| JaLCDOI | 10.18926/14834 |
|---|---|
| Title Alternative | HRCT上の肺のLow Attenuation Areaおよび肺機能により評価された高齢者善喘息の特徴 |
| FullText URL | 72_009_015.pdf |
| Author | Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Nishida, Norikazu| Takata, Shingo| Yokoi, Tadashi| Nakai, Mutsuo| Tanizaki, Yoshiro| |
| Abstract | The clinical significance of low attenuation area <-950 HU of the lungs on high - resolution computed tomography (HRCT) was evaluated in 80 patients with asthma in relation to patient age, CT number, pulmonary function including % residusal volume (% RV) and % DLco, and generation of leukotrienes B4 and C4 by leucocytes.
1. The % LAA (<- 950 HU) of the lungs showed a tendency to increase significantly with aging; the % LAA was significantly larger in elderly patients over the age of 60 years than in those under the age of 49 years. The CT number was also significantlyincreased with aging.
2. The values of % FVC, % FEV1.0, and FEV1.0% were
significantly decreased in elderly patients over age 70 compared with the values in those under age 49.
3. The value of % residual volume (% RV) tended to increase significantly with aging; the value in patients over the age of 70 years was significantly larger in those between the ages of 50 and 59 (p |
| Keywords | low attenuation area of the lung CT number residual volume DLco aging |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2002-02-01 |
| Volume | volume72 |
| Start Page | 9 |
| End Page | 15 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308131 |
| JaLCDOI | 10.18926/14893 |
|---|---|
| Title Alternative | Clinical research for hospitalized patients with community-acquired pneumonia from 2002 to 2007 |
| FullText URL | 076_012_017.pdf |
| Author | Takata, Shingo| Hosaki, Yasuhiro| Ashida, Kozo| Hamada, Masanori| Iwagaki, Naofumi| Kikuchi, Hiroshi| Mitsunobu, Fumihiro| |
| Abstract | 当院に入院した市中肺炎症例の臨床像を明らかにし, 日本呼吸器学会2007年成人市中肺炎診療ガイドラインによる市中肺炎の重症度分類の妥当性を検討した｡2002年４月から2007年３月までの過去５年間に当院に入院した, 30歳から95歳までの市中肺炎109名142例 (男性72名102例, 女性37名40例) を対象に, その臨床像を検討した｡平均年齢は74.8歳で,65歳未満26例, 65歳以上75歳未満の前期高齢者30例, 75歳以上の後期高齢者86例であった｡ 肺炎重症度は軽症21例, 中等症99例, 重症17例, 超重症５例であった｡抗菌薬の選択に関して軽症では21例中18例, 中等症では99例中92例, 重症では17例中16例がガイドラインに準じていたが, 超重症では全例でガイドラインに準じていなかった｡平均入院日数は軽症28.4日,中等症39.9日, 重症48.5日, 超重症45.2日であった｡死亡例は, 軽症では無く, 中等症群７例, 重症群４例, 超重症群３例の計14例で, 死亡例の平均年齢は81.8歳であった｡重症度が悪化するにつれ, 高齢, BUN高値, 低酸素血症, 意識障害, 低血圧の頻度は増加傾向にあった｡79例で慢性呼吸器疾患を合併し, 慢性呼吸器疾患合併群では有意に呼吸器関連死亡が多かった｡日本呼吸器学会2007年成人市中肺炎診療ガイドラインは, 本邦の肺炎の重症度別症 例解析に適していると考えられた｡ |
| Keywords | 日本呼吸器学会2007年成人市中肺炎診療ガイドライン (the Guideline for communityacquired pneumonia edited by the Japanese Respiratory Society) 市中肺炎 (community-acquired pneumonia) 呼吸器関連死亡 (respiratory system-related death) 高齢者 (elderly) 慢性呼吸器疾患 (chronic pulmonary disease) |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2008-03-01 |
| Volume | volume76 |
| Start Page | 12 |
| End Page | 17 |
| ISSN | 1348-1258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308574 |
| JaLCDOI | 10.18926/14912 |
|---|---|
| FullText URL | 071_073_075.pdf |
| Author | Ashida, Kozo| Tsugeno, Hirofumi| Hosaki, Yasuhiro| Mitsunobu, Fumihiro| Mifune, Takashi| Nishida, Norikazu| Okamoto, Makoto| Takata, Shingo| Tanizaki, Yoshiro| Tsuji, Takao| |
| Abstract | 症例は80才，女性。76才時［平成7年11月］より肝機能異常［アルカリフォスファターゼ高値］を認め，肝機能異常出現1年7ケ月後，血清学的検索で原発性胆汁性肝硬変症が疑われたが，無治療にて外来で経過を観察を行った。アルカリフォスファターゼ値は漸増傾向を示し，トランスアミナーゼ値の異常も伴ってきたため，平成12年11月精査目的で入院。組織検査等で無症候性原発性胆汁性肝硬変症［PBC］と診断した。PBCは中年・女性に好発する疾患で，高齢【特に後期高齢者］での発症は極めて稀である。4年間の自然経過も含め，興味深いと考えられたので報告する。 |
| Keywords | 原発性胆汁性肝硬変症 (primary biliary cirrhosis) 高齢 (elderly) 自然経過 (natural course) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2001-02-01 |
| Volume | volume71 |
| Start Page | 73 |
| End Page | 75 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308230 |
| JaLCDOI | 10.18926/14956 |
|---|---|
| Title Alternative | MR-angiographyで経過を観察しえた慢性関節リウマチに合併した巨細胞動脈炎の1例 |
