| Author | Ebinuma, Takayuki| Soga, Yoshihiko| Sato, Takamaro| Matsunaga, Kazuyuki| Kudo, Chieko| Maeda, Hiroshi| Maeda, Yoshinobu| Tanimoto, Mitsune| Takashiba, Shogo| |
|---|---|
| Published Date | 2014-06 |
| Publication Title | Supportive Care in Cancer |
| Volume | volume22 |
| Issue | issue6 |
| Content Type | Journal Article |
| Title Alternative | An investigator initiated phase II clinical trial of tamibarotene (AM80G) for chronic graft-versus-host disease |
|---|---|
| FullText URL | 127_133.pdf |
| Author | Nishimori, Hisakazu| Maeda, Yoshinobu| |
| Keywords | 臨床研究中核病院 慢性GVHD タミバロテン 同種造血幹細胞移植 Th17 |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2015-08-03 |
| Volume | volume127 |
| Issue | issue2 |
| Start Page | 133 |
| End Page | 137 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.127.133 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2015 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.127.133 |
| NAID | 130005096255 |
| Author | Iwatani, Kayoko| Takata, Katsuyoshi| Sato, Yasuharu| Miyata-Takata, Tomoko| Iwaki, Noriko| Cui, Wei| Sawada-Kitamura, Seiko| Sonobe, Hiroshi| Tamura, Maiko| Saito, Katsuhiko| Miyatani, Katsuya| Yamasaki, Rie| Yamadori, Ichiro| Fujii, Nobuharu| Terasaki, Yasushi| Maeda, Yoshinobu| Tanimoto, Mitsune| Nakamura, Naoya| Yoshino, Tadashi| |
|---|---|
| Published Date | 2014-07 |
| Publication Title | Human Pathology |
| Volume | volume45 |
| Issue | issue7 |
| Content Type | Journal Article |
| Author | Sugiyama, Haruko| Maeda, Yoshinobu| Nishimori, Hisakazu| Yamasuji, Yoshiko| Matsuoka, Ken-ichi| Fujii, Nobuharu| Kondo, Eisei| Shinagawa, Katsuji| Tanaka, Takehiro| Takeuchi, Kengo| Teshima, Takanori| Tanimoto, Mitsune| |
|---|---|
| Published Date | 2014-02 |
| Publication Title | Biology of Blood and Marrow Transplantation |
| Volume | volume20 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Sonoi, Norihiro| Soga, Yoshihiko| Maeda, Hiroshi| Ichimura, Koichi| Yoshino, Tadashi| Aoyama, Kazutoshi| Fujii, Nobuharu| Maeda, Yoshinobu| Tanimoto, Mitsune| Logan, Richard| Raber-Durlacher, Judith| Takashiba, Shogo| |
|---|---|
| Published Date | 2012-07 |
| Publication Title | Odontology |
| Volume | volume100 |
| Issue | issue2 |
| Content Type | Journal Article |
| Title Alternative | Molecular targeted therapy in myeloma and lymphoma |
|---|---|
| FullText URL | 126_143.pdf |
| Author | Saeki, Kyosuke| Maeda, Yoshinobu| Tanimoto, Mitsune| |
| Keywords | 骨髄腫 リンパ腫 分子標的治療薬 |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-08-01 |
| Volume | volume126 |
| Issue | issue2 |
| Start Page | 143 |
| End Page | 150 |
| ISSN | 0030-1558 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.143 |
| NAID | 130004685266 |
| Title Alternative | Molecular targeted therapies in leukemia |
|---|---|
| FullText URL | 126_49.pdf |
| Author | Maeda, Yoshinobu| Tanimoto, Mitsune| |
| Keywords | 白血病 分子標的薬 チロシンキナーゼ阻害薬 |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-04-01 |
| Volume | volume126 |
| Issue | issue1 |
| Start Page | 49 |
| End Page | 54 |
| ISSN | 0030-1558 |
| Related Url | http://www.okayama-u.ac.jp/user/oma/ |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.49 |
| Author | 杉浦 裕子| 曽我 賢彦| 前田 嘉信| |
|---|---|
| Published Date | 2010-09-01 |
| Publication Title | 造血細胞移植now&future |
| Volume | volume20 |
| Content Type | Article |
| Author | Hayashi, Eiko| Takata, Katsuyoshi| Sato, Yasuharu| Tashiro, Yukie| Tachiyama, Yoshiro| Sawada-Kitamura, Seiko| Hiramatsu, Yasushi| Sugiguchi, Shun| Nose, Soichiro| Hirokawa, Mitsuyoshi| Ando, Midori| Abd Mader, Lamia| Maeda, Yoshinobu| Tanimoto, Mitsune| Yoshino, Tadashi| |
|---|---|
| Published Date | 2013-09 |
