Author Nakarai, Asuka| Kato, Jun| Hiraoka, Sakiko| Kuriyama, Motoaki| Inokuchi, Toshihiro| Takei, Daisuke| Moritou, Yuki| Akita, Mitsuhiro| Takahashi, Sakuma| Harada, Keita| Okada, Hiroyuki| Yamamoto, Kazuhide|
Published Date 2013-12-02
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue3
Content Type Journal Article
Author Iwamuro, Masaya| Okada, Hiroyuki| Harada, Keita| Kanzaki, Hiromitsu| Hori, Keisuke| Kita, Masahide| Kawano, Seiji| Kawahara, Yoshiro| Tanaka, Takehiro| Yamamoto, Kazuhide|
Published Date 2016-12-01
Publication Title Journal of Okayama Medical Association
Volume volume128
Issue issue3
Content Type Journal Article
Title Alternative Adenocarcinoma in the jejunum 20 years after surgery for familial adenomatous polyposis
FullText URL 129_111.pdf
Author Sugihara, Yuusaku| Kawano, Seiji| Harada, Keita| Takashima, Shiho| Takei, Daisuke| Inokuchi, Toshihiro| Takahara, Masahiro| Hiraoka, Sakiko| Mori, Yoshiko| Kishimoto, Hiroyuki| Nagasaka, Takeshi| Okada, Hiroyuki|
Abstract A 58-year-old Japanese man visited a local clinic for the evaluation of a stomachache. He was diagnosed with intestinal obstruction. His medical history included a proctocolectomy at the age of 38 years, due to familial adenomatous polyposis (FAP). He was referred to our institution, where he underwent a computed tomography examination and endoscopy of the small intestine. The pathological diagnosis was adenocarcinoma. No invasive or metastatic lesions were observed. Therefore, partial resection of the ileum with lymphadenectomy and reconstruction of the ileostomy were performed. Pathological examination revealed that the tumor was type 2, pT3 (SS) , pN1, pPM0, pDM0, pRM0, INFb, ly1, v1, pEX0, PN0. Twenty-nine days after the surgery, the patient was diagnosed with lung metastasis and he underwent lung radiofrequency ablation. We suggest that long-term follow-up is necessary for patients after surgery for FAP, because of the risk of malignant disease developing in other organs.
Keywords 家族性大腸腺腫症 (familial adenomatous polyposis) 小腸癌 (jejunal cancer) 小腸内視鏡検査 (small intestine endoscope)
Publication Title Journal of Okayama Medical Association
Published Date 2017-08-01
Volume volume129
Issue issue2
Start Page 111
End Page 114
ISSN 0030-1558
Related Url https://doi.org/10.4044/joma.129.111
language Japanese
Copyright Holders Copyright (c) 2017 岡山医学会
File Version publisher
DOI 10.4044/joma.129.111
NAID 130006039373
Title Alternative Achalasia treated with per-oral endoscopic myotomy (POEM)
FullText URL 129_115.pdf
Author Sugihara, Yuusaku| Harada, Keita| Kato, Ryo| Yamauchi, Kenji| Takashima, Shiho| Takei, Daisuke| Inokuchia, Toshihiro| Takahara, Masahiro| Kawano, Seiji| Hiraoka, Sakiko| Tanabe, Shunsuke| Noma, Kazuhiro| Shirakawa, Yasuhiro| Manabe, Noriaki| Inoue, Haruhiro| Okada, Hiroyuki|
Abstract Esophageal achalasia is a disorder of the lower esophageal sphincter muscle. Patients present with dysphagia, chest pain, vomiting, and aspiration. Esophageal achalasia had traditionally been treated with esophageal achalasia balloon dilatation and the Heller-Dor method, but in recent years, the use of per-oral endoscopic myotomy (POEM) has increased. Our patient, a 39-yr-old male, began experiencing dysphagia 4 years prior to his referral to our hospital. Based on the results of esophagogastroduodenoscopy, esophageal radiography and high-resolution manometry, we made the diagnosis of esophageal achalasia (Chicago classification type I) . After informed consent from the patient and his family and approval from our hospital's ethics committee were obtained, we performed a POEM. The patient was discharged on the 4th day post-surgery. At the 1-year post-operative examination, no worsening of symptoms and no relapse were observed. POEM is an excellent treatment method for esophageal achalasia from the perspective of therapeutic effect and prevention of invasion. We recommend that it be considered as the first-choice treatment for achalasia. However, accessibility to the procedure itself is limited due to the few adequately trained operators worldwide. POEM should thus be performed by an expert operator at a high-volume center.