| FullText URL | 069_035_039.pdf |
| Author | Harada, Seishi| Mitsunobu, Fumihiro| Kodama, Fumiko| Hosaki, Yasuhiro| Mifune, Takashi| Tsugeno, Hirofumi| Okamoto, Makoto| Yumoto, Eiichiro| Takata, Shingo| Tanizaki, Yoshiro| |
| Abstract | We report a patient who developed giant cell (temporal) arteritis during treatment of rheumatoid arthritis. The patient was a 57-year-old Japanese woman and had been well controlled with anti-rheumatic drugs, when she presented to our hospital with severe bitemporal headaches and marked fatigue. An exclusive diagnosis was rapidly made and she was diagnosed as having giant cell arteritis based on the classification criteria by American College of Reumatology. Additionally, magnetic resonance (MR) angiography was performed, from which stenotic change in the bilateral superficial temporal arteries was strongly suspected and then corticosteroid therapy was quickly started. The patient followed an uneventful course without developing any complications such as visual dysfunctions. Therapeutic effect was confirmed by MR-angiographic findings obtained 4 weeks after the initiation of therapy. |
| Keywords | 巨細胞動脈炎 (giant cell arteritis) 側頭動脈炎 (temporal arteritis) 慢性関節リウマチ (rheumatoid arthritis) MRアンギオグラフィー (MR-angiography) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1998-12 |
| Volume | volume69 |
| Start Page | 35 |
| End Page | 39 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308121 |
| JaLCDOI | 10.18926/14900 |
|---|---|
| Title Alternative | Fluticasone 投与にもかかわらず症状が軽快ぜすn-3系不飽和脂肪酸強化食による食事療法及びモンテルカストが著効した気管支喘息の１例 |
| FullText URL | 076_053_059.pdf |
| Author | Takata, Shingo| Ashida, Kozo| Hosaki, Yasuhiro| Hamada, Masanori| Iwagaki, Naofumi| Kikuchi, Hiroshi| Mitsunobu, Fumihiro| |
| Abstract | A 25-year-old woman had the chief complaint of recurrent episodes of dyspnea and wheeze. Asthma had been diagnosed at infant years and sometimes experienced asthma attacks. She graduated senior high school and entered technical school in Tokyo. She received fluticasone (400μg daily) but exacerbation continued after she became an office clerk. She returned Kurashiki in October 2001 but had wheeze and asthma exacerbations. She was admitted to our hospital for evaluation and treatment of bronchial asthma on August 2, 2002. After admission, her symptoms subsided within some days. She was treated with montelukast and perilla seed oil-rich supplementation . The number of eosinophils decreased, decrease was observed in leukotriene (LT) B4 generation and in LTC4 generation, and pulmonary function improved following montelukast and perilla seed oil-rich supplementation for 4 weeks. The patient had no exacerbation under treatment and was discharged from the hospital on September 2, 2002. For some patients with persistent asthma, inhaled corticosteroids may fail to achieve adequate control possibly because corticosteroids do not completely inhibit the synthesis and release of cysteinyl leukotrienes (cysLTs) in the lung. Montelukast blocks the interaction of cysLTs with their receptor and resulting downstream events and perilla seed oil-rich diet suppresses LT generation. Combination therapy with montelukast and perilla seed oil-rich diet is more effective than montelukast or perilla seed oil-rich diet alone because of additive effects of montelukast with perilla seed oil-rich diet. We suggest that montelukast and perilla seed oil-rich supplementation are effective options when bronchial asthma patients receive inhaled corticosteroid but exacerbation continues. |
| Keywords | モンテルカスト (montelukast) 気管支喘息 (bronchial asthma) ロイコトリエンC4 (leukotriene C4) エゴマ油食 (perilla seed oil-rich supplementation) フルチカゾン (fluticasone) |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2008-03-01 |
| Volume | volume76 |
| Start Page | 53 |
| End Page | 59 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308179 |
| JaLCDOI | 10.18926/14960 |
