ID | 31590 |
JaLCDOI | |
フルテキストURL | |
著者 |
Segawa, Yoshihiko
Okayama Univresity
Ohnoshi, Taisuke
Okayama University
Hiraki, Shunkichi
Okayama Red Cross Hospital
Ueoka, Hiroshi
Okayama University
Kamei, Haruhito
Okayama University
Shibayama, Takuo
Okayama University
Miyatake, Kazuyo
Okayama University
Genda, ken-ichi
Okayama University
Matsumura, Tadashi
Okayama University
Kimura, Ikuro
Okayama University
|
抄録 | In an attempt to elucidate the tumor properties relating to responsiveness to chemotherapy, we examined immunohistochemically the expression of P-glycoprotein (P-gp) and carcinoembryonic antigen (CEA) in small cell lung cancer (SCLC) tumors. Tumor specimens from 33 patients were obtained at the time of diagnosis and relapse. Four patients expressed P-gp in their initial tumors, and 7 others did in recurrent tumors. The overall response rate to chemotherapy of the initial tumors was 75% for P-gp-positive initial tumors and 86% for P-gp-negative tumors, whereas the disease-free and overall survival times were significantly shorter in the former than the latter. Three patients showed CEA in their initial tumors, and 5 others did in recurrent tumors. The patients with CEA-positive initial tumors tended to relapse earlier than those with CEA-negative tumors. In addition, recurrent tumors expressing CEA were resistant to salvage chemotherapy. A clear correlation between CEA expression by tumors and the CEA level in the serum was observed at diagnosis as well as at relapse. These findings indicate that P-gp and/or CEA expression by a tumor and elevated CEA level in the serum may predict refractoriness of the tumor to chemotherapy. |
キーワード | small cell lung cancer
immunohistochemistry
drug resistance
P-glycoprotein
carcinoembryonic antigen
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1993-06
|
巻 | 47巻
|
号 | 3号
|
出版者 | Okayama University Medical School
|
開始ページ | 181
|
終了ページ | 189
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
Web of Science KeyUT |