| JaLCDOI | 10.18926/AMO/66924 |
|---|---|
| FullText URL | 78_2_151.pdf |
| Author | Komatsubara, Tadashi| Tazawa, Hiroshi| Hasei, Joe| Omori, Toshinori| Sugiu, Kazuhisa| Mochizuki, Yusuke| Demiya, Koji| Yoshida, Aki| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| Abstract | Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors. |
| Keywords | soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 151 |
| End Page | 161 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/53556 |
|---|---|
| FullText URL | 69_4_205.pdf |
| Author | Okada, Yoshiki| Endo, Hirosuke| Mitani, Shigeru| Fujiwara, Kazuo| Tetsunaga, Tomonori| Kagawa, Yohei| Fujii, Yosuke| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| Abstract | Total hip arthroplasty (THA) is the most effective treatment for advanced or end-stage hip osteoarthritis. However, venous thromboembolism (VTE) remains one of its unresolved complications. We reviewed the records of 322 patients undergoing primary THA and investigated the efficacy of anticoagulant prophylaxis for VTE. Our study cohort consisted of 60 patients who received no anticoagulants, 100 patients who received a factor Xa inhibitor (fondaparinux), 100 patients who received low molecular weight heparin (enoxaparin), and 62 patients who selectively received no anticoagulant prophylaxis due to perioperative bleeding, weight, and/or hemoglobin concentration. Enhanced 64-slice multidetector row computed tomography was performed postoperatively for 7 days in all cases. The incidence of VTE in the four groups was 15ｵ, 9.0ｵ, 6.0ｵ, and 6.4ｵ, respectively. The incidence of VTE was significantly lower in the groups receiving anticoagulant prophylaxis and the group selectively receiving no anticoagulant prophylaxis than in the group receiving no anticoagulants. Complications of fondaparinux therapy included hepatic dysfunction in 4 cases (4.0ｵ), minor bleeding in 2 cases (2.0ｵ), persistent wound drainage in 3 cases (3.0ｵ), and eruption in 1 case (1.0ｵ). The complications of enoxaparin therapy were persistent wound drainage in 1 case (1.0ｵ) and progression of anemia in 1 case (1.0ｵ). The incidence of VTE was low in patients who selectively received no anticoagulant prophylaxis, so we conclude that anticoagulant prophylaxis should be used selectively in THA cases. |
| Keywords | total hip arthroplasty venous thromboembolism anticoagulant prophylaxis complications |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-08 |
| Volume | volume69 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 205 |
| End Page | 212 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26289911 |
| Web of Science KeyUT | 000365519100003 |
| Related Url | http://doi.org/10.18926/AMO/53680 |
| Author | Yoneda, Yasushi| Ito, Sachio| Kunisada, Toshiyuki| Morimoto, Yuki| Kanzaki, Hirotaka| Yoshida, Aki| Shimizu, Kenji| Ozaki, Toshifumi| Ouchida, Mamoru| |
|---|---|
| Published Date | 2013-10-09 |
| Publication Title | PLoS ONE |
| Volume | volume8 |
| Issue | issue10 |
| Content Type | Journal Article |
| FullText URL | fulltext.pdf Tables.pdf Fig1.tif Fig2.tif Supplementary Tables.pdf Supplementary Fig.pdf |
|---|---|
| Author | Yamamoto, Hiromasa| Namba, Kei| Yamamoto, Haruchika| Toji, Tomohiro| Soh, Junichi| Shien, Kazuhiko| Suzawa, Ken| Kurosaki, Takeshi| Otani, Shinji| Okazaki, Mikio| Sugimoto, Seiichiro| Yamane, Masaomi| Takahashi, Katsuhito| Kunisada, Toshiyuki| Oto, Takahiro| Toyooka, Shinichi| |
| Keywords | Metastatic lung tumor Sarcoma Metastasectomy Survival rate Neutrophil-to-lymphocyte ratio (NLR) |
| Note | This is a post-peer-review, pre-copyedit version of an article published in Surgery Today. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00595-020-02093-5. | |
| Published Date | 2020-08-03 |
| Publication Title | Surgery Today |
| Publisher | Springer |
| ISSN | 0941-1291 |
| NCID | AA10824685 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32747982 |
| DOI | 10.1007/s00595-020-02093-5 |
| Web of Science KeyUT | 000555382600001 |
| Related Url | isVersionOf https://doi.org/10.1007/s00595-020-02093-5 |
| FullText URL | CORR477_8_1892.pdf |
|---|---|
| Author | Kunisada, Toshiyuki| Fujiwara, Tomohiro| Hasei, Joe| Nakata, Eiji| Senda, Masuo| Ozaki, Toshifumi| |
| Published Date | 2019-08 |
| Publication Title | Clinical Orthopaedics and Related Research |
| Volume | volume477 |
| Issue | issue8 |
| Publisher | Lippincott, Williams & Wilkins |
| Start Page | 1892 |
| End Page | 1901 |
| ISSN | 0009-921X |
| NCID | AA00607942 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 30985613 |
| DOI | 10.1097/CORR.0000000000000764 |
| Web of Science KeyUT | 000509664400024 |
| Related Url | isVersionOf https://doi.org/10.1097/CORR.0000000000000764 |
| FullText URL | fulltext.pdf figures.pdf SuppleFigures.pdf |
|---|---|
| Author | Mochizuki, Yusuke| Tazawa, Hiroshi| Demiya, Koji| Kure, Miho| Kondo, Hiroya| Komatsubara, Tadashi| Sugiu, Kazuhisa| Hasei, Joe| Yoshida, Aki| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| Keywords | Oncolytic adenovirus hTERT Immunogenic cell death ATP CD8 |
| Note | This is a post-peer-review, pre-copyedit version of an article published in Cancer Immunology, Immunotherapy. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00262-020-02774-7.| |
| Published Date | 2020-11-05 |
| Publication Title | Cancer Immunology, Immunotherapy |
| Volume | volume70 |
| Publisher | Springer |
| Start Page | 1405 |
| End Page | 1417 |
| ISSN | 0340-7004 |
| NCID | AA00598499 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 33151368 |
| DOI | 10.1007/s00262-020-02774-7 |
| Web of Science KeyUT | 000586350500002 |
| Related Url | isVersionOf https://doi.org/10.1007/s00262-020-02774-7 |
| JaLCDOI | 10.18926/AMO/49047 |
|---|---|
| FullText URL | 66_6_499.pdf |
| Author | Sugimoto, Yoshihisa| Tanaka, Masato| Nakahara, Ryuichi| Misawa, Haruo| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| Abstract | An 11 year-old girl had 66 degrees of kyphosis in the thoracolumbar junction. For the purpose of planning for kyphosis correction, we created a 3-D, full-scale model of the spine and consulted spinal navigation. Three-dimensional models are generally used as tactile guides to verify the surgical approach and portray the anatomic relations specific to a given patient. We performed posterior fusion from Th10 to L3, and vertebral column resection of Th12 and L1. Screw entry points, directions, lengths and diameters were determined by reference to navigation. Both tools were useful in the bone resection. We could easily detect the posterior element to be resected using the 3D model. During the anterior bony resection, navigation helped us to check the disc level and anterior wall of the vertebrae, which were otherwise difficult to detect due to their depth in the surgical field. Thus, the combination of navigation and 3D models helped us to safely perform surgery for a patient with complex spinal deformity. |
| Keywords | congenital scoliosis kyphosis navigation 3-dimensional models |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-12 |
| Volume | volume66 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 499 |
| End Page | 502 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23254585 |
| Web of Science KeyUT | 000312966100010 |
| JaLCDOI | 10.18926/AMO/48560 |
|---|---|
| FullText URL | 66_3_213.pdf |
| Author | Kataoka, Masaki| Kunisada, Toshiyuki| Tanaka, Masato| Takeda, Ken| Itani, Satoru| Sugimoto, Yoshihisa| Misawa, Haruo| Senda, Masuo| Nakahara, Shinnosuke| Ozaki, Toshifumi| |
| Abstract | There are a variety of treatment options for patients with spinal metastasis, and predicting prognosis is essential for selecting the proper treatment. The purpose of the present study was to identify the significant prognostic factors for the survival of patients with spinal metastasis. We retrospectively reviewed 143 patients with spinal metastasis. The median age was 61 years. Eleven factors reported previously were analyzed using the Cox proportional hazards model:gender, age, performance status, neurological deficits, pain, type of primary tumor, metastasis to major organs, previous chemotherapy, disease-free interval before spinal metastasis, multiple spinal metastases, and extra-spinal bone metastasis. The average survival of study patients after the first visit to our clinic was 22 months. Multivariate survival analysis demonstrated that type of primary tumor (hazard ratio [HR]＝6.80, p＜0.001), metastasis to major organs (HR＝2.01, p＝0.005), disease-free interval before spinal metastasis (HR＝1.77, p＝0.028), and extra-spinal bone metastasis (HR＝1.75, p＝0.017) were significant prognostic factors. Type of primary tumor was the most powerful prognostic factor. Other prognostic factors may differ among the types of primary tumor and may also be closely associated with primary disease activity. Further analysis of factors predicting prognosis should be conducted with respect to each type of primary tumor to help accurately predict prognosis. |
