| FullText URL | fulltext.pdf |
|---|---|
| Author | Kano, Yuzuki| Yamaguchi, Satoshi| Mise, Koki| Kawakita, Chieko| Onishi, Yasuhiro| Kurooka, Naoko| Sugawara, Ryosuke| Albuayjan, Haya Hamed Hassan| Nakatsuka, Atsuko| Eguchi, Jun| Wada, Jun| |
| Keywords | diabetes mellitus diabetic nephropathy metabolism obesity tubular epithelium |
| Published Date | 2023-12-08 |
| Publication Title | Kidney360 |
| Volume | volume5 |
| Issue | issue2 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Start Page | 182 |
| End Page | 194 |
| ISSN | 2641-7650 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | Copyright © 2023 The Author(s). |
| File Version | publisher |
| PubMed ID | 38062578 |
| DOI | 10.34067/kid.0000000000000333 |
| Web of Science KeyUT | 001178403800002 |
| Related Url | isVersionOf https://doi.org/10.34067/kid.0000000000000333 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamaguchi, Satoshi| Zhang, Dongxiao| Katayama, Akihiro| Kurooka, Naoko| Sugawara, Ryosuke| Albuayjan, Haya Hamed Hassan| Nakatsuka, Atsuko| Eguchi, Jun| Wada, Jun| |
| Keywords | non-coding RNAs microRNA adipose tissues Adipogenesis mTORC1 |
| Published Date | 2022-01-03 |
| Publication Title | Frontiers In Endocrinology |
| Volume | volume12 |
| Publisher | Frontiers Media SA |
| Start Page | 750261 |
| ISSN | 1664-2392 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Yamaguchi, Zhang, Katayama, Kurooka, Sugawara, Albuayjan, Nakatsuka, Eguchi and Wada. |
| File Version | publisher |
| PubMed ID | 35046889 |
| DOI | 10.3389/fendo.2021.750261 |
| Web of Science KeyUT | 000745695800001 |
| Related Url | isVersionOf https://doi.org/10.3389/fendo.2021.750261 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Mise, Koki| Imamura, Mariko| Yamaguchi, Satoshi| Watanabe, Mayu| Higuchi, Chigusa| Katayama, Akihiro| Miyamoto, Satoshi| Uchida, Haruhito A.| Nakatsuka, Atsuko| Eguchi, Jun| Hida, Kazuyuki| Nakato, Tatsuaki| Tone, Atsuhito| Teshigawara, Sanae| Matsuoka, Takashi| Kamei, Shinji| Murakami, Kazutoshi| Shimizu, Ikki| Miyashita, Katsuhiro| Ando, Shinichiro| Nunoue, Tomokazu| Yoshida, Michihiro| Yamada, Masao| Shikata, Kenichi| Wada, Jun| |
| Keywords | cardiovascular event diabetes lectins N-glycans urinary biomarkers |
| Published Date | 2021-05-24 |
| Publication Title | Frontiers In Cardiovascular Medicine |
| Volume | volume8 |
| Publisher | Frontiers Media SA |
| Start Page | 668059 |
| ISSN | 2297-055X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| PubMed ID | 34109226 |
| NAID | 120007053373 |
| DOI | 10.3389/fcvm.2021.668059 |
| Web of Science KeyUT | 000658156400001 |
| Related Url | isVersionOf https://doi.org/10.3389/fcvm.2021.668059 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nunoue, Tomokazu| Yamaguchi, Satoshi| Teshigawara, Sanae| Katayama, Akihiro| Nakatsuka, Atsuko| Eguchi, Jun| Niki, Toshiro| Wada, Jun| |
| Published Date | 2021-03-16 |
| Publication Title | Scientific Reports |
| Volume | volume11 |
| Issue | issue1 |
| Publisher | Nature |
| Start Page | 5991 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2021 |
| File Version | publisher |
| PubMed ID | 33727589 |
| NAID | 120007004155 |
| DOI | 10.1038/s41598-021-85080-1 |