Keywords POEM 食道アカラシア (esophageal achalasia)
Publication Title Journal of Okayama Medical Association
Published Date 2017-08-01
Volume volume129
Issue issue2
Start Page 115
End Page 121
ISSN 0030-1558
Related Url https://doi.org/10.4044/joma.129.115
language Japanese
Copyright Holders Copyright (c) 2017 岡山医学会
File Version publisher
DOI 10.4044/joma.129.115
NAID 130006039377
FullText URL fulltext.pdf
Author Hiraoka, Sakiko| Takashima, Shiho| Inokuchi, Toshihiro| Nakarai, Asuka| Takahara, Masahiro| Harada, Keita| Seki, Yasuhiro| Watanabe, Katsunori| Kato, Jun| Okada, Hiroyuki|
Keywords Colitis ulcerative Fecal calprotectin Quantitative fecal immunochemical test Latex agglutination turbidimetric immunoassay Mucosal healing
Published Date 2018-12-14
Publication Title Intestinal Research
Volume volume17
Issue issue2
Publisher Korean Association for the Study of Intestinal Diseases
Start Page 202
End Page 209
ISSN 1598-9100
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Copyright 2019. Korean Association for the Study of Intestinal Diseases
File Version publisher
PubMed ID 30541228
DOI 10.5217/ir.2018.00086
Web of Science KeyUT 000466136800006
Related Url isVersionOf https://doi.org/10.5217/ir.2018.00086
FullText URL fulltext.pdf
Author Yasutomi, Eriko| Hiraoka, Sakiko| Yamamoto, Shumpei| Oka, Shohei| Hirai, Mami| Yamasaki, Yasushi| Inokuchi, Toshihiro| Kinugasa, Hideaki| Takahara, Masahiro| Harada, Keita| Kato, Jun| Okada, Hiroyuki|
Keywords ulcerative colitis salicylates mesalazine sulfasalazine
Published Date 2019-12-02
Publication Title Journal of Clinical Medicine
Volume volume8
Issue issue12
Publisher MDPI
ISSN 2077-0383
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 by the authors.
File Version publisher
PubMed ID 31810227
DOI 10.3390/jcm8122109
Web of Science KeyUT 000506640400082
Related Url isVersionOf https://doi.org/10.3390/jcm8122109
FullText URL SR9_1_11934.pdf
Author Takahara, Masahiro| Takaki, Akinobu| Hiraoka, Sakiko| Adach, Takuya| Shimomura, Yasuyuki| Matsushita, Hiroshi| Nguyen Tien Thi Thuy| Koike, Kazuko| Ikeda, Airi| Takashima, Shiho| Yamasaki, Yasushi| Inokuchi, Toshihiro| Kinugasa, Hideaki| Sugihara, Yusaku| Harada, Keita| Eikawa, Shingo| Morita, Hidetoshi| Udono, Heiichiro| Okada, Hiroyuki|
Published Date 2019-8-15
Publication Title Scientific Reports
Volume volume9
Publisher Nature Publishing Group
Start Page 11934
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2019
File Version publisher
PubMed ID 31417110
DOI 10.1038/s41598-019-48331-w
Web of Science KeyUT 000480680800048
Related Url isVersionOf https://doi.org/10.1038/s41598-019-48331-w
FullText URL fulltext.pdf
Author Sugihara, Yuusaku| Hiraoka, Sakiko| Yasutomi, Eriko| Oka, Shohei| Yamasaki, Yasushi| Inokuchi, Toshihiro| Kinugasa, Hideaki| Takahara, Masahiro| Morito, Yuki| Takahashi, Sakuma| Harada, Keita| Tanaka, Takehiro| Otsuka, Fumio| Okada, Hiroyuki|
Keywords graft-vs.-host disease terminal ileum allo-hematopoietic stem cell transplantation villous atrophy endoscopy
Published Date 2020-02-21
Publication Title Experimental and Therapeutic Medicine
Volume volume19
Issue issue4
Publisher Spandidos Publications
Start Page 3076
End Page 3080
ISSN 1792-0981
NCID AA12610820
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Sugiharaet al.
File Version publisher
PubMed ID 32256795
DOI 10.3892/etm.2020.8538
Web of Science KeyUT 000523637100082
Related Url isVersionOf https://doi.org/10.3892/etm.2020.8538
FullText URL fulltext.pdf
Author Baba, Yuki| Kawano, Seiji| Kono, Yoshiyasu| Inokuchi, Toshihiro| Kanzaki, Hiromitsu| Iwamuro, Masaya| Harada, Keita| Kawahara, Yoshiro| Okada, Hiroyuki|
Keywords obscure gastrointestinal bleeding overt previous bleeding vascular lesions chronic kidney disease
Published Date 2020-06-01
Publication Title Internal Medicine
Volume volume59
Issue issue11
Publisher The Japanese Society of Internal Medicine
Start Page 1345
End Page 1350
ISSN 1349-7235
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 32023585
DOI 10.2169/internalmedicine.3628-19
Web of Science KeyUT 000537806600001
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.3628-19
JaLCDOI 10.18926/AMO/60363
FullText URL 74_4_265.pdf
Author Inokuchi, Toshihiro| Hiraoka, Sakiko| Yasutomi, Eriko| Oka, Shohei| Yamasaki, Yasushi| Kinugasa, Hideaki| Takahar, Masahiro| Kawano, Seiji| Harada, Keita| Okada, Hiroyuki| Kato, Jun|
Abstract Determining factors that predict a favorable disease course without anti-tumor necrosis factor (TNF) agents would help establish a more cost-effective strategy for Crohn’s disease (CD). A retrospective chart review was performed for CD patients with disease durations > 10 years who had not received anti-TNF agents as first-line therapy. Patients were divided into 2 groups: those who received neither anti-TNF agents nor bowel resection (G1), and those who had received an anti-TNF agent and/or bowel resection (G2). The patient backgrounds, therapies and clinical courses were compared between the groups. A total of 62 CD patients met the inclusion criteria (males: 71%; median duration of follow-up: 19 years). Six patients were included in G1; they were significantly less likely to have upper gastrointestinal lesions than G2 (p=0.007). A multivariate analysis revealed that the significant factors for avoidance of bowel resection without anti-TNF treatment were non-stricturing and non-penetrating behaviors, and absence of upper gastrointestinal lesions at the diagnosis (hazard ratios 0.41 and 0.52; p=0.004 and 0.04, respectively). In consideration of the long treatment course of CD, patients with non-stricturing and non-penetrating behaviors and no upper gastrointestinal lesions should not be treated with anti-TNF agents as first-line therapy.
Keywords Crohn’s disease anti-TNF agent upper gastrointestinal lesion bamboo joint-like appearance
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-08
Volume volume74
Issue issue4
Publisher Okayama University Medical School
Start Page 265
End Page 274
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32843757
Web of Science KeyUT 000562508700001
NAID 120006880202
FullText URL fulltext.pdf
Author Kinugasa, Hideaki| Hiraoka, Sakiko| Nouso, Kazuhiro| Yamamoto, Shumpei| Hirai, Mami| Terasawa, Hiroyuki| Yasutomi, Eriko| Oka, Shohei| Ohmori, Masayasu| Yamasaki, Yasushi| Inokuchi, Toshihiro| Takahara, Masahiro| Harada, Keita| Tanaka, Takehiro| Okada, Hiroyuki|
Keywords IBD-associated neoplasia IBD-associated cancer Liquid biopsy ctDNA
Published Date 2020-12-03
Publication Title BMC Cancer
Volume volume20
Issue issue1
Publisher BMC
Start Page 1188
ISSN 1471-2407
NCID AA12034763
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 33272240
DOI 10.1186/s12885-020-07699-z
Web of Science KeyUT 000597268700004
Related Url isVersionOf https://doi.org/10.1186/s12885-020-07699-z
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Tanaka, Takehiro| Sugihara, Yuusaku| Harada, Keita| Hiraoka, Sakiko| Kondo, Yoshitaka| Okada, Hiroyuki|
Keywords endometriosis subepithelial lesion submucosal tumor cecum colonoscopy
Published Date 2021
Publication Title Internal Medicine
Volume volume60
Issue issue11
Publisher Japanese Society of Internal Medicine
Start Page 1697
End Page 1701
ISSN 0918-2918
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 33390498
DOI 10.2169/internalmedicine.6418-20
Web of Science KeyUT 000659353300007
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.6418-20
FullText URL fulltext.pdf
Author Yasutomi, Eriko| Inokuchi, Toshihiro| Hiraoka, Sakiko| Takei, Kensuke| Igawa, Shoko| Yamamoto, Shumpei| Ohmori, Masayasu| Oka, Shohei| Yamasaki, Yasushi| Kinugasa, Hideaki| Takahara, Masahiro| Harada, Keita| Furukawa, Masaki| Itoshima, Kouichi| Okada, Ken| Otsuka, Fumio| Tanaka, Takehiro| Mitsuhashi, Toshiharu| Kato, Jun| Okada, Hiroyuki|
Published Date 2021-05-27
Publication Title Scientific Reports
Volume volume11
Issue issue1
Publisher Nature Research
Start Page 11086
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021
File Version publisher
PubMed ID 34045529
NAID 120007089817
DOI 10.1038/s41598-021-90441-x
Web of Science KeyUT 000658389400001
Related Url isVersionOf https://doi.org/10.1038/s41598-021-90441-x
FullText URL fulltext.pdf
Author Yamamoto, Shumpei| Kinugasa, Hideaki| Yamasaki, Yasushi| Hirai, Mami| Ako, Soichiro| Takei, Kensuke| Igawa, Shoko| Yasutomi, Eriko| Oka, Shohei| Ohmori, Masayasu| Inokuchi, Toshihiro| Harada, Keita| Hiraoka, Sakiko| Nouso, Kazuhiro| Tanaka, Takehiro| Okada, Hiroyuki|
Keywords colorectal ESD PECS electrocoagulation syndrome immunosuppressants and steroids post-ESD fever
Published Date 2021-12-09
Publication Title DEN Open
Volume volume2
Issue issue1
Publisher Wiley
Start Page e83
ISSN 2692-4609
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Authors.
File Version publisher
PubMed ID 35310725
DOI 10.1002/deo2.83
Web of Science KeyUT 001047024900091
Related Url isVersionOf https://doi.org/10.1002/deo2.83
FullText URL fulltext.pdf
Author Yamada, Yuto| Fujiwara, Masaki| Shimazu, Taichi| Etoh, Tsuyoshi| Kodama, Masafumi| So, Ryuhei| Matsushita, Takanori| Yoshimura, Yusaku| Horii, Shigeo| Fujimori, Maiko| Takahashi, Hirokazu| Nakaya, Naoki| Miyaji, Tempei| Hinotsu, Shiro| Harada, Keita| Okada, Hiroyuki| Uchitomi, Yosuke| Yamada, Norihito| Inagaki, Masatoshi|
Published Date 2022-06
Publication Title BMJ Open
Volume volume12
Issue issue6
Publisher BMJ Publishing Group
Start Page e060621
ISSN 2044-6055
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Author(s) (or their employer(s)) 2022.
