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ID 52019
フルテキストURL
著者
Noda, Yohei Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg
Nishizaki, Kazunori Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg Kaken ID
Yoshinobu, Junko Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg
Orita, Yorihisa Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg Kaken ID
Tsujigiwa, Hidetsugu Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Oral Pathol & Med
Yamada, Masao Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Virol Kaken ID researchmap
抄録
Conclusion: Bone marrow-derived cells can be engrafted in the olfactory bulb and a few cells can differentiate into mitral/tufted cells in the olfactory bulb. Objectives: To investigate whether bone marrow-derived cells can be engrafted into the olfactory bulb and differentiate into neurons and glial cells after methimazole administration. Methods: Bone marrow of GFP (green fluorescence protein) mice was transplanted into lethally irradiated recipient mice. Immunostaining was performed to confirm the cell types of bone marrow-derived cells expressing GFP. Results: GFP-positive cells were observed in the olfactory bulb at 2 days after methimazole administration. The number of dendritic GFP-positive cells increased up to 30 days after methimazole administration and then decreased. Double immunostaining for GFP and Iba1 or TBX21 showed that a large population of the GFP-positive cells had characteristics of microglia/macrophages and a few cells had characteristics of mitral/tufted cells.
キーワード
Transplantation
regeneration
olfaction
mitral cells
microglia
発行日
2013-09
出版物タイトル
Acta Oto-laryngologica
133巻
9号
開始ページ
951
終了ページ
956
ISSN
0001-6489
資料タイプ
学術雑誌論文
オフィシャル URL
http://dx.doi.org/10.3109/00016489.2013.803153
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/51950
言語
English
論文のバージョン
author
査読
有り
DOI
Web of Science KeyUT