| Publication Title | Human Pathology |
| Volume | volume44 |
| Issue | issue9 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/51868 |
|---|---|
| FullText URL | 67_5_319.pdf |
| Author | Murakawa, Kiminaka| Sato, Tomoaki| Maeda, Yoshinobu| Kitamura, Yoshihisa| Tanimoto, Mitsune| Sendo, Toshiaki| |
| Abstract | Graft-versus-host disease (GVHD) is a major concern in transplantation patients. Gut GVHD is accompanied by diarrhea, abdominal pain, and/or melena. Although oral treatment with corticosteroids (CSs) is effective in treating gut GVHD, it can cause adverse reactions that affect the entire body. Topical administration of CSs can be effective in treating diseases in which lesions are limited locally, because adverse reactions can then be alleviated. In this study, we examine and discuss an enteric-coated beclomethasone dipropionate (BDP) capsule (BDP-EC) formulated at Okayama University Hospital. The BDP-EC did not dissolve in solution 1 (pH1.2), and began disintegrating in solution 2 (pH6.8) after 5min, with a mean dissolution rate at 15min of 85%. We then used the capsule to treat a patient who developed gut GVHD after allogeneic hematopoietic stem cell transplantation. Clinically, the frequency of diarrhea decreased after BDP-EC administration. In addition, we were able to decrease the prednisolone equivalent dose. Symptoms associated with adverse reactions to BDP were not observed during the hospitalization period. These findings suggest that the administration of BDP-EC in the early stages of gut GVHD may allow a reduction in the initial doses of systemic CSs. |
| Keywords | beclomethasone intestinal graft-versus-host disease enteric-coated capsule in-hospital formulation |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-10 |
| Volume | volume67 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 319 |
| End Page | 324 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24145732 |
| Web of Science KeyUT | 000325836100006 |
| Author | Takata, Katsuyoshi| Sato, Yasuharu| Nakamura, Naoya| Tokunaka, Mami| Miki, Yukari| Kikuti, Yara Yukie| Igarashi, Kazuhiko| Ito, Etsuro| Harigae, Hideo| Kato, Seiichi| Hayashi, Eiko| Oka, Takashi| Hoshii, Yoshinobu| Tari, Akira| Okada, Hiroyuki| Mohamado, ABD Alkader Lamia| Maeda, Yoshinobu| Tanimoto, Mitsune| Kinoshita, Tomohiro| Yoshino, Tadashi| |
|---|---|
| Published Date | 2013-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue2 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/49251 |
|---|---|
| FullText URL | 67_1_1.pdf |
| Author | Nishimori, Hisakazu| Maeda, Yoshinobu| Tanimoto, Mitsune| |
| Abstract | Graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic stem cell transplantation. Chronic GVHD often presents with clinical manifestations that resemble those observed in autoimmune diseases. Standard treatment is 1-2mg/kg/day of prednisone or an equivalent dose of methylprednisolone, with continued administration of a calcineurin inhibitor for steroid sparing. However, the prognosis of steroid-refractory chronic GVHD remains poor. Classically, chronic GVHD was said to involve predominantly Th2 responses. We are now faced with a more complex picture, involving possible roles for thymic dysfunction, transforming growth factor-β (TGF-β) and platelet-derived growth factor (PDGF), B cells and autoantibodies, and Th1/Th2/Th17 cytokines, as well as regulatory T cells (Tregs), in chronic GVHD. More detailed research on the pathophysiology of chronic GVHD may facilitate the establishment of novel strategies for its prevention and treatment. |
| Keywords | chronic GVHD Th17 Am80 regulatory T cell (Treg) steroid-refractory |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-02 |