| Keywords | spine metastasis survival prognostic factor cancer |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-06 |
| Volume | volume66 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 213 |
| End Page | 219 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22729101 |
| Web of Science KeyUT | 000305669700004 |
| JaLCDOI | 10.18926/AMO/48692 |
|---|---|
| FullText URL | 66_4_363.pdf |
| Author | Tanaka, Masato| Sugimoto, Yoshihiro| Misawa, Haruo| Takigawa, Tomoyuki| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| Abstract | Spinal deformity is an important clinical manifestation after surgery for spinal cord tumors. One-third of patients who receive laminectomies and irradiation of the spinal column develop scoliosis, kyphosis, or kyphoscoliosis. Recent reports indicate good results after scoliosis surgery using segmental pedicle screws and a navigation system, but these reported studies have not included surgery for post-laminectomy kyphosis. Hooks and wires are ineffective in such patients who undergo laminectomy, and there are also high perioperative risks with insertion of pedicle screws because landmarks have been lost. Here, we report on the 5-year follow-up of a 13-year-old male patient with post-laminectomy and post-irradiation thoracic kyphoscoliosis after surgical treatment of spinal astrocytoma. Posterior segmental pedicle screw fixation was performed safely using a computer-assisted technique. The authors present the first case report for treatment of this condition using a navigation system. |
| Keywords | astrocytoma scoliosis kyphoscoliosis navigation segmental pedicle screw fixation |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-08 |
| Volume | volume66 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 363 |
| End Page | 368 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22918210 |
| Web of Science KeyUT | 000307918900010 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Katayama, Haruyoshi| Fujimura, Atsushi| Huang, Rongsheng| Otani, Yusuke| Itano, Takuto| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Nakata, Eiji| Ozaki, Toshifumi| |
| Keywords | benserazide cancer stem cell catecholamine synthase malignant peripheral nerve sheath tumor Schwann cell vesicular monoamine transporter |
| Published Date | 2024-01-26 |
| Publication Title | Cancer Science |
| Volume | volume115 |
| Issue | issue3 |
| Publisher | Wiley |
| Start Page | 871 |
| End Page | 882 |
| ISSN | 1347-9032 |
| NCID | AA11808050 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Authors. |
| File Version | publisher |
| PubMed ID | 38279513 |
| DOI | 10.1111/cas.16077 |
| Web of Science KeyUT | 001149722500001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.16077 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fujiwara, Tomohiro| Healey, John| Ogura, Koichi| Yoshida, Aki| Kondo, Hiroya| Hata, Toshiaki| Kure, Miho| Tazawa, Hiroshi| Nakata, Eiji| Kunisada, Toshiyuki| Fujiwara, Toshiyoshi| Ozaki, Toshifumi| |
| Keywords | sarcoma tumor-associated macrophage prognosis clinical trial immunotherapy |
| Published Date | 2021-03-03 |
| Publication Title | Cancers |
| Volume | volume13 |
| Issue | issue5 |
| Publisher | MDPI |
| Start Page | 1086 |
| ISSN | 2072-6694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| PubMed ID | 33802565 |
| NAID | 120007008531 |
| DOI | 10.3390/cancers13051086 |
| Web of Science KeyUT | 000627955600001 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers13051086 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakata, Eiji| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Nakahara, Ryuichi| Katayama, Haruyoshi| Itano, Takuto| Ozaki, Toshifumi| |
| Keywords | Soft tissue sarcomas Forearm Function Prognosis |
| Note | The version of record of this article, first published in Journal of Orthopaedic Surgery and Research, is available online at Publisher’s website: http://dx.doi.org/10.1186/s13018-023-04088-7| |
| Published Date | 2023-08-14 |
| Publication Title | Journal of Orthopaedic Surgery and Research |
| Volume | volume18 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 599 |
| ISSN | 1749-799X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37580775 |
| DOI | 10.1186/s13018-023-04088-7 |
| Web of Science KeyUT | 001049196400001 |
| Related Url | isVersionOf https://doi.org/10.1186/s13018-023-04088-7 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kunisada, Toshiyuki| Hasei, Joe| Fujiwara, Tomohiro| Nakata, Eiji| Yokoo, Suguru| Demiya, Koji| Ozaki, Toshifumi| |
| Published Date | 2020-12-09 |
| Publication Title | Scientific Reports |
| Volume | volume10 |
| Issue | issue1 |
| Publisher | Nature Research |
| Start Page | 21578 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2020 |
| File Version | publisher |
| PubMed ID | 33299043 |
| DOI | 10.1038/s41598-020-78409-9 |
| Web of Science KeyUT | 000608956800002 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-020-78409-9 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ise, Masato| Nakata, Eiji| Katayama, Yoshimi| Hamada, Masanori| Kunisada, Toshiyuki| Fujiwara, Tomohiro| Nakahara, Ryuichi| Takihira, Shouta| Sato, Kohei| Akezaki, Yoshiteru| Senda, Masuo| Ozaki, Toshifumi| |
| Keywords | psychological distress distress and impact thermometer bone and soft tissue tumor surgery |
| Published Date | 2021-05-01 |
| Publication Title | Healthcare |
| Volume | volume9 |
| Issue | issue5 |
| Publisher | MDPI |
| Start Page | 566 |
| ISSN | 2227-9032 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| NAID | 120007042388 |
| DOI | 10.3390/healthcare9050566 |
| Web of Science KeyUT | 000654015500001 |
| Related Url | isVersionOf https://doi.org/10.3390/healthcare9050566 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takihira, Shota| Yamada, Daisuke| Osone, Tatsunori| Takao, Tomoka| Sakaguchi, Masakiyo| Hakozaki, Michiyuki| Itano, Takuto| Nakata, Eiji| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Ozaki, Toshifumi| Takarada, Takeshi| |
| Note | The version of record of this article, first published in British Journal of Cancer, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41416-024-02632-8| |
| Published Date | 2024-03-06 |
| Publication Title | British Journal of Cancer |
| Publisher | Springer Science and Business Media LLC |
| ISSN | 0007-0920 |
| NCID | AA00574355 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 38448751 |
| DOI | 10.1038/s41416-024-02632-8 |
| Web of Science KeyUT | 001180796100003 |
| Related Url | isVersionOf https://doi.org/10.1038/s41416-024-02632-8 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Joko, Ryoji| Yamada, Daisuke| Nakamura, Masahiro| Yoshida, Aki| Takihira, Shota| Takao, Tomoka| Lu, Ming| Sato, Kohei| Ito, Tatsuo| Kunisada, Toshiyuki| Nakata, Eiji| Ozaki, Toshifumi| Takarada, Takeshi| |
| Keywords | PRRX1 Osteosarcoma Tumor malignancy Invasion Drug resistance Connectivity map analysis |
| Published Date | 2021-01 |
| Publication Title | Translational Oncology |
| Volume | volume14 |
| Issue | issue1 |
| Publisher | Elsevier |
| Start Page | 100960 |
| ISSN | 1936-5233 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors. |
| File Version | publisher |
| PubMed ID | 33395745 |
| DOI | 10.1016/j.tranon.2020.100960 |
| Web of Science KeyUT | 000604582300006 |
| Related Url | isVersionOf https://doi.org/10.1016/j.tranon.2020.100960 |
| FullText URL | fulltext20210628-1.pdf Figure_20210628-1.pdf Supple_Figure_20210628-1.pdf Supple_Table_20210628-1.pdf |
|---|---|
| Author | Sugiu, Kazuhisa| Tazawa, Hiroshi| Hasei, Joe| Yamakawa, Yasuaki| Omori, Toshinori| Komatsubara, Tadashi| Mochizuki, Yusuke| Kondo, Hiroya| Osaki, Shuhei| Fujiwara, Tomohiro| Yoshida, Aki| Kunisada, Toshiyuki| Ueda, Koji| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| Keywords | Osteosarcoma Chemoresistance MDR1 Oncolytic adenovirus p53 |
