ID | 32825 |
JaLCDOI | |
FullText URL | |
Author |
Nakajima, Hirofumi
Shimomura, Hiroyuki
Ikeda, Fusao
Umeoka, Fumi
Chengyu, Piao
Taniguchi, Hideaki
Ohnishi, Yasuhiro
Takagi, Shin-jiro
Fujioka, Shin-ichi
Shiratori, Yasushi
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Abstract | To improve the efficacy of interferon (IFN) treatment for chronic hepatitis C, we have proposed the twice-daily administration of IFN-beta as a promising induction therapy. In this study, we demonstrated differences between the clearance of circulating HCV-RNA and the induction of anti-viral actions during the first 2 weeks of treatment. Nine patients with a high viral load and genotype 1b were randomly assigned to 3 groups: group A received 3MU of IFN-beta twice a day at intervals of 5 and 19 h; group B received 3MU of IFN-beta twice a day at intervals of 10 and 14 h; group C received 6MU of IFN-alpha once a day with ribavirin. The expression of OAS2, PKR, and MxA in peripheral blood mononuclear cells (PBMCs) were quantified by real-time polymerase chain reaction method. The viral clearance showed a bi-phasic pattern, and those in the second phase of groups A and B were significantly steeper than that of group C. The peak level of OAS2 during the first phase was correlated with the first phase decay. The MxA expression tended to be higher in group A and B than in group C. The expression of these 3 proteins tended to decrease at day 6 in group C, but increase in groups A and B. These might make differences in the viral decay during the second phase |
Keywords | chronic hepatitis C(CHC)
interferon(IFN)beta
hepatitis C virus(HCV)dynamics
antiviral actions
real time PCR
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Amo Type | Article
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Publication Title |
Acta Medica Okayama
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Published Date | 2003-10
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Volume | volume57
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Issue | issue5
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Publisher | Okayama University Medical School
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Start Page | 217
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End Page | 225
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |