ID | 31646 |
JaLCDOI | |
フルテキストURL | |
著者 |
Kohka, Hideo
Okayama University
Iwagaki, Hiromi
Okayama University
Kobashi, Kenta
Okayama University
Saito, Shinnya
Okayama University
Isozaki, Hiroshi
Okayama University
Takakura, Norihisa
Okayama University
Tanaka, Noriaki
Okayama University
|
抄録 | Corticoids are well known for their immunosuppressive properties. Interleukin-10 (IL-10) is an intrinsic antiinflammatory peptide in immune diseases, originally identified as cytokine synthesis inhibitory factor. We examined the effect of hydrocortisone sodium succinate (HSS) on the production of IL-10 by human peripheral blood mononuclear cells (PBMCs). PBMCs from healthy volunteers and cancer-burden patients were preincubated separately with or without HSS for 1 h, then stimulated with 5 microg/ml lipopolysaccharide (LPS). Production of IL-10 by human PBMCs was detected with LPS stimulation and its production was higher in cancer-burden patients than in normal volunteers, although this was not statistically significant. HSS suppressed production of IL-10 by LPS-stimulated PBMCs in a dose-dependent manner both in normal volunteers and in cancer-burden patients. These results indicate that, in addition to their antiinflammatory properties, corticoids act to restore the immunosuppressive states even in cancer-burden states |
キーワード | steroid
interleukin-10
cancer-burden state
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1999-02
|
巻 | 53巻
|
号 | 1号
|
出版者 | Okayama University Medical School
|
開始ページ | 55
|
終了ページ | 59
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
Web of Science KeyUT |