Abe, Koji - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Clinical and Pathological Benefit of Twendee X in Alzheimer's Disease Transgenic Mice with Chronic Cerebral Hypoperfusion

FullText URL	JSCD28_7_1993.pdf Fig.pdf
Author	Liu, Xia\| Yamashita, Toru\| Shang, Jingwei\| Shi, Xiaowen\| Morihara, Ryuta\| Huang, Yong\| Sato, Kota\| Takemoto, Mami\| Hishikawa, Nozomi\| Ohta, Yasuyuki\| Abe, Koji\|
Keywords	APP23 mice Alzheimer's disease anti-inflammatory antioxidative chronic cerebral hypoperfusion
Published Date	2019-07-31
Publication Title	Journal of Stroke and Cerebrovascular Diseases
Volume	volume28
Issue	issue7
Publisher	Elsevier
Start Page	1993
End Page	2002
ISSN	10523057
NCID	AA10780852
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	31029568
DOI	10.1016/j.jstrokecerebrovasdis.2019.03.029
Web of Science KeyUT	000470969200037
Related Url	isVersionOf https://doi.org/10.1016/j.jstrokecerebrovasdis.2019.03.029

A unique Japanese CPEO family with a novel homozygous m.14819 T > G (p. S25A) substitution

FullText URL	JNS400_145.pdf Fig.pdf
Author	Nomura, Emi\| Ohta, Yasuyuki\| Tadokoro, Koh\| Sato, Kota\| Sasaki, Ryo\| Takahashi, Yoshiaki\| Yamashita, Toru\| Takemoto, Mami\| Hishikawa, Nozomi\| Goto, Yu-ichi\| Abe, Koji\|
Keywords	CPEO Homozygous Mitochondrial DNA
Published Date	2019-05-15
Publication Title	Journal of the Neurological Sciences
Volume	volume400
Publisher	Elsevier
Start Page	145
End Page	147
ISSN	0022510X
NCID	AA00703265
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2019 Elsevier B.V. All rights reserved.
File Version	author
PubMed ID	30951992
DOI	10.1016/j.jns.2019.03.029
Web of Science KeyUT	000466828000028
Related Url	isVersionOf https://doi.org/10.1016/j.jns.2019.03.029

A novel familial prion disease causing pan-autonomic-sensory neuropathy and cognitive impairment

FullText URL	K0005478_other1.pdf
Author	Matsuzono, Kosuke\| Ikeda, Yoshio\| Liu, Wentao\| Kurata, Tomoko\| Deguchi, Shoko\| Deguchi, Kentaro\| Abe, Koji\|
Keywords	Prion disease Novelgene mutation 2bp deletion in codon 178 stopcodon at codon 195 Sensoryneuropathy HSAN Pan-autonomicfailure Familial case
Note	岡山大学審査学位副論文\|
Published Date	2013-05
Publication Title	European journal of neurology
Volume	volume20
Issue	issue5
Publisher	Wiley
Start Page	e67
End Page	e69
ISSN	1351-5101
NCID	AA11015934
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	https://creativecommons.org/licenses/by-nc-sa/4.0/deed.ja
File Version	author
PubMed ID	23577609
Web of Science KeyUT	000317609800003
Related Url	https://doi.org/10.1111/ene.12089 http://ousar.lib.okayama-u.ac.jp/55031

第26回日本脳循環代謝学会総会報告

Title Alternative	The 26th Annual Meeting of the Japanese Society of Cerebral Blood Flow and Metabolism
FullText URL	127_161.pdf
Author	Abe, Koji\|
Publication Title	岡山医学会雑誌
Published Date	2015-08-03
Volume	volume127
Issue	issue2
Start Page	161
End Page	162
ISSN	0030-1558
Related Url	isVersionOf https://doi.org/10.4044/joma.127.161
language	Japanese
Copyright Holders	Copyright (c) 2015 岡山医学会
File Version	publisher
DOI	10.4044/joma.127.161
NAID	130005096246

Eosinophil Cationic Protein Shows Survival Effect on H9c2 Cardiac Myoblast Cells with Enhanced Phosphorylation of ERK and Akt/GSK-3β under Oxidative Stress

