FullText URL fulltext.pdf
Author Nakahara, Momoko| Ekuni, Daisuke| Kataoka, Kota| Yokoi, Aya| Uchida-Fukuhara, Yoko| Fukuhara, Daiki| Kobayashi, Terumasa| Toyama, Naoki | Saho, Hikari| Islam, Md Monirul| Iwasaki, Yoshiaki| Morita, Manabu|
Keywords lifestyle dental health behavior oral health oral hygiene gingivitis behavioral sciences
Published Date 2021-01-05
Publication Title International Journal of Environmental Research and Public Health
Volume volume18
Issue issue1
Publisher MDPI
Start Page 324
ISSN 1660-4601
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
PubMed ID 33466244
DOI 10.3390/ijerph18010324
Web of Science KeyUT 000606664400001
Related Url isVersionOf https://doi.org/10.3390/ijerph18010324
FullText URL fulltext.pdf
Author Afify, Said M.| Calle, Anna Sanchez| Hassan, Ghmkin| Kumon, Kazuki| Nawara, Hend M.| Zahra, Maram H.| Mansour, Hager M.| Khayrani, Apriliana Cahya| Alam, Md Jahangir| Du, Juan| Seno, Akimasa| Iwasaki, Yoshiaki| Seno, Masaharu|
Keywords Cancer models Cancer stem cells
Published Date 2020-03-17
Publication Title British Journal of Cancer
Volume volume122
Issue issue9
Publisher Springer Nature
Start Page 1378
End Page 1390
ISSN 0007-0920
NCID AA00574355
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © Authors
File Version publisher
PubMed ID 32203212
DOI 10.1038/s41416-020-0792-z
Web of Science KeyUT 000519841900001
Related Url isVersionOf https://doi.org/10.1038/s41416-020-0792-z
FullText URL fulltext.pdf
Author Saho, Hikari| Taniguchi-Tabata, Ayano| Ekuni, Daisuke| Yokoi, Aya| Kataoka, Kouta| Fukuhara, Daiki| Toyama, Naoki | Islam, Md Monirul| Sawada, Nanami| Nakashima, Yukiho| Nakahara, Momoko| Deguchi, Junya| Uchida-Fukuhara, Yoko| Yoneda, Toshiki| Iwasaki, Yoshiaki| Morita, Manabu|
Keywords secondhand smoke dental caries permanent dentition young adult
Published Date 2020-11-20
Publication Title International Journal of Environmental Research and Public Health
Volume volume17
Issue issue22
Publisher MDPI
Start Page 8623
ISSN 1660-4601
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 33233610
DOI 10.3390/ijerph17228623
Web of Science KeyUT 000594343500001
Related Url isVersionOf https://doi.org/10.3390/ijerph17228623
FullText URL fulltext.pdf
Author Fukuhara, Daiki| Ekuni, Daisuke| Kataoka, Kota| Taniguchi-Tabata, Ayano| Uchida-Fukuhara, Yoko| Toyama, Naoki | Yoneda, Toshiki| Sugiura, Yoshio| Islam, Monirul| Saho, Hikari| Iwasaki, Yoshiaki| Morita, Manabu|
Published Date 2020-07-23
Publication Title PLoS ONE
Volume volume15
Issue issue7
Publisher Public Library of Science
Start Page e0236259
ISSN 1932-6203
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Fukuhara et al.
