | AA10827774 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by The Japanese Society of Internal Medicine |
| File Version | author |
| PubMed ID | 31787696 |
| DOI | 10.2169/internalmedicine.3689-19 |
| Web of Science KeyUT | 000521137500011 |
| Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.3689-19 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Makimoto, Go| Ohashi, Kadoaki| Taniguchi, Kohei| Soh, Junichi| Taniguchi, Akihiko| Miyahara, Nobuaki| Toyooka, Shinichi| Yoshino, Tadashi| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| Keywords | IgG4-related disease Pleural effusion Adenosine deaminase Pleural biopsy Spontaneous remission |
| Published Date | 2019 |
| Publication Title | Respiratory Medicine Case Reports |
| Volume | volume28 |
| Publisher | Elsevier |
| Start Page | 100938 |
| ISSN | 2213-0071 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Authors. |
| File Version | publisher |
| PubMed ID | 31667074 |
| DOI | 10.1016/j.rmcr.2019.100938 |
| Web of Science KeyUT | 000511444900052 |
| Related Url | isVersionOf https://doi.org/10.1016/j.rmcr.2019.100938 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Itano, Junko| Ohashi, Kadoaki| Senoo, Satoru| Oda, Naohiro| Nishii, Kazuya| Taniguchi, Akihiko| Miyahara, Nobuaki| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| Keywords | Axillary lymphadenitis Mycobacterium avium complex infection Mycobacterium intracellulare |
| Published Date | 2019 |
| Publication Title | Respiratory Medicine Case Reports |
| Volume | volume28 |
| Publisher | Elsevier |
| Start Page | 100947 |
| ISSN | 2213-0071 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Authors. |
| File Version | publisher |
| PubMed ID | 31681532 |
| DOI | 10.1016/j.rmcr.2019.100947 |
| Web of Science KeyUT | 000511444900001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.rmcr.2019.100947 |
| FullText URL | J_Thorac_Oncol_201907017.pdf |
|---|---|
| Author | Makimoto, Go| Ohashi, Kadoaki| Tomida, Shuta| Nishii, Kazuya| Matsubara, Takehiro| Kayatani, Hiroe| Higo, Hisao| Ninomiya, Kiichiro| Sato, Akiko| Watanabe, Hiromi| Kano, Hirohisa| Ninomiya, Takashi| Kubo, Toshio| Rai, Kammei| Ichihara, Eiki| Hotta, Katsuyuki| Tabata, Masahiro| Toyooka, Shinichi| Takata, Minoru| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| Keywords | ALK G1202R Alectinib Amphiregulin MET NSCLC |
| Published Date | 2019-07-30 |
| Publication Title | Journal of Thoracic Oncology |
| Volume | volume14 |
| Issue | issue11 |
| Publisher | Elsevier |
| Start Page | 2009 |
| End Page | 2018 |
| ISSN | 15560864 |
| NCID | AA12058455 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved. |
| File Version | author |
| PubMed ID | 31374369 |
| DOI | 10.1016/j.jtho.2019.07.017 |
| Web of Science KeyUT | 000492678300025 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jtho.2019.07.017 |
| JaLCDOI | 10.18926/AMO/54499 |
|---|---|
| FullText URL | 70_4_243.pdf |
| Author | Osawa, Masahiro| Ohashi, Kadoaki| Kubo, Toshio| Ichihara, Eiki| Takata, Saburo| Takigawa, Nagio| Takata , Minoru| Tanimoto, Mitsune| Kiura, Katsuyuki| |
| Abstract | Vandetanib (ZactimaTM) is a novel, orally available inhibitor of both vascular endothelial growth factor receptor-2 (VEGFR-2) and epidermal growth factor receptor (EGFR) tyrosine kinase. In the present study, a line of transgenic mice with a mouse Egfr gene mutation (delE748-A752) corresponding to a human EGFR mutation (delE746-A750) was established. The transgenic mice developed atypical adenomatous hyperplasia to adenocarcinoma of the lung at around 5 weeks of age and died of lung tumors at approximately 17 weeks of age. In the mice treated with vandetanib (6mg/kg/day), these lung tumors disappeared and the phosphorylations of EGFR and VEGFR-2 were reduced in lung tissues to levels comparable to those of non-transgenic control mice. The median overall survival time of the transgenic mice was 28 weeks in the vandetanib-treated group and 17 weeks in the vehicle-treated group. Vandetanib significantly prolonged the survival of the transgenic mice (log-rank test, p＜0.01); resistance to vandetanib occurred at 20 weeks of age and the animals died from their lung tumors at about 28 weeks of age. These data suggest that vandetanib could suppress the progression of tumors harboring an activating EGFR mutation. |
| Keywords | vandetanib VEGFR EGFR nonsmall cell lung cancer transgenic mouse |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-08 |
| Volume | volume70 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 243 |
| End Page | 253 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27549668 |
| Web of Science KeyUT | 000384748600003 |
| Title Alternative | A prospective cohort study to define the clinical and pathological features of lung cancers harboring HER2 gene aberrations (the HER2-CS Study) and a phase II study of trastuzumab emtansine (recombinant) in patients with HER2-positive non-small cell lung cancer who recurred, progressed after standard chemotherapy, or were primarily refractory to standard chemotherapy |
|---|---|
| FullText URL | 127_127.pdf |
| Author | Kiura, Katsuyuki| Hotta, Katsuyuki| Sato, Akiko| Ohashi, Kadoaki| Ninomiya, Takashi| Minnami, Daisuke| Tabata, Masahiro| Kubo, Toshio| Kato, Yuka| Hirata, Taizo| |
| Keywords | 臨床研究中核病院 国立研究開発法人日本医療研究開発機構 文部科学省橋渡し研究加速ネットワークプログラム HER2-CS study trastuzumab emtansine |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2015-08-03 |
| Volume | volume127 |
| Issue | issue2 |
| Start Page | 127 |
| End Page | 132 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.127.127 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2015 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.127.127 |
| NAID | 130005096256 |
| Author | Yasugi, Masayuki| Takigawa, Nagio| Ochi, Nobuaki| Ohashi, Kadoaki| Harada, Daijiro| Ninomiya, Takashi| Murakami, Toshi| Honda, Yoshihiro| Ichihara, Eiki| Tanimoto, Mitsune| Kiura, Katsuyuki| |
|---|---|
| Published Date | 2014-08-15 |
| Publication Title | Experimental Cell Research |
| Volume | volume326 |
| Issue | issue2 |
| Content Type | Journal Article |
