Title Alternative Complete response of primary esophageal endocrine cell carcinoma resected after neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil
FullText URL 126_39.pdf
Author Maeda, Naoaki| Shirakawa, Yasuhiro| Koujima, Takeshi| Ohara, Toshiaki| Tanabe, Shunsuke| Noma, Kazuhiro| Sakurama, Kazuhumi| Fujiwara, Toshiyosi|
Abstract  Esophageal endocrine cell carcinoma is extremely rare. We report a case of esophageal endocrine cell carcinoma showing histological complete response to neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil (DCF). A 66-year-old man had been experiencing epigastralgia, and a type 2 tumor in the thoracic part of esophagus was detected by upper endoscopy. The biopsy showed endocrine cell carcinoma. PET/CT, endoscopy and an esophagogram showed that the patient had a 70-mm scaled type 2 tumor in the middle thoracic esophagus, and they also revealed lymph node metastases (no. 106recR). We diagnosed a cT3cN1cM0 cStage III tumor. With two courses of DCF treatment, both the primary tumor and lymph node metastases showed a partial response. We performed a subtotal esophagectomy with three-field lymph node dissection. The pathological examination of the resected specimens revealed no malignant cells in the esophagus or lymph nodes, and we concluded that the pathological effect of the DCF treatment was Grade 3.
Keywords 食道癌(esophageal cancer) 内分泌細胞癌(endocrine cell carcinoma) DCF療法(DCF treatment)
Publication Title 岡山医学会雑誌
Published Date 2014-04-01
Volume volume126
Issue issue1
Start Page 39
End Page 43
ISSN 0030-1558
language Japanese
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
DOI 10.4044/joma.126.39
NAID 130004505807
Title Alternative A patient with primary malignant melanoma of the esophagus who underwent esophagectomy
FullText URL 126_45.pdf
Author Maeda, Naoaki| Shirakawa, Yasuhiro| Koujima, Takeshi| Ohara, Toshiaki| Tanabe, Shunsuke| Noma, Kazuhiro| Sakurama, Kazuhumi| Fujiwara, Toshiyosi|
Abstract  We report the case of a 61-old-man with a primary malignant melanoma of the esophagus, an extremely rare and highly aggressive malignancy. He presented with dysphagia, and we performed an upper gastrointestinal endoscopy that detected a tumor in the thoracic part of the esophagus. The biopsy showed malignant melanoma. PET/CT, endoscopy and an esophagogram showed that a 70-mm scaled type 2+1 tumor in the thoracic esophagus and no metastases. We diagnosed a cT3cN0cM0 cStage II tumor. We then performed a subtotal esophagectomy with two-field lymph node dissection and esophagogastrostomy via a retrosternal route. The pathological examination of the resected specimens confirmed that the type 2+1 tumor was PMME (pT2N0M0 pStage II). We administered six courses of postoperative adjuvant chemotherapy with dacarbazine, and the patient has had no recurrence for 17 months after the surgery.
Keywords 食道(esophagus) 悪性黒色腫(malignant melanoma)
Publication Title 岡山医学会雑誌
Published Date 2014-04-01
Volume volume126
Issue issue1
Start Page 45
End Page 48
ISSN 0030-1558
language Japanese
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
DOI 10.4044/joma.126.45
NAID 130004505808
Author Fujiwara, Y.| Yamada, T.| Naomoto, Y.| Yamatsuji, T.| Shirakawa, Y.| Tanabe, S.| Noma, K.| Kimura, T.| Aoki, H.| Matsukawa, H.| Kimura, M.| Nonaka, Y.| Sasaki, H.| Onoda, T.| Otawa, Y.| Takaoka, M.| Fukazawa, T.| Ohno, Y.| Fujiwara, T.|
Published Date 2013-12
Publication Title Journal of Hospital Infection
Volume volume85
Issue issue4
Content Type Journal Article
FullText URL fulltext.pdf
Author Ishikawa, Wataru| Kikuchi, Satoru| Ogawa, Toshihiro| Tabuchi, Motoyasu| Tazawa, Hiroshi| Kuroda, Shinji| Noma, Kazuhiro| Nishizaki, Masahiko| Kagawa, Shunsuke| Urata, Yasuo| Fujiwara, Toshiyoshi|
Keywords peritoneal metastasis adenovirus gastric cancer intraperitoneal chemotherapy paclitaxel oncolytic virus
Published Date 2020-09-25
Publication Title Molecular Therapy - Oncolytics
Volume volume18
Publisher Cell Press
Start Page 262
End Page 271
ISSN 2372-7705
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 32728614
DOI 10.1016/j.omto.2020.06.021
Web of Science KeyUT 000575168700023
Related Url isVersionOf https://doi.org/10.1016/j.omto.2020.06.021
