| JaLCDOI | 10.18926/AMO/53999 |
|---|---|
| FullText URL | 70_1_13.pdf |
| Author | Arum Tri Wahyuningsih| Shen, Lianhua| Kobayashi, Kazuko| Sasaki, Takanori| Takenaka, Fumiaki| Hanada, Takahisa| Akehi, Masaru| Akahoshi, Akiya| Ozeki, Eiichi| Ando, Eiji| Matsuura, Eiji| |
| Abstract | Intact β2-glycoprotein I (iβ2GPI) is a glycoprotein that regulates coagulation and fibrinolysis. Nicked β2GPI (nβ2GPI) possesses an angiogenic property at a relatively low concentration, and an antiangiogenic property at a high concentration. Here we investigated the functions of βi 2GPI and nβ2GPI in vascular endothelial growth factor (VEGF)-A-induced endothelial cell proliferation and tube formation. We used noninvasive PET imaging to analyze the in vivo distribution of intravenously injected β2GPI variants in tumor lesions in mice. iβ2GPI was incubated with plasmin to obtain nβ2GPI, and its N-terminal sequence was analyzed. nβ2GPI had at least one other cleavage site upstream of the β2GPIʼs domain V, whereas the former plasmin-cleavage site locates between K317 and T318. Both of intact and nicked β2GPI significantly inhibited the VEGF-A-induced cell proliferation and the tube formation of human umbilical vein endothelial cells (HUVECs). PET imaging visualized considerably distributed intensities of all tested β2GPI variants in tumor lesions of pancreatic tumor cell-xenografts. These results indicate that β2GPI may be physiologically and pathophysiologically important in the regulation of not only coagulation and fibrinolysis, but also angiogenesis. |
| Keywords | β2-glycoprotein I (β2GPI) angiogenesis vascular endothelial growth factor-A (VEGF-A) positron emission tomography (PET) imaging |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-02 |
| Volume | volume70 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 13 |
| End Page | 24 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26899605 |
| Web of Science KeyUT | 000371288700002 |
| Author | Xian, Wen Tan| Kobayashi, Kazuko| Lianhua, Shen| Inagaki, Junko| Ide, Masahiro| Hwang, Siaw San| Matsuura, Eiji| |
|---|---|
| Keywords | Food science Food analysis Rice bran extract (RBE) Functional food Phytochemicals Atherosclerosis Oxidative stress Inflammation Antioxidant Anti-inflammation Oxidized lipoprotein (oxLDL) |
| Published Date | 2020-12 |
| Publication Title | Heliyon |
| Volume | volume6 |
| Issue | issue12 |
| Publisher | Elsevier |
| Start Page | e05743 |
| ISSN | 2405-8440 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors. |
| File Version | publisher |
| DOI | 10.1016/j.heliyon.2020.e05743 |
| Related Url | isVersionOf https://doi.org/10.1016/j.heliyon.2020.e05743 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Lim, Melissa Siaw Han| Ohtsuki, Takashi| Takenaka, Fumiaki| Kobayashi, Kazuko| Akehi, Masaru| Uji, Hirotaka| Kobuchi, Hirotsugu| Sasaki, Takanori| Ozeki, Eiichi| Matsuura, Eiji| |
| Keywords | theranostics single chain variable fragment of IgG (scFv) drug delivery system (DDS) photodynamic therapy (PDT) PET imaging accelerated blood clearance (ABC) cell penetrating peptide (CPP) siRNA ATP-binding cassette subfamily G member 2 (ABCG2) |
| Published Date | 2021-02-18 |
| Publication Title | Life |
| Volume | volume11 |
| Issue | issue2 |
| Publisher | MDPI |
| Start Page | 158 |
| ISSN | 2075-1729 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| PubMed ID | 33670777 |
| DOI | 10.3390/life11020158 |
| Web of Science KeyUT | 000622756700001 |
| Related Url | isVersionOf https://doi.org/10.3390/life11020158 |
| FullText URL | fulltext20210421_2.pdf |
|---|---|
| Author | Lim, Melissa Siaw Han| Nishiyama, Yuki| Ohtsuki, Takashi| Watanabe, Kazunori| Kobuchi, Hirotsugu| Kobayashi, Kazuko| Matsuura, Eiji| |
| Keywords | Lactosome ABCG2 siRNA Cancer siRNA delivery Photodynamic therapy Polymeric micelle Photosensitizer Photochemical internalization |
| Note | ©2021 Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.xphs.2021.01.026] . | |
