JaLCDOI 10.18926/AMO/54413
フルテキストURL 70_3_151.pdf
著者 Wada, Jun| Nakatsuka, Atsuko|
抄録 The mitochondria are involved in active and dynamic processes, such as mitochondrial biogenesis, fission, fusion and mitophagy to maintain mitochondrial and cellular functions. In obesity and type 2 diabetes, impaired oxidation, reduced mitochondrial contents, lowered rates of oxidative phosphorylation and excessive reactive oxygen species (ROS) production have been reported. Mitochondrial biogenesis is regulated by various transcription factors such as peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), peroxisome proliferator-activated receptors (PPARs), estrogen-related receptors (ERRs), and nuclear respiratory factors (NRFs). Mitochondrial fusion is promoted by mitofusin 1 (MFN1), mitofusin 2 (MFN2) and optic atrophy 1 (OPA1), while fission is governed by the recruitment of dynamin-related protein 1 (DRP1) by adaptor proteins such as mitochondrial fission factor (MFF), mitochondrial dynamics proteins of 49 and 51 kDa (MiD49 and MiD51), and fission 1 (FIS1). Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) and PARKIN promote DRP1-dependent mitochondrial fission, and the outer mitochondrial adaptor MiD51 is required in DRP1 recruitment and PARKIN-dependent mitophagy. This review describes the molecular mechanism of mitochondrial dynamics, its abnormality in diabetes and obesity, and pharmaceuticals targeting mitochondrial biogenesis, fission, fusion and mitophagy.
キーワード fusion fission oxidative stress mitochondria diabetes
Amo Type Review
発行日 2016-06
出版物タイトル Acta Medica Okayama
70巻
3号
出版者 Okayama University Medical School
開始ページ 151
終了ページ 158
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 27339203
Web of Sience KeyUT 000379406100001
著者 Watanabe, Mayu| Nakatsuka, Atsuko| Murakami, Kazutoshi| Inoue, Kentaro| Terami, Takahiro| Higuchi, Chigusa| Katayama, Akihiro| Teshigawara, Sanae| Eguchi, Jun| Ogawa, Daisuke| Watanabe, Eijiro| Wada, Jun| Makino, Hirofumi|
発行日 2014-05-25
出版物タイトル PLOS ONE
9巻
3号
資料タイプ 学術雑誌論文
著者 Ogawa, Daisuke| Eguchi, Jun| Wada, Jun| Terami, Naoto| Hatanaka, Takashi| Tachibana, Hiromi| Nakatsuka, Atsuko| Sato Horiguchi, Chikage| Nishii, Naoko| Makino, Hirofumi|
発行日 2014-01-22
出版物タイトル PLOS ONE
9巻
1号
資料タイプ 学術雑誌論文
著者 Nakatsuka, Atsuko| Matsuyama, Makoto| Yamaguchi, Satoshi| Katayama, Akihiro| Eguchi, Jun| Murakami, Kazutoshi| Teshigawara, Sanae| Ogawa, Daisuke| Wada, Nozomu| Yasunaka, Tetsuya| Ikeda, Fusao| Takaki, Akinobu| Watanabe, Eijiro| Wada, Jun|
発行日 2016-02-17
出版物タイトル Scientific Reports
6巻
資料タイプ 学術雑誌論文
著者 Katayama, Akihiro| Nakatsuka, Atsuko| Eguchi, Jun| Murakami, Kazutoshi| Teshigawara, Sanae| Kanzaki, Motoko| Nunoue, Tomokazu| Hida, Kazuyuki| Wada, Nozomu| Yasunaka, Tetsuya| Ikeda, Fusao| Takaki, Akinobu| Yamamoto, Kazuhide| Kiyonari, Hiroshi| Makino, Hirofumi| Wada, Jun|
発行日 2015
出版物タイトル Scientific reports
5巻
資料タイプ 学術雑誌論文
著者 Terami, Takahiro| Wada, Jun| Inoue, Kentaro| Nakatsuka, Atsuko| Ogawa, Daisuke| Teshigawara, Sanae| Murakami, Kazutoshi| Katayama, Akihiro| Eguchi, Jun| Makino, Hirofumi|
発行日 2013-10-22
出版物タイトル International Journal of Nephrology and Renovascular Disease
6巻
資料タイプ 学術雑誌論文
著者 Inoue, Kentaro| Wada, Jun| Eguchi, Jun| Nakatsuka, Atsuko| Teshigawara, Sanae| Murakami, Kazutoshi| Ogawa, Daisuke| Terami, Takahiro| Katayama, Akihiro| Tone, Atsuhito| Iseda, Izumi| Hida, Kazuyuki| Yamada, Masao| Ogawa, Tomohisa| Makino, Hirofumi|
発行日 2013-10-15
出版物タイトル PLoS ONE
8巻
10号
資料タイプ 学術雑誌論文
タイトル(別表記) The 2013 Incentive Award of the Okayama Medical Association in Cardiovascular and Pulmonary Research (2013 Sunada Prize)
フルテキストURL 126_95.pdf
著者 中司 敦子|
備考 平成25年度岡山医学会賞紹介記事 (The 2013 Okayama Medical Association Award)
出版物タイトル 岡山医学会雑誌
発行日 2014-08-01
126巻
2号
出版者 岡山医学会
出版者(別表記) Okayama Medical Association
開始ページ 95
終了ページ 98
ISSN 0030-1558
NCID AN00032489
資料タイプ 学術雑誌論文
関連URL http://www.okayama-u.ac.jp/user/oma/
言語 Japanese
