| JaLCDOI | 10.18926/14901 |
|---|---|
| Title Alternative | IgG4-related disease |
| FullText URL | 076_060_065.pdf |
| Author | Hiramatsu, Kazuhisa| Asano, Motoi| Matsushita, Koki| Miyoshi, Tomoko| Nakamura, Sukio| Mizushima, Takaaki| Koide, Norio| Kataoka, Hitomi| Ochi, Koji| Mitsunobu, Fumihiro| |
| Abstract | IgG4関連疾患は21世紀になって提唱された新しい疾患である｡組織学的にはIgG4陽性形質細胞やリンパ球浸潤が涙腺, 唾液腺, 後腹膜, 膵臓, 胆管などで起こり, 臨床的にはMikulicz病, 後腹膜線維症, 自己免疫膵炎, 糖尿病, 原発性硬化性胆管炎類似の胆管病変などを呈する全身性疾患であり, ステロイド治療に対する良好な反応性を認める｡その診断基準は確立されておらず, われわれは, ①血清IgG4の高値, ②本疾患に特徴的な臓器の障害(唾液腺,涙腺, 膵臓, 後腹膜), ③組織学的にIgG4陽性形質細胞とリンパ球の浸潤の確認, の３項目のうち２項目以上認めれば, IgG4関連疾患とするという診断基準を提言する｡ |
| Keywords | IgG4関連疾患 (IgG4-related disease) 自己免疫膵炎 (autoimmune pancreatitis) Mikulicz病 (Mikulicz's disease) 後腹膜線維症 (retroperitoneal fibrosis) |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2008-03-01 |
| Volume | volume76 |
| Start Page | 60 |
| End Page | 65 |
| ISSN | 1348-1258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308383 |
| JaLCDOI | 10.18926/14810 |
|---|---|
| Title Alternative | 6種類の血中膵酵素値に及ぼす加齢および性の影響 |
| FullText URL | 74_057_061.pdf |
| Author | Seno, Toshinobu| Ochi, Koji| Mizushima, Takaaki| Shinji, Toshiyuki| Koide, Norio| |
| Abstract | The serum levels of some pancreatic enzymes have been reported to be affected by age and gender. Currently, serum total amylase, pancreatic isoamylase (P-amylase) , lipase , trypsin (ogen) , pancreatic phospholipase A(2) (PLA(2)) , and elastase I are utilized in diagnosing pancreatic diseases. We here compared age and gender-related alterations of these six pancreatic enzymes in healthy subjects to delineate different properties among the enzymes. Subjects were 155 males and 172 females between ages 20 and 79 years who were apparently healthy, and were stratified by age and sex. PLA(2) and elastase I were assayed by RIA, trypsin (ogen) by EIA and others by activity. The pancreatic enzymes, except PLA(2), were significantly elevated with age, although they declined in males in the 260 age group. There were significant sex differences in total amylase and P-amylase. Total amylase was significantly higher in females than in males in the 260 age group, P-amylase in the 40-49 age group. Age should be considered in the valuation of serum enzymes except PLA(2), sex difference should be considered in the valuation of amylase (total and P-amylase). |
| Keywords | pancreatic enzyme amylase phospholipase A(2) aging gender |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2004-02-01 |
| Volume | volume74 |
| Start Page | 57 |
| End Page | 61 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308272 |
| JaLCDOI | 10.18926/14771 |
|---|---|
| Title Alternative | 食道痛細胞におけるWntのベータカテ二ンTCF経路の活性化の検討 |
| FullText URL | 73_075_080.pdf |
| Author | Mizushima, Takaaki| Ochi, Koji| Emori, Yasuyuki| Tanioka, Hiroaki| Sawa, Kiminari| Fujioka, Shinichi| Shinji, Toshiyuki| Koide, Norio| Tanizaki, Yoshiro| |
| Abstract | Although, accumulation of nuclear and cytoplasmic beta-catenin has been observed in ESCCs, mutation of APC and beta-catenin are not found in ESCCs. Therefore, another mechanism for cytoplasmic beta- catenin accumulation might exist in ESCCs. Materials and Methods: Human ESCCs cell lines and the 293 stable transfectants expressing Wnt-1, Wnt-5A, and Wnt-7A were cultured under standard conditions. The TOPFlash or FOPFlash reporter plasmids were transfected. Results: Transfected mutant beta-catenin as well as an axin fragment harbing the GSK3 beta interaction domain, the latter a potent GSK3 beta inhibitor. both robustly activated pTOPFlash in ESCCs cells. When pTOPFlash/pFOPFlash reporters were transfected in ESCCs cell lines followed by cocultivation with 293 cells that stably express Wnt -1, all cell lines except one demonstrated TCF mediated transcriptional. But, cells were co- cultured, Wnt - 7A or Wnt - 5A did not activate TCF mediated transcription in a cell number dependent fashion. Discussion; We report the activation of TCF promoter gene by extemal Wnt stimuli in ESCCs cells. |
| Keywords | esophageal carcinoma Wnt TCF beta-catenin |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 75 |
| End Page | 80 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308224 |
| Author | 水島 孝明| |
|---|---|
| Published Date | 1998-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
