| Author | Nogami, Tomohiro| Shien, Tadahiko| Tanaka, Takehiro| Nishiyama, Keiko| Mizoo, Taeko| Iwamto, Takayuki| Ikeda, Hirokuni| Taira, Naruto| Doihara, Hiroyoshi| Miyoshi, Shinichiro| |
|---|---|
| Published Date | 2012-03-10 |
| Publication Title | Breast Cancer |
| Content Type | Journal Article |
| Author | Yamamoto, Sumiharu| Okazaki, Mikio| Yamane, Masaomi| Miyoshi, Kentaro| Otani, Shinji| Kakishita, Tomokazu| Yoshida, Osamu| Waki, Naohisa| Toyooka, Shinichi| Oto, Takahiro| Sano, Yoshifumi| Miyoshi, Shinichiro| |
|---|---|
| Published Date | 2012-03 |
| Publication Title | Transplant Immunology |
| Volume | volume26 |
| Issue | issue2-3 |
| Content Type | Journal Article |
| Author | Miyoshi, Kentaroh| Oto, Takahiro| Otani, Shinji| Tanaka, Shin| Harada, Masaaki| Kakishita, Tomokazu| Hori, Shiro| Waki, Naohisa| Yamane, Masaomi| Miyoshi, Shinichiro| |
|---|---|
| Published Date | 2011-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue3 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/46852 |
|---|---|
| FullText URL | 65_4_265.pdf |
| Author | Kojima, Katsuhide| Kato, Katsuya| Oto, Takahiro| Mitsuhashi, Toshiharu| Shinya, Takayoshi| Sei, Tetsuro| Okumura, Yoshihiro| Sato, Shuhei| Miyoshi, Shinichiro| Kanazawa, Susumu| |
| Abstract | To determine the effectiveness of living-donor lobar lung transplantation (LDLLT), it is necessary to predict the recipient's postoperative lung function. Traditionally, Date's formula, also called the segmental ratio, has used the number of lung segments to estimate the forced vital capacity (FVC) of grafts in LDLLT. To provide a more precise estimate of graft FVC, we calculated the volumes of the lower lobe and total lung using three-dimensional computed tomography (3D-CT) and the volume ratio between them. We calculated the volume ratio in 52 donors and tested the difference between the segmental volume ratios with a one-tailed t-test. We also calculated the predicted graft FVC in 21 LDLLTs using the segmental ratio pFVC(c) and the volume ratio pFVC(v), and then found the Pearson's correlation coefficients for both pFVC(c) and pFVC(v) with the recipients' actual FVC (rFVC) measured spirometrically 6 months after surgery. Significant differences were found between the segmental ratio and the average volume ratio for both sides (right, p＝0.03;left, p＝0.0003). Both pFVC(c) and pFVC(v) correlated significantly with rFVC at 6 months after surgery (p＝0.007 and 0.006). Both the conventional and the volumetric methods provided FVC predictions that correlated significantly with measured postoperative FVC. |
| Keywords | living-donor lobar lung transplantation 3D-CT volumetry |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-08 |
| Volume | volume65 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 265 |
| End Page | 268 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21860533 |
| Web of Science KeyUT | 000294236700007 |
| JaLCDOI | 10.18926/AMO/46629 |
|---|---|
| FullText URL | 65_3_179.pdf |
| Author | Teramen, Hirotake| Tsukuda, Kazunori| Tanaka, Norimitsu| Ueno, Tsuyoshi| Kubo, Takafumi| Ando, Midori| Soh, Junichi| Asano, Hiroaki| Pass, Harvery I.| Toyooka, Shinichi| Miyoshi, Shinichiro| |
| Abstract | Suppression of p21 has been implicated in the genesis and progression of many human malignancies. DNA methylation is an important mechanism of gene silencing in human malignancies. In this study, we examined the expression status and aberrant methylaion of p21 in lung cancers and malignant pleural mesotheliomas (MPM). We used 12 small cell lung cancer (SCLC) cell lines, 13 non-small cell lung cancer (NSCLC) cell lines, 50 primary NSCLCs, 6 MPM cell lines and 10 primary MPMs. The expression and methylation of p21 was examined by reverse transcription-PCR (RT-PCR), Western blotting and methylation-specific PCR (MSP) assay. Loss of p21 protein expression was observed in 7 SCLC cell lines (58.3%), 5 NSCLC cell lines (38.5%) and 3 MPM cell lines (50%) while mRNA expression was lost in 2 SCLC cell lines (16.7%), 2 NSCLC cell lines (15.4%) and none of the MPM cell lines. Aberrant methylation of p21 was found in 8.3% of SCLC cell lines, 30.2% of NSCLCs and 6.3% of MPMs. Among primary NSCLCs, methylation in adenocarcinomas was significantly more frequent than in squamous cell carcinomas. Loss of p21 expression was frequently observed in lung cancers and MPMs and aberrant methylation was one of the mechanisms of suppression of p21, especially in NSCLCs. |
| Keywords | p21 methylation lung cancer mesothelioma |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-06 |
| Volume | volume65 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 179 |
| End Page | 184 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21709715 |
| Web of Science KeyUT | 000292017500004 |
| Author | Miyoshi, Shinichiro| |
|---|---|
| Published Date | 2009-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue3 |
| Content Type | Journal Article |