| Published Date | 2021-04-30 |
| Publication Title | Journal of Pharmaceutical Sciences |
| Volume | volume110 |
| Publisher | Elsevier |
| Start Page | 1788 |
| End Page | 1798 |
| ISSN | 00223549 |
| NCID | AA00704450 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 33529684 |
| DOI | 10.1016/j.xphs.2021.01.026 |
| Web of Science KeyUT | 000631863100036 |
| Related Url | isVersionOf https://doi.org/10.1016/j.xphs.2021.01.026 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Liu, Qingping| Kobayashi, Kazuko| Furukawa, Jun-ichi| Inagaki, Junko| Sakairi, Nobuo| Iwado, Akimasa| Yasuda, Tatsuji| Koike, Takao| Voelker, Dennis R.| Matsuura, Eiji| |
| Keywords | antiphospholipid syndrome atherosclerosis autoantibody beta(2)-glycoprotein I oxidized LDL omega-oxidation |
| Published Date | 2002-09 |
| Publication Title | Journal Of Lipid Research |
| Volume | volume43 |
| Issue | issue9 |
| Publisher | Elsevier |
| Start Page | 1486 |
| End Page | 1495 |
| ISSN | 0022-2275 |
| NCID | AA00701215 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2002 by Lipid Research, Inc. |
| File Version | publisher |
| PubMed ID | 12235181 |
| DOI | 10.1194/jlr.M20063-JLR200 |
| Web of Science KeyUT | 000178252900016 |
| Related Url | isVersionOf https://doi.org/10.1194/jlr.M20063-JLR200 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kobayashi, Kazuko| Kishi, Makoto| Atsumi, Tatsuya| Bertolaccini, Maria L.| Makino, Hirofumi| Sakairi, Nobuo| Yamamoto, Itaru| Yasuda, Tatsuji| Khamashta, Munther A.| Hughes, Graham R. V.| Koike, Takao| Voelker, Dennis R.| Matsuura, Eiji| |
| Keywords | antiphospholipid syndrome arterial thrombosis autoantibody |
| Published Date | 2003-04 |
| Publication Title | Journal Of Lipid Research |
| Volume | volume44 |
| Issue | issue4 |
| Publisher | Elsevier |
| Start Page | 716 |
| End Page | 726 |
| ISSN | 0022-2275 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2003 by Lipid Research, Inc. |
| File Version | publisher |
| PubMed ID | 12562869 |
| DOI | 10.1194/jlr.M200329-JLR200 |
| Web of Science KeyUT | 000182214500007 |
| Related Url | isVersionOf https://doi.org/10.1194/jlr.M200329-JLR200 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tabuchi, Masako| Inoue, Katsumi| Usui-Kataoka, Hitomi| Kobayashi, Kazuko| Teramoto, Misako| Takasugi, Koji| Shikata, Kenichi| Yamamura, Masahiro| Ando, Kenji| Nishida, Keiichiro| Kasahara, Junko| Kume, Noriaki| Lopez, Luis R.| Mitsudo, Kazuaki| Nobuyoshi, Masakiyo| Yasuda, Tatsuji| Kita, Toru| Makino, Hirofumi| Matsuura, Eiji| |
| Keywords | beta 2-glycoprotein I oxidized LDL/beta 2-glycoprotein I complexes diabetes mellitus oxidized LDL |
| Published Date | 2007-04 |
| Publication Title | Journal Of Lipid Research |
| Volume | volume48 |
| Issue | issue4 |
| Publisher | ELSEVIER |
| Start Page | 768 |
| End Page | 781 |
| ISSN | 0022-2275 |
| NCID | AA00701215 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2007 by the American Society for Biochemistry and Molecular Biology, Inc. |
| File Version | publisher |
| PubMed ID | 17261875 |
| DOI | 10.1194/jlr.M600414-JLR200 |
| Web of Science KeyUT | 000245627100003 |
| Related Url | isVersionOf https://doi.org/10.1194/jlr.M600414-JLR200 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fithroni, Abdul Basith| Kobayashi, Kazuko| Uji, Hirotaka| Ishimoto, Manabu| Akehi, Masaru| Ohtsuki, Takashi| Matsuura, Eiji| |
| Keywords | boron neutron capture therapy (BNCT) biologically self-degradable amphipathic polymer (Lactosome) hydrophobic boron cluster carborane isomers or o-carborane alkylated derivatives molecular glue effect |
| Published Date | 2022-10-21 |
| Publication Title | CELLS |
| Volume | volume11 |
| Issue | issue20 |
| Publisher | MDPI |
| Start Page | 3307 |
| ISSN | 2073-4409 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 36291173 |
| DOI | 10.3390/cells11203307 |
| Web of Science KeyUT | 000872497500001 |
| Related Url | isVersionOf https://doi.org/10.3390/cells11203307 |