| Volume | volume67 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 8 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23439503 |
| Web of Science KeyUT | 000316829900001 |
| Author | Soga, Yoshihiko| Maeda, Yoshinobu| Ishimaru, Fumihiko| Tanimoto, Mitsune| Maeda, Hiroshi| Nishimura, Fusanori| Takashiba, Shogo| |
|---|---|
| Published Date | 2011-07 |
| Publication Title | Supportive Care in Cancer |
| Volume | volume19 |
| Issue | issue7 |
| Content Type | Journal Article |
| Author | Takahashi, Kanayo| Soga, Yoshihiko| Murayama, Yumeno| Udagawa, Mika| Nishimoto, Hitomi| Sugiura, Yuko| Maeda, Yoshinobu| Tanimoto, Mitsune| Takashiba, Shogo| |
|---|---|
| Published Date | 2010-01 |
| Publication Title | Supportive Care in Cancer |
| Volume | volume18 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Soga, Yoshihiko| Yamasuji, Yoshiko| Kudo, Chieko| Matsuura-Yoshimoto, Kaori| Yamabe, Kokoro| Sugiura, Yuko| Maeda, Yoshinobu| Ishimaru, Fumihiko| Tanimoto, Mitsune| Nishimura, Fusanori| Takashiba, Shogo| |
|---|---|
| Published Date | 2009-05 |
| Publication Title | Supportive Care in Cancer |
| Volume | volume17 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Soga, Yoshihiko| Sugiura, Yuko| Takahashi, Kanayo| Nishimoto, Hitomi| Maeda, Yoshinobu| Tanimoto, Mitsune| Takashiba, Shogo| |
|---|---|
| Published Date | 2011-02 |
| Publication Title | Supportive Care in Cancer |
| Volume | volume19 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Nishimori, Hisakazu| Maeda, Yoshinobu| Tanimoto, Mitsune| |
|---|---|
| Published Date | 2012-12-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Asakura, Shoji| Hashimoto, Daigo| Takashima, Shuichiro| Sugiyama, Haruko| Maeda, Yoshinobu| Akashi, Koichi| Tanimoto, Mitsune| Teshima, Takanori| |
|---|---|
| Published Date | 2012-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/47266 |
|---|---|
| FullText URL | 65_6_403.pdf |
| Author | Waseda, Koichi| Tanimoto, Yasushi| Ichiba, Shingo| Miyahara, Nobuaki| Murakami, Toshi| Ochi, Nobuaki| Terado, Michihisa| Nagano, Osamu| Maeda, Yoshinobu| Kanehiro, Arihiko| Ujike, Yoshihito| Tanimoto, Mitsune| |
| Abstract | Bronchiolitis obliterans (BO) is a disease with a poor prognosis, and a key factor that limits long-term survival after allogeneic hematopoietic stem cell transplantation (HSCT). We here report a case of a 31-year woman with acute lymphatic leukemia, which was treated by chemotherapy and HSCT, and consequently developed BO 2 years after HSCT. A non-tuberculous mycobacterial infection occurred and showed gradual exacerbation. She started taking anti-mycobacterial drugs, but lost appetite, felt tired and finally lost consciousness one month after beginning medication. Arterial blood gas revealed marked hypercapnia. Using extracorporeal life support (ECLS), the carbon dioxide concentration was reduced and her consciousness recovered. To our knowledge, this is the first case in which ECLS was successfully used for hypercapnia in a patient with BO. |
| Keywords | extracorporeal life support hypercapnia bronchiolitis obliterans noninvasive positive pressure ventilation |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-12 |
| Volume | volume65 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 403 |
| End Page | 406 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22189481 |
| Web of Science KeyUT | 000298516900007 |
| Author | Itou Nao| Maeda Yoshinobu| Hayashi Toyohiko| |
|---|---|
| Published Date | 2009-11-11 |
| Publication Title | Proceedings : Fifth International Workshop on Computational Intelligence & Applications |
| Volume | volume2009 |
| Issue | issue1 |
| Content Type | Conference Paper |