|---|---|
| Title Alternative | n-3系脂肪散を強化した食事療法が有効と考えられた肺気腫の一例 |
| FullText URL | 069_049_056.pdf |
| Author | Tsugeno, Hirofumi| Ashida, Kozo| Mitsunobu, Fumihiro| Mifune, Takashi| Okamoto, Makoto| Hosaki, Yasuhiro| Tanizaki, Yoshiro| Tsuji, Takao| |
| Abstract | An effective treatment for the advanced stages of chronic obstructive pulmonary disease (COPD) has not been established yet. We report our recent experience of one patient with pulmonary emphysema treated by dietary supplementation of n-3 fatty acid for two months. He presented improvements in clinical symptoms and pulmonary function, and suppression of leukotriene B(4) generation by peripheral leukocytes. We consequently suppose that dietary treatment with n-3 fatty acids (perilla seed oil) may offer benefits for the treatment of pulmonary emphysema by competitively inhiabiting the conversion of arachidonicacid to leukotrienes and prostanoids. |
| Keywords | pulmonary emphysema n-3 fatty acid leukotriene diet therapy |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1998-12 |
| Volume | volume69 |
| Start Page | 49 |
| End Page | 56 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308253 |
| JaLCDOI | 10.18926/14962 |
|---|---|
| Title Alternative | ステロイド依存性重症難治性気管支喘息症例における胃粘膜病変の検討 |
| FullText URL | 069_063_067.pdf |
| Author | Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Harada, Seishi| Okamoto, Makoto| Yumoto, Eiichirou| Takata, Shingo| Tanizaki, Yoshiro| |
| Abstract | Recently, we experienced two asthmatic patients with advanced gastric cancer. The two patients had steroid-dependent intractable asthma (SDIA) who had been on administration of corticosteroids for more than 2 years. To determine the influence of pathophysiology of SDIA on stomach mucous lesion, gastroscopic examinations and immunological examinations were performed in eight patients with SDIA, compared with 25 patient with non-SDIA. In patients with SDIA, gastric cancer, its precursor condition and immunosuppressive state were observed. These results suggest that the immunosuppressive state in SDIA induced by the long-term administration of corticosteroids may lead to the risk of gastric cancer development. |
| Keywords | ステロイド依存性重症難治性 (steroid-dependent intractable asthma (SDIA)) 胃癌 (gastric cancer) 免疫抑制 (immunosuppression) リンパ球 (lymphocytes) IgG |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1998-12 |
| Volume | volume69 |
| Start Page | 63 |
| End Page | 67 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308665 |
| JaLCDOI | 10.18926/15094 |
|---|---|
| Title Alternative | 気管支喘息に対する複合温泉療法の作用機序 2.内分泌･自律神経系および心因的要素に対する効果 |
| FullText URL | 067_092_098.pdf |
| Author | Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Saito, Katsuyoshi| |
| Abstract | Actions of spa therapy on endocrine-autonomic nerve system and psychological factors were analyzed in patients with bronchial asthma. In endocrine function, serum levels of cortisol and ACTH tended to increase after spa therapy. In autonomic nerve system, decrease in concentrations of serum adrenalin and noradrenalin was observed after spa therapy, and the difference between the initial levels before spa therapy and the levels after the therapy was significant in serum levels of adrenalin. However, serum levels of substance P and Bradykinin were not affected by spa therapy. To evaluate the action of spa therapy on mental condition in patients with asthma, four kinds of psychological tests, CMI, SDS, CAl and SD, were carried out. Improvement of mental disorders in patients with asthma is observed after spa therapy in all psychological tests. These results suggest that spa therapy acts effectively on endocrine-autonomic nerve system and improve psychological conditions. |
| Keywords | Bronchial asthma (気管支喘息) Spa therapy (温泉療法) Endocrine-autonomic nerve system (内分泌・自律神経系) Psychological disorders (心的要素) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 92 |
