| FullText URL | fulltext.pdf |
|---|---|
| Author | Sukegawa, Shintaro | Kawai, Hotaka| Nakano, Keisuke| Takabatake, Kiyofumi| Kanno, Takahiro| Nagatsuka, Hitoshi| Furuki, Yoshihiko| |
| Keywords | poly-L-lactide uncalcined and unsintered hydroxyapatite biocompatibility osteoconductivity mesenchymal stem cell |
| Published Date | 2019-11-08 |
| Publication Title | Materials |
| Volume | volume12 |
| Issue | issue22 |
| Publisher | MDPI |
| Start Page | 3681 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 by the authors. |
| File Version | publisher |
| PubMed ID | 31717278 |
| DOI | 10.3390/ma12223681 |
| Web of Science KeyUT | 000502284400038 |
| Related Url | isVersionOf https://doi.org/10.3390/ma12223681 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ono, Sawako| Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Nagatsuka, Hitoshi| |
| Keywords | YAP ΔNp63 oral epithelial dysplasia carcinoma in situ oral squamous cell carcinoma |
| Published Date | 2019-05-28 |
| Publication Title | International Journal of Medical Sciences |
| Volume | volume16 |
| Issue | issue5 |
| Publisher | Ivyspring International Publisher |
| Start Page | 766 |
| End Page | 773 |
| ISSN | 1449-1907 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 Ivyspring International Publisher. |
| File Version | publisher |
| PubMed ID | 31217745 |
| DOI | 10.7150/ijms.29995 |
| Web of Science KeyUT | 000534739100002 |
| Related Url | isVersionOf https://doi.org/10.7150/ijms.29995 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sukegawa, Shintaro| Kanno, Takahiro| Yamamoto, Norio| Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Nagatsuka, Hitoshi| Furuki, Yoshihiko| |
| Keywords | mandibular condylar fracture unsintered hydroxyapatite poly-l-lactide composite plate bioactive resorbable plate biomechanical loading evaluation fracture fixation |
| Published Date | 2019-05-13 |
| Publication Title | Materials |
| Volume | volume12 |
| Issue | issue9 |
| Publisher | MDPI |
| Start Page | 1557 |
| ISSN | 1996-1944 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 by the authors. |
| File Version | publisher |
| PubMed ID | 31085981 |
| DOI | 10.3390/ma12091557 |
| Web of Science KeyUT | 000469757500198 |
| Related Url | isVersionOf https://doi.org/10.3390/ma12091557 |
| FullText URL | IntJMolSci_20_8_1973.pdf |
|---|---|
| Author | Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Yoshida, Saori| Maeda, Hatsuhiko| Kawakami, Toshiyuki| Nagatsuka, Hitoshi| |
| Keywords | cell differentiation epithelial-mesenchymal interaction immunohistochemistry malignant transformation notch signaling odontogenic tumor pleomorphic adenoma |
| Published Date | 2019-04-23 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume20 |
| Issue | issue8 |
| Publisher | MDPI |
| Start Page | 1973 |
| ISSN | 14220067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 by the authors. |
| File Version | publisher |
| PubMed ID | 31018488 |
| DOI | 10.3390/ijms20081973 |
| Web of Science KeyUT | 000467648700171 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms20081973 |
| FullText URL | IJO54_1_283.pdf |
|---|---|
| Author | Shimizu, Rieko| Ibaragi, Soichiro| Eguchi, Takanori| Kuwajima, Daisuke| Kodama, Shinichi| Nishioka, Takashi| Okui, Tatsuo| Obata, Kyoichi| Takabatake, Kiyofumi| Kawai, Hotaka| Ono, Kisho| Okamoto, Kuniaki| Nagatsuka, Hitoshi| Sasaki, Akira| |
| Keywords | nicotine head and neck squamous cell carcinoma lymph node metastasis cetuximab |
| Published Date | 2018-11-12 |
| Publication Title | International Journal of Oncology |
| Volume | volume54 |
| Issue | issue1 |
| Publisher | Spandidos Publications |
| Start Page | 283 |
| End Page | 294 |
| ISSN | 1019-6439 |
| NCID | AA10992511 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 30431077 |