JaLCDOI	10.18926/AMO/53521
FullText URL	69_3_145.pdf
Author	Ishii, Hiroko\| Kamikawa, Shigeshi\| Hirohata, Satoshi\| Mizutani, Akifumi\| Abe, Koji\| Seno, Masaharu\| Oohashi, Toshitaka\| Ninomiya, Yoshifumi\|
Abstract	Eosinophil cationic protein (ECP) is well known as a cationic protein contained in the basic granules of activated eosinophils. Recent studies have reported that ECP exhibits novel activities on various types of cells, including rat neonatal cardiomyocytes. Here we evaluated the effects of ECP on rat cardiac myoblast H9c2 cells. Our results showed that ECP enhanced the survival of the cells, in part by promoting the ERK and Akt/GSK-3β signaling pathways. ECP attenuated the cytotoxic effects of H2O2 on H9c2 cells as well as the production of reactive oxygen species, the number of apoptotic cells and caspase 3/7 activity in the cells. In conclusion, ECP activated the ERK and Akt/GSK-3β pathways, resulting in anti-oxidative effects on H9c2 cells that attenuated apoptosis.
Keywords	ECP reactive oxygen species Akt ERK
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2015-06
Volume	volume69
Issue	issue3
Publisher	Okayama University Medical School
Start Page	145
End Page	153
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2015 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	26101190
Web of Science KeyUT	000356903000003

慢性頭痛の診療ガイドライン

Author	Matsuura, Tohru\| Abe, Koji\|
Published Date	2014-12-01
Publication Title	岡山医学会雑誌
Volume	volume126
Issue	issue3
Content Type	Journal Article

Impaired response of hypoxic sensor protein HIF-1 alpha and its downstream proteins in the spinal motor neurons of ALS model mice

Author	Sato, Kota\| Morimoto, Nobutoshi\| Kurata, Tomoko\| Mimoto, Takafumi\| Miyazaki, Kazunori\| Ikeda, Yoshio\| Abe, Koji\|
Published Date	2012-09-14
Publication Title	Brain Research
Volume	volume1473
Content Type	Journal Article

Reducing Hemorrhagic Complication by Dabigatran Via Neurovascular Protection After Recanalization With Tissue Plasminogen Activator in Ischemic Stroke of Rat

Author	Kono, Syoichiro\| Deguchi, Kentaro\| Omote, Yoshio\| Yunoki, Taijun\| Yamashita, Toru\| Kurata, Tomoko\| Ikeda, Yoshio\| Abe, Koji\|
Published Date	2014-01
Publication Title	Journal of Neuroscience Research
Volume	volume92
Issue	issue1
Content Type	Journal Article

Clinical and Pathological Improvement in Stroke-Prone Spontaneous Hypertensive Rats Related to the Pleiotropic Effect of Cilostazol

Author	Omote, Yoshio\| Deguchi, Kentaro\| Tian, FengFeng\| Kawai, Hiromi\| Kurata, Tomoko\| Yamashita, Toru\| Ohta, Yasuyuki\| Abe, Koji\|
Published Date	2012-06
Publication Title	Stroke
Volume	volume43
Issue	issue6
Content Type	Journal Article

認知症の治療ガイドライン

Title Alternative	Guidelines for the treatment of dementia
FullText URL	126_155.pdf
Author	Kurata, Tomoko\| Abe, Koji\|
Publication Title	岡山医学会雑誌
Published Date	2014-08-01
Volume	volume126
Issue	issue2
Start Page	155
End Page	157
ISSN	0030-1558
language	Japanese
Copyright Holders	Copyright (c) 2014 岡山医学会
File Version	publisher
DOI	10.4044/joma.126.155
NAID	130004685268

てんかん治療ガイドラインについて

Author	Morimoto, Nobutoshi\| Abe, Koji\|
Published Date	2014-04-01
Publication Title	岡山医学会雑誌
Volume	volume126
Issue	issue1
Content Type	Journal Article

In vivo optical imaging for evaluating the efficacy of edaravone after transient cerebral ischemia in mice

Author	Liu, Ning\| Shang, Jingwei\| Tian, Fengfeng\| Nishi, Hiroyoshi\| Abe, Koji\|
Published Date	2011-06-23
Publication Title	Brain Research
Volume	volume1397
Content Type	Journal Article

細菌性髄膜炎の治療ガイドライン

Author	Ikeda, Yoshio\| Abe, Koji\|
Published Date	2013-12-02
Publication Title	岡山医学会雑誌
Volume	volume125
Issue	issue3
Content Type	Journal Article