| End Page | 98 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307879 |
| JaLCDOI | 10.18926/15093 |
|---|---|
| Title Alternative | 気管支喘息に対する複合温泉療法の作用機序 1.温泉療法の評価方法との関連 |
| FullText URL | 067_085_091.pdf |
| Author | Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | Action mechanisms of complex spa therapy (swimming training in a hot spring pool, inhalation with iodine salt solution, and fango therapy) were studied in relation to patient age, clinical asthma type, and airway inflammation. Actions of spa therapy were observed by two clinical effects : direct and indirect effects. Improvement of subjective symptoms, ventilatory function, and bronchial hyperresponsiveness was observed as direct effects of spa therapy, and improvement of suppressed function of adrenocortical glands as indirect effects of the therapy. The clinical effects of spa therapy were higher in patients over the age of 40. Regarding clinical asthma type, the effects were larger in patients with type Ib and type II asthma than in those with type Ia. The efficacy of spa therapy was closely related with airway inflammation in patients with type Ib and type II asthma. |
| Keywords | complex spa therapy (複合温泉療法) clinical asthma type (臨床病型) ventilatory function (換気機能) bronchial hyperresponsiveness (気道過敏性) adrenocortical glands (副腎皮質) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 85 |
| End Page | 91 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307192 |
| JaLCDOI | 10.18926/15298 |
|---|---|
| Title Alternative | ステロイド依存性重症難治性喘息に対する複合温泉療法の作用機序 |
| FullText URL | 063_001_006.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Takatori, Akimasa| Okuda, Hiroyuki| Ochi, Koji| Harada, Hideo| Kimura, Ikuro| |
| Abstract | Effects of complex spa therapy, which comprises swimming training in a hot spring pool, inhalation of iodine salt solution and fango therapy, were analyzed in patients with steroid-dependent intractable asthma (SDIA) by comparison between the subjects with and without efficacy of the therapy. 1. The complex spa therapy was effective in the patients with lower levels of FEV(1.0%) and % PEFR. 2. The complex spa therapy was not always effective in the patients with a low value of % V(25), which represents depressed airflow in the small airways. 3. The efficacy of the complex spa therapy was found in the patients showing a low value of % V(25) accompanied by BAL neutrophilia, but not found in those without increased proportion (more than 10% ) of neutrophils in BAL fluid. The results reveal that the complex spa therapy is effective in patients with SDIA showing low values of FEV(1.0%) and % PEFR, and in those with a low value of % V(25) and BAL neutrophilia. |
| Keywords | complex spa therapy (複合温泉療法) ventilatory function (換気機能) BAL neutrophilia (BAL好中球増多) bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307537 |
| JaLCDOI | 10.18926/15096 |
|---|---|
| Title Alternative | 気管支喘息に対する複合温泉療法の作用機序 3.気道炎症反応との関連 |
| FullText URL | 067_099_106.pdf |
| Author | Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | The degree and characteristic of airway inflammation were evaluated by the proportions of bronchoalveolar lavage (BAL) cells. Clinical asthma types such as Ia. simple bronchoconstriction, Ib. bronchoconstriction + hypersecretion, and Ⅱ. bronchiolar obstruction correlate with airway inflammation. The increased proportion BAL neutrophils is characteristic of type Ⅱ asthma, and increase in BAL eosinophil count is often observed in type Ib asthma. Bronchial hyperresponsiveness also correlates with airway inflammation. Action of spa therapy has been speculated to be related to airway inflammation, since the therapy has no action inhibiting IgE-mediated allergic reaction. In fact, spa therapy is more effective in patients with type Ib and type Ⅱ than in those with type Ia showing slight degree of airway inflammation. Bronchial hyperresponsiveness is also improved by spa therapy. From a point of view, the direct action of spa therapy may be to clean airways and improve damaged mucous membrane of the airways, leading to suppression of airway inflammation. |
