| Author | Kitagawa, Masashi| Sugiyama, Hitoshi| Morinaga, Hiroshi| Inoue, Tatsuyuki| Takiue, Keiichi| Ogawa, Ayu| Yamanari, Toshio| Kikumoto, Yoko| Uchida, Haruhito Adam| Kitamura, Shinji| Maeshima, Yohei| Nakamura, Kazufumi| Ito, Hiroshi| Makino, Hirofumi| |
|---|---|
| Published Date | 2013-02-19 |
| Publication Title | PLoS ONE |
| Volume | volume8 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Takiue, Keiichi| Sugiyama, Hitoshi| Inoue, Tatsuyuki| Morinaga, Hiroshi| Kikumoto, Yoko| Kitagawa, Masashi| Kitamura, Shinji| Maeshima, Yohei| Wang, Dahong| Masuoka, Noriyoshi| Ogino, Keiki| Makino, Hirofumi| |
|---|---|
| Published Date | 2012-05-25 |
| Publication Title | BMC Nephrology |
| Volume | volume13 |
| Issue | issue14 |
| Content Type | Journal Article |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tsuchida-Nishiwaki, Mariko| Uchida, Haruhito A.| Takeuchi, Hidemi| Nishiwaki, Noriyuki| Maeshima, Yohei| Saito, Chie| Sugiyama, Hitoshi| Wada, Jun| Narita, Ichiei| Watanabe, Tsuyoshi| Matsuo, Seiichi| Makino, Hirofumi| Hishida, Akira| Yamagata, Kunihiro| |
| Published Date | 2021-07-22 |
| Publication Title | Scientific Reports |
| Volume | volume11 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 14990 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2021 |
| File Version | publisher |
| PubMed ID | 34294784 |
| DOI | 10.1038/s41598-021-94467-z |
| Web of Science KeyUT | 000682802200023 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-021-94467-z |
| Author | Katayama, Akihiro| Nakatsuka, Atsuko| Eguchi, Jun| Murakami, Kazutoshi| Teshigawara, Sanae| Kanzaki, Motoko| Nunoue, Tomokazu| Hida, Kazuyuki| Wada, Nozomu| Yasunaka, Tetsuya| Ikeda, Fusao| Takaki, Akinobu| Yamamoto, Kazuhide| Kiyonari, Hiroshi| Makino, Hirofumi| Wada, Jun| |
|---|---|
| Published Date | 2015 |
| Publication Title | Scientific reports |
| Volume | volume5 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/50405 |
|---|---|
| FullText URL | 67_3_129.pdf |
| Author | Nakatsuka, Atsuko| Wada, Jun| Makino, Hirofumi| |
| Abstract | In recent years, many researchers have emphasized the importance of metabolic syndrome based on its increasing prevalence and its adverse prognosis due to associated chronic vascular complications. Upstream of a cluster of metabolic and vascular disorders is the accumulation of visceral adipose tissue, which plays a central role in the pathophysiology. In the accumulation of adipose tissues, cell cycle regulation is tightly linked to cellular processes such as proliferation, hypertrophy and apoptosis. In addition, various cell cycle abnormalities have also been observed in other tissues, such as kidneys and the cardiovascular system, and they are critically involved in the progression of disease. Here, we discuss cell cycle abnormalities in metabolic syndrome in various tissues. Furthermore, we describe the role of nuclear receptors in cell growth and survival, and glucose and lipid metabolism in the whole body. Therapeutic strategies for modulating various cell cycles in metabolic disorders by targeting nuclear receptors may overcome obesity and its chronic vascular complications in the future. |
| Keywords | nuclear receptor cell cycle metabolic syndrome diabetic nephropathy |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-06 |
| Volume | volume67 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 129 |
| End Page | 134 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23804135 |
| Web of Science KeyUT | 000320747900001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kobayashi, Kazuko| Kishi, Makoto| Atsumi, Tatsuya| Bertolaccini, Maria L.| Makino, Hirofumi| Sakairi, Nobuo| Yamamoto, Itaru| Yasuda, Tatsuji| Khamashta, Munther A.| Hughes, Graham R. V.| Koike, Takao| Voelker, Dennis R.| Matsuura, Eiji| |
| Keywords | antiphospholipid syndrome arterial thrombosis autoantibody |
| Published Date | 2003-04 |
| Publication Title | Journal Of Lipid Research |
| Volume | volume44 |
| Issue | issue4 |
| Publisher | Elsevier |
| Start Page | 716 |
| End Page | 726 |
| ISSN | 0022-2275 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2003 by Lipid Research, Inc. |
| File Version | publisher |
| PubMed ID | 12562869 |
| DOI | 10.1194/jlr.M200329-JLR200 |
| Web of Science KeyUT | 000182214500007 |
| Related Url | isVersionOf https://doi.org/10.1194/jlr.M200329-JLR200 |
| FullText URL | Mod_Rheumatol_26_5_730.pdf |
|---|---|
