ID | 31331 |
JaLCDOI | |
FullText URL | |
Author |
Kawakami, Yasuhiro
Suemaru, Katsuya
Araki, Hiroaki
Gomita, Yutaka
Tanizaki, Yoshiro
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Abstract | The cross-sensitization to stereotyped behavior between mazindol (MZD) and methamphetamine (MAP) was investigated in rats. MZD (5 and 10 mg/kg/day, p.o.), MAP (5 and 10 mg/kg/day, p.o.) and saline (1 ml/kg, p.o.) were administered once daily for a week. Challenge with MZD (10 mg/kg, p.o.) on the 8th day caused markedly stereotyped behavior in MAP-pretreated group compared with the saline-pretreated control group. MAP (10 mg/kg, p.o.)-induced stereotyped behavior on the 8th day was also greater in MZD-pretreated group rather than the saline-pretreated control group. These results suggest that repeated MZD and MAP administration cross-sensitizes to their stereotype-producing effects. |
Keywords | mazindoi
methamphetamine
cross-sensitization
stereotyped behavior
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Amo Type | Article
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Publication Title |
Acta Medica Okayama
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Published Date | 1998-06
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Volume | volume52
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Issue | issue3
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Publisher | Okayama University Medical School
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Start Page | 169
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End Page | 171
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |