JaLCDOI | 10.18926/AMO/30956 |
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FullText URL | fulltext.pdf |
Author | Doi, Hideyuki| Nishida, Keiichiro| Yorimitsu, Masanori| Komiyama, Takamitsu| Kadota, Yasutaka| Tetsunaga, Tomonori| Yoshida, Aki| Kubota, Satoshi| Takigawa, Masaharu| Ozaki, Toshifumi| |
Abstract | Mechanical stress plays a key role in the pathogenesis of cartilage destruction seen in osteoarthritis (OA). We investigated the effect of cyclic tensile stress (CTS) on the anabolic and catabolic gene expression of rat cultured normal chondrocytes using the Flexercell strain unit. The effects of interleukin (IL)-4, a chondroprotective cytokine, on the changes in gene expression induced by CTS were also investigated. CTS (7% elongation at 0.5 Hz) for 24 h did not affect the expression of aggrecan and type II collagen, whereas CTS significantly upregulated matrix metalloproteinase (MMP)-13 and cathepsin B mRNA expression by chondrocytes. IL-1beta expression was also signifi cantly upregulated by CTS up to 12 h. The upregulation of MMP-13 was observed at 3 h, which was earlier than that of IL-1beta. Furthermore, pre-treatment with IL-4 (10 ng/ml) suppressed both MMP-13 and cathepsin B induction by mechanical stress, as well as CTS-induced IL-1beta expression. Our results suggest that IL-4 might have a therapeutic value in the treatment of OA by downregulation of mechanical stress-induced MMP-13 and cathepsin B expression by chondrocytes. |
Keywords | IL-4 MMP cathepsin B mechanical stress aggrecanase |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2008-04 |
Volume | volume62 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 119 |
End Page | 126 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 18464888 |
Web of Science KeyUT | 000255297600008 |
Author | Asano, Masahiro| Kubota, Satoshi| Nakanishi, Tohru| Nishida, Takashi| Yamaai, Tomoichiro| Yosimichi, Gen| Ohyama, Kazumi| Sugimoto, Tomosada| Murayama, Yoji| Takigawa, Masaharu| |
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Published Date | 2005-10-05 |
Publication Title | Cell Communication and Signaling |
Volume | volume3 |
Issue | issue1 |
Content Type | Journal Article |
Author | Moritani, Norifumi H| Kubota, Satoshi| Sugahara, Toshio| Takigawa, Masaharu| |
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Published Date | 2005-04-15 |
Publication Title | Cell Communication and Signaling |
Volume | volume3 |
Issue | issue1 |
Content Type | Journal Article |
FullText URL | Fulltext.pdf fig.pdf table.pdf |
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Author | Matsumoto, Yohsuke| Motoki, Takahiro| Kubota, Satoshi| Takigawa, Masaharu| Tsubouchi, Hirohito| Gohda, Eiichi| |
Keywords | hepatocyte growth factor valproic acid histone deacetylase inhibitor butyric acid trichostatin A induction tumor invasion dermal fibroblast |
Note | Published with permission from the copyright holder. This is a author's copy,as published in Biochemical and Biophysical Research Communications, 2008 Vol.366 Issue.1 pp.110-116 | |
Published Date | 2008-02-01 |
Publication Title | Biochemical and Biophysical Research Communications |
Volume | volume366 |
Issue | issue1 |
Publisher | Academic Press |
Start Page | 110 |
End Page | 116 |
ISSN | 0006-291X |
NCID | AA00564395 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 18053801 |
DOI | 10.1016/j.bbrc.2007.11.089 |
Web of Science KeyUT | 000252392400018 |
Author | Miyake, Yoshiaki| Furumatsu, Takayuki| Kubota, Satoshi| Kawata, Kazumi| Ozaki, Toshifumi| Takigawa, Masaharu| |
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Published Date | 2011-06-03 |
