ID | 30306 |
JaLCDOI | |
FullText URL | |
Author |
Tsutsumi, Koji
Saeki, Kiyomi
|
Abstract | In the presence of extracellular Ca2+, 6,7-dihydro-6,8,8, 10-tetramethyl-8H-pyrano [3, 2-g] chromone-2-carboxylic acid (EAA) had an inhibitory effect on the substance P-induced histamine release from rat peritoneal mast cells. Not only Ca2+ but also Mg2+, Sr2+ and Ba2+ were effective in enhancing the activity of EAA. Marked tachyphylaxis to EAA developed irrespective of the presence or absence of extracellular Ca2+. Cross-tachyphylaxis was observed between EAA and disodium cromoglycate (DSCG). These results indicate that the mode of action of EAA is similar, but not identical, with that of DSCG. |
Keywords | 6
7-dihydro-6
8
8
10-tetramethyl-8H-pyrano(3
2-g) chromone-2-carboxylic acid (EAA)
disodium cromoglycate
histamine release
alkaline-earth metal ions
substance P
|
Amo Type | Article
|
Publication Title |
Acta Medica Okayama
|
Published Date | 1984-08
|
Volume | volume38
|
Issue | issue4
|
Publisher | Okayama University Medical School
|
Start Page | 367
|
End Page | 374
|
ISSN | 0386-300X
|
NCID | AA00508441
|
Content Type |
Journal Article
|
language |
English
|
File Version | publisher
|
Refereed |
True
|
PubMed ID | |
Web of Science KeyUT |