| Keywords | Spa therapy (温泉療法) Airway inflammation (気道炎症反応) BAL eosinophilia (BAL好酸球増多) BAL neutrophilia (BAL好中球増多) Bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 99 |
| End Page | 106 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307894 |
| JaLCDOI | 10.18926/15303 |
|---|---|
| Title Alternative | 気管支喘息におけるActivated Tリンパ球について,喘息発作との関連 |
| FullText URL | 064_011_016.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Kawaraya, Masashi| Harada, Hideo| Tada, Shinya| Kimura, Ikuro| |
| Abstract | The number of CD4(+) T-Iymphocytes, CD4/CD8 ratio, and the number of IL2R(+) T-Iymphocytes (CD25) were examined in 14 patients with bronchial asthma, and the results were compared in three different asthma stages : symptom-free stage, wheeze stage, and attack stage. 1. The proportion of blood CD4(+) T-lymphocytes was more decreased in patients with asthma attacks than in those without symptoms. The CD4/CD8 ratio was also more decreased in patients with attacks than in those without symptoms. However, these differences were not significant. 2. The proportion of blood activated T cells (IL2R(+) cells, CD25) was significantly increased in patients with attacks than in those without symptoms. The proportion of activated T cells in 5 asthma patients was 2.9±0.8% in symptom-free stage and 6.6±1.1% in attack stage(p<0.001). These findings show that numbers of activated T-lymphocytes in peripheral blood were increased during asthma attacks, and this increase suggests the participation of activated T cells in the pathogenesis of asthma. |
| Keywords | CD4(+) T cells (CD4(+)リンパ球) CD4／CD8 ratio (CD4／CD8比) IL2R(+) T cells (IL2R(+)Tリンパ球) bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 11 |
| End Page | 16 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307394 |
| JaLCDOI | 10.18926/15008 |
|---|---|
| Title Alternative | 中高年発症型喘息患者におけるIgE系アレルギー反応の加令による変化 |
| FullText URL | 067_050_056.pdf |
| Author | Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Yokota, Satoshi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | Age-related changes in IgE-mediated allergic reaction were examined in patients with late onset asthma, whose asthma occured over the age at onset of 40. 1. The number of patients with a high serum IgE level over 3001U/mℓ was larger in those between the ages at onset of 40 and 49 and over age at onset 60 than in those between the ages at onset 50 and 59. 2. A positive RAST score to Hdm and cockroach allergens was more frequently found in patients between 40 and 49 and over age 60 at onset compared to those between 50 and 59 at onset. In contrast, the number of patients with a positive RAST to Candida was larger in those between 50 and 59 at onset than in those of between 40 and 49 and over 60 at onset. 3. Severe asthma was more frequently and slight asthma was less frequently observed in patients between 50 and 59 at onset than in those of the other age at onset groups. These results suggest that IgE-mediated allergic reaction in patients between the ages at onset of 50 and 59 is different from that in those with early onset asthma, and that the reaction in patients between the ages at onset 40 and 49 and over 60 resembles to the reaction in those with early onset asthma. |
| Keywords | IgE RAST 吸入抗原 (inhalant Allergen) 気管支喘息 (Bronchial asthma) 加令 (aging) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 50 |
| End Page | 56 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307989 |
| JaLCDOI | 10.18926/14766 |
|---|---|
| FullText URL | 73_044_048.pdf |
| Author | Ashida, Kozo| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Nishida, Norikazu| Nagata, Takuya| Yokoi, Tadashi| Takata, Shingo| Tanizaki, Yoshiro| |