| Author | Sada, Ken-ei| Harigai, Masayoshi| Amano, Koichi| Atsumi, Tatsuya| Fujimoto, Shouichi| Yuzawa, Yukio| Takasaki, Yoshinari| Banno, Shogo| Sugihara, Takahiko| Kobayashi, Masaki| Usui, Joichi| Yamagata, Kunihiro| Homma, Sakae| Dobashi, Hiroaki| Tsuboi, Naotake| Ishizu, Akihiro| Sugiyama, Hitoshi| Okada, Yasunori| Arimura, Yoshihiro| Matsuo, Seiichi| Makino, Hirofumi| |
| Keywords | Antineutrophil cytoplasmic antibody-associated vasculitis Eosinophilic granulomatosis with polyangiitis Granulomatosis with polyangiitis Inception cohort Microscopic polyangiitis |
| Note | This is an Accepted Manuscript of an article published by Taylor & Francis Group| |
| Published Date | 2016-03-11 |
| Publication Title | Modern Rheumatology |
| Volume | volume26 |
| Issue | issue5 |
| Publisher | Taylor & Francis |
| Start Page | 730 |
| End Page | 737 |
| ISSN | 1439-7595 |
| NCID | AA1157187X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | author |
| PubMed ID | 26873424 |
| DOI | 10.3109/14397595.2016.1140274 |
| Web of Science KeyUT | 000393120600018 |
| Related Url | https://doi.org/10.3109/14397595.2016.1140274 |
| Author | Sugiyama, Koichi| Sada, Ken-ei| Kurosawa, Michiko| Wada, Jun| Makino, Hirofumi| |
|---|---|
| Published Date | 2013-02 |
| Publication Title | Clinical and Experimental Nephrology |
| Volume | volume17 |
| Issue | issue1 |
| Content Type | Journal Article |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Watanabe, Haruki| Sada, Ken-ei| Harigai, Masayoshi| Amano, Koichi| Dobashi, Hiroaki| Takasaki, Yoshinari| Fujimoto, Shouichi| Atsumi, Tatsuya| Yamagata, Kunihiro| Homma, Sakae| Arimura, Yoshihiro| Makino, Hirofumi| Research Committee of Intractable Vasculitis Syndrome (JPVAS) & Research Committee of Intractable Renal Disease of the Ministry of Health, Labour, and Welfare of Japan| |
| Published Date | 2021-03-04 |
| Publication Title | Scientific Reports |
| Volume | volume11 |
| Issue | issue1 |
| Publisher | Nature Research |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 33664381 |
| NAID | 120007027577 |
| DOI | 10.1038/s41598-021-84627-6 |
| Web of Science KeyUT | 000626140000051 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-021-84627-6 |
| JaLCDOI | 10.18926/AMO/52789 |
|---|---|
| FullText URL | 68_4_235.pdf |
| Author | Ono, Tetsuichiro| Shikata, Kenichi| Obika, Mikako| Miyatake, Nobuyuki| Kodera, Ryo| Hirota, Daisyo| Wada, Jun| Kataoka, Hitomi| Ogawa, Daisuke| Makino, Hirofumi| |
| Abstract | The aim of this study was to clarify the factors associated with the remission and/or regression of microalbuminuria in Japanese patients with type 2 diabetes mellitus. We retrospectively analyzed the data of 130 patients with type 2 diabetes mellitus with microalbuminuria for 2-6 years (3.39±1.31 years). Remission was defined as improving from microalbuminuria to normoalbuminuria using the albumin/creatinine ratio (ACR), and regression of microalbuminuria was defined as a decrease in ACR of 50% or more from baseline. Progression of microalbuminuria was defined as progressing from microalbuminuria to overt proteinuria during the follow-up period. Among 130 patients with type 2 diabetes mellitus with microalbuminuria, 57 and 13 patients were defined as having remission and regression, respectively, while 26 patients progressed to overt proteinuria. Sex (female), higher HDL cholesterol and lower HbA1c were determinant factors associated with remission/regression of microalbuminuria by logistic regression analysis. Lower systolic blood pressure (SBP) was also correlated with remission/regression, but not at a significant level. These results suggest that proper control of blood glucose, BP and lipid profiles may be associated with remission and/or regression of type 2 diabetes mellitus with microalbuminuria in clinical practice. |
| Keywords | microalbuminuria type 2 diabetes mellitus remission regression |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-08 |
| Volume | volume68 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 235 |
| End Page | 241 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25145409 |
| Web of Science KeyUT | 000340687500005 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52828 |
| FullText URL | 8_setouchi_project_en.pdf |
|---|---|
| Author | Makino, Hirofumi| |
| Published Date | 2023-03 |
| Publication Title | Setouchi Sustainability and Well-being Research Project Final Report |