Publication Title | Biochemical and Biophysical Research Communications |
Volume | volume409 |
Issue | issue2 |
Content Type | Journal Article |
Author | Kikuchi, Takeshi| Kubota, Satoshi| Asaumi, Koji| Kawaki, Harumi| Nishida, Takashi| Kawata, Kazumi| Mitani, Shigeru| Tabata, Yasuhiko| Ozaki, Toshifumi| Takigawa, Masaharu| |
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Published Date | 2008-06 |
Publication Title | Tissue Engineering Part A |
Volume | volume14 |
Issue | issue6 |
Content Type | Journal Article |
Author | Maeda-Uematsu, Aya| Kubota, Satoshi| Kawaki, Harumi| Kawata, Kazumi| Miyake, Yoshiaki| Hattori, Takako| Nishida, Takashi| Moritani, Norifumi| Lyons, Karen M.| Iida, Seiji| Takigawa, Masaharu| |
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Published Date | 2014-05 |
Publication Title | Journal of Cellular Biochemistry |
Volume | volume115 |
Issue | issue5 |
Content Type | Journal Article |
Author | Hara, Emilio Satoshi| Ono, Mitsuaki| Eguchi, Takanori| Kubota, Satoshi| Hai, Thanh Pham| Sonoyama, Wataru| Tajima, Shoji| Takigawa, Masaharu| Stuart K., Calderwood| Kuboki, Takuo| |
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Published Date | 2013-12-27 |
Publication Title | PLOS ONE |
Volume | volume8 |
Issue | issue12 |
Content Type | Journal Article |
FullText URL | Mod_Rheumatol_26_6_940.pdf fig.pdf tbl.jpg fig_all.zip |
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Author | Hara, Chikako| Kubota, Satoshi| Nishida, Takashi| Hiasa, Miki| Hattori, Takako| Aoyama, Eriko| Moriyama, Yoshinori| Kamioka, Hiroshi| Takigawa, Masaharu| |
Keywords | CCN family Cartilage Megakaryocyte Platelet Regeneration |
Note | This is an Accepted Manuscript of an article published by Taylor & Francis Group| This fulltext availavle in Nov 2017| |
Published Date | 2016-11 |
Publication Title | Modern Rheumatology |
Volume | volume26 |
Issue | issue6 |
Publisher | Taylor & Francis |
Start Page | 940 |
End Page | 949 |
ISSN | 1439-7595 |
NCID | AA1157187X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
File Version | author |
PubMed ID | 26915735 |
DOI | 10.3109/14397595.2016.1155255 |
Web of Science KeyUT | 000393121500022 |
Related Url | isVersionOf https://doi.org/10.3109/14397595.2016.1155255 |
FullText URL | JE_19_0022.pdf Fig.pdf |
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Author | Fu, Shanqi| Kuwahara, Miho| Uchida, Yoko| Kondo, Sei| Hayashi, Daichi| Shimomura, Yuji| Takagaki, Asami| Nishida, Takashi| Maruyama, Yusuke| Ikegame, Mika| Hattori, Atsuhiko| Kubota, Satoshi| Hattori, Takako| |
Published Date | 2019-03-01 |
Publication Title | Journal of Endocrinology |
Volume | volume241 |
Issue | issue2 |
Publisher | BIOSCIENTIFICA |
Start Page | 161 |
End Page | 173 |
ISSN | 0022-0795 |
NCID | AA00697140 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 30889551 |
DOI | 10.1530/JOE-19-0022 |
Web of Science KeyUT | 000468623300006 |
Related Url | isVersionOf https://doi.org/10.1530/JOE-19-0022 |
FullText URL | fulltext.pdf |
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Author | Kubota, Satoshi| Ishikawa, Takanori| Kawata, Kazumi| Hattori, Takako| Nishida, Takashi| |
Keywords | retrotransposon endogenous retrovirus chondrocyte cartilage skeletal development |
Published Date | 2020-02-25 |
Publication Title | International Journal of Molecular Sciences |
Volume | volume21 |
Issue | issue5 |
Publisher | MDPI |
Start Page | 1564 |
ISSN | 1422-0067 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by the authors. |
File Version | publisher |
PubMed ID | 32106563 |
DOI | 10.3390/ijms21051564 |
Web of Science KeyUT | 000524908500015 |
Related Url | isVersionOf https://doi.org/10.3390/ijms21051564 |
FullText URL | fulltext.pdf |
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Author | Hoshijima, Mitsuhiro| Hattori, Takako| Aoyama, Eriko| Nishida, Takashi| Kubota, Satoshi| Kamioka, Hiroshi| Takigawa, Masaharu| |
Keywords | cellular communication network factor 2 CCN2 CTGF Rab14 yeast two-hybrid chondrocyte ER stress aggrecan |
Published Date | 2020-04-16 |
Publication Title | International Journal of Molecular Sciences |
Volume | volume21 |
Issue | issue8 |
Publisher | MDPI |
ISSN | 1422-0067 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by the authors. |
File Version | publisher |
PubMed ID | 32316324 |
DOI | 10.3390/ijms21082769 |
Web of Science KeyUT | 000535565300111 |
Related Url | isVersionOf https://doi.org/10.3390/ijms21082769 |
FullText URL | fulltext.pdf |
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Author | Taha, Eman A.| Sogawa, Chiharu| Okusha, Yuka| Kawai, Hotaka| Oo, May Wathone| Elseoudi, Abdellatif| Lu, Yanyin| Nagatsuka, Hitoshi| Kubota, Satoshi| Satoh, Ayano| Okamoto, Kuniaki| Eguchi, Takanori| |
Keywords | matrix metalloproteinase 3 (MMP3) extracellular vesicles (EVs) tumoroid tumor organoid tumorigenesis three-dimensional (3D) culture system |
Published Date | 2020-05-16 |
Publication Title | Cancers |
Volume | volume12 |
Issue | issue5 |
Publisher | MDPI |
Start Page | 1260 |
ISSN | 2072-6694 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by the authors. |
File Version | publisher |
PubMed ID | 32429403 |
DOI | 10.3390/cancers12051260 |
Web of Science KeyUT | 000539246000201 |
Related Url | isVersionOf https://doi.org/10.3390/cancers12051260 |
FullText URL | fulltest20210407_04.pdf |
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Author | Akashi, Sho| Nishida, Takashi| Mizukawa, Tomomi| Kawata, Kazumi| Takigawa, Masaharu| Iida, Seiji| Kubota, Satoshi| |
Keywords | Bone metastasis Breast cancer CCN2 Glycolysis Warburg effect |
Note | This is an Accepted Manuscript of an article published by Elsevier| © 2020 Japanese Association for Oral Biology. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.job.2020.07.001] .| |
Published Date | 2020-08-11 |
Publication Title | Journal of Oral Biosciences |
Volume | volume62 |
Issue | issue3 |
Publisher | Elsevier |
Start Page | 280 |
End Page | 288 |
ISSN | 13490079 |
NCID | AA11896386 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 32791309 |
DOI | 10.1016/j.job.2020.07.001 |
Web of Science KeyUT | 000572657700009 |
Related Url | isVersionOf https://doi.org/10.1016/j.job.2020.07.001 |
FullText URL | fulltext.pdf |
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Author | Kuwahara, Miho| Kadoya, Koichi| Kondo, Sei| Fu, Shanqi| Miyake, Yoshiko| Ogo, Ayako| Ono, Mitsuaki| Furumatsu, Takayuki| Nakata, Eiji| Sasaki, Takako| Minagi, Shogo| Takigawa, Masaharu| Kubota, Satoshi| Hattori, Takako| |
Keywords | cellular communication network factor 3 CCN3 NOV primary chondrocytes aging oxidative stress senescence p21 p53 SASP |
Published Date | 2020-10-13 |
Publication Title | International Journal of Molecular Sciences |
Volume | volume21 |
Issue | issue20 |
Publisher | MDPI |
Start Page | 7556 |
ISSN | 1422-0067 |
NCID | AA12038549 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by the authors. |
File Version | publisher |
PubMed ID | 33066270 |
DOI | 10.3390/ijms21207556 |
Web of Science KeyUT | 000585557400001 |
Related Url | isVersionOf https://doi.org/10.3390/ijms21207556 |
FullText URL | fulltext.pdf |
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Author | Nishida, Takashi| Kubota, Satoshi| |
Keywords | Mechanoreceptors Cellular communication network factor 2 (CCN2) Mechanical stress Chondrocytes |