File Version publisher
PubMed ID 32702010
DOI 10.1371/journal.pone.0236259
Web of Science KeyUT 000575913700064
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0236259
FullText URL fulltext.pdf
Author Uchida-Fukuhara, Yoko| Ekuni, Daisuke| Islam, Md Monirul| Kataoka, Kota| Taniguchi-Tabata, Ayano| Fukuhara, Daiki| Toyama, Naoki | Kobayashi, Terumasa| Fujimori, Kohei| Sawada, Nanami| Iwasaki, Yoshiaki| Morita, Manabu|
Keywords salivary microbiome sequence analysis young adult dental caries saliva oral health
Published Date 2020-05-25
Publication Title International Journal of Environmental Research and Public Health
Volume volume17
Issue issue10
Publisher MDPI
Start Page 3713
ISSN 1660-4601
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32466124
DOI 10.3390/ijerph17103713
Web of Science KeyUT 000539300900370
Related Url isVersionOf https://doi.org/10.3390/ijerph17103713
FullText URL fulltext.pdf
Author Islam, Md Monirul| Ekuni, Daisuke| Toyama, Naoki | Taniguchi-Tabata, Ayano| Kataoka, Kota| Uchida-Fukuhara, Yoko| Fukuhara, Daiki| Saho, Hikari| Sawada, Nanami| Nakashima, Yukiho| Iwasaki, Yoshiaki| Morita, Manabu|
Keywords sleep quality sleep duration periodontal disease university students
Published Date 2020-04-27
Publication Title International Journal of Environmental Research and Public Health
Volume volume17
Issue issue9
Publisher MDPI
ISSN 1660-4601
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32349308
DOI 10.3390/ijerph17093034
Web of Science KeyUT 000535745400058
Related Url isVersionOf https://doi.org/10.3390/ijerph17093034
FullText URL fulltext.pdf
Author Islam, Md Monirul| Ekuni, Daisuke| Toyama, Naoki | Kobayashi, Terumasa| Fujimori, Kohei| Uchida, Yoko| Fukuhara, Daiki| Taniguchi-Tabata, Ayano| Kataoka, Kota| Iwasaki, Yoshiaki| Morita, Manabu|
Keywords salivary microbiome periodontal health status oral hygiene cohort study young adults
Published Date 2020-03-09
Publication Title International Journal of Environmental Research and Public Health
Volume volume17
Issue issue5
Publisher MDPI
Start Page 1764
ISSN 1660-4601
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32182740
DOI 10.3390/ijerph17051764
Web of Science KeyUT 000522389200304
Related Url isVersionOf https://doi.org/10.3390/ijerph17051764
FullText URL OL18_3_2756.pdf
Author Seno, Akimasa| Murakami, Chikae| El‑Aarag, Bishoy| Iwasaki, Yoshiaki| Ohara, Toshiaki| Seno, Masaharu|
Keywords cancer stem cell conditioned medium mouse embryonic stem cells
Published Date 2019-09
Publication Title Oncology Letters
Volume volume18
Issue issue3
Publisher Spandidos Publications
Start Page 2756
End Page 2762
ISSN 1792-1074
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © Seno et al.
File Version publisher
PubMed ID 31452753
DOI 10.3892/ol.2019.10614
Web of Science KeyUT 000487675500075
Related Url isVersionOf https://doi.org/10.3892/ol.2019.10614
FullText URL JOC61_1_133.pdf
Author Taniguchi-Tabata, Ayano| Ekuni, Daisuke| Azuma, Tetsuji| Yoneda, Toshiki| Yamane-Takeuchi, Mayu| Kataoka, Kota| Mizuno, Hirofumi| Miyai, Hisataka| Iwasaki, Yoshiaki| Morita, Manabu|
Keywords lactate dehydrogenase gingivitis; screening young adults cross-sectional study
Published Date 2019-03-28
Publication Title Journal of Oral Science
Volume volume61
Issue issue1
Publisher Nihon University School of Dentistry
Start Page 133
End Page 139
ISSN 1343-4934
NCID AA11208439
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 30814390
DOI 10.2334/josnusd.18-0038
Web of Science KeyUT 000462712900019
Related Url isVersionOf https://doi.org/10.2334/josnusd.18-0038
FullText URL ijerph16_5_00690.pdf
Author Toyama, Naoki| Ekuni, Daisuke| Taniguchi-Tabata, Ayano| Kataoka, Kota| Yamane-Takeuchi, Mayu| Fujimori, Kohei| Kobayashi, Terumasa| Fukuhara, Daiki| Irie, Koichiro| Azuma, Tetsuji| Iwasaki, Yoshiaki| Morita, Manabu|
Keywords bruxism cohort study malocclusion underweight young adults
Published Date 2019-02-26
Publication Title International Journal of Environmental Research and Public Health
Volume volume16
Issue issue5
Publisher MDPI
Start Page 690
ISSN 1660-4601
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 by the authors
File Version publisher
PubMed ID 30813621
DOI 10.3390/ijerph16050690
Web of Science KeyUT 000462664200015
Related Url isVersionOf https://doi.org/10.3390/ijerph16050690
JaLCDOI 10.18926/AMO/53560
FullText URL 69_4_237.pdf
Author Nanba, Shintarou| Ikeda, Fusao| Fujioka, Shin-ichi| Araki, Yasuyuki| Takaguchi, Kouichi| Hashimoto, Noriaki| Seki, Hiroyuki| Takaki, Akinobu| Iwasaki, Yoshiaki| Yamamoto, Kazuhide|
Abstract The effectiveness of extending treatment duration as response guided therapy was previously reported for chronic hepatitis C (CHC) genotype 1, but is still controversial for genotype 2. The present study is a retrospective cohort study to investigate the effectiveness of extending treatment duration in therapy with pegylated interferon and ribavirin for patients with CHC genotype 2 by focusing on the timing at which patients obtained undetectable HCV RNA. A total of 306 patients who obtained undetectable HCV RNA by week 24 of treatment and completed 24 weeks of treatment were enrolled. Rapid virological response (RVR) to standard therapy was achieved by 122 patients (51オ), and 89オ of them obtained sustained virological response (SVR), while 69オ of non-RVR patients achieved SVR. Non-RVR patients with undetectable HCV RNA at week 8, and insufficient adherence<80オ pegylated interferon and ribavirin during the first 24 weeks, significantly improved their SVR rate by extended therapy. Among patients receiving extended therapy, drug adherences did not differ between SVR and non-SVR patients, indicating that extending treatment duration might compensate for insufficient antiviral effects due to insufficient drug adherences. This finding might be useful in creating a guideline for extending treatment duration for patients with CHC genotype 2.
