Author Toyota, Teruaki| Kataoka, Takahiro| Nishiyama, Yuichi| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2012
Publication Title Mediators of Inflammation
Volume volume2012
Content Type Journal Article
JaLCDOI 10.18926/AMO/52009
FullText URL 67_6_359.pdf
Author Katashima, Kazunori| Kuroda, Masahiro| Ashida, Masakazu| Sasaki, Takanori| Taguchi, Takehito| Matsuzaki, Hidenobu| Murakami, Jun| Yanagi, Yoshinobu| Hisatomi, Miki| Hara, Marina| Kato, Hirokazu| Ohmura, Yuichi| Kobayashi, Tomoki| Kanazawa, Susumu| Harada, Sosuke| Takemoto, Mitsuhiro| Ohno, Seiichiro| Mimura, Seiichi| Asaumi, Junichi|
Abstract It is well known that many tumor tissues show lower apparent diffusion coefficient (ADC) values, and that several factors are involved in the reduction of ADC values. The aim of this study was to clarify how much each factor contributes to decreases in ADC values. We investigate the roles of cell density, extracellular space, intracellular factors, apoptosis and necrosis in ADC values using bio-phantoms. The ADC values of bio-phantoms, in which Jurkat cells were encapsulated by gellan gum, were measured by a 1.5-Tesla magnetic resonance imaging device with constant diffusion time of 30sec. Heating at 42℃ was used to induce apoptosis while heating at 48℃ was used to induce necrosis. Cell death after heating was evaluated by flow cytometric analysis and electron microscopy. The ADC values of bio-phantoms including non-heated cells decreased linearly with increases in cell density, and showed a steep decline when the distance between cells became less than 3μm. The analysis of ADC values of cells after destruction of cellular structures by sonication suggested that approximately two-thirds of the ADC values of cells originate from their cellular structures. The ADC values of bio-phantoms including necrotic cells increased while those including apoptotic cells decreased. This study quantitatively clarified the role of the cellular factors and the extracellular space in determining the ADC values produced by tumor cells. The intermediate diffusion time of 30msec might be optimal to distinguish between apoptosis and necrosis.
Keywords ADC apoptosis necrosis hyperthermia cell density
Amo Type Original Article
Published Date 2013-12
Publication Title Acta Medica Okayama
Volume volume67
Issue issue6
Publisher Okayama University Medical School
Start Page 359
End Page 367
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 24356720
Web of Sience KeyUT 000328915700004
Author Kataoka, Takahiro| Nishiyama, Yuichi| Yamato, Keiko| Teraoka, Junichi| Morii, Yuji| Sakoda, Akihiro| Ishimori, Yuu| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2012-07-31
Publication Title Journal of Radiation Research
Volume volume53
Issue issue6
Content Type Journal Article
Author Kataoka, Takahiro| Yamato, Keiko| Nishiyama, Yuichi| Morii, Yuji| Etani, Reo| Takata, Yuji| Hanamoto, Katsumi| Kawabe, Atsuishi| Sakoda, Akihiro| Ishimori, Yuu| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2012-10
Publication Title Renal Failure
Volume volume34
Issue issue9
Content Type Journal Article
Author Kataoka, Takahiro| Sakoda, Akihiro| Yoshimoto, Masaaki| Nakagawa, Shinya| Toyota, Teruaki| Nishiyama, Yuichi| Yamato, Keiko| Ishimori, Yuu| Kawabe, Atsushi| Hanamoto, Katsumi| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2011-07
Publication Title Radiation Protection Dosimetry
Volume volume146
Issue issue1-3
Content Type Journal Article
Author Kataoka, Takahiro| Yoshimoto, Masaaki| Nakagawa, Shinya| Mizuguchi, Yuko| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2009-09
Publication Title Journal of Clinical Biochemistry and Nutrition
Volume volume45
Issue issue2
Content Type Journal Article
Author Nakagawa, Shinya| Kataoka, Takahiro| Mizuguchi, Yuko| Yoshimoto, Masaaki| Sakoda, Akihiro| Nomura, Takaharu| Wang, Da-Hong| Kawabe, Atsushi| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2008-07
Publication Title Journal of Clinical Biochemistry and Nutrition
Volume volume43
Issue issue1
Content Type Journal Article
Author Kataoka, Takahiro| Mizuguchi, Yuko| Yoshimoto, Masaaki| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2007-11-21
Publication Title Journal of Radiation Research
Volume volume48
Issue issue6
Content Type Journal Article
Author Yamaoka, Kiyonori| Kataoka, Takahiro| Nomura, Takaharu| Taguchi, Takehito| Wang, Da-Hong| Mori, Shuji| Hanamoto, Katsumi| Kira, Shohei|
Published Date 2004-05-07
Publication Title Journal of Radiation Research
Volume volume45
Issue issue1
Content Type Journal Article
Author Kataoka, Takahiro| Teraoka, Junichi| Sakoda, Akihiro| Nishiyama, Yuichi| Yamato, Keiko| Monden, Mayuko| Ishimori, Yuu| Nomura, Takaharu| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2012-04-01
Publication Title Inflammation
Volume volume35
Issue issue2
Content Type Journal Article
Author Kataoka, Takahiro| Nishiyama, Yuichi| Toyota, Teruaki| Yoshimoto, Masaaki| Sakoda, Akihiro| Ishimori, Yuu| Aoyama, Yutaka| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2011-12-01
Publication Title Inflammation
Volume volume34
Issue issue6
Content Type Journal Article
Author Yoshimoto, Masaaki| Kataoka, Takahiro| Toyota, Teruaki| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2012-02-01
Publication Title Inflammation
Volume volume35
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/32301
FullText URL fulltext.pdf
Author Endo, Ryutaro| Murakami, Shinichiro| Masuda, Yu| Taguchi, Takehito| Ohtsuka, Aiji| Nishizaki, Kazunori| Murakami, Takuro|
Abstract <p>The present study showed that many neurons in the adult rat brain possessed a perineuronal sulfated proteoglycan surface coat which reacted to cationic iron colloid and aldehyde fuchsin. This surface coat was stained supravitally with Ehrlich's methylene blue and doubly stained with Ehrlich's methylene blue and aldehyde fuchsin. The surface coat was also stained with Gomori's ammoniacal silver and doubly stained with Gomori's ammoniacal silver and cationic iron colloid. The surface coat was usually expressed together with a nerve cell surface glycoprotein net detectable with lectin Wisteria floribunda agglutinin. These findings indicate that the perineuronal proteoglycan surface coat is identical to Cajal's superficial reticulum and contains some collagenous elements. It was further demonstrated that collagenase digestion erased Gomori's ammoniacal silver impregnation within the perineuronal proteoglycan surface coat.</p>
Keywords brain extracellular matrix perineuronal proteoglycans cell surface glycoproteins
Amo Type Article
Published Date 2000-06
Publication Title Acta Medica Okayama
Volume volume54
Issue issue3
Publisher Okayama University Medical School
Start Page 111
End Page 118
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 10925735
Web of Sience KeyUT 000087965700003
JaLCDOI 10.18926/AMO/32280
FullText URL fulltext.pdf
Author Su, Wei-Dong| Ohtsuka, Aiji| Taguchi, Takehito| Murakami, Takuro|
Abstract <p>The accessory ascending cervical artery (Murakami et al., 1996), which arises from the subclavian artery and ascends between the scalenus anterior and medius muscles, was studied in 87 Japanese adult cadavers (174 sides), with special attention being given to its origin, distribution, and relationship to other arteries at the cervical or scalenus region. In 154 sides (88.5%), the accessory ascending cervical artery was found to originate from the subclavian artery behind the scalenus anterior muscle, and to branch out to the scalenus anterior and medius muscles as well as those entering the 5th and 6th intervertebral foramens along the 6th and 7th cervical nerves. This artery arose independently in 105 sides. The accessory ascending cervical artery issued off or formed a common trunk with the transverse cervical artery and/or costocervical trunk in 49 sides. In cases lacking the accessory ascending cervical artery, it was usually compensated for by the costocervial trunk and/or transverse cervical artery (18 sides). Common trunk formation with the vertebral, internal thoracic, or suprascapular arteries was not observed. The authors suggest that the accessory ascending cervical artery, the transverse cervical artery, and the costocervical trunk should be grouped into one arterial system, a system that may be a remnant of the precostal longitudinal anastomoses of intersegmental arteries of the dorsal aorta behind the scalenus anterior muscle.</p>
Keywords accessory ascending cervical artery transverse cervical artery costocervical trunk scalenus anterior muscle subclavian artery
Amo Type Article
Published Date 2000-12
Publication Title Acta Medica Okayama
Volume volume54
Issue issue6
Publisher Okayama University Medical School
Start Page 243
End Page 252
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 11132917
Web of Sience KeyUT 000166042900002
