| ID | 58029 |
| FullText URL | |
| Author |
Wang, Ning
Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
Świtalska, Marta
Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
Wang, Li
Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
ORCID
Shaban, Elkhabiry
Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
Hossain, Md Imran
Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
El Sayed, Ibrahim El Tantawy
Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
Wietrzyk, Joanna
Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
Inokuchi, Tsutomu
Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
ORCID
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| Abstract | Cryptolepine, neocryptolepine and isocryptolepine are naturally occurring indoloquinoline alkaloids with various spectrum of biological properties. Structural modification is an extremely effective means to improve their bioactivities. This review enumerates several neocryptolepine and isocryptolepine analogues with potent antiproliferative activity against MV4-11 (leukemia), A549 (lung cancer), HCT116 (colon cancer) cell lines in vitro. Its activity towards normal mouse fibroblasts BALB/3T3 was also evaluated. Furthermore, structure activity relationships (SAR) are briefly discussed. The anticancer screening of neocryptolepine derivatives was performed in order to determine their cytotoxic and growth inhibitory activities across the JFCR39 cancer cell line panel.
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| Keywords | cryptolepine
neocryptolepine
isocryptolepine
antiproliferative activity
structure activity relationships
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| Published Date | 2019-06-05
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| Publication Title |
Molecures
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| Volume | volume24
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| Issue | issue11
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| Publisher | MDPI
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| ISSN | 1420-3049
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| Content Type |
Journal Article
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| language |
English
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| OAI-PMH Set |
岡山大学
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| Copyright Holders | © 2019 by the authors.
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| File Version | publisher
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| PubMed ID | |
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| Related Url | isVersionOf https://doi.org/10.3390/molecules24112121
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| License | http://creativecommons.org/licenses/by/4.0/
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