ID | 31646 |
JaLCDOI | |
FullText URL | |
Author |
Kohka, Hideo
Iwagaki, Hiromi
Kobashi, Kenta
Saito, Shinnya
Isozaki, Hiroshi
Takakura, Norihisa
Tanaka, Noriaki
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Abstract | Corticoids are well known for their immunosuppressive properties. Interleukin-10 (IL-10) is an intrinsic antiinflammatory peptide in immune diseases, originally identified as cytokine synthesis inhibitory factor. We examined the effect of hydrocortisone sodium succinate (HSS) on the production of IL-10 by human peripheral blood mononuclear cells (PBMCs). PBMCs from healthy volunteers and cancer-burden patients were preincubated separately with or without HSS for 1 h, then stimulated with 5 microg/ml lipopolysaccharide (LPS). Production of IL-10 by human PBMCs was detected with LPS stimulation and its production was higher in cancer-burden patients than in normal volunteers, although this was not statistically significant. HSS suppressed production of IL-10 by LPS-stimulated PBMCs in a dose-dependent manner both in normal volunteers and in cancer-burden patients. These results indicate that, in addition to their antiinflammatory properties, corticoids act to restore the immunosuppressive states even in cancer-burden states |
Keywords | steroid
interleukin-10
cancer-burden state
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Amo Type | Article
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Publication Title |
Acta Medica Okayama
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Published Date | 1999-02
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Volume | volume53
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Issue | issue1
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Publisher | Okayama University Medical School
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Start Page | 55
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End Page | 59
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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File Version | publisher
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Refereed |
True
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Web of Science KeyUT |