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ID 58029
フルテキストURL
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著者
Wang, Ning Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
Świtalska, Marta Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
Wang, Li Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University ORCID
Shaban, Elkhabiry Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
Hossain, Md Imran Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
El Sayed, Ibrahim El Tantawy Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
Wietrzyk, Joanna Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
Inokuchi, Tsutomu Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University ORCID Kaken ID publons researchmap
抄録
Cryptolepine, neocryptolepine and isocryptolepine are naturally occurring indoloquinoline alkaloids with various spectrum of biological properties. Structural modification is an extremely effective means to improve their bioactivities. This review enumerates several neocryptolepine and isocryptolepine analogues with potent antiproliferative activity against MV4-11 (leukemia), A549 (lung cancer), HCT116 (colon cancer) cell lines in vitro. Its activity towards normal mouse fibroblasts BALB/3T3 was also evaluated. Furthermore, structure activity relationships (SAR) are briefly discussed. The anticancer screening of neocryptolepine derivatives was performed in order to determine their cytotoxic and growth inhibitory activities across the JFCR39 cancer cell line panel.
キーワード
cryptolepine
neocryptolepine
isocryptolepine
antiproliferative activity
structure activity relationships
発行日
2019-06-05
出版物タイトル
Molecures
24巻
11号
出版者
MDPI
ISSN
1420-3049
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
© 2019 by the authors.
論文のバージョン
publisher
PubMed ID
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.3390/molecules24112121
ライセンス
http://creativecommons.org/licenses/by/4.0/