| Abstract | The influence of cigarette smoke on pulmonary function, airflow, lung volume, and transfer factor in patients with asthma was examined in 40 subjects over the age of 70 years (20 ever-smokers and 20 never-smokers), and 20 patients with pulmonary emphysema over age 70 (all ex-smokers). The ventilatory parameters showing airflow limitation (% FEV(1) and FEV(1)%) were not significantly different between ever-smokers and never-smokers of elderly asthmatics. In contrast, % FEV(1) and FEV(1) % values were significantly lower in patients with pulmonary emphysema than in those with asthma with or without a history of smoking. The % RV value was significantly larger and % DLco value was significantly more decreased in ever-smokers compared with neversmokers of the elderly asthmatics. However, there were no significant differences in % RV and % DLco values between asthmatics with a history of smoking and patients with pulmonary emphysema. The results show that cigarette smoke inflluences % RV and % DLco, but not % FEV(1) and FEV(1) %, suggesting airflow limitation of large and moderate size airways. |
| Keywords | cigarette smoking FEV(1) % % RV % DLco elderly asthmatics |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 44 |
| End Page | 48 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308159 |
| JaLCDOI | 10.18926/15312 |
|---|---|
| Title Alternative | 老年者気管支喘息における気道炎症細胞.喘息重症度と関連した気道細胞反応の特徴 |
| FullText URL | 064_083_088.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Nakagiri, Yoshiyasu| Harada, Hideo| Kimura, Ikuro| |
| Abstract | Cellular composition of bronchoalveolar lavage (BAL) fluid was examined in 11 elderly asthmatics over the age of 70, and the results were compared with those of 11 younger asthmatics under the age of 50. In the subjects with mild asthma, the proportion of BAL cells in the elderly subjects was 86.2% macrophages, 11.0% lymphocytes, 1.9% neutrophils, 0.9% eosinophils and 0.08% basophilic cells. The proportion of neutrophils and eosinophils in the BAL fluid was slightly higher in younger subjects with mild asthma compared with that in elderly subjects, although no significant difference was found between the two groups. In subjects with severe asthma, the proportions of lymphocytes, neutrophils, eosinophils and basophilic cells were more increased in both younger and older patients compared to those with mild asthma, and a significant increase in the number of BAL eosinophils was found in younger subjects with severe asthma compared to those with mild asthma (p < 0.05). However, no significant difference was present in the proportion of BAL cells between younger and older patients with severe asthma. The results reveal that BAL cells are more increased in subjects with suvere asthma than in those with mild asthma in both younger and older subjects, and show the possibility that this increase is more predominant in neutrophils in older subjects and in eosinophils in younger subjects. |
| Keywords | Neutrophils (好中球) Eosinophils (好酸球) Bronchoalveolar lavage (気管支肺胞洗浄) asthma severity (喘息重症度) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 83 |
| End Page | 88 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307736 |
| JaLCDOI | 10.18926/14755 |
|---|---|
| Title Alternative | 高齢者喘息における喫煙による気道過敏性の亢進について |
| FullText URL | 73_025_030.pdf |
| Author | Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Nishida, Norikazu| Nagata, Takuya| Takata, Shingo| Yokoi, Tadashi| Tanizaki, Yoshiro| |
