| FullText URL | fulltext20240226-03.pdf |
|---|---|
| Author | Zhou, Wenhao| Kawashima, Shusuke| Ishino, Takamasa| Kawase, Katsushige| Ueda, Youki| Yamashita, Kazuo| Watanabe, Tomofumi| Kawazu, Masahito| Dansako, Hiromichi| Suzuki, Yutaka| Nishikawa, Hiroyoshi| Inozume, Takashi| Nagasaki, Joji| Togashi, Yosuke| |
| Keywords | cancer immunology follicular helper T cell cytotoxic CD4+ T cell CXCL13 T cell exhaustion stem-like progenitor exhaustion terminally differentiated exhaustion PD-1 LAG-3 TCF1 |
| Note | Immune checkpoint inhibitors exert clinical efficacy against various types of cancer through reinvigoration of exhausted CD8+ T cells that attack cancer cells directly in the tumor microenvironment (TME). Using single-cell sequencing and mouse models, we show that CXCL13, highly expressed in tumor-infiltrating exhausted CD8+ T cells, induces CD4+ follicular helper T (TFH) cell infiltration, contributing to anti-tumor immunity. Furthermore, a part of the TFH cells in the TME exhibits cytotoxicity and directly attacks major histocompatibility complex-II-expressing tumors. TFH-like cytotoxic CD4+ T cells have high LAG-3/BLIMP1 and low TCF1 expression without self-renewal ability, whereas non-cytotoxic TFH cells express low LAG-3/BLIMP1 and high TCF1 with self-renewal ability, closely resembling the relationship between terminally differentiated and stem-like progenitor exhaustion in CD8+ T cells, respectively. Our findings provide deep insights into TFH-like CD4+ T cell exhaustion with helper progenitor and cytotoxic differentiated functions, mediating anti-tumor immunity orchestrally with CD8+ T cells.| |
| Published Date | 2024-02-27 |
| Publication Title | Cell Reports |
| Volume | volume43 |
| Issue | issue2 |
| Publisher | Elsevier BV |
| Start Page | 113797 |
| ISSN | 2211-1247 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Author(s). |
| File Version | publisher |
| PubMed ID | 38363680 |
| DOI | 10.1016/j.celrep.2024.113797 |
| Web of Science KeyUT | 001185865700001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.celrep.2024.113797 |
| Author | Dansako, Hiromichi| Ikeda, Masanori| Ariumi, Yasuo| Togashi, Yosuke| Kato, Nobuyuki| |
|---|---|
| Keywords | double-stranded RNA hepatitis C virus innate immunity RIG-I-like receptor RNA virus |
| Note | This is the accepted version of the following article: Dansako, H., Ikeda, M., Ariumi, Y., Togashi, Y. and Kato, N. (2023), Hepatitis C virus NS5B triggers an MDA5-mediated innate immune response by producing dsRNA without the replication of viral genomes. FEBS J. https://doi.org/10.1111/febs.16980, which has been published in final form at https://doi.org/10.1111/febs.16980| This fulltext file will be available in Oct. 2024.| |
| Published Date | 2023-10-27 |
| Publication Title | The FEBS Journal |
| Publisher | Wiley |
| ISSN | 1742-464X |
| NCID | AA11998513 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Federation of European Biochemical Societies. |
| File Version | author |
| PubMed ID | 37863517 |
| DOI | 10.1111/febs.16980 |
| Web of Science KeyUT | 001091349500001 |
| Related Url | isVersionOf https://doi.org/10.1111/febs.16980 |
| Author | Kemmotsu, Naoya| Ninomiya, Kiichiro| Kunimasa, Kei| Ishino, Takamasa| Nagasaki, Joji| Otani, Yoshihiro| Michiue, Hiroyuki| Ichihara, Eiki| Ohashi, Kadoaki| Inoue, Takako| Tamiya, Motohiro| Sakai, Kazuko| Ueda, Youki| Dansako, Hiromichi| Nishio, Kazuto| Kiura, Katsuyuki| Date, Isao| Togashi, Yosuke| |
|---|---|
| Keywords | cancer immunotherapy intracranial metastasis intracranial progression memory precursor effector T cell nonsmall-cell lung cancer |
| Note | This is the peer reviewed version of the following article: [Kemmotsu, N, Ninomiya, K, Kunimasa, K, et al. Low frequency of intracranial progression in advanced NSCLC patients treated with cancer immunotherapies. Int J Cancer. 2023; 1-11. doi:10.1002/ijc.34700], which has been published in final form at [https://doi.org/10.1002/ijc.34700]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in Aug. 2024.| |
| Published Date | 2023-08-23 |
| Publication Title | International Journal of Cancer |
| Publisher | Wiley |
| ISSN | 0020-7136 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 UICC. |
| File Version | author |
| PubMed ID | 37611176 |
| DOI | 10.1002/ijc.34700 |
| Web of Science KeyUT | 001069876600001 |
| Related Url | isVersionOf https://doi.org/10.1002/ijc.34700 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kemmotsu, Naoya| Zhu, Li| Nagasaki, Joji| Otani, Yoshihiro| Ueda, Youki| Dansako, Hiromichi| Fang, Yue| Date, Isao| Togashi, Yosuke| |
