ID | 52019 |
FullText URL | |
Author |
Noda, Yohei
Yoshinobu, Junko
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Abstract | Conclusion: Bone marrow-derived cells can be engrafted in the olfactory bulb and a few cells can differentiate into mitral/tufted cells in the olfactory bulb. Objectives: To investigate whether bone marrow-derived cells can be engrafted into the olfactory bulb and differentiate into neurons and glial cells after methimazole administration. Methods: Bone marrow of GFP (green fluorescence protein) mice was transplanted into lethally irradiated recipient mice. Immunostaining was performed to confirm the cell types of bone marrow-derived cells expressing GFP. Results: GFP-positive cells were observed in the olfactory bulb at 2 days after methimazole administration. The number of dendritic GFP-positive cells increased up to 30 days after methimazole administration and then decreased. Double immunostaining for GFP and Iba1 or TBX21 showed that a large population of the GFP-positive cells had characteristics of microglia/macrophages and a few cells had characteristics of mitral/tufted cells.
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Keywords | Transplantation
regeneration
olfaction
mitral cells
microglia
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Published Date | 2013-09
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Publication Title |
Acta Oto-laryngologica
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Volume | volume133
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Issue | issue9
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Start Page | 951
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End Page | 956
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ISSN | 0001-6489
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Content Type |
Journal Article
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Official Url | http://dx.doi.org/10.3109/00016489.2013.803153
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Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/51950
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language |
English
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File Version | author
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Refereed |
True
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DOI | |
Web of Science KeyUT |