Keywords hepatitis C virus interferon genotype 2 response-guided therapy
Amo Type Original Article
Published Date 2015-08
Publication Title Acta Medica Okayama
Volume volume69
Issue issue4
Publisher Okayama University Medical School
Start Page 237
End Page 244
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26289915
Web of Science KeyUT 000365519100007
JaLCDOI 10.18926/AMO/53520
FullText URL 69_3_137.pdf
Author Seki, Hiroyuki| Ikeda, Fusao| Nanba, Shintaro| Moritou, Yuki| Takeuchi, Yasuto| Yasunaka, Tetsuya| Onishi, Hideki| Miyake, Yasuhiro| Takaki, Akinobu| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Nakamura, Minoru| Yamamoto, Kazuhide|
Abstract A predictive marker of the rapid progression to hepatic failure is desired for patients with asymptomatic primary biliary cirrhosis (aPBC). We performed a systematic cohort analysis of 101 patients diagnosed as having aPBC and the rapid progression to liver failure in some, by focusing on cholestasis. Cholestasis was assessed by aberrant keratin7 (K-7) expressions in the patientsʼ hepatocytes. Intralobular expressions of K-7 were found in 9 of the 101 patients. The grades of K-7 expression were significantly associated with the levels of alanine aminotransferase, alkaline phosphatase, and total bilirubin at the time of diagnosis, but not with bile duct loss or cholestasis. Stepwise logistic regression analysis revealed that high grades of K-7 expression correlated positively with high levels of total bilirubin. During the follow-up period, 8 patients developed jaundice, and the mean period until the development of jaundice was 5.2 years. The proportional hazards models for the risk of developing jaundice identified a high grade of aberrant K-7 expression in hepatocytes as the only significant risk factor. Aberrant K-7 expression in hepatocytes can be used as an additional marker to predict rapid progression to liver failure in patients with aPBC at the time of diagnosis.
Keywords primary biliary cirrhosis keratin 7 hepatic failure
Amo Type Original Article
Published Date 2015-06
Publication Title Acta Medica Okayama
Volume volume69
Issue issue3
Publisher Okayama University Medical School
Start Page 137
End Page 144
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26101189
Web of Science KeyUT 000356903000002
Author Shoji, Bon| Ikeda, Fusao| Fujioka, Shin-ichi| Kobashi, Haruhiko| Yasunaka, Tetsuya| Miyake, Yasuhiro| Shiraha, Hidenori| Takaki, Akinobu| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Yamamoto, Kazuhide|
Published Date 2010-11
Publication Title Journal of Gastroenterology
Volume volume45
Issue issue11
Content Type Journal Article
Author Takeuchi, Yasuto| Ikeda, Fusao| Moritou, Yuki| Hagihara, Hiroaki| Yasunaka, Tetsuya| Kuwaki, Kenji| Miyake, Yasuhiro| Ohnishi, Hideki| Nakamura, Shinichiro| Shiraha, Hidenori| Takaki, Akinobu| Iwasaki, Yoshiaki| Nouso, Kazuhiro| Yamamoto, Kazuhide|
Published Date 2013-03
Publication Title Journal of Gastroenterology
Volume volume48
Issue issue3
Content Type Journal Article
Author Moritou, Yuki| Ikeda, Fusao| Takeuchi, Yasuto| Seki, Hiroyuki| Nanba, Shintaro| Iwasaki, Yoshiaki| Yamamoto, Kazuhide|
Published Date 2014-02
Publication Title Journal of Clinical Microbiology
Volume volume52
Issue issue2
Content Type Journal Article
JaLCDOI 10.18926/AMO/52898
FullText URL 68_5_291.pdf
Author Tsuzaki, Ryuichiro| Takaki, Akinobu| Yagi, Takahito| Ikeda, Fusao| Koike, Kazuko| Iwasaki, Yoshiaki| Shiraha, Hidenori| Miyake, Yasuhiro| Sadamori, Hiroshi| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Nobuoka, Daisuke| Utsumi, Masashi| Nakayama, Eiichi| Fujiwara, Toshiyoshi| Yamamoto, Kazuhide|
Abstract It is not known how the immune system targets hepatitis C virus (HCV)-infected HLA-mismatched hepatocytes under immune-suppressed conditions after orthotopic liver transplantation (OLT). In addition, the relationship between the HCV-specific immune response and IL28B variants as predictors of HCV clearance has not been well-characterized. We determined the IL28B polymorphisms for 57 post-OLT HCV carriers, and we assessed the HCV-specific immune responses by measuring the peripheral blood mononuclear cell-derived HCV-specific interferon-gamma (IFN-γ) response using an enzyme-linked immunospot assay. At 1-3 years after OLT, patients with no active hepatitis showed higher total spots on the immunospot assay. At>3 years after OLT, patients with resolved HCV showed higher levels of core, NS3, NS5A, and total spots compared to the chronic hepatitis patients. The IL28B major genotype in the donors correlated with higher spot counts for NS5A and NS5B proteins at 1-3 years after OLT. In the post-OLT setting, the HCV-specific immune response could be strongly induced in patients with no active hepatitis with an IL28B major donor or sustained virological response. Strong immune responses in the patients with no active hepatitis could only be maintained for 3 years and diminished later. It may be beneficial to administer IFN treatment starting 3 years after OLT, to induce the maximum immunological effect.