FullText URL fulltext.pdf
Author Sato, Hiroaki| Noma, Kazuhiro| Ohara, Toshiaki| Kawasaki, Kento| Akai, Masaaki| Kobayashi, Teruki| Nishiwaki, Noriyuki| Narusaka, Toru| Komoto, Satoshi| Kashima, Hajime| Katsura, Yuki| Kato, Takuya| Kikuchi, Satoru| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kobayashi, Hisataka| Fujiwara, Toshiyoshi|
Published Date 2022-11-23
Publication Title Scientific Reports
Volume volume12
Issue issue1
Publisher Nature Portfolio
Start Page 20152
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022
File Version publisher
PubMed ID 36418422
DOI 10.1038/s41598-022-24313-3
Web of Science KeyUT 000887936300054
Related Url isVersionOf https://doi.org/10.1038/s41598-022-24313-3
FullText URL fulltext.pdf
Author Takagi, Kosei| Noma, Kazuhiro| Nagai, Yasuo| Kikuchi, Satoru| Umeda, Yuzo| Yoshida, Ryuichi| Fuji, Tomokazu| Yasui, Kazuya| Tanaka, Takehiro| Kashima, Hajime| Yagi, Takahito| Fujiwara, Toshiyoshi|
Keywords ampullary carcinoma carcinomas of the papilla of Vater cancer-associated fibroblast outcome survival recurrence
Published Date 2023-03-16
Publication Title Frontiers in Oncology
Volume volume13
Publisher Frontiers Media
Start Page 1072106
ISSN 2234-943X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Takagi, Noma, Nagai, Kikuchi, Umeda, Yoshida, Fuji, Yasui, Tanaka, Kashima, Yagi and Fujiwara.
File Version publisher
PubMed ID 37007101
DOI 10.3389/fonc.2023.1072106
Web of Science KeyUT 000961528000001
Related Url isVersionOf https://doi.org/10.3389/fonc.2023.1072106
JaLCDOI 10.18926/AMO/65149
FullText URL 77_2_193.pdf
Author Ikeda, Tomohiro| Noma, Kazuhiro| Okura, Kazuki| Katayama, Sho| Takahashi, Yusuke| Maeda, Naoaki| Tanabe, Shunsuke| Wakita, Akiyuki| Hamada, Masanori| Fujiwara, Toshiyoshi| Senda, Masuo|
Abstract This retrospective study aimed to investigate the validity of a 30-sec chair stand test (CS-30) as a simple test to assess exercise tolerance and clinical outcomes in 53 Japanese patients with esophageal cancer. There was a strong correlation between the results of CS-30 and the 6-min walk test (6MWT), the gold standard for assessing exercise tolerance (r=0.759). Furthermore, fewer patients whose CS-30 score was greater than 16 (the cutoff value defined based on 6MWT) experienced pneumonia in their postoperative course. These results suggest that exercise tolerance could be assessed using CS-30, and its cutoff value may be useful in predicting postoperative pneumonia risk.
Keywords esophageal cancer exercise tolerance rehabilitation
Amo Type Short Communication
Publication Title Acta Medica Okayama
Published Date 2023-04
Volume volume77
Issue issue2
Publisher Okayama University Medical School
Start Page 193
End Page 197
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37094957
Web of Science KeyUT 000982503800009
FullText URL fulltext.pdf
Author Komoto, Satoshi| Noma, Kazuhiro| Kato, Takuya| Kobayashi, Teruki| Nishiwaki, Noriyuki| Narusaka, Toru| Sato, Hiroaki| Katsura, Yuki| Kashima, Hajime| Kikuchi, Satoru| Ohara, Toshiaki| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords cancer-associated fibroblast chemotherapy radiotherapy esophageal cancer tumor microenvironment
Published Date 2023-05-30
Publication Title Cancers
Volume volume15
Issue issue11
Publisher MDPI
Start Page 2971
ISSN 2072-6694
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
PubMed ID 37296933
DOI 10.3390/cancers15112971
Web of Science KeyUT 001006082400001
Related Url isVersionOf https://doi.org/10.3390/cancers15112971
FullText URL fulltext.pdf
Author Matsumoto, Tasuku| Noma, Kazuhiro| Maeda, Naoaki| Kato, Takuya| Moriwake, Kazuya| Kawasaki, Kento| Hashimoto, Masashi| Tanabe, Shunsuke| Shirakawa, Yasuhiro| Fujiwara, Toshiyoshi|
Keywords T4 esophageal cancer Chemoradiotherapy Esophagectomy Two-stage operation
Note The version of record of this article, first published in Surgical Case Reports, is available online at Publisher’s website: http://dx.doi.org/10.1186/s40792-023-01692-x|
Published Date 2023-06-26
Publication Title Surgical Case Reports
Volume volume9
Issue issue1
Publisher Springer
Start Page 119
ISSN 2198-7793
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023.