脳梗塞の治療ガイドライン

Author	Deguchi, Kentaro\| Abe, Koji\|
Published Date	2013-08-01
Publication Title	岡山医学会雑誌
Volume	volume125
Issue	issue2
Content Type	Journal Article

Strong neuroprotection with a novel platinum nanoparticle against ischemic stroke- andtissue plasminogen activator-related brain damages in mice

Author	Takamiya, M.\| Miyamoto, Y.\| Yamashita, T.\| Deguchi, K.\| Ohta, Y.\| Abe, K.\|
Published Date	2012-09-27
Publication Title	Neuroscience
Volume	volume221
Content Type	Journal Article

In vivo imaging of autophagy in a mouse stroke model

FullText URL	Autophagy_6_8_1107-1114.pdf
Author	Tian, FengFeng\| Deguchi, Kentaro\| Yamashita, Toru\| Ohta, Yasuyuki\| Morimoto, Nobutoshi\| Shang, Jingwei\| Zhang, Xuemei\| Liu, Ning\| Ikeda, Yoshio\| Matsuura, Tohru\| Abe, Koji\|
Keywords	autophagy apoptosis GFP-LC3 Tg mice in vivo imaging tMCAO
Published Date	2010-11-16
Publication Title	Autophagy
Volume	volume6
Issue	issue8
Start Page	1107
End Page	1114
ISSN	1554-8627
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	20930570
DOI	10.4161/auto.6.8.13427
Web of Science KeyUT	000284258900010
Official Url	http://doi.org/10.4161/auto.6.8.13427\|
Related Url	http://ousar.lib.okayama-u.ac.jp/metadata/49128

パーキンソン病の治療ガイドライン

Author	Kurata, Tomoko\| Abe, Koji\|
Published Date	2013-04-01
Publication Title	岡山医学会雑誌
Volume	volume125
Issue	issue1
Content Type	Journal Article

神経内科領域の難治性疾患診療

Author	Ikeda, Yoshio\| Abe, Koji\|
Published Date	2011-12-01
Publication Title	岡山医学会雑誌
Volume	volume123
Issue	issue3
Content Type	Journal Article

Therapeutic Approaches to Vascular Protection in Ischemic Stroke

JaLCDOI	10.18926/AMO/46846
FullText URL	65_4_219.pdf
Author	Yamashita, Toru\| Abe, Koji\|
Abstract	Reperfusion with recombinant tissue plasminogen activator (tPA) sometimes causes catastrophic hemorrhagic transformation (HT) in the ischemic brain. Consequently, the application of tPA has been strictly limited. Recent studies have indicated that matrix metalloproteinases (MMPs), especially MMP-9, play a critical role in blood brain barrier (BBB) disruption in the ischemic brain, leading to brain edema and HT. In the ischemic brain, free radicals and exogenous tPA itself can trigger MMP-9 activation through several signaling pathways containing LDL receptor-related protein (LRP) and proteinase-activated receptor 1 (PAR1). Therapeutic targeting of free radicals and MMP-9/t-PA related signaling pathways might be promising approaches to minimizing catastrophic HT in acute stroke patients. We provide an overview of the available scientific reports to improve our understanding of the mechanisms leading to HT, and highlight recent progress in the development of new therapeutic strategies for preventing HT in the post-stroke brain.
Keywords	cerebral ischemia hemorrhagic transformation activator free radical matrix metalloproteinase-9
Amo Type	Review
Publication Title	Acta Medica Okayama
Published Date	2011-08
Volume	volume65
Issue	issue4
Publisher	Okayama University Medical School
Start Page	219
End Page	223
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2011 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	21860527
Web of Science KeyUT	000294236700001

ラット出血性梗塞モデルにおけるエダラボンのneurovascular unit保護効果

Author	Yamashita, Toru\| Kamiya, Tatsushi\| Deguchi, Kentaro\| Inaba, Toshiki\| Zhang, Hanzhe\| Shang, Jingwei\| Miyazaki, Kazunori\| Ohtsuka, Aiji\| Katayama, Yasuo\| Abe, Koji\|
Published Date	2010-12-01
Publication Title	岡山医学会雑誌
Volume	volume122
Issue	issue3
Content Type	Journal Article