| Web of Science KeyUT | 000630512100015 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-021-85080-1 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakatsuka, Atsuko| Yamaguchi, Satoshi| Eguchi, Jun| Kakuta, Shigeru| Iwakura, Yoichiro| Sugiyama, Hitoshi| Wada, Jun| |
| Published Date | 2021-03-19 |
| Publication Title | Communications Biology |
| Volume | volume4 |
| Issue | issue1 |
| Publisher | Nature |
| Start Page | 373 |
| ISSN | 2399-3642 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2021 |
| File Version | publisher |
| PubMed ID | 33742129 |
| NAID | 120007004153 |
| DOI | 10.1038/s42003-021-01902-y |
| Web of Science KeyUT | 000631555700003 |
| Related Url | isVersionOf https://doi.org/10.1038/s42003-021-01902-y |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nojima, Ichiro| Eikawa, Shingo| Tomonobu, Nahoko| Hada, Yoshiko| Kajitani, Nobuo| Teshigawara, Sanae| Miyamoto, Satoshi| Tone, Atsuhito| Uchida, Haruhito A.| Nakatsuka, Atsuko| Eguchi, Jun| Shikata, Kenichi| Udono, Heiichiro| Wada, Jun| |
| Keywords | Cytokines Diabetes Endocrine system and metabolic diseases Immunology Tumour immunology |
| Published Date | 2020-09-10 |
| Publication Title | Scientific Reports |
| Volume | volume10 |
| Issue | issue1 |
| Publisher | Nature Research |
| Start Page | 14928 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2020 |
| File Version | publisher |
| PubMed ID | 32913271 |
| DOI | 10.1038/s41598-020-71946-3 |
| Web of Science KeyUT | 000571915100049 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-020-71946-3 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Katayama, Akihiro| Tone, Atsuhito| Watanabe, Mayu| Teshigawara, Sanae| Miyamoto, Satoshi| Eguchi, Jun| Nakatsuka, Atsuko| Shikata, Kenichi| Wada, Jun| |
| Keywords | Hypoglycemia Predictive low glucose management (PLGM) Type 1 diabetes mellitus (T1DM) Sensor-augmented pump therapy (SAP) |
| Note | This is a post-peer-review, pre-copyedit version of an article published in Diabetology International. The final authenticated version is available online at: http://dx.doi.org/10.1007/s13340-019-00408-7.| |
| Published Date | 2019-09-16 |
| Publication Title | Diabetology International |
| Volume | volume11 |
| Issue | issue2 |
| Publisher | Springer |
| Start Page | 97 |
| End Page | 104 |
| ISSN | 2190-1678 |
| NCID | AA12503387 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32206479 |
| NAID | 40022198977 |
| DOI | 10.1007/s13340-019-00408-7 |
| Web of Science KeyUT | 000520711100004 |
| Related Url | isVersionOf https://doi.org/10.1007/s13340-019-00408-7 |
| JaLCDOI | 10.18926/AMO/54413 |
|---|---|
| FullText URL | 70_3_151.pdf |
| Author | Wada, Jun| Nakatsuka, Atsuko| |
| Abstract | The mitochondria are involved in active and dynamic processes, such as mitochondrial biogenesis, fission, fusion and mitophagy to maintain mitochondrial and cellular functions. In obesity and type 2 diabetes, impaired oxidation, reduced mitochondrial contents, lowered rates of oxidative phosphorylation and excessive reactive oxygen species (ROS) production have been reported. Mitochondrial biogenesis is regulated by various transcription factors such as peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), peroxisome proliferator-activated receptors (PPARs), estrogen-related receptors (ERRs), and nuclear respiratory factors (NRFs). Mitochondrial fusion is promoted by mitofusin 1 (MFN1), mitofusin 2 (MFN2) and optic atrophy 1 (OPA1), while fission is governed by the recruitment of dynamin-related protein 1 (DRP1) by adaptor proteins such as mitochondrial fission factor (MFF), mitochondrial dynamics proteins of 49 and 51 kDa (MiD49 and MiD51), and fission 1 (FIS1). Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) and PARKIN promote DRP1-dependent mitochondrial fission, and the outer mitochondrial adaptor MiD51 is required in DRP1 recruitment and PARKIN-dependent mitophagy. This review describes the molecular mechanism of mitochondrial dynamics, its abnormality in diabetes and obesity, and pharmaceuticals targeting mitochondrial biogenesis, fission, fusion and mitophagy. |
| Keywords | fusion fission oxidative stress mitochondria diabetes |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-06 |
| Volume | volume70 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 151 |
| End Page | 158 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27339203 |
| Web of Science KeyUT | 000379406100001 |
| Author | Watanabe, Mayu| Nakatsuka, Atsuko| Murakami, Kazutoshi| Inoue, Kentaro| Terami, Takahiro| Higuchi, Chigusa| Katayama, Akihiro| Teshigawara, Sanae| Eguchi, Jun| Ogawa, Daisuke| Watanabe, Eijiro| Wada, Jun| Makino, Hirofumi| |
|---|---|
| Published Date | 2014-05-25 |
| Publication Title | PLOS ONE |
| Volume | volume9 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Ogawa, Daisuke| Eguchi, Jun| Wada, Jun| Terami, Naoto| Hatanaka, Takashi| Tachibana, Hiromi| Nakatsuka, Atsuko| Sato Horiguchi, Chikage| Nishii, Naoko| Makino, Hirofumi| |
|---|---|
| Published Date | 2014-01-22 |
| Publication Title | PLOS ONE |
| Volume | volume9 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Nakatsuka, Atsuko| Matsuyama, Makoto| Yamaguchi, Satoshi| Katayama, Akihiro| Eguchi, Jun| Murakami, Kazutoshi| Teshigawara, Sanae| Ogawa, Daisuke| Wada, Nozomu| Yasunaka, Tetsuya| Ikeda, Fusao| Takaki, Akinobu| Watanabe, Eijiro| Wada, Jun| |
|---|---|
| Published Date | 2016-02-17 |
| Publication Title | Scientific Reports |
| Volume | volume6 |
| Content Type | Journal Article |
| Author | Katayama, Akihiro| Nakatsuka, Atsuko| Eguchi, Jun| Murakami, Kazutoshi| Teshigawara, Sanae| Kanzaki, Motoko| Nunoue, Tomokazu| Hida, Kazuyuki| Wada, Nozomu| Yasunaka, Tetsuya| Ikeda, Fusao| Takaki, Akinobu| Yamamoto, Kazuhide| Kiyonari, Hiroshi| Makino, Hirofumi| Wada, Jun| |
|---|---|
| Published Date | 2015 |
| Publication Title | Scientific reports |
| Volume | volume5 |
| Content Type | Journal Article |
| Author | Terami, Takahiro| Wada, Jun| Inoue, Kentaro| Nakatsuka, Atsuko| Ogawa, Daisuke| Teshigawara, Sanae| Murakami, Kazutoshi| Katayama, Akihiro| Eguchi, Jun| Makino, Hirofumi| |
|---|---|
| Published Date | 2013-10-22 |
| Publication Title | International Journal of Nephrology and Renovascular Disease |
| Volume | volume6 |
| Content Type | Journal Article |
| Author | Inoue, Kentaro| Wada, Jun| Eguchi, Jun| Nakatsuka, Atsuko| Teshigawara, Sanae| Murakami, Kazutoshi| Ogawa, Daisuke| Terami, Takahiro| Katayama, Akihiro| Tone, Atsuhito| Iseda, Izumi| Hida, Kazuyuki| Yamada, Masao| Ogawa, Tomohisa| Makino, Hirofumi| |
|---|---|
| Published Date | 2013-10-15 |
| Publication Title | PLoS ONE |
| Volume | volume8 |
| Issue | issue10 |
| Content Type | Journal Article |