File Version publisher
PubMed ID 37358692
DOI 10.1186/s40792-023-01692-x
Web of Science KeyUT 001016770100001
Related Url isVersionOf https://doi.org/10.1186/s40792-023-01692-x
Author Yoshimoto, Masashi| Kagawa, Shunsuke| Kajioka, Hiroki| Taniguchi, Atsuki| Kuroda, Shinji| Kikuchi, Satoru| Kakiuchi, Yoshihiko| Yagi, Tomohiko| Nogi, Shohei| Teraishi, Fuminori| Shigeyasu, Kunitoshi| Yoshida, Ryuichi| Umeda, Yuzo| Noma, Kazuhiro| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords Aspirin Ticagrelor P-selectin Platelet Time-lapse imaging
Note © 2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Jul. 2024.|
Published Date 2023-07-28
Publication Title Cancer Letters
Volume volume567
Publisher Elsevier BV
Start Page 216260
ISSN 0304-3835
NCID AA00598513
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Elsevier B.V.
File Version author
PubMed ID 37295551
DOI 10.1016/j.canlet.2023.216260
Web of Science KeyUT 001020524700001
Related Url isVersionOf https://doi.org/10.1016/j.canlet.2023.216260
Author Yamada, Eiji| Shirakawa, Yasuhiro| Yamatsuji, Tomoki| Sakuma, Leon| Takaoka, Munenori| Yamada, Takako| Noma, Kazuhiro| Sakurama, Kazufumi| Fujiwara, Yasuhiro| Tanabe, Shunsuke| Nagasaka, Takeshi| Fujiwara, Toshiyoshi| Naomoto, Yoshio|
Published Date 2012-12
Publication Title Journal of Surgical Research
Volume volume178
Issue issue2
Content Type Journal Article
JaLCDOI 10.18926/AMO/52407
FullText URL 68_2_111.pdf
Author Shirakawa, Yasuhiro| Noma, Kazuhiro| Maeda, Naoaki| Katsube, Ryoichi| Tanabe, Shunsuke| Ohara, Toshiaki| Sakurama, Kazufumi| Fujiwara, Toshiyoshi|
Abstract Thoracoscopic esophagectomy in the prone position (TEPP) might enable solo-surgery in cases requiring resection of the esophagus and the surrounding lymph nodes due to the associated advantages of good exposure of the surgical field and ergonomic considerations for the surgeon. However, no one approach can be for all patients requiring extensive lymphadenectomy. We recently developed an assistant-based procedure to standardize exposure of the surgical field. Patients were divided into 1 of 2 groups:a pre-standardization group (n=37) and a post-standardization group (n=28). The thoracoscopic operative time was significantly shorter (p=0.0037) in the post-standardization group (n=28; 267±31min) than in the pre-standardization group (n=37;301±53min). Further, learning curve analysis using the moving average method showed stabilization of the thoracoscopic operative time after the standardization. No significant differences were found in the number of mediastinal lymph nodes dissected or intraoperative blood loss between the 2 groups. There were also no significant differences in the complication rate. Assistant-based surgery and standardization of the procedure resulted in a well-exposed and safe surgical field. TEPP decreased the operative time, even in patients requiring extensive lymphadenectomy.
