著者 Toyota, Teruaki| Kataoka, Takahiro| Nishiyama, Yuichi| Taguchi, Takehito| Yamaoka, Kiyonori|
発行日 2012
出版物タイトル Mediators of Inflammation
2012巻
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/52009
フルテキストURL 67_6_359.pdf
著者 Katashima, Kazunori| Kuroda, Masahiro| Ashida, Masakazu| Sasaki, Takanori| Taguchi, Takehito| Matsuzaki, Hidenobu| Murakami, Jun| Yanagi, Yoshinobu| Hisatomi, Miki| Hara, Marina| Kato, Hirokazu| Ohmura, Yuichi| Kobayashi, Tomoki| Kanazawa, Susumu| Harada, Sosuke| Takemoto, Mitsuhiro| Ohno, Seiichiro| Mimura, Seiichi| Asaumi, Junichi|
抄録 It is well known that many tumor tissues show lower apparent diffusion coefficient (ADC) values, and that several factors are involved in the reduction of ADC values. The aim of this study was to clarify how much each factor contributes to decreases in ADC values. We investigate the roles of cell density, extracellular space, intracellular factors, apoptosis and necrosis in ADC values using bio-phantoms. The ADC values of bio-phantoms, in which Jurkat cells were encapsulated by gellan gum, were measured by a 1.5-Tesla magnetic resonance imaging device with constant diffusion time of 30sec. Heating at 42℃ was used to induce apoptosis while heating at 48℃ was used to induce necrosis. Cell death after heating was evaluated by flow cytometric analysis and electron microscopy. The ADC values of bio-phantoms including non-heated cells decreased linearly with increases in cell density, and showed a steep decline when the distance between cells became less than 3μm. The analysis of ADC values of cells after destruction of cellular structures by sonication suggested that approximately two-thirds of the ADC values of cells originate from their cellular structures. The ADC values of bio-phantoms including necrotic cells increased while those including apoptotic cells decreased. This study quantitatively clarified the role of the cellular factors and the extracellular space in determining the ADC values produced by tumor cells. The intermediate diffusion time of 30msec might be optimal to distinguish between apoptosis and necrosis.
キーワード ADC apoptosis necrosis hyperthermia cell density
Amo Type Original Article
発行日 2013-12
出版物タイトル Acta Medica Okayama
67巻
6号
出版者 Okayama University Medical School
開始ページ 359
終了ページ 367
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 24356720
Web of Sience KeyUT 000328915700004
著者 Kataoka, Takahiro| Nishiyama, Yuichi| Yamato, Keiko| Teraoka, Junichi| Morii, Yuji| Sakoda, Akihiro| Ishimori, Yuu| Taguchi, Takehito| Yamaoka, Kiyonori|
発行日 2012-07-31
出版物タイトル Journal of Radiation Research
53巻
6号
資料タイプ 学術雑誌論文
著者 Kataoka, Takahiro| Yamato, Keiko| Nishiyama, Yuichi| Morii, Yuji| Etani, Reo| Takata, Yuji| Hanamoto, Katsumi| Kawabe, Atsuishi| Sakoda, Akihiro| Ishimori, Yuu| Taguchi, Takehito| Yamaoka, Kiyonori|
発行日 2012-10
出版物タイトル Renal Failure
34巻
9号
資料タイプ 学術雑誌論文
著者 Kataoka, Takahiro| Sakoda, Akihiro| Yoshimoto, Masaaki| Nakagawa, Shinya| Toyota, Teruaki| Nishiyama, Yuichi| Yamato, Keiko| Ishimori, Yuu| Kawabe, Atsushi| Hanamoto, Katsumi| Taguchi, Takehito| Yamaoka, Kiyonori|
発行日 2011-07
出版物タイトル Radiation Protection Dosimetry
146巻
1-3号
資料タイプ 学術雑誌論文
著者 Kataoka, Takahiro| Yoshimoto, Masaaki| Nakagawa, Shinya| Mizuguchi, Yuko| Taguchi, Takehito| Yamaoka, Kiyonori|
発行日 2009-09
出版物タイトル Journal of Clinical Biochemistry and Nutrition
45巻
2号
資料タイプ 学術雑誌論文
著者 Nakagawa, Shinya| Kataoka, Takahiro| Mizuguchi, Yuko| Yoshimoto, Masaaki| Sakoda, Akihiro| Nomura, Takaharu| Wang, Da-Hong| Kawabe, Atsushi| Taguchi, Takehito| Yamaoka, Kiyonori|
発行日 2008-07
出版物タイトル Journal of Clinical Biochemistry and Nutrition
43巻
1号
資料タイプ 学術雑誌論文
著者 Kataoka, Takahiro| Mizuguchi, Yuko| Yoshimoto, Masaaki| Taguchi, Takehito| Yamaoka, Kiyonori|
発行日 2007-11-21
出版物タイトル Journal of Radiation Research
48巻
6号
資料タイプ 学術雑誌論文
著者 Yamaoka, Kiyonori| Kataoka, Takahiro| Nomura, Takaharu| Taguchi, Takehito| Wang, Da-Hong| Mori, Shuji| Hanamoto, Katsumi| Kira, Shohei|
発行日 2004-05-07
出版物タイトル Journal of Radiation Research
45巻
1号
資料タイプ 学術雑誌論文
著者 Kataoka, Takahiro| Teraoka, Junichi| Sakoda, Akihiro| Nishiyama, Yuichi| Yamato, Keiko| Monden, Mayuko| Ishimori, Yuu| Nomura, Takaharu| Taguchi, Takehito| Yamaoka, Kiyonori|
発行日 2012-04-01
出版物タイトル Inflammation
35巻
2号
資料タイプ 学術雑誌論文
著者 Kataoka, Takahiro| Nishiyama, Yuichi| Toyota, Teruaki| Yoshimoto, Masaaki| Sakoda, Akihiro| Ishimori, Yuu| Aoyama, Yutaka| Taguchi, Takehito| Yamaoka, Kiyonori|
発行日 2011-12-01
出版物タイトル Inflammation
34巻
6号
資料タイプ 学術雑誌論文
著者 Yoshimoto, Masaaki| Kataoka, Takahiro| Toyota, Teruaki| Taguchi, Takehito| Yamaoka, Kiyonori|
発行日 2012-02-01
出版物タイトル Inflammation
35巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/32301
フルテキストURL fulltext.pdf
著者 Endo, Ryutaro| Murakami, Shinichiro| Masuda, Yu| Taguchi, Takehito| Ohtsuka, Aiji| Nishizaki, Kazunori| Murakami, Takuro|
抄録 <p>The present study showed that many neurons in the adult rat brain possessed a perineuronal sulfated proteoglycan surface coat which reacted to cationic iron colloid and aldehyde fuchsin. This surface coat was stained supravitally with Ehrlich's methylene blue and doubly stained with Ehrlich's methylene blue and aldehyde fuchsin. The surface coat was also stained with Gomori's ammoniacal silver and doubly stained with Gomori's ammoniacal silver and cationic iron colloid. The surface coat was usually expressed together with a nerve cell surface glycoprotein net detectable with lectin Wisteria floribunda agglutinin. These findings indicate that the perineuronal proteoglycan surface coat is identical to Cajal's superficial reticulum and contains some collagenous elements. It was further demonstrated that collagenase digestion erased Gomori's ammoniacal silver impregnation within the perineuronal proteoglycan surface coat.</p>
キーワード brain extracellular matrix perineuronal proteoglycans cell surface glycoproteins
Amo Type Article
発行日 2000-06
出版物タイトル Acta Medica Okayama
54巻
3号
出版者 Okayama University Medical School
開始ページ 111
終了ページ 118
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 10925735
Web of Sience KeyUT 000087965700003
JaLCDOI 10.18926/AMO/32280
フルテキストURL fulltext.pdf
著者 Su, Wei-Dong| Ohtsuka, Aiji| Taguchi, Takehito| Murakami, Takuro|
抄録 <p>The accessory ascending cervical artery (Murakami et al., 1996), which arises from the subclavian artery and ascends between the scalenus anterior and medius muscles, was studied in 87 Japanese adult cadavers (174 sides), with special attention being given to its origin, distribution, and relationship to other arteries at the cervical or scalenus region. In 154 sides (88.5%), the accessory ascending cervical artery was found to originate from the subclavian artery behind the scalenus anterior muscle, and to branch out to the scalenus anterior and medius muscles as well as those entering the 5th and 6th intervertebral foramens along the 6th and 7th cervical nerves. This artery arose independently in 105 sides. The accessory ascending cervical artery issued off or formed a common trunk with the transverse cervical artery and/or costocervical trunk in 49 sides. In cases lacking the accessory ascending cervical artery, it was usually compensated for by the costocervial trunk and/or transverse cervical artery (18 sides). Common trunk formation with the vertebral, internal thoracic, or suprascapular arteries was not observed. The authors suggest that the accessory ascending cervical artery, the transverse cervical artery, and the costocervical trunk should be grouped into one arterial system, a system that may be a remnant of the precostal longitudinal anastomoses of intersegmental arteries of the dorsal aorta behind the scalenus anterior muscle.</p>
キーワード accessory ascending cervical artery transverse cervical artery costocervical trunk scalenus anterior muscle subclavian artery
Amo Type Article
発行日 2000-12
出版物タイトル Acta Medica Okayama
54巻
6号
出版者 Okayama University Medical School
開始ページ 243
終了ページ 252