| Abstract | Influence of cigarette smoking on the pathogenesis of asthma in the elderly remains controversial. This study was undertaken to clarify the influence of cigarette smoking on IgE-mediated allergy, bronchial hyperresponsiveness, and the generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leukocytes in 48 elderly patients (25 patients with a history of smoking for more than 20 years and 23 never-smokers) with asthma over the age of 70 years. 1. The incidence of positive IgE antibodies for inhalant allergens was significantly higher in asthmatics with a history of smoking than in never-smokers of asthmatics. 2. In bronchial hyperresponsiveness for methacholine, the Cmin was significantly lower in ever-smokers than in never-smokers of elderly asthmatics. 3. The generation of LB4 was significantly increased in patients with a history of smoking compared with those without a smoking history. However, the difference in LTC4 generation was not significant between ever-smokers and never-smokers of asthmatics. These results suggest that cigarette smoking increases bronchial hyperresponsiceness through IgE-mediated allergy and LTB4 generation. |
| Keywords | cigarette smoking IgE - mediated allergy elderly asthmatics bronchial hyperresponsiveness |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 25 |
| End Page | 30 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308038 |
| JaLCDOI | 10.18926/AMO/65749 |
|---|---|
| FullText URL | 77_4_387.pdf |
| Author | Kataoka, Takahiro| Habu, Hiroshi| Tanaka, Ayumi| Naoe, Shota| Murakami, Kaito| Fujimoto, Yuki| Yukimine, Ryohei| Takao, Soshi| Mitsunobu, Fumihiro| Yorifuji, Takashi| Yamaoka, Kiyonori| |
| Abstract | No epidemiological studies have examined the health effects of daily bathing in radon hot springs. In this cross-sectional study, we investigated the associations between radon hot spring bathing and health conditions. The target population was 5,250 adults ≥ 20 years old in the town of Misasa, Japan. We collected information about the participants’ bathing habits and alleviation of a variety of disease symptoms, and their self-rated health (SRH). Unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CI) were calculated. In both the adjusted and unadjusted models of hypertension, significant associations between the > 1×/week hot spring bathing and the alleviation of hypertension symptoms were observed compared to the group whose hot spring bathing was <1×/week: adjusted model, OR 5.40 (95%CI: 1.98-14.74); unadjusted model, 3.67 (1.50-8.99) and for gastroenteritis: adjusted model, 9.18 (1.15-72.96); unadjusted model, 7.62 (1.59-36.49). Compared to the no-bathing group, higher SRH was significantly associated with both bathing < 1×/week: unadjusted model, 2.27 (1.53-3.37) and > 1×/week: adjusted model, 1.91 (1.15-3.19). These findings suggest that bathing in radon hot springs is associated with higher SRH and the alleviation of hypertension and gastroenteritis. |
| Keywords | radon hot spring bathing habit self-rated health cross-section study |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-08 |
| Volume | volume77 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 387 |
| End Page | 394 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37635139 |
| Web of Science KeyUT | 001163659800003 |
| JaLCDOI | 10.18926/15332 |
|---|---|
| Title Alternative | 気管支肺胞洗浄液中リンパ球増多と患者年齢およびIgE系アレルギー反応との関連について |
| FullText URL | 064_097_104.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kimura, Ikuro| |
| Abstract | The proportion and number of lymphocytes in the airways were analyzed in 15 patients with a high proportion of lymphocytes in bronchoalveolar lavage (BAL) fluid (more than 30%) and in 17 patients with less than 20% of BAL lymphocytes. 1. Both atopic and nonatopic asthma patients with a high proportion of BAL lymphocytes were aged more than 50 years. In contrast, the age of patients with less than 20% of BAL lymphocytes ranged widely, from 29 to 63 years, in the two asthma types. 2. Age at onset of the disease, serum IgE levels, and ventilatory function test were not related to the proportion of BAL lymphocytes. 3. In patients with a high proportion of BAL lymphocytes, the mean proportion of these cells was 47.3% in atopic patients and 36.4% in non-atopic patients, i. e., there was no significant difference between the two asthma types. The absolute number of BAL lymphocytes in these patients was significantly higher in atopic (5.62×10(6)) than in nonatopic asthma (0.77×10(6)) (p<0.01). These findings show that an increased number of lymphocytes in the airways is clearly related to patient age and IgE-mediated allergic reaction. |