著作権者 Copyright (c) 2014 岡山医学会
論文のバージョン publisher
査読 有り
DOI 10.4044/joma.126.95
NAID 130004685276
Sort Key 5
Eprints Journal Name joma
参考文献 1) Hida K, Wada J, Zhang H, Hiragushi K, Tsuchiyama Y, Shikata K, Makino H : Identification of genes specifically expressed in the accumulated visceral adipose tissue of OLETF rats. J Lipid Res (2000) 41, 1615-1622. 2) Nakatsuka A, Wada J, Iseda I, Teshigawara S, Higashio K, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Hida K, Eguchi J, et al. : Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex. Diabetes (2012) 61, 2823-2832. 3) Hida K, Wada J, Eguchi J, Zhang H, Baba M, Seida A, Hashimoto I, Okada T, Yasuhara A, Nakatsuka A, Shikata K, Hourai S, Futami J, et al. : Visceral adipose tissue-derived serine protease inhibitor : a unique insulin-sensitizing adipocytokine in obesity. Proc Natl Acad Sci U S A (2005) 102, 10610-10615. 4) Chevalier M, Rhee H, Elguindi EC, Blond SY : Interaction of murine BiP/GRP78 with the DnaJ homologue MTJ1. J Biol Chem (2000) 275, 19620-19627. 5) Arzoine L, Zilberberg N, Ben-Romano R, Shoshan-Barmatz V : Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity. J Biol Chem (2009) 284, 3946-3955. 6) Gonzalez-Gronow M, Kaczowka SJ, Payne S, Wang F, Gawdi G, Pizzo SV : Plasminogen structural domains exhibit different functions when associated with cell surface GRP78 or the voltage-dependent anion channel. J Biol Chem (2007) 282, 32811-32820.
著者 Kurose, Yuko| Wada, Jun| Kanzaki, Motoko| Teshigawara, Sanae| Nakatsuka, Atsuko| Murakami, Kazutoshi| Inoue, Kentaro| Terami, Takahiro| Katayama, Akihiro| Watanabe, Mayu| Higuchi, Chigusa| Eguchi, Jun| Miyatake, Nobuyuki| Makino, Hirofumi|
発行日 2013-01-22
出版物タイトル BMC Nephrology
14巻
資料タイプ 学術雑誌論文
著者 Inoue, Junko| Wada, Jun| Teshigawara, Sanae| Hida, Kazuyuki| Nakatsuka, Atsuko| Takatori, Yuji| Kojo, Shoichirou| Akagi, Shigeru| Nakao, Kazushi| Miyatake, Nobuyuki| McDonald, John F.| Makino, Hirofumi|
発行日 2012-12-03
出版物タイトル BMC Nephrology
13巻
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/50405
フルテキストURL 67_3_129.pdf
著者 Nakatsuka, Atsuko| Wada, Jun| Makino, Hirofumi|
抄録 In recent years, many researchers have emphasized the importance of metabolic syndrome based on its increasing prevalence and its adverse prognosis due to associated chronic vascular complications. Upstream of a cluster of metabolic and vascular disorders is the accumulation of visceral adipose tissue, which plays a central role in the pathophysiology. In the accumulation of adipose tissues, cell cycle regulation is tightly linked to cellular processes such as proliferation, hypertrophy and apoptosis. In addition, various cell cycle abnormalities have also been observed in other tissues, such as kidneys and the cardiovascular system, and they are critically involved in the progression of disease. Here, we discuss cell cycle abnormalities in metabolic syndrome in various tissues. Furthermore, we describe the role of nuclear receptors in cell growth and survival, and glucose and lipid metabolism in the whole body. Therapeutic strategies for modulating various cell cycles in metabolic disorders by targeting nuclear receptors may overcome obesity and its chronic vascular complications in the future.
キーワード nuclear receptor cell cycle metabolic syndrome diabetic nephropathy
Amo Type Review
発行日 2013-06
出版物タイトル Acta Medica Okayama
67巻
3号
出版者 Okayama University Medical School
開始ページ 129
終了ページ 134
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 23804135
Web of Sience KeyUT 000320747900001
著者 Nakatsuka, Atsuko| Wada, Jun| Iseda, Izumi| Teshigawara, Sanae| Higashio, Kanji| Murakami, Kazutoshi| Kanzaki, Motoko| Inoue, Kentaro| Terami, Takahiro| Katayama, Akihiro| Hida, Kazuyuki| Eguchi, Jun| Horiguchi, Chikage Sato| Ogawa, Daisuke| Matsuki, Yasushi| Hiramatsu, Ryuji| Yagita, Hideo| Kakuta, Shigeru| Iwakura, Yoichiro| Makino, Hirofumi|
発行日 2012-11
出版物タイトル Diabetes
61巻
11号
資料タイプ 学術雑誌論文