| Note | This is a post-peer-review, pre-copyedit version of an article published in Cancer Chemotherapy and Pharmacology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00280-021-04310-5| |
| Published Date | 2021-6-10 |
| Publication Title | Cancer Chemotherapy and Pharmacology |
| Volume | volume88 |
| Issue | issue3 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 513 |
| End Page | 524 |
| ISSN | 0344-5704 |
| NCID | AA00598397 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 34114067 |
| DOI | 10.1007/s00280-021-04310-5 |
| Web of Science KeyUT | 000659839700002 |
| Related Url | isVersionOf https://doi.org/10.1007/s00280-021-04310-5 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Omori, Toshinori| Tazawa, Hiroshi| Yamakawa, Yasuaki| Osaki, Shuhei| Hasei, Joe| Sugiu, Kazuhisa| Komatsubara, Tadashi| Fujiwara, Tomohiro| Yoshida, Aki| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| Keywords | Gastric yolk sac Tumor-like carcinoma Adenocarcinoma; Alpha-fetoprotein |
| Published Date | 2021-04-22 |
| Publication Title | PLoS ONE |
| Volume | volume16 |
| Issue | issue4 |
| Publisher | Public Library Science |
| Start Page | e0250643 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 Omori et al. |
| File Version | publisher |
| PubMed ID | 33886686 |
| NAID | 120007045007 |
| DOI | 10.1371/journal.pone.0250643 |
| Web of Science KeyUT | 000644138300019 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0250643 |
| JaLCDOI | 10.18926/AMO/54807 |
|---|---|
| FullText URL | 70_6_449.pdf |
| Author | Watanabe, Noriyuki| Sugimoto, Yoshihisa| Tanaka, Masato| Mazaki, Tetsuro| Arataki, Shinya| Takigawa, Tomoyuki| Kataoka, Masaki| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| Abstract | Metastatic epidural spinal cord compression (MESCC) is a common complication in patients with a malignant tumor, but it is difficult to decide the proper time to perform the necessary surgery. Here we analyzed the prognostic factors for postoperative walking ability. We retrospectively reviewed the cases of 112 MESCC patients treated surgically at our institute and divided them into ambulatory (n＝ 88) and non-ambulatory (n＝24) groups based on their American Spinal Injury Association (ASIA) Impairment Scale grades at the final follow-up. We also classified the patients preoperatively using the revised Tokuhashi score. We assessed the correlation between preoperative or intraoperative factors and postoperative walking ability in both groups. Of the 10 patients classified preoperatively as grade A or B, 2 (20 ) were ambulatory at the final follow-up. Of the 102 patients classified preoperatively as grade C, D or E, 86 (84 ) were ambulatory at the final follow-up (p＜0.001). There were no significant differences between the groups in the average total Tokuhashi score. Our analysis revealed that the severity of paralysis significantly affects neurological recovery in patients with MESCC. Patients with MESCC should receive surgery before the preoperative ASIA Impairment Scale grade falls below grade C. |
| Keywords | metastatic epidural spinal cord compression American Spinal Injury Association Impairment Scale Tokuhashi score walking ability prognostic factor |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-12 |
| Volume | volume70 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 449 |
| End Page | 453 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28003669 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakata, Eiji| Sugihara, Shinsuke| Sugawara, Yoshifumi| Nakahara, Ryuichi| Furumatsu, Takayuki| Tetsunaga, Tomonori| Kunisada, Toshiyuki| Nakanishi, Kazuo| Ozaki, Toshifumi| |
| Keywords | bone metastasis multidisciplinary treatment skeletal-related event malignant spinal cord compression neurological deficit |
| Published Date | 2020-02-20 |
| Publication Title | Oncology Letters |
| Volume | volume19 |
| Issue | issue4 |
| Publisher | Spandidos Publications |
| Start Page | 3137 |
| End Page | 3144 |
| ISSN | 1792-1074 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Nakata et al. |
| File Version | publisher |
| PubMed ID | 32218864 |
| DOI | 10.3892/ol.2020.11415 |
| Web of Science KeyUT | 000523763900064 |
| Related Url | isVersionOf https://doi.org/10.3892/ol.2020.11415 |