Keywords interferon gamma ELISPOT assay single nucleotide polymorphisms dendritic cell CD4 T cell
Amo Type Original Article
Published Date 2014-10
Publication Title Acta Medica Okayama
Volume volume68
Issue issue5
Publisher Okayama University Medical School
Start Page 291
End Page 302
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25338486
Web of Science KeyUT 000343269300006
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/53129
JaLCDOI 10.18926/AMO/52894
FullText URL 68_5_263.pdf
Author Namba, Shihoko| Miyake, Kayoko| Ikeda, Fusao| Hazama, Tomoko| Hitobe, Yu| Yamasaki, Noriko| Shiraha, Hidenori| Takaki, Akinobu| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Yamamoto, Kazuhide|
Abstract Nursing support might help patients with chronic hepatitis C (CHC) remain in good mental and physical condition during interferon (IFN) therapy. However, the effects of nursing support have not been studied adequately in this context. This case-control study evaluated the effects of nursing support during IFN therapy. Twenty-four CHC patients who received pegylated IFN and ribavirin were enrolled. Nurses advised patients on the maintenance of their mental and physical condition at weekly visits, based on the results of written questionnaires. An additional 24 patients who received IFN therapy without nursing support and who were matched for age, sex, platelet count, viral serogroup and IFN regimen were selected with propensity score matching as controls. The patients with nursing support during IFN therapy achieved higher sustained virological responses (79%) than those without nursing support (58%). Adherence to the IFN and ribavirin regimens at 24 weeks of therapy were slightly higher in the patients with nursing support than those without it, but these differences were not statistically significant. Adherence to ribavirin after 24 weeks of therapy was significantly higher in those with nursing support than those without it (93% and 66%, p=0.045). These results suggested that nursing support services could contribute to the virological responses of CHC patients by promoting drug-regimen adherence.
Keywords chronic hepatitis C nursing support interferon therapy
Amo Type Original Article
Published Date 2014-10
Publication Title Acta Medica Okayama
Volume volume68
Issue issue5
Publisher Okayama University Medical School
Start Page 263
End Page 268
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25338482
Web of Science KeyUT 000343269300002
Author Mizutani, Shinsuke| Ekuni, Daisuke| Furuta, Michiko| Tomofuji, Takaaki| Irie, Koichiro| Azuma, Tetsuji| Kojima, Azusa| Nagase, Jun| Iwasaki, Yoshiaki| Morita, Manabu|
Published Date 2012-09
Publication Title Journal of Clinical Periodontology
Volume volume39
Issue issue9
Content Type Journal Article
Author Matsushita, Hiroshi| Ikeda, Fusao| Iwasaki, Yoshiaki| Seki, Hiroyuki| Nanba, Shintaro| Takeuchi, Yasuto| Moritou, Yuki| Yasunaka, Tetsuya| Onishi, Hideki| Miyake, Yasuhiro| Takaki, Akinobu| Nouso, Kazuhiro| Yamamoto, Kazuhide|
Published Date 2014-02
Publication Title Journal of Gastroenterology and Hepatology
Volume volume29
Issue issue2
Content Type Journal Article
Author Tatsukawa, Masashi| Takaki, Akinobu| Shiraha, Hidenori| Koike, Kazuko| Iwasaki, Yoshiaki| Kobashi, Haruhiko| Fujioka, Shin-Ichi| Sakaguchi, Kohsaku| Yamamoto, Kazuhide|
Published Date 2011-10-21
Publication Title BMC Cancer
Volume volume11
Content Type Journal Article