| Keywords | abscopal effect dendritic cell hydrogen peroxide radiosensitizer radiotherapy tumor-draining lymph node |
| Published Date | 2023-07-23 |
| Publication Title | Cancer Science |
| Volume | volume114 |
| Issue | issue10 |
| Publisher | Wiley |
| Start Page | 3848 |
| End Page | 3856 |
| ISSN | 1347-9032 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Authors. |
| File Version | publisher |
| PubMed ID | 37485636 |
| DOI | 10.1111/cas.15911 |
| Web of Science KeyUT | 001034657700001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.15911 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Watanabe, Tomofumi| Ishino, Takamasa| Ueda, Youki| Nagasaki, Joji| Sadahira, Takuya| Dansako, Hiromichi| Araki, Motoo| Togashi, Yosuke| |
| Keywords | antibody-dependent cell cytotoxicity cytotoxic T-lymphocyte-associated antigen 4 immune checkpoint inhibitors regulatory T cell renal cell carcinoma |
| Published Date | 2023-02-10 |
| Publication Title | Cancer Science |
| Publisher | Wiley |
| ISSN | 1347-9032 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Authors. |
| File Version | publisher |
| PubMed ID | 36762794 |
| DOI | 10.1111/cas.15756 |
| Web of Science KeyUT | 000940385500001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.15756 |
| JaLCDOI | 10.18926/AMO/53335 |
|---|---|
| FullText URL | 69_2_71.pdf |
| Author | Hiramoto, Hiroki| Dansako, Hiromichi| Takeda, Midori| Satoh, Shinya| Wakita, Takaji| Ikeda, Masanori| Kato, Nobuyuki| |
| Abstract | Persistent infection with hepatitis C virus (HCV) often causes chronic hepatitis, and then shows a high rate of progression to liver cirrhosis and hepatocellular carcinoma. To clarify the mechanism of the persistent HCV infection is considered to be important for the discovery of new target(s) for the development of anti-HCV strategies. In the present study, we found that the expression level of annexin A1 (ANXA1) in human hepatoma cell line Li23-derived D7 cells was remarkably lower than that in parental Li23 cells, whereas the susceptibility of D7 cells to HCV infection was much higher than that of Li23 cells. Therefore, we hypothesized that ANXA1 negatively regulates persistent HCV infection through the inhibition of viral RNA replication. The results revealed that HCV production was significantly inhibited without a concomitant reduction in the amount of lipid droplets in the D7 cells stably expressing exogenous ANXA1. Further, we demonstrated that ANXA1 negatively regulated the step of viral RNA replication rather than that of viral entry in human hepatocytes. These results suggest that ANXA1 would be a novel target for the development of anti-HCV strategies. |
| Keywords | HCV annexin A1 Li23 cell line Li23-derived D7 cells HCV-JFH-1 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-04 |
| Volume | volume69 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 71 |
| End Page | 78 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25899628 |
| Web of Science KeyUT | 000353181700001 |
| Author | Dansako, Hiromichi| Ueda, Youki| Okumura, Nobuaki| Satoh, Shinya| Sugiyama, Masaya| Mizokami, Masashi| Ikeda, Masanori| Kato, Nobuyuki| |
|---|---|
| Published Date | 2015 |
| Publication Title | The FEBS journal |
| Content Type | Journal Article |
| Author | Kato, Nobuyuki| Sejima, Hiroe| Ueda, Youki| Mori, Kyoko| Satoh, Shinya| Dansako, Hiromichi| Ikeda, Masanori| |
|---|---|
| Published Date | 2014-03-13 |
| Publication Title | PLOS ONE |
| Volume | volume9 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Ueda, Youki| Takeda, Midori| Mori, Kyoko| Dansako, Hiromichi| Wakita, Takaji| Kim, Hye-Sook| Sato, Akira| Wataya, Yusuke| Ikeda, Masanori| Kato, Nobuyuki| |
|---|---|
| Published Date | 2013-08-30 |
| Publication Title | PLOS ONE |
| Volume | volume8 |
| Issue | issue8 |
| Content Type | Journal Article |
| Author | Kuroki, Misao| Ariumi, Yasuo| Hijikata, Makoto| Ikeda, Masanori| Dansako, Hiromichi| Wakita, Takaji| Shimotohno, Kunitada| Kato, Nobuyuki| |
|---|---|
| Published Date | 2013-01-11 |
| Publication Title | Biochemical and Biophysical Research Communications |
| Volume | volume430 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Ariumi, Yasuo| Kuroki, Misao| Dansako, Hiromichi| Abe, Kenichi| Ikeda, Masanori| Wakita, Takaji| Kato, Nobuyuki| |
|---|---|
| Published Date | 2010-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume122 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Dansako, Hiromichi| |
|---|---|
| Published Date | 2004-09-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