JaLCDOI 10.18926/AMO/31759
FullText URL fulltext.pdf
Author Yamamoto, Ryosuke| Taguchi, Takehito| Murakami, Takuro|
Abstract <p>The adductor pollicis muscle was studied in fifty hands of Japanese adult cadavers of both sexes. The radial portion of the oblique head of the adductor pollicis muscle has carpal and metacarpal origins and an insertion into the wing tendon of the extensor apparatus. This portion was located dorsal to the palmar metacarpophalangeal articular nerve and superficial palmar metacarpal artery. Thus, the radial portion of the oblique head of the adductor pollicis muscle (more strictly, the slips dorsal to the palmar-penetrating twig of the ulnar nerve) is similar to the palmar interosseous muscles, except that its slips cannot be clearly distinguished from each other.</p>
Keywords adductor pollicis muscle palmar interosseous muscle deep palmar artery deep palmar nerve wing tendon
Amo Type Article
Published Date 1987-06
Publication Title Acta Medica Okayama
Volume volume41
Issue issue3
Publisher Okayama University Medical School
Start Page 99
End Page 103
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 3630764
Web of Sience KeyUT A1987H962300002
JaLCDOI 10.18926/AMO/31711
FullText URL fulltext.pdf
Author Kosaka, Motohiro| Horiuchi, Kanji| Nishida, Keiichiro| Taguchi, Takehito| Murakami, Takuro| Ohtsuka, Aiji|
Abstract <p>The celiac and mesenteric arterial system including the left gastric, splenic, common hepatic, and superior mesenteric arteries shows various types of origins, courses, ramifications and anastomoses. In order to explain the various expressions of this system, we have proposed a typological model, in which celiacomesenteric arteries develop as paired or bilaterally symmetrical primordial vessels originated from the anterior aspect of the aorta, and these vessels anastomose each other with longitudinal and horizontal pathways. Here, we report 3 unusual cases characterized by arterial rings, formed by the left gastric, left accessory hepatic, proper hepatic, anterior pancreaticoduodenal, and dorsal pancreatic arteries. The dorsal pancreatic and anterior pancreaticoduodenal arteries are located to the right and left of the embryonic pancreas developing in the dorsal mesentery, respectively. Such hepatopancreatic arterial rings simultaneously containing right and left elements can only be explained using our typological model, in which the concept of paired arteries or bilateral symmetry is introduced.</p>
Keywords arterial variation celiac trunk superior mesenteric artery typology bilateral symmetry
Amo Type Article
Published Date 2002-10
Publication Title Acta Medica Okayama
Volume volume56
Issue issue5
Publisher Okayama University Medical School
Start Page 245
End Page 253
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 12530508
Web of Sience KeyUT 000178668100005
JaLCDOI 10.18926/AMO/31092
FullText URL fulltext.pdf
Author Murakami, Takuro| Tsubouchi, Mari| Tubouchi, Yutaka| Taguchi, Takehito| Ohtsuka, Aiji|
Abstract <p>Neurons with strongly negatively charged surface coats were recognized in mammalian, avian, reptilian, amphibian and piscine brains. Many large-sized neurons had strongly negatively charged surface coats in the visual cortex and brain stem of the cow, cat, guinea pig, mouse, quail and parakeet. Such neurons were also seen in the brain stem of the lower vertebrates such as the house lizard, Japanese terrapin, bullfrog, newt, carp and sweetfish.</p>
Keywords central nervous system neurons negatively charged surface coats proteoglycans
Amo Type Article
Published Date 1994-08
Publication Title Acta Medica Okayama
Volume volume48
Issue issue4
Publisher Okayama University Medical School
Start Page 195
End Page 197
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7817774
Web of Sience KeyUT A1994PE51400004
Author Liu, Jing-Jie| Ohtani, Osamu| Kiuta, Akio| Ohtsuka, Aiji| Taguchi, Takehito| Murakami, Takuro| Sano, Tadashi|
Published Date 1988
Publication Title 岡山医学会雑誌
Volume volume100
Issue issue1-2
Content Type Journal Article
Author Murakami, Takuro| Taguchi, Takehito| Ohtsuka, Aiji|
Published Date 1993-02-27
Publication Title 岡山医学会雑誌
Volume volume105
Issue issue1-2
Content Type Journal Article
Author Murakami, Takuro| Hitomi, Sayoko| Sato, Tohru| Piao, Da Xun| Ohtsuka, Aiji| Taguchi, Takehito|
Published Date 1996-06-29
Publication Title 岡山医学会雑誌
Volume volume108
Issue issue3-6
Content Type Journal Article