ID | 30306 |
JaLCDOI | |
フルテキストURL | |
著者 |
Tsutsumi, Koji
Okayama University
Saeki, Kiyomi
Okayama Univresity
|
抄録 | In the presence of extracellular Ca2+, 6,7-dihydro-6,8,8, 10-tetramethyl-8H-pyrano [3, 2-g] chromone-2-carboxylic acid (EAA) had an inhibitory effect on the substance P-induced histamine release from rat peritoneal mast cells. Not only Ca2+ but also Mg2+, Sr2+ and Ba2+ were effective in enhancing the activity of EAA. Marked tachyphylaxis to EAA developed irrespective of the presence or absence of extracellular Ca2+. Cross-tachyphylaxis was observed between EAA and disodium cromoglycate (DSCG). These results indicate that the mode of action of EAA is similar, but not identical, with that of DSCG. |
キーワード | 6
7-dihydro-6
8
8
10-tetramethyl-8H-pyrano(3
2-g) chromone-2-carboxylic acid (EAA)
disodium cromoglycate
histamine release
alkaline-earth metal ions
substance P
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1984-08
|
巻 | 38巻
|
号 | 4号
|
出版者 | Okayama University Medical School
|
開始ページ | 367
|
終了ページ | 374
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
Web of Science KeyUT |