| Content Type | Research Paper |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| Author | Tsuji, Kenji| Kitamura, Shinji| Makino, Hirofumi| |
|---|---|
| Published Date | 2014-04-25 |
| Publication Title | Biochemical and Biophysical Research Communications |
| Volume | volume447 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/52143 |
|---|---|
| FullText URL | 68_1_43.pdf |
| Author | Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki| |
| Abstract | The link between lifestyle modification and changes in both proteinuria and estimated glomerular filtration rates (eGFRs) was evaluated in Japanese subjects with proteinuria who were not taking medications. We used data from 51 men (35.8±10.0 years) and 74 women (38.0±11.0 years) with proteinuria at baseline and a 1-year follow up. eGFR was defined by a new equation developed specifically for Japanese subjects. Subjects were given advice for dietary and lifestyle improvement at the initial appointment. At the 1-year follow up, eGFR was increased in both sexes, but not at significant levels. (men:p＝0.7709, women:p＝0.2180). Proteinuria was also improved in many subjects. A decrease in proteinuria may be associated with improving eGFR in Japanese. |
| Keywords | proteinuria estimated glomerular filtration rate (eGFR) lifestyle modification |
| Amo Type | Short Communication |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-02 |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 43 |
| End Page | 46 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24553488 |
| Web of Science KeyUT | 000331592800007 |
| Author | Nakayama, Kazunori| Nakao, Kazushi| Takatori, Yuji| Inoue, Junko| Kojo, Shoichirou| Akagi, Shigeru| Fukushima, Masaki| Wada, Jun| Makino, Hirofumi| |
|---|---|
| Published Date | 2013-12-18 |
| Publication Title | International Journal of Nephrology and Renovascular Disease |
| Volume | volume7 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/49041 |
|---|---|
| FullText URL | 66_6_449.pdf |
| Author | Hanayama, Yoshihisa| Uchida, Haruhito Adam| Nakamura, Yoshio| Makino, Hirofumi| |
| Abstract | Angiotensin receptor blockers (ARBs) are the first-line antihypertensive agents. In clinical practice, it is often difficult to achieve the recommended blood pressure level by ARBs in their ordinal dosages alone. This study examined the practical efficacy of a combination therapy of ARB with thiazide diuretics for lowering morning home blood pressure (MHBP) in comparison to high-dose ARB therapy in patients with morning hypertension administered an ordinal dosage of ARB. This study was performed in a prospective, randomized, open-labeled and blind-endpoint fashion. Patients were considered to have morning hypertension when their self-measured systolic MHBPs were 135mmHg or higher, irrespective of their diastolic MHBP and office blood pressures (OBPs). Forty-eight outpatients with morning hypertension receiving the ordinal dosage of ARB were given either losartan/hydrochlorothiazide (n＝26) or high-dose ARB (n＝22) in place of their previously prescribed ARB. No change in any medication was permitted during this period. Decreases of both systolic and diastolic MHBP after 3 months of treatment were significantly greater in the losartan/hydrochlorothiazide group than in the high-dose ARB group (p＜0.05, respectively). The ratio of adverse events was somewhat high (23.1% in the losartan/hydrochlorothiazide group, 9.1% in the high-dose ARB group, respectively). However, there were no significant differences in any particular adverse event between groups. This study suggested losartan/hydrochlorothiazide might be superior to high-dose ARB for reducing morning home blood pressure. |
| Keywords | losartan hydrochlorothiazide morning blood pressure angiotensin II hyperuricemia |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-12 |
| Volume | volume66 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 449 |
| End Page | 459 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23254579 |
| Web of Science KeyUT | 000312966100004 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/49736 |
| JaLCDOI | 10.18926/AMO/52138 |
|---|---|
| FullText URL | 68_1_7.pdf |
| Author | Horimoto, Naoya| Kitamura, Shinji| Tsuji, Kenji| Makino, Hirofumi| |