File Version publisher
PubMed ID 35701062
DOI 10.1136/bmjopen-2021-060621
Web of Science KeyUT 000811702800009
Related Url isVersionOf https://doi.org/10.1136/bmjopen-2021-060621
FullText URL fulltext.pdf
Author Takahara, Masahiro| Hiraoka, Sakiko| Ohmori, Masayasu| Takeuchi, Keiko| Takei, Kensuke| Yasutomi, Eriko| Igawa, Shoko| Yamamoto, Shumpei| Yamasaki, Yasushi| Inokuchi, Toshihiro| Kinugasa, Hideaki| Harada, Keita| Ohnishi, Hideki| Okada, Hiroyuki|
Keywords bowel wall thickness Mayo endoscopic subscore classification transabdominal ultrasonography ulcerative colitis
Published Date 2022-09-15
Publication Title Internal Medicine
Volume volume61
Issue issue18
Publisher The Japanese Society of Internal Medicine
Start Page 2703
End Page 2709
ISSN 0918-2918
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 35185047
DOI 10.2169/internalmedicine.8827-21
Web of Science KeyUT 000857218300001
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.8827-21
JaLCDOI 10.18926/AMO/65969
FullText URL 77_5_471.pdf
Author Oka, Shohei| Harada, Keita| Yamamoto, Shumpei| Yasutomi, Eriko| Igawa, Shoko| Ohmori, Masayasu| Hirai, Mami| Yamasaki, Yasushi| Inokuchi, Toshihiro| Kinugasa, Hideaki| Takahara, Masahiro| Hiraoka, Sakiko| Okada, Hiroyuki|
Abstract Although the clinical usefulness of colonoscopy has been established, the procedure remains painful for many patients. This study was designed to clarify the factors predicting colonoscopy-related pain. We evaluated 283 consecutive patients who completed a first-ever, total colonoscopy without sedatives or analgesics. The severity of pain symptoms was evaluated by a numeric rating scale (NRS) in a questionnaire immediately after the colonoscopy. Patient backgrounds and endoscopic findings were analyzed to evaluate their association with pain. Out of 283 patients, 53 scored their pain 0-1 on the NRS while 48 scored it 6-10. We defined the colonoscopies of the former and latter patients as painless and painful, respectively, and compared the two. Multivariate analyses revealed that low body weight (OR 4.95, 95%CI 1.89-12.99) and longer intubation time (OR 3.63, 95%CI 1.46-9.03) were significant risk factors for painful colonoscopy. To identify factors contributing to the increased intubation time, we divided subjects into short- and long-intubation-time groups based on a median insertion time of 7 min. Older age (OR 2.28, 95%CI 1.31-3.98), previous abdominal surgery (OR 1.93, 95%CI 1.13-3.32) and findings of invasive cancer (OR 10.90, 95%CI 1.34-88.90) were significant factors for longer intubation time.
Keywords colonoscopy colonoscopy-related pain comfortable colonoscopy
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-10
Volume volume77
Issue issue5
Publisher Okayama University Medical School
Start Page 471
End Page 478
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37899258
Web of Science KeyUT 001108661600004
JaLCDOI 10.18926/AMO/66674
FullText URL 78_1_079.pdf
Author Takahara, Masahiro| Hiraoka, Sakiko| Ohmori, Masayasu| Takeuchi, Keiko| Takei, Kensuke| Aoyama, Yuki| Yasutomi, Eriko| Igawa, Shoko| Inokuchi, Toshihiro| Toyosawa, Junki| Yamasaki, Yasushi| Kinugasa, Hideaki| Harada, Keita| Onishi, Hideki| Okada, Hiroyuki|
Abstract This study examined the utility of the combined use of transabdominal ultrasonography (TUS) and fecal immunochemical testing (FIT) to detect mucosal inflammation, vis-a-vis the Mayo endoscopic subscore (MES), in ulcerative colitis (UC). Sixty-three UC patients who underwent TUS and FIT were retrospectively enrolled. For TUS, the colon was divided into five segments, and the bowel wall thickness was measured and evaluated. The accuracy of FIT (> 100 ng/ml) in detecting mucosal inflammation (MES>0) was 0.93, whereas that of TUS (BWT>2 mm) in each segment was 0.84-0.97. The combined use of TUS and FIT may be helpful in noninvasive treatment strategies.
Keywords transabdominal ultrasonography fecal immunochemical test ulcerative colitis Mayo endoscopic subscore
Amo Type Short Communication
Publication Title Acta Medica Okayama
Published Date 2024-02
Volume volume78
Issue issue1
Publisher Okayama University Medical School
Start Page 79
End Page 83
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38419318