Published Date | 2020-11 |
Publication Title | Japanese Dental Science Review |
Volume | volume56 |
Issue | issue1 |
Publisher | Elsevier |
Start Page | 119 |
End Page | 126 |
ISSN | 1882-7616 |
NCID | AA12334461 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | publisher |
PubMed ID | 33088364 |
DOI | 10.1016/j.jdsr.2020.07.001 |
Web of Science KeyUT | 000598681800016 |
Related Url | isVersionOf https://doi.org/10.1016/j.jdsr.2020.07.001 |
FullText URL | fulltext.pdf |
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Author | Nishida, Takashi| Kubota, Satoshi| |
Keywords | Mechanoreceptors Cellular communication network factor 2 (CCN2) Mechanical stress Chondrocytes |
Published Date | 2020-10-09 |
Publication Title | Japanese Dental Science Review |
Volume | volume56 |
Issue | issue1 |
Publisher | Elsevier |
Start Page | 119 |
End Page | 126 |
ISSN | 1882-7616 |
NCID | AA12334461 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 The Authors. |
File Version | publisher |
PubMed ID | 33088364 |
DOI | 10.1016/j.jdsr.2020.07.001 |
Web of Science KeyUT | 000598681800016 |
Related Url | isVersionOf https://doi.org/10.1016/j.jdsr.2020.07.001 |
FullText URL | fulltext20210407_02.pdf |
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Author | Elseoudi, Abdellatif| Nishida, Takashi| Mizukawa, Tomomi| Hattori, Takako| Kawata, Kazumi| Taha, Eman A.| Takigawa, Masaharu| Kubota, Satoshi| |
Keywords | FGF-1 CCN2 Osteoarthritis Chondrocytes Cartilage |
Note | This is an Accepted Manuscript of an article published by Springer| This fulltext is available in Jan 2022| |
Published Date | 2021-1-4 |
Publication Title | Journal of Cell Communication and Signaling |
Volume | volume15 |
Issue | issue1 |
Publisher | Springer Science and Business Media LLC |
Start Page | 81 |
End Page | 91 |
ISSN | 1873-9601 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 33398720 |
DOI | 10.1007/s12079-020-00600-4 |
Web of Science KeyUT | 000604809900001 |
Related Url | isVersionOf https://doi.org/10.1007/s12079-020-00600-4 |
FullText URL | fulltext20210407_3.pdf |
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Author | Mizukawa, Tomomi| Nishida, Takashi| Akashi, Sho| Kawata, Kazumi| Kikuchi, Sumire| Kawaki, Harumi| Takigawa, Masaharu| Kamioka, Hiroshi| Kubota, Satoshi| |
Note | This is an Accepted Manuscript of an article published by Wiley| This fulltext is available in Mar 2022| |
Published Date | 2021-03-03 |
Publication Title | Journal of Cellular Physiology |
Publisher | Wiley |
ISSN | 0021-9541 |
NCID | AA00694856 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 33655492 |
DOI | 10.1002/jcp.30348 |
Web of Science KeyUT | 000624456400001 |
Related Url | isVersionOf https://doi.org/10.1002/jcp.30348 |
FullText URL | fulltext20210817-1.pdf |
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Author | Kawata, Kazumi| Narita, Keishi| Washio, Ayako| Kitamura, Chiaki| Nishihara, Tatsuji| Kubota, Satoshi| Takeda, Sen| |
Keywords | Primary cilia IFT88 Odontoblast Odontoblast differentiation Canonical Wnt/β-catenin signaling pathway |
Note | This is an Accepted Manuscript of an article published by Elsevier. © 2021 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.bone.2021.116001| |
Published Date | 2021-9 |
Publication Title | Bone |
Volume | volume150 |
Publisher | Elsevier BV |
Start Page | 116001 |
ISSN | 8756-3282 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 Elsevier Inc. All rights reserved. |
File Version | author |
PubMed ID | 33975031 |
DOI | 10.1016/j.bone.2021.116001 |
Web of Science KeyUT | 000670402300004 |
Related Url | isVersionOf https://doi.org/10.1016/j.bone.2021.116001 |