ID | 31590 |
JaLCDOI | |
FullText URL | |
Author |
Segawa, Yoshihiko
Ohnoshi, Taisuke
Hiraki, Shunkichi
Ueoka, Hiroshi
Kamei, Haruhito
Tabata, Masahiro
Kaken ID
researchmap
Shibayama, Takuo
Miyatake, Kazuyo
Genda, ken-ichi
Matsumura, Tadashi
Kimura, Ikuro
|
Abstract | In an attempt to elucidate the tumor properties relating to responsiveness to chemotherapy, we examined immunohistochemically the expression of P-glycoprotein (P-gp) and carcinoembryonic antigen (CEA) in small cell lung cancer (SCLC) tumors. Tumor specimens from 33 patients were obtained at the time of diagnosis and relapse. Four patients expressed P-gp in their initial tumors, and 7 others did in recurrent tumors. The overall response rate to chemotherapy of the initial tumors was 75% for P-gp-positive initial tumors and 86% for P-gp-negative tumors, whereas the disease-free and overall survival times were significantly shorter in the former than the latter. Three patients showed CEA in their initial tumors, and 5 others did in recurrent tumors. The patients with CEA-positive initial tumors tended to relapse earlier than those with CEA-negative tumors. In addition, recurrent tumors expressing CEA were resistant to salvage chemotherapy. A clear correlation between CEA expression by tumors and the CEA level in the serum was observed at diagnosis as well as at relapse. These findings indicate that P-gp and/or CEA expression by a tumor and elevated CEA level in the serum may predict refractoriness of the tumor to chemotherapy. |
Keywords | small cell lung cancer
immunohistochemistry
drug resistance
P-glycoprotein
carcinoembryonic antigen
|
Amo Type | Article
|
Publication Title |
Acta Medica Okayama
|
Published Date | 1993-06
|
Volume | volume47
|
Issue | issue3
|
Publisher | Okayama University Medical School
|
Start Page | 181
|
End Page | 189
|
ISSN | 0386-300X
|
NCID | AA00508441
|
Content Type |
Journal Article
|
language |
English
|
File Version | publisher
|
Refereed |
True
|
PubMed ID | |
Web of Science KeyUT |