Title Alternative | An investigator initiated phase II clinical trial of tamibarotene (AM80G) for chronic graft-versus-host disease |
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FullText URL | 127_133.pdf |
Author | Nishimori, Hisakazu| Maeda, Yoshinobu| |
Keywords | 臨床研究中核病院 慢性GVHD タミバロテン 同種造血幹細胞移植 Th17 |
Publication Title | 岡山医学会雑誌 |
Published Date | 2015-08-03 |
Volume | volume127 |
Issue | issue2 |
Start Page | 133 |
End Page | 137 |
ISSN | 0030-1558 |
Related Url | isVersionOf https://doi.org/10.4044/joma.127.133 |
language | Japanese |
Copyright Holders | Copyright (c) 2015 岡山医学会 |
File Version | publisher |
DOI | 10.4044/joma.127.133 |
NAID | 130005096255 |
JaLCDOI | 10.18926/AMO/49251 |
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FullText URL | 67_1_1.pdf |
Author | Nishimori, Hisakazu| Maeda, Yoshinobu| Tanimoto, Mitsune| |
Abstract | Graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic stem cell transplantation. Chronic GVHD often presents with clinical manifestations that resemble those observed in autoimmune diseases. Standard treatment is 1-2mg/kg/day of prednisone or an equivalent dose of methylprednisolone, with continued administration of a calcineurin inhibitor for steroid sparing. However, the prognosis of steroid-refractory chronic GVHD remains poor. Classically, chronic GVHD was said to involve predominantly Th2 responses. We are now faced with a more complex picture, involving possible roles for thymic dysfunction, transforming growth factor-β (TGF-β) and platelet-derived growth factor (PDGF), B cells and autoantibodies, and Th1/Th2/Th17 cytokines, as well as regulatory T cells (Tregs), in chronic GVHD. More detailed research on the pathophysiology of chronic GVHD may facilitate the establishment of novel strategies for its prevention and treatment. |
Keywords | chronic GVHD Th17 Am80 regulatory T cell (Treg) steroid-refractory |
Amo Type | Review |
Publication Title | Acta Medica Okayama |
Published Date | 2013-02 |
Volume | volume67 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 1 |
End Page | 8 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 23439503 |
Web of Science KeyUT | 000316829900001 |
FullText URL | fulltext20240213-01.pdf |
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Author | Urata, Tomohiro| Naoi, Yusuke| Jiang, Aixiang| Boyle, Merrill| Sunami, Kazutaka| Imai, Toshi| Nawa, Yuichiro| Hiramatsu, Yasushi| Yamamoto, Kazuhiko| Fujii, Soichiro| Yoshida, Isao| Yano, Tomofumi| Chijimatsu, Ryota| Murakami, Hiroyuki| Ikeuchi, Kazuhiro| Kobayashi, Hiroki| Tani, Katsuma| Ujiie, Hideki| Inoue, Hirofumi| Tomida, Shuta| Yamamoto, Akira| Kondo, Takumi| Fujiwara, Hideaki| Asada, Noboru| Nishimori, Hisakazu| Fujii, Keiko| Fujii, Nobuharu| Matsuoka, Ken-ichi| Sawada, Keisuke| Momose, Shuji| Tamaru, Jun-ichi| Nishikori, Asami| Sato, Yasuharu| Yoshino, Tadashi| Maeda, Yoshinobu| Scott, David W.| Ennishi, Daisuke| |
Published Date | 2023-12-14 |
Publication Title | Blood Advances |
Volume | volume7 |
Issue | issue24 |
Publisher | American Society of Hematology |
Start Page | 7459 |
End Page | 7470 |
ISSN | 2473-9529 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 by The American Society of Hematology. |
File Version | publisher |
PubMed ID | 37552496 |
DOI | 10.1182/bloodadvances.2023010402 |
Web of Science KeyUT | 001141306600001 |
Related Url | isVersionOf https://doi.org/10.1182/bloodadvances.2023010402 |
JaLCDOI | 10.18926/AMO/66915 |
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FullText URL | 78_2_123.pdf |
Author | Saeki, Kyosuke| Fujiwara, Hideaki| Seike, Keisuke| Kuroi, Taiga| Nishimori, Hisakazu| Tanaka, Takehiro| Matsuoka, Ken-ichi| Fujii, Nobuharu| Maeda, Yoshinobu| |
Abstract | Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HCT), but its pathogenesis remains unclear. Recently, haplo-identical HCT with post-transplant cyclophosphamide (Haplo-HCT with PTCY) was found to achieve a low incidence rate of acute GVHD and chronic GVHD. However, while the pathogenesis of acute GVHD following Haplo-HCT with PTCY has been well investigated, that of chronic GVHD remains to be elucidated, especially in HLA-matched HCT with PTCY. Based on its safety profile, PTCY is currently applied for the human leucocyte antigen (HLA)-matched HCT setting. Here, we investigated the mechanisms of chronic GVHD following HLA-matched HCT with PTCY using a well-defined mouse chronic GVHD model. PTCY attenuated clinical and pathological chronic GVHD by suppressing effector T-cells and preserving regulatory T-cells compared with a control group. Additionally, we demonstrated that cyclosporine A (CsA) did not show any additional positive effects on attenuation of GVHD in PTCY-treated recipients. These results suggest that monotherapy with PTCY without CsA could be a promising strategy for the prevention of chronic GVHD following HLA-matched HCT. |
Keywords | GVHD posttransplant cyclophosphamide hematopoietic cell transplantation HLA-identical |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2024-04 |
Volume | volume78 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 123 |
End Page | 134 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 38688830 |