Keywords thoracoscopic esophagectomy prone position standardization
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2014-04
Volume volume68
Issue issue2
Publisher Okayama University Medical School
Start Page 111
End Page 117
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 24743786
Web of Science KeyUT 000334652700006
FullText URL fulltext.pdf
Author Nogi, Shohei| Noma, Kazuhiro| Hashimoto, Masashi| Kato, Takuya| Maeda, Naoaki| Tanabe, Shunsuke| Shirakawa, Yasuhiro| Fujiwara, Toshiyoshi|
Keywords Heterotopic gastric mucosa Esophagus Adenocarcinoma
Note The version of record of this article, first published in Surgical Case Reports, is available online at Publisher’s website: http://dx.doi.org/10.1186/s40792-023-01707-7|
Published Date 2023-07-20
Publication Title Surgical Case Reports
Volume volume9
Issue issue1
Publisher Springer
Start Page 132
ISSN 2198-7793
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023.
File Version publisher
PubMed ID 37470880
DOI 10.1186/s40792-023-01707-7
Web of Science KeyUT 001029997500001
Related Url isVersionOf https://doi.org/10.1186/s40792-023-01707-7
FullText URL fulltext20221020-1.pdf figure20221020-1.pdf table20221020-1.pdf ASO_Takata_Supplementary.pdf
Author Takata, Nobuo| Kikuchi, Satoru| Kuroda, Shinji| Tanabe, Shunsuke| Maeda, Naoaki| Noma, Kazuhiro| Takahashi, Ayako| Umeda, Yuzo| Shikata, Kenichi| Ozaki, Kazuhide| Fujiwara, Toshiyoshi|
Keywords Gastric cancer Gastrectomy Body weight loss Skeletal muscle loss Nutritional counseling
Note This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1245/s10434-022-12572-3| This fulltext is available in Sep. 2023.|
Published Date 2022-09-25
Publication Title Annals of Surgical Oncology
Volume volume30
Issue issue2
Publisher Springer Science and Business Media LLC
Start Page 1110
End Page 1118
ISSN 1068-9265
NCID AA11016573
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Society of Surgical Oncology 2022
File Version author
PubMed ID 36161371
DOI 10.1245/s10434-022-12572-3
Web of Science KeyUT 000858651900003
Related Url isVersionOf https://doi.org/10.1245/s10434-022-12572-3
JaLCDOI 10.18926/AMO/49672
FullText URL 67_2_123.pdf
Author Tanabe, Shunsuke| Shirakawa, Yasuhiro| Takehara, Yuko| Maeda, Naoaki| Katsube, Ryoichi| Ohara, Toshiaki| Sakurama, Kazufumi| Noma, Kazuhiro| Fujiwara, Toshiyoshi|
Abstract An 80-year-old woman, who had been administered α-glucosidase inhibitor for diabetes, was brought to the hospital with the sensation of abdominal fullness and pain. Abdominal computed tomography indicated pneumatosis cystoides intestinalis (PCI) in the small intestinal wall, with free air within the abdomen. A blood examination showed no increases in white blood cells or C-reactive protein level. The patientʼs condition improved with conservative therapy. PCI with pneumoperitoneum induced by α-glucosidase inhibitor is rare, with only 27 cases (excluding the present case) reported in Japan to date. In PCI with pneumoperitoneum, differentiation from gastrointestinal perforation is important and following the clinical symptoms over time is vital.
Keywords pneumatosis cystoides intestinalis pneumoperitoneum α-glucosidase inhibitor
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2013-04
Volume volume67
Issue issue2
Publisher Okayama University Medical School
Start Page 123
End Page 128
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23603930
Web of Science KeyUT 000317801700008
FullText URL fulltext20221215-1.pdf figures20221215-1.pdf Supple_Figures20221215-1.pdf Supple_Table20221215-1.pdf
Author Kajiwara, Yoshinori| Tazawa, Hiroshi| Yamada, Motohiko| Kanaya, Nobuhiko| Fushimi, Takuro| Kikuchi, Satoru| Kuroda, Shinji| Ohara, Toshiaki| Noma, Kazuhiro| Yoshida, Ryuichi| Umeda, Yuzo| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Keywords Pancreatic cancer Chemoresistance MDSC GM-CSF Oncolytic virus
Note This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00262-022-03334-x| This full-text of the article will be available in Nov. 2023.|
Published Date 2022-11-27
Publication Title Cancer Immunology, Immunotherapy
Volume volume72
Issue issue5
Publisher Springer Science and Business Media LLC
Start Page 1285
End Page 1300
ISSN 0340-7004
NCID AA00598499
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
File Version author
PubMed ID 36436021
DOI 10.1007/s00262-022-03334-x
Web of Science KeyUT 000889040300003
Related Url isVersionOf https://doi.org/10.1007/s00262-022-03334-x
FullText URL fulltext.pdf
Author Kikuchi, Satoru| Matsusaki, Takashi| Mitsuhashi, Toshiharu| Kuroda, Shinji| Kashima, Hajime| Takata, Nobuo| Mitsui, Ema| Kakiuchi, Yoshihiko| Noma, Kazuhiro| Umeda, Yuzo| Morimatsu, Hiroshi| Fujiwara, Toshiyoshi|
Published Date 2024-01-18
Publication Title BJS Open
Volume volume8
Issue issue1
Publisher Oxford University Press
Start Page zrad161
ISSN 2474-9842
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024.