| Keywords | BAL lymphocytes patient age IgE-mediated allergic reaction bronchial asthma |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 97 |
| End Page | 104 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307637 |
| JaLCDOI | 10.18926/14953 |
|---|---|
| Title Alternative | 肺気腫患者におけるロイコトリエンB4,C4産生能と高分解能CTによる平均CT値との関連 |
| FullText URL | 069_015_020.pdf |
| Author | Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Harada, Seishi| Yumoto, Eiichiro| Takata, Shingo| Ochi, Koji| Harada, Hideo| Hasegawa, Harumi| |
| Abstract | The generation of leukotrienes B4 (LTB4) and C4 (LTC4) by peripheral leukocytes stimulated with Ca ionophore A23187 was examined in 17 patients with pulmonary emphysema. They were divided into three groups according to the mean CT number; A (<-940 HU), B (-940 ≦, <-930 HU), and C (-930 HU ≦ ).1. The values of FVC (% predicted), FEV1.0% and DLco (% predicted) showed a tendency to decrease as the mean CT number was smaller. The value of % FVC was significantly lower in patients with group A than in those with group C (p<0.05). 2. The generation of both LTB4 and LTC4 was significantly higher in patients with emphysema compared to the generation in healthy subjects (LTB4;p<0.05, LTC4;P<0.05). 3. The generation of LTB4 and LTC4 in patients with emphysema was higher as the mean CT number was larger (severity of the disease become less). The LTC4 production was significantly higher in patients with group C(mild or moderate type of emphysema) than in those with group A(advanced type of emphysema). These results suggest that the generation of LTB4 and LTC4 is higher in patients with mild or moderate type of emphysema than in those with advanced type of the disease. |
| Keywords | emphysema mean CT number LTB4 LTC4 |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1998-12 |
| Volume | volume69 |
| Start Page | 15 |
| End Page | 20 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308094 |
| JaLCDOI | 10.18926/AMO/32622 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuharu| Ochi, Koji| Harada, Hideo| Soda, Ryo| Takahashi, Kiyoshi| Kimura, Ikuro| |
| Abstract | Twenty-one patients with atopic asthma were classified into three types according to their symptoms (clinical diagnosis): Ia, simple bronchoconstriction; Ib, bronchoconstriction + hypersecretion; and II, bronchiolar obstruction, and this classification was compared with a classification made according to clinical findings and examinations (score diagnosis). Type Ib asthma was characterized by the increased incidence of eosinophils in bronchoalveolar lavage fluid (BALF), while type II was characterized by ventilatory dysfunction in small airways and the increased incidence of neutrophils in BALF. Four patients, whose expectoration was between 50 and 99ml/day, of the 12 with type Ia assessed by clinical diagnosis were evaluated as type Ib by score diagnosis. One patient with type II by clinical diagnosis was assessed as questionable type II by score diagnosis. In the other 16 patients, the clinical and score diagnoses were the same. |
| Keywords | bronchial asthma classification ventilatory function cellular composition of BALF sore diagnosis |
| Amo Type | Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 1992-08 |
| Volume | volume46 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 295 |
| End Page | 301 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 1442153 |
| Web of Science KeyUT | A1992JL44200010 |