| Abstract | Immunosuppressive agents are generally administered to treat kidney diseases. However, it is unclear whether renal stem/progenitor cells are directly affected by the immunosuppressive agents. We used normal rat kidney cells, ureteric bud cells and rat kidney stem/progenitor cells in this study. Mizoribine (MZR), cyclophosphamide (CPA) and cyclosporine (CyA) were added to the culture media of these cells. We evaluated the effects of these immunosuppressive agents on cell proliferation using an electrical cell-substrate impedance sensing system (ECIS) and their effects on the process of renal regeneration using the ischemia-reperfusion (I/R) injury rat model. The ECIS data showed that proliferation of each of the 3 types of cells was significantly suppressed by MZR. MZR treatment enhanced renal tubular injury in ischemia-reperfusion (I/R) injured rats, and significantly decreased levels of M-phase cells and Nestin-positive cells. These results suggested that MZR inhibits the cell cycle of renal stem/progenitor cells;thus, physicians should take note that MZR might affect not only inflammation but also renal regeneration. |
| Keywords | cell biology immunosuppression stem cells |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-02 |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 7 |
| End Page | 15 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24553483 |
| Web of Science KeyUT | 000331592800002 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52247 |
| Author | Kagawa, Hidetoshi| Hiromasa, Tsutomu| Hara, Takayuki| Takaki, Ayako| Yamanaka, Ryutaro| Sada, Ken-ei| Makino, Hirofumi| |
|---|---|
| Published Date | 2012-10 |
| Publication Title | Clinical and Experimental Nephrology |
| Volume | volume16 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Terasaka, Tomohiro| Otsuka, Fumio| Tsukamoto, Naoko| Nakamura, Eri| Inagaki, Kenichi| Toma, Kishio| Ogura-Ochi, Kanako| Glidewell-Kenney, Christine| Lawson, Mark A.| Makino, Hirofumi| |
|---|---|
| Published Date | 2013-12-05 |
| Publication Title | Molecular and Cellular Endocrinology |
| Volume | volume381 |
| Issue | issue1-2 |
| Content Type | Journal Article |
| Author | Ogawa, Daisuke| Eguchi, Jun| Wada, Jun| Terami, Naoto| Hatanaka, Takashi| Tachibana, Hiromi| Nakatsuka, Atsuko| Sato Horiguchi, Chikage| Nishii, Naoko| Makino, Hirofumi| |
|---|---|
| Published Date | 2014-01-22 |
| Publication Title | PLOS ONE |
| Volume | volume9 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/53117 |
|---|---|
| FullText URL | 69_1_1.pdf |
| Author | Watatani, Hiroyuki| Yamasaki, Hiroko| Maeshima, Yohei| Nasu, Tatsuyo| Hinamoto, Norikazu| Ujike, Haruyo| Sugiyama, Hitoshi| Sakai, Yoshiki| Tanabe, Katsuyuki| Makino, Hirofumi| |
| Abstract | Diabetic nephropathy is the most common pathological disorder predisposing patients to end-stage renal disease. Considering the increasing prevalence of type 2 diabetes mellitus worldwide, novel therapeutic approaches are urgently needed. ONO-1301 is a novel sustained-release prostacyclin analog that inhibits thromboxane A2 synthase. Here we examined the therapeutic effects of the intermittent administration of slow-release ONO-1301 (SR-ONO) on diabetic nephropathy in obese type 2 diabetes mice, as well as its direct effects on mesangial cells. The subcutaneous injection of SR-ONO (3mg/kg) every 3 wks did not affect the obesity or hyperglycemia in the db/db obese mice used as a model of type 2 diabetes, but it significantly ameliorated their albuminuria, glomerular hypertrophy, glomerular accumulation of type IV collagen, and monocyte/macrophage infiltration, and also the increase of TGF-β1, α-smooth muscle actin (α-SMA) and MCP-1 compared to vehicle treatment. In cultured mouse mesangial cells, ONO-1301 concentration-dependently suppressed the increases in TGF-β, type IV collagen, α-SMA, MCP-1 and fibronectin induced by high ambient glucose, at least partly through prostacyclin (PGI2) receptor-mediated signaling. Taken together, these results suggest the potential therapeutic efficacy of the intermittent administration of SR-ONO against type 2 diabetic nephropathy, possibly through protective effects on mesangial cells. |
| Keywords | prostacyclin ONO-1301 diabetic nephropathy TGF-β1 diabetes mellitus |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-02 |
| Volume | volume69 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 15 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25703166 |
| Web of Science KeyUT | 000349740300001 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/53128 |