| Title Alternative | The 2013 Incentive Award of the Okayama Medical Association in Cardiovascular and Pulmonary Research (2013 Sunada Prize) |
|---|---|
| FullText URL | 126_95.pdf |
| Author | Nakatsuka, Atsuko| |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-08-01 |
| Volume | volume126 |
| Issue | issue2 |
| Start Page | 95 |
| End Page | 98 |
| ISSN | 0030-1558 |
| Related Url | http://www.okayama-u.ac.jp/user/oma/ |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.95 |
| NAID | 130004685276 |
| Author | Kurose, Yuko| Wada, Jun| Kanzaki, Motoko| Teshigawara, Sanae| Nakatsuka, Atsuko| Murakami, Kazutoshi| Inoue, Kentaro| Terami, Takahiro| Katayama, Akihiro| Watanabe, Mayu| Higuchi, Chigusa| Eguchi, Jun| Miyatake, Nobuyuki| Makino, Hirofumi| |
|---|---|
| Published Date | 2013-01-22 |
| Publication Title | BMC Nephrology |
| Volume | volume14 |
| Content Type | Journal Article |
| Author | Inoue, Junko| Wada, Jun| Teshigawara, Sanae| Hida, Kazuyuki| Nakatsuka, Atsuko| Takatori, Yuji| Kojo, Shoichirou| Akagi, Shigeru| Nakao, Kazushi| Miyatake, Nobuyuki| McDonald, John F.| Makino, Hirofumi| |
|---|---|
| Published Date | 2012-12-03 |
| Publication Title | BMC Nephrology |
| Volume | volume13 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/50405 |
|---|---|
| FullText URL | 67_3_129.pdf |
| Author | Nakatsuka, Atsuko| Wada, Jun| Makino, Hirofumi| |
| Abstract | In recent years, many researchers have emphasized the importance of metabolic syndrome based on its increasing prevalence and its adverse prognosis due to associated chronic vascular complications. Upstream of a cluster of metabolic and vascular disorders is the accumulation of visceral adipose tissue, which plays a central role in the pathophysiology. In the accumulation of adipose tissues, cell cycle regulation is tightly linked to cellular processes such as proliferation, hypertrophy and apoptosis. In addition, various cell cycle abnormalities have also been observed in other tissues, such as kidneys and the cardiovascular system, and they are critically involved in the progression of disease. Here, we discuss cell cycle abnormalities in metabolic syndrome in various tissues. Furthermore, we describe the role of nuclear receptors in cell growth and survival, and glucose and lipid metabolism in the whole body. Therapeutic strategies for modulating various cell cycles in metabolic disorders by targeting nuclear receptors may overcome obesity and its chronic vascular complications in the future. |
| Keywords | nuclear receptor cell cycle metabolic syndrome diabetic nephropathy |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-06 |
| Volume | volume67 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 129 |
| End Page | 134 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23804135 |
| Web of Science KeyUT | 000320747900001 |
| Author | Nakatsuka, Atsuko| Wada, Jun| Iseda, Izumi| Teshigawara, Sanae| Higashio, Kanji| Murakami, Kazutoshi| Kanzaki, Motoko| Inoue, Kentaro| Terami, Takahiro| Katayama, Akihiro| Hida, Kazuyuki| Eguchi, Jun| Horiguchi, Chikage Sato| Ogawa, Daisuke| Matsuki, Yasushi| Hiramatsu, Ryuji| Yagita, Hideo| Kakuta, Shigeru| Iwakura, Yoichiro| Makino, Hirofumi| |
|---|---|
| Published Date | 2012-11 |
| Publication Title | Diabetes |
| Volume | volume61 |
| Issue | issue11 |
| Content Type | Journal Article |