| DOI | 10.3892/ijo.2018.4631 |
| Web of Science KeyUT | 000451845400025 |
| Related Url | isVersionOf https://doi.org/10.3892/ijo.2018.4631 |
| JaLCDOI | 10.18926/AMO/50408 |
|---|---|
| FullText URL | 67_3_153.pdf |
| Author | Yamamoto, Masanao| Fujita, Hirofumi| Katase, Naoki| Inoue, Keiji| Nagatsuka, Hitoshi| Utsumi, Kozo| Sasaki, Junzo| Ohuchi, Hideyo| |
| Abstract | Ever since protoporphyrin IX (PpIX) was discovered to accumulate preferentially in cancer cells after 5-aminolevulinic acid (ALA) treatment, photodynamic treatment or therapy (PDT) has been developed as an exciting new treatment option for cancer patients. However, the level of PpIX accumulation in oral cancer is fairly low and insufficient for PDT. Ferrochelatase (FECH) and ATP-binding cassette transporter G2 (ABCG2) are known to regulate PpIX accumulation. In addition, serum enhances PpIX export by ABCG2. We investigated here whether and how inhibitors of FECH and ABCG2 and their combination could improve PpIX accumulation and PDT efficacy in an oral cancer cell line in serum-containing medium. ABCG2 inhibitor and the combination of ABCG2 and FECH inhibitors increased PpIX in the presence of fetal bovine serum (FBS) in an oral cancer cell line. Analysis of ABCG2 gene silencing also revealed the involvement of ABCG2 in the regulation of PpIX accumulation. Inhibitors of FECH and ABCG2, and their combination increased the efficiency of ALA-PDT even in the presence of FBS. ALA-PDT-induced cell death was accompanied by apoptotic events and lipid peroxidation. These results suggest that accumulation of PpIX is determined by the activities of ABCG2 and FECH and that treatment with a combination of their inhibitors improves the efficacy of PDT for oral cancer, especially in the presence of serum. |
| Keywords | 5-aminolevulinic acid protoporphyrin IX oncology photodynamic therapy apoptosis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-06 |
| Volume | volume67 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 153 |
| End Page | 164 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23804138 |
| Web of Science KeyUT | 000320747900004 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/50681 |
| Author | Yanagi, Yoshinobu| Fujita, Mariko| Hisatomi, Miki| Matsuzaki, Hidenobu| Konouchi, Hironobu| Katase, Naoki| Nagatsuka, Hitoshi| Asaumi, Jun-ichi| |
|---|---|
| Published Date | 201012 |
| Publication Title | Oral Radiology |
| Volume | volume26 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Watanabe, Nobuyuki| Takaoka, Munenori| Sakurama, Kazufumi| Tomono, Yasuko| Hatakeyama, Shinji| Ohmori, Osamu| Motoki, Takayuki| Shirakawa, Yasuhiro| Yamatsuji, Tomoki| Haisa, Minoru| Matsuoka, Junji| Beer, David G.| Nagatsuka, Hitoshi| Tanaka, Noriaki| Naomoto, Yoshio| |
|---|---|
| Published Date | 2010-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume122 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Maki, Yu| Murakami, Jun| Asaumi, Jun-ichi| Tsujigiwa, Hidetsugu| Nagatsuka, Hitoshi| Kokeguchi, Susumu| Fukui, Kazuhiro| Kawai, Noriko| Yanagi, Yoshinobu| Kuroda, Masahiro| Tanaka, Noriaki| Matsubara, Nagahide| Kishi, Kanji| |
|---|---|
| Published Date | 2005-7 |
| Publication Title | Oral Oncology |
| Volume | volume41 |
| Issue | issue10 |
| Content Type | Journal Article |
| Author | Murakami, Jun| Asaumi, Jun-ichi| Kawai, Noriko| Tsujigiwa, Hidetsugu| Yanagi, Yoshinobu| Nagatsuka, Hitoshi| Inoue, Tetsuyoshi| Kokeguchi, Susumu| Kawasaki, Shoji| Kuroda, Masahiro| Tanaka, Noriaki| Matsubara, Nagahide| Kishi, Kanji| |
|---|---|
| Published Date | 2005-07 |
| Publication Title | Cancer Chemotherapy and Pharmacology |
| Volume | volume56 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | 長塚 仁| |
|---|---|
| Published Date | 1991-03-28 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