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 11132917
Web of Sience KeyUT 000166042900002
JaLCDOI 10.18926/AMO/31759
フルテキストURL fulltext.pdf
著者 Yamamoto, Ryosuke| Taguchi, Takehito| Murakami, Takuro|
抄録 <p>The adductor pollicis muscle was studied in fifty hands of Japanese adult cadavers of both sexes. The radial portion of the oblique head of the adductor pollicis muscle has carpal and metacarpal origins and an insertion into the wing tendon of the extensor apparatus. This portion was located dorsal to the palmar metacarpophalangeal articular nerve and superficial palmar metacarpal artery. Thus, the radial portion of the oblique head of the adductor pollicis muscle (more strictly, the slips dorsal to the palmar-penetrating twig of the ulnar nerve) is similar to the palmar interosseous muscles, except that its slips cannot be clearly distinguished from each other.</p>
キーワード adductor pollicis muscle palmar interosseous muscle deep palmar artery deep palmar nerve wing tendon
Amo Type Article
発行日 1987-06
出版物タイトル Acta Medica Okayama
41巻
3号
出版者 Okayama University Medical School
開始ページ 99
終了ページ 103
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 3630764
Web of Sience KeyUT A1987H962300002
JaLCDOI 10.18926/AMO/31711
フルテキストURL fulltext.pdf
著者 Kosaka, Motohiro| Horiuchi, Kanji| Nishida, Keiichiro| Taguchi, Takehito| Murakami, Takuro| Ohtsuka, Aiji|
抄録 <p>The celiac and mesenteric arterial system including the left gastric, splenic, common hepatic, and superior mesenteric arteries shows various types of origins, courses, ramifications and anastomoses. In order to explain the various expressions of this system, we have proposed a typological model, in which celiacomesenteric arteries develop as paired or bilaterally symmetrical primordial vessels originated from the anterior aspect of the aorta, and these vessels anastomose each other with longitudinal and horizontal pathways. Here, we report 3 unusual cases characterized by arterial rings, formed by the left gastric, left accessory hepatic, proper hepatic, anterior pancreaticoduodenal, and dorsal pancreatic arteries. The dorsal pancreatic and anterior pancreaticoduodenal arteries are located to the right and left of the embryonic pancreas developing in the dorsal mesentery, respectively. Such hepatopancreatic arterial rings simultaneously containing right and left elements can only be explained using our typological model, in which the concept of paired arteries or bilateral symmetry is introduced.</p>
キーワード arterial variation celiac trunk superior mesenteric artery typology bilateral symmetry
Amo Type Article
発行日 2002-10
出版物タイトル Acta Medica Okayama
56巻
5号
出版者 Okayama University Medical School
開始ページ 245
終了ページ 253
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 12530508
Web of Sience KeyUT 000178668100005
JaLCDOI 10.18926/AMO/31092
フルテキストURL fulltext.pdf
著者 Murakami, Takuro| Tsubouchi, Mari| Tubouchi, Yutaka| Taguchi, Takehito| Ohtsuka, Aiji|
抄録 <p>Neurons with strongly negatively charged surface coats were recognized in mammalian, avian, reptilian, amphibian and piscine brains. Many large-sized neurons had strongly negatively charged surface coats in the visual cortex and brain stem of the cow, cat, guinea pig, mouse, quail and parakeet. Such neurons were also seen in the brain stem of the lower vertebrates such as the house lizard, Japanese terrapin, bullfrog, newt, carp and sweetfish.</p>
キーワード central nervous system neurons negatively charged surface coats proteoglycans
Amo Type Article
発行日 1994-08
出版物タイトル Acta Medica Okayama
48巻
4号
出版者 Okayama University Medical School
開始ページ 195
終了ページ 197
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 7817774
Web of Sience KeyUT A1994PE51400004
著者 劉 晶潔| 大谷 修| 菊田 彰夫| 大塚 愛二| 田口 勇仁| 村上 宅郎| 佐能 正|
発行日 1988
出版物タイトル 岡山医学会雑誌
100巻
1-2号
資料タイプ 学術雑誌論文
著者 村上 宅郎| 田口 勇仁| 大塚 愛二|
発行日 1993-02-27
出版物タイトル 岡山医学会雑誌
105巻
1-2号
資料タイプ 学術雑誌論文
著者 村上 宅郎| 人見 さよ子| 佐藤 徹| 朴 大勛| 大塚 愛二| 田口 勇仁|
発行日 1996-06-29
出版物タイトル 岡山医学会雑誌
108巻
3-6号
資料タイプ 学術雑誌論文