File Version publisher
PubMed ID 38242571
DOI 10.1093/bjsopen/zrad161
Web of Science KeyUT 001148373800007
Related Url isVersionOf https://doi.org/10.1093/bjsopen/zrad161
Author Hanzawa, Shunya| Kikuchi, Satoru| Kuroda, Shinji| Shoji, Ryohei| Kashima, Hajime| Matsumi, Yuki| Takahashi, Ayako| Kakiuchi, Yoshihiko| Takagi, Kosei| Tanabe, Shunsuke| Noma, Kazuhiro| Kagawa, Shunsuke| Shikata, Kenichi| Fujiwara, Toshiyoshi|
Note This is an Accepted Manuscript of an article published by Taylor & Francis in Nutrition and Cancer on 15 Apr 2024, available at: https://doi.org/10.1080/01635581.2024.2340782.| This fulltext file will be available in Apr. 2025.|
Published Date 2024-04-15
Publication Title Nutrition and Cancer
Publisher Informa UK Limited
ISSN 0163-5581
NCID AA00325612
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 38619145
DOI 10.1080/01635581.2024.2340782
Web of Science KeyUT 001202947500001
Related Url isVersionOf https://doi.org/10.1080/01635581.2024.2340782
FullText URL fulltext.pdf
Author Ihara, Hiroki| Yoshio, Kotaro| Tanabe, Shunsuke| Sugiyama, Soichi| Hashimoto, Masashi| Maeda, Naoaki| Akagi, Shinsuke| Takao, Soshi| Noma, Kazuhiro| Hiraki, Takao|
Keywords Radiation therapy Esophageal squamous cell carcinoma Recurrence 18F-fluorodeoxyglucose positron emission tomography Survival
Note The version of record of this article, first published in Esophagus, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10388-023-01000-4|
Published Date 2023-04-07
Publication Title Esophagus
Volume volume20
Issue issue3
Publisher Springer Science and Business Media LLC
Start Page 548
End Page 556
ISSN 1612-9059
NCID AA11885266
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023
File Version publisher
PubMed ID 37027045
DOI 10.1007/s10388-023-01000-4
Web of Science KeyUT 000964113700001
Related Url isVersionOf https://doi.org/10.1007/s10388-023-01000-4
FullText URL fulltext.pdf
Author Kawasaki, Kento| Noma, Kazuhiro| Kato, Takuya| Ohara, Toshiaki| Tanabe, Shunsuke| Takeda, Yasushige| Matsumoto, Hijiri| Nishimura, Seitaro| Kunitomo, Tomoyoshi| Akai, Masaaki| Kobayashi, Teruki| Nishiwaki, Noriyuki| Kashima, Hajime| Maeda, Naoaki| Kikuchi, Satoru| Tazawa, Hiroshi| Shirakawa, Yasuhiro| Fujiwara, Toshiyoshi|
Keywords Esophageal cancer Cancer-associated fibroblasts Programmed cell death 1 Program cell death ligand 1 Immune checkpoint inhibitors
Note The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00262-023-03531-2|
Published Date 2023-09-05
Publication Title Cancer Immunology, Immunotherapy
Volume volume72
Issue issue11
Publisher Springer Science and Business Media LLC
Start Page 3787
End Page 3802
ISSN 0340-7004
NCID AA00598499
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023
File Version publisher
PubMed ID 37668710
DOI 10.1007/s00262-023-03531-2
Web of Science KeyUT 001062743200002
Related Url isVersionOf https://doi.org/10.1007